EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia
The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, we demonstrated that EP300-ZNF384 substantially induces the transcription of IL3RA and the... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 2, 2024 Category: Molecular Biology Authors: Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang, Fanzhi Yan, Wentao Sun, Wenjuan Zhang, Qingqing Zhang, Xihui Fu, Zhenghui Lang, Chenyang Chu, Boyang Zou, Beibei Gao, Bilian Jin, Zhijie Kang, Quentin Liu & hellip; Tags: Research Source Type: research
Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma
Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems. In China, the primary risk factor for HC... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 1, 2024 Category: Molecular Biology Authors: Zhuo Li, Na Zhang, Zewen Dong, Xin Wang, Jian Zhou, Juan Gao, Yunyun Yang, Jing Li, Feng Guan, Yue Zhou and Zengqi Tan Tags: Research Source Type: research
Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis
KIFC3 is a member of Kinesin-14 family motor proteins, which play a variety of roles such as centrosome cohesion, cytokinesis, vesicles transportation and cell proliferation in mitosis. Here, we investigated t... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 29, 2024 Category: Molecular Biology Authors: Jia-Qian Ju, Hao-Lin Zhang, Yue Wang, Lin-Lin Hu and Shao-Chen Sun Tags: Research Source Type: research
High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer
In normal colon tissue, oestrogen receptor alpha (ER α) is expressed at low levels, while oestrogen receptor beta (ERβ) is considered the dominant subtype. However, in colon carcinomas, the ERα/β ratio is often... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Geriolda Topi, Shakti Ranjan Satapathy, Souvik Ghatak, Karin Hellman, Fredrik Ek, Roger Olsson, Roy Ehrnstr öm, Marie-Louise Lydrup and Anita Sjölander Tags: Research Source Type: research
M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment
Macrophages release not only cytokines but also extracellular vesicles (EVs). which are small membrane-derived nanovesicles with virus-like properties transferring cellular material between cells. Until now, t... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 27, 2024 Category: Molecular Biology Authors: Stefano Tacconi, Francesco Vari, Carolina Sbarigia, Diana Vardanyan, Serena Longo, Francesco Mura, Federica Angil è, Audrey Jalabert, Ferninand Blangero, Assia Eljaafari, Laurence Canaple, Daniele Vergara, Francesco Paolo Fanizzi, Marco Rossi, Claire Cro Tags: Research Source Type: research
Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1
Chemoresistance is associated with tumor relapse and unfavorable prognosis. Multiple mechanisms underlying chemoresistance have been elucidated, including stemness and DNA damage repair. Here, the involvement ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 27, 2024 Category: Molecular Biology Authors: Yuhong Xia, Shan Wang, Yu Sun, Wei Wang, Shijie Chang, Zhongbo Zhang and Chenghai Zhao Tags: Research Source Type: research
Rolapitant treats lung cancer by targeting deubiquitinase OTUD3
Lung cancer is cancer with the highest morbidity and mortality in the world and poses a serious threat to human health. Therefore, discovering new treatments is urgently needed to improve lung cancer prognosis... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 27, 2024 Category: Molecular Biology Authors: Tongde Du, Quan Gu, Yonghui Zhang, Yujie Gan, Rongrui Liang, Wenzhu Yang, Ya Lu, Chenxin Xu, Jianzhong Wu, Rong Ma, Haixia Cao, Jingwei Jiang, Juan Wang and Jifeng Feng Tags: Research Source Type: research
Polyploidy and mTOR signaling: a possible molecular link
Polyploidy is typically described as the condition wherein a cell or organism has more than two complete sets of chromosomes. Occurrence of polyploidy is a naturally occurring phenomenon in the body ’s developm... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 27, 2024 Category: Molecular Biology Authors: Debopriya Choudhury, Dhruba Ghosh, Meghna Mondal, Didhiti Singha, Ramesh Pothuraju and Pushkar Malakar Tags: Review Source Type: research
From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy
Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge. Currently, there is no effective treatm... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 27, 2024 Category: Molecular Biology Authors: R. J. A. Veltrop, M. M. Kukk, K. Topouzidou, L. Didden, A. Muchir, F. G. van Steenbeek, L. J. Schurgers and M. Harakalova Tags: Review Source Type: research
Correction: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 26, 2024 Category: Molecular Biology Authors: Tao Jiang, Hao Xiao, Bin Li, Hangyuan He, Hui Wang and Liaobin Chen Tags: Correction Source Type: research
Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF- κB signaling in diabetic kidney disease
The incidence of diabetic kidney disease (DKD) continues to rapidly increase, with limited available treatment options. One of the hallmarks of DKD is persistent inflammation, but the underlying molecular mech... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 25, 2024 Category: Molecular Biology Authors: Siyuan Cui, Xin Chen, Jiayu Li, Wei Wang, Deqi Meng, Shenglong Zhu and Shiwei Shen Tags: Research Source Type: research
Tumor-derived miR-6794-5p enhances cancer growth by promoting M2 macrophage polarization
Solid tumors promote tumor malignancy through interaction with the tumor microenvironment, resulting in difficulties in tumor treatment. Therefore, it is necessary to understand the communication between cells... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 23, 2024 Category: Molecular Biology Authors: Jae Yeon Choi, Hyun Jeong Seok, Dong Hyeon Lee, Eunju Lee, Tae-Jin Kim, Sangwoo Bae, Incheol Shin and In Hwa Bae Tags: Research Source Type: research
Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances
Methicillin-resistant Staphylococcus aureus (MRSA) represents a global threat, necessitating the development of effective solutions to combat this emerging superbug. In response to selective pressures within heal... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 22, 2024 Category: Molecular Biology Authors: Nirmeen Aboelnaga, Salma W. Elsayed, Nehal Adel Abdelsalam, Salma Salem, Nehal A. Saif, Manar Elsayed, Shehab Ayman, Maha Nasr and Mohamed Elhadidy Tags: Review Source Type: research
Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis
The proinflammatory cytokines and arachidonic acid (AA)-derived eicosanoids play a key role in cartilage degeneration in osteoarthritis (OA). The lysophosphatidylcholine acyltransferase 3 (LPCAT3) preferential... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 22, 2024 Category: Molecular Biology Authors: Vijay Kondreddy, Rajkumar Banerjee, B. L. A. Prabhavathi Devi, Kathirvel Muralidharan and Selvakumar Piramanayagam Tags: Research Source Type: research
Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry
Calcium (Ca2+) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via calcium release-activated calcium (CRAC) channels rep... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 21, 2024 Category: Molecular Biology Authors: Vikas Bhuria, Tobias Franz, Conny Baldauf, Martin B öttcher, Nicolas Chatain, Steffen Koschmieder, Tim H. Brümmendorf, Dimitrios Mougiakakos, Burkhart Schraven, Sascha Kahlfuß and Thomas Fischer Tags: Research Source Type: research
