Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination
Synaptosomal-associated protein 25 (SNAP25) exerts protective effects against postoperative cognitive dysfunction (POCD) by promoting PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy and repressing casp... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 15, 2023 Category: Molecular Biology Authors: Wei Wang, Wenwei Gao, Ping Gong, Wenqin Song, Xueshan Bu, Jiabao Hou, Lei Zhang and Bo Zhao Tags: Research Source Type: research
Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis
Type 2 diabetes mellitus (T2DM) induced diabetes-associated cognitive dysfunction (DACD) that seriously affects the self-management of T2DM patients, is currently one of the most severe T2DM-associated complic... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 15, 2023 Category: Molecular Biology Authors: Wenxin Tang, Chaoying Yan, Shuxuan He, Mengyu Du, Bo Cheng, Bin Deng, Shan Zhu, Yansong Li and Qiang Wang Tags: Research Source Type: research
Molecular pathways in the development of HPV-induced oropharyngeal cancer
Oropharyngeal cancer, a subset of head and neck cancer, is increasingly recognized as a unique clinical entity primarily influenced by high-risk human papillomavirus (HPV) infections, particularly HPV-16. This... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 14, 2023 Category: Molecular Biology Authors: Muhammad Ikram Ullah, Maria V. Mikhailova, Ali G. Alkhathami, Nestor Cuba Carbajal, Manuel Enrique Chenet Zuta, Irodakhon Rasulova, Mazin A. A. Najm, Munther Abosoda, Ali Alsalamy and Mahamedha Deorari Tags: Review Source Type: research
An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor
Viruses communicate with their hosts through interactions with proteins, lipids, and carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via receptor-mediated endocytosis. Ma... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 14, 2023 Category: Molecular Biology Authors: Irfan Ahmad, Seyede Narges Fatemi, Mohammad Ghaheri, Ali Rezvani, Dorsa Azizi Khezri, Mohammad Natami, Saman Yasamineh, Omid Gholizadeh and Zahra Bahmanyar Tags: Review Source Type: research
YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications
Yes-associated protein (YAP) is a pivotal regulator in cellular proliferation, survival, differentiation, and migration, with significant roles in embryonic development, tissue repair, and tumorigenesis. At th... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 14, 2023 Category: Molecular Biology Authors: Qimei Lin, Jiasong Cao, Jing Yu, Yu Zhu, Yongmei Shen, Shuqi Wang, Yixin Wang, Zhen Liu and Ying Chang Tags: Review Source Type: research
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 6, 2023 Category: Molecular Biology Authors: Anna Marlene Schmid, Agnieszka Razim, Magdalena Wysmo łek, Daniela Kerekes, Melissa Haunstetter, Paul Kohl, Georgii Brazhnikov, Nora Geissler, Michael Thaler, Eliška Krčmářová, Martin Šindelář, Tamara Weinmayer, Jiří Hrdý, Katy Schmidt, Peter Tags: Correction Source Type: research
Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwide. Lung cancer treatment options primarily rely on chemoradiotherapy, surgery, targeted... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 6, 2023 Category: Molecular Biology Authors: Huihui Li, Zexin Chen, Ning Chen, Yun Fan, Yaping Xu and Xiaoling Xu Tags: Review Source Type: research
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
This study aimed to identify an orcl1 mutation in a patient with Dent-2 Disease and investigate the underlying mechanisms. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 5, 2023 Category: Molecular Biology Authors: Limin Huang, Yingying Zhang, Haidong Fu, Weizhong Gu and Jianhua Mao Tags: Research Source Type: research
New insights into the stemness of adoptively transferred T cells by γc family cytokines
T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in hematologic malignancies. It relie... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 4, 2023 Category: Molecular Biology Authors: Mengshi Luo, Wenjian Gong, Yuewen Zhang, Huayi Li, Ding Ma, Kongming Wu, Qinglei Gao and Yong Fang Tags: Review Source Type: research
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, and post-transla... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 4, 2023 Category: Molecular Biology Authors: Mengjuan Xuan, Xinyu Gu, Juan Li, Di Huang, Chen Xue and Yuting He Tags: Review Source Type: research
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewe... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Lei Yu, Yi Wei, Tong Lu, Zhengqi Li, Shimin Lai, Yan Yan, Changhui Chen and Weiping Wen Tags: Research Source Type: research
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in G αs-Gαi coupling to the β2-adrenergic receptor
In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate (cAMP) concentration through Gαs coupling, but interestingly, β2A... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 30, 2023 Category: Molecular Biology Authors: Mingli Ge, Li Wu, Feng He, Yu Tai, Ruhong Fang, Dafei Han, Paipai Guo, Hao Liu, Yong Hu, Shenglin Xu, Wei Wei and Qingtong Wang Tags: Research Source Type: research
Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators. Accumulating evidence points to interactions between NK cells ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 29, 2023 Category: Molecular Biology Authors: Zhiyuan Ning, Ying Liu, Daji Guo, Wei-Jye Lin and Yamei Tang Tags: Review Source Type: research
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require life-long treatment due to leukaemic stem cell (LSC) persistence. LSCs reside in the b... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 29, 2023 Category: Molecular Biology Authors: Caroline Busch, Theresa Mulholland, Michele Zagnoni, Matthew Dalby, Catherine Berry and Helen Wheadon Tags: Research Source Type: research
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regulating cell cycle, cell proliferation, and intracellular substance metabolism. Piwi-inte... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 29, 2023 Category: Molecular Biology Authors: Zeyu Wu, Xiao Yu, Shuijun Zhang, Yuting He and Wenzhi Guo Tags: Review Source Type: research
