p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling. Although the abnormalities are primarily prompt... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 2, 2023 Category: Molecular Biology Authors: Ali Ahmadi, Sajjad Ahrari, Jafar Salimian, Zahra Salehi, Mehrdad Karimi, Alireza Emamvirdizadeh, Sadegh Azimzadeh Jamalkandi and Mostafa Ghanei Tags: Review Source Type: research
Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential
Cells have been increasingly known to release extracellular vesicles (EVs) to the extracellular environment under physiological and pathological conditions. A plethora of studies have revealed that EVs contain... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 31, 2023 Category: Molecular Biology Authors: Wenxiu Liu, Meiqi Jin, Qiuyan Chen, Qiaoyu Li, Xiaoyan Xing, Yun Luo and Xiaobo Sun Tags: Review Source Type: research
Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction
Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, account for a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial dysfunction is the initial and ro... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 30, 2023 Category: Molecular Biology Authors: Chongxiang Xue, Keyu Chen, Zezheng Gao, Tingting Bao, LiShuo Dong, Linhua Zhao, Xiaolin Tong and Xiuyang Li Tags: Review Source Type: research
Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inherita... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 30, 2023 Category: Molecular Biology Authors: Juan Du, Tianyi Huang, Zhen Zheng, Shuai Fang, Hongxia Deng and Kaitai Liu Tags: Review Source Type: research
The destruction of mucosal barriers, epithelial remodeling, and impaired mucociliary clearance: possible pathogenic mechanisms of Pseudomonas aeruginosa and Staphylococcus aureus in chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a pathological condition characterized by persistent inflammation in the upper respiratory tract and paranasal sinuses. The epithelium serves as the first line of defense agains... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 30, 2023 Category: Molecular Biology Authors: Zahra Chegini, Milad Noei, Jaber Hemmati, Mohammad Reza Arabestani and Aref Shariati Tags: Review Source Type: research
Intracellular remodeling associated with endoplasmic reticulum stress modifies biomechanical compliance of bladder cells
Bladder cells face a challenging biophysical environment: mechanical cues originating from urine flow and regular contraction to enable the filling voiding of the organ. To ensure functional adaption, bladder ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 30, 2023 Category: Molecular Biology Authors: Livia Gruber, Maximilian Jobst, Endre Kiss, Martina Karasov á, Bernhard Englinger, Walter Berger and Giorgia Del Favero Tags: Research Source Type: research
Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress
Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 30, 2023 Category: Molecular Biology Authors: Yan Peng, Rongmei Qu, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Wenqing Liu, Jinhui Zhu, Junxin Chen, Xiaoqing Li, Jingxing Dai and Jun Ouyang Tags: Research Source Type: research
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC
When ectopically overexpressed, anticancer genes, such as TRAIL, PAR4 and ORCTL3, specifically destroy tumour cells without harming untransformed cells. Anticancer genes can not only serve as powerful tumour spec... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 20, 2023 Category: Molecular Biology Authors: Motasim Masood, Qize Ding, Adam D. Cawte, David S. Rueda, Stefan W. Grimm, Ernesto Yag üe and Mona El-Bahrawy Tags: Research Source Type: research
Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway
Exosomes are small extracellular vesicles that play important roles in intercellular communication and have potential therapeutic applications in regenerative medicine. Dermal mesenchymal stem cells (DMSCs) ar... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 20, 2023 Category: Molecular Biology Authors: Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun and Taeho Kwon Tags: Research Source Type: research
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
E. coli O83 (Colinfant Newborn) is a Gram-negative (G-) probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration offer... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 20, 2023 Category: Molecular Biology Authors: Anna Marlene Schmid, Agnieszka Razim, Magdalena Wysmo łek, Daniela Kerekes, Melissa Haunstetter, Paul Kohl, Georgii Brazhnikov, Nora Geissler, Michael Thaler, Eliška Krčmářová, Martin Šindelář, Tamara Weinmayer, Jiří Hrdý, Katy Schmidt, Peter Tags: Research Source Type: research
NF- κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF- κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and dri... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Amy Oh, Makayla Pardo, Anaelena Rodriguez, Connie Yu, Lisa Nguyen, Olin Liang, Anna Chorzalska and Patrycja M. Dubielecka Tags: Review Source Type: research
Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma
Hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis among all head-and-neck cancers, and treatment options are limited. Tumor microenvironment (TME) analysis can help identify new therapeuti... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Zhimou Cai, Lin Chen, Siyu Chen, Ruihua Fang, Xiaolin Chen and Wenbin Lei Tags: Research Source Type: research
Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation
Macrophage filopodia, which are dynamic nanotube-like protrusions, have mainly been studied in the context of pathogen clearance. The mechanisms by which they facilitate intercellular communication and mediate... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Xiaodong Zhu, Yu Zhao, Yuqiu Liu, Wen Shi, Junlan Yang, Zhihong Liu and Xiaoliang Zhang Tags: Research Source Type: research
Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism
Adrenal gland is the synthesis and secretion organ of glucocorticoid, which is crucial to fetal development and postnatal fate. Recently, we found that prenatal dexamethasone exposure (PDE) could cause adrenal... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Zheng He, Jinzhi Zhang, Yawen Chen, Can Ai, Xiaohan Gong, Dan Xu and Hui Wang Tags: Research Source Type: research
Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension
Familial hyperkalemic hypertension (FHHt), also known as Pseudohypoaldosteronism type II (PHAII) or Gordon syndrome is a rare Mendelian disease classically characterized by hyperkalemia, hyperchloremic metabol... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 16, 2023 Category: Molecular Biology Authors: Prashant Sharma and Harish E. Chatrathi Tags: Review Source Type: research
