Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages

Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppression through multiple cell intrinsic mechanisms. However, release of extracellular vesicle...

Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Stoyan Tankov, Marija Petrovic, Marc Lecoultre, Felipe Espinoza, Nadia El-Harane, Viviane Bes, Sylvie Chliate, Darel Martinez Bedoya, Olivier Jordan, Gerrit Borchard, Denis Migliorini, Val érie Dutoit and Paul R. Walker Tags: Research Source Type: research