The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage
Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2 macrophages playing a crucial role in this progression. The ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Min Pu, Jing Zhang, Fuyan Hong, Yan Wang, Chengwei Zhang, Yongcheng Zeng, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao and Ti Zhou Tags: Research Source Type: research
Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields
Every single cell can communicate with other cells in a paracrine manner via the production of nano-sized extracellular vesicles. This phenomenon is conserved between prokaryotic and eukaryotic cells. In eukar... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Halimeh Mobarak, Farzin Javid, Maryam Taghavi Narmi, Narges Mardi, Fatemeh Sadeghsoltani, Parisa Khanicheragh, Samaneh Narimani, Mahdi Mahdipour, Emel Sokullu, Ferzane Valioglu and Reza Rahbarghazi Tags: Review Source Type: research
IL13R α2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway
Previous research has revealed that the 18 glycoside hydrolase gene family (GH18) member Chitinase 3-like 1 (Chi3l1) can regulate osteoclast differentiation and bone resorption. However, its downstream recepto... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Weifeng Xu, Rui Chao, Xinru Xie, Yi Mao, Xinwei Chen, Xuzhuo Chen and Shanyong Zhang Tags: Research Source Type: research
Pediococcus acidilactici reduces tau pathology and ameliorates behavioral deficits in models of neurodegenerative disorders
Alzheimer ’s disease (AD), affecting many elders worldwide, is characterized by A-beta and tau-related cognitive decline. Accumulating evidence suggests that brain iron accumulation is an important characterist... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Yong Zhang, Weiyi Qian, Yitong Zhang, Yan Ma, Jiamin Qian, Jinping Li, Xun Wei, Yan Long and Xiangyuan Wan Tags: Research Source Type: research
K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3
K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hype... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Rebekka Gei ßert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J. Smit, Manfred Jücker, Andre Menke and Klaudia Giehl Tags: Research Source Type: research
Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson ’s disease
Parkinson ’s disease (PD), a chronic and severe neurodegenerative disease, is pathologically characterized by the selective loss of nigrostriatal dopaminergic neurons. Dopamine (DA), the neurotransmitter produc... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 29, 2024 Category: Molecular Biology Authors: Bing Chen, Qian Zhang, Xiaoru Zhong, Xinwei Zhang, Xin Liu, Hongyang Wang, Fan Yang, Jingjing Zhang, Jingnan Huang, Yin-Kwan Wong, Piao Luo, Jigang Wang and Jichao Sun Tags: Research Source Type: research
PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia
The crosstalk between astrocytes and microglia plays a pivotal role in neuroinflammation following ischemic stroke, and phenotypic distribution of these cells can change with the progression of ischemic stroke... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 29, 2024 Category: Molecular Biology Authors: Li Peng, Yanyan Ji, Yixin Li, Yan You and Yang Zhou Tags: Research Source Type: research
Integrin β-1 in disorders and cancers: molecular mechanisms and therapeutic targets
Integrin β-1 (ITGB1) is a crucial member of the transmembrane glycoprotein signaling receptor family and is also central to the integrin family. It forms heterodimers with other ligands, participates in intrace... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 26, 2024 Category: Molecular Biology Authors: Chen Su, Jie Mo, Shuilin Dong, Zhibin Liao, Bixiang Zhang and Peng Zhu Tags: Review Source Type: research
14 –3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer
Over the past decade, the role of the 14 –3-3 protein has received increasing interest. Seven subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its specificity. The 14–3-3ε prot... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 26, 2024 Category: Molecular Biology Authors: Yue Zhang, Man Yan, Yongjun Yu, Jiangping Wang, Yuqi Jiao, Minying Zheng and Shiwu Zhang Tags: Review Source Type: research
Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage
The functions of macrophages are governed by distinct polarization phenotypes, which can be categorized as either anti-tumor/M1 type or pro-tumor/M2 type. Glycosylation is known to play a crucial role in vario... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 26, 2024 Category: Molecular Biology Authors: Xin He, Bowen Wang, Wenli Deng, Jinhua Cao, Zengqi Tan, Xiang Li and Feng Guan Tags: Research Source Type: research
Macrophage barrier in the tumor microenvironment and potential clinical applications
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a diverse array of immune cells and stromal components. Within this intricate context, tumor-associated macrophages (TAMs) exh... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 26, 2024 Category: Molecular Biology Authors: Shuai Ji, Yuqing Shi and Bo Yin Tags: Review Source Type: research
Targeting the macrophage immunocheckpoint: a novel insight into solid tumor immunotherapy
Tumor immunotherapy, which targets immune checkpoints, presents a promising strategy for the treatment of various cancer types. However, current clinical data indicate challenges in its application to solid tu... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 25, 2024 Category: Molecular Biology Authors: Bei Zhou, Yan Yang, Yan Kang, Jingjing Hou and Yun Yang Tags: Review Source Type: research
Copper nanoparticles and silver nanoparticles impair lymphangiogenesis in zebrafish
Lymphatic system distributes in almost all vertebrate tissues and organs, and plays important roles in the regulation of body fluid balance, lipid absorption and immune monitoring. Although CuNPs or AgNPs accu... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 25, 2024 Category: Molecular Biology Authors: YuanYuan Jing, ZhiPeng Tai and Jing-Xia Liu Tags: Research Source Type: research
The oncogenic mechanisms of the Janus kinase-signal transducer and activator of transcription pathway in digestive tract tumors
Digestive tract tumors are heterogeneous and involve the dysregulation of multiple signaling pathways. The Janus kinase-signal transducer and activator of transcription (JAK –STAT) pathway plays a notable role ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 25, 2024 Category: Molecular Biology Authors: Ruihong Zhao, Zhangmin Hu, Xiaoli Zhang, Shujuan Huang, Guodong Yu, Zhe Wu, Wei Yu, Juan Lu and Bing Ruan Tags: Review Source Type: research
Intratumoral microorganisms in tumors of the digestive system
Tumors of the digestive system pose a significant threat to human health and longevity. These tumors are associated with high morbidity and mortality rates, leading to a heavy economic burden on healthcare sys... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 25, 2024 Category: Molecular Biology Authors: Mengjuan Xuan, Xinyu Gu, Yingru Liu, Li Yang, Yi Li, Di Huang, Juan Li and Chen Xue Tags: Review Source Type: research
