Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages
Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppression through multiple cell intrinsic mechanisms. However, release of extracellular vesicle... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Stoyan Tankov, Marija Petrovic, Marc Lecoultre, Felipe Espinoza, Nadia El-Harane, Viviane Bes, Sylvie Chliate, Darel Martinez Bedoya, Olivier Jordan, Gerrit Borchard, Denis Migliorini, Val érie Dutoit and Paul R. Walker Tags: Research Source Type: research
CD73 mitigates ZEB1 expression in papillary thyroid carcinoma
ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. S... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Samlai Vedovatto, Fernanda Dittrich Oliveira, Luiza Cherobini Pereira, Thamiris Becker Scheffel, Liziane Raquel Beckenkamp, Ana Paula Santin Bertoni, M árcia Rosângela Wink and Guido Lenz Tags: Research Source Type: research
Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis
Paraquat (PQ) is an irreplaceable insecticide in many countries for the advantage of fast-acting and broad-spectrum. However, PQ was classified as the most prevailing poisoning substance for suicide with no sp... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Jing Du, Lingyan Yu, Xinyi Yang, Fangchun Shao, Jun Xia, Weidong Jin, Yinhao Zhang, Guojie Lei, Ying Wang, Yanchun Li and Jun Zhang Tags: Research Source Type: research
Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer ’s disease
Patients with Alzheimer ’s disease (AD) are often co-morbid with unprovoked seizures, making clinical diagnosis and management difficult. Although it has an important role in both AD and epilepsy, abnormal γ-am... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Rui Mao, Mengsha Hu, Xuan Liu, Lei Ye, Bingsong Xu, Min Sun, Siyi Xu, Wenxuan Shao, Yi Tan, Yun Xu, Feng Bai and Shu Shu Tags: Research Source Type: research
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream sig... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Mol Tags: Research Source Type: research
TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions
Calcium is a ubiquitous intracellular messenger that regulates the expression of various genes involved in cell proliferation, differentiation, and motility. The involvement of calcium in diverse metabolic pat... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Laxman Manandhar, Raghbendra Kumar Dutta, Pradeep Devkota, Arun Chhetri, Xiaofan Wei, Channy Park, Hyug Moo Kwon and Raekil Park Tags: Research Source Type: research
Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This proce... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Xi Wang, Jiameng Liu, Chaoming Mao and Yufei Mao Tags: Review Source Type: research
Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2024 Category: Molecular Biology Authors: Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang and Gang Liu Tags: Research Source Type: research
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to tumorigenic effects. However, the m... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2024 Category: Molecular Biology Authors: Jie Jia, Lianhui Zhu, Xihua Yue, Shuocheng Tang, Shuaiyang Jing, Chuanting Tan, Yulei Du, Jingkai Gao, Intaek Lee and Yi Qian Tags: Research Source Type: research
Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1
Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and specific underlying mechanisms of action remain unclear. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Hui Luo, Ning Liu and Chao Lin Tags: Research Source Type: research
High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes
Ovarian stimulation (OS) during assisted reproductive technology (ART) appears to be an independent factor influencing the risk of low birth weight (LBW). Previous studies identified the association between LB... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Xueyan Lu, Jiaqin Mao, Chenxi Qian, Hui Lei, Fei Mu, Huijun Sun, Song Yan, Zheng Fang, Jie Lu, Qian Xu, Jie Dong, Danjie Su, Jingjing Wang, Ni Jin, Shuqiang Chen and Xiaohong Wang Tags: Research Source Type: research
Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review
Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwide. It is characterized by proteinuria, glomerular damage, and renal fibrosis, leading t... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Shiwan Hu, Xing Hang, Yu Wei, Han Wang, Lili Zhang and Linhua Zhao Tags: Review Source Type: research
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes, and is mediated by over 520 protein kinases in humans and other mammals... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Brian G. Poll, Kirby T. Leo, Venky Deshpande, Nipun Jayatissa, Trairak Pisitkun, Euijung Park, Chin-Rang Yang, Viswanathan Raghuram and Mark A. Knepper Tags: Research Source Type: research
Liquid plasma promotes angiogenesis through upregulation of endothelial nitric oxide synthase-induced extracellular matrix metabolism: potential applications of liquid plasma for vascular injuries
Applications of nonthermal plasma have expanded beyond the biomedical field to include antibacterial, anti-inflammatory, wound healing, and tissue regeneration. Plasma enhances epithelial cell repair; however,... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Sung Un Kang, Haeng Jun Kim, Sukhwal Ma, Doo-Yi Oh, Jeon Yeob Jang, Chorong Seo, Yun Sang Lee and Chul-Ho Kim Tags: Research Source Type: research
Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the e... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 17, 2024 Category: Molecular Biology Authors: Xiaotong Xu, Yi Han, Binlong Zhang, Quanzhong Ren, Juan Ma and Sijin Liu Tags: Review Source Type: research
