Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This proce... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Xi Wang, Jiameng Liu, Chaoming Mao and Yufei Mao Tags: Review Source Type: research
Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2024 Category: Molecular Biology Authors: Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang and Gang Liu Tags: Research Source Type: research
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to tumorigenic effects. However, the m... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2024 Category: Molecular Biology Authors: Jie Jia, Lianhui Zhu, Xihua Yue, Shuocheng Tang, Shuaiyang Jing, Chuanting Tan, Yulei Du, Jingkai Gao, Intaek Lee and Yi Qian Tags: Research Source Type: research
Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1
Although the neurotransmitter dopamine (DA) plays a crucial pathophysiologic role after traumatic brain injury (TBI), its function and specific underlying mechanisms of action remain unclear. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Hui Luo, Ning Liu and Chao Lin Tags: Research Source Type: research
High estrogen during ovarian stimulation induced loss of maternal imprinted methylation that is essential for placental development via overexpression of TET2 in mouse oocytes
Ovarian stimulation (OS) during assisted reproductive technology (ART) appears to be an independent factor influencing the risk of low birth weight (LBW). Previous studies identified the association between LB... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Xueyan Lu, Jiaqin Mao, Chenxi Qian, Hui Lei, Fei Mu, Huijun Sun, Song Yan, Zheng Fang, Jie Lu, Qian Xu, Jie Dong, Danjie Su, Jingjing Wang, Ni Jin, Shuqiang Chen and Xiaohong Wang Tags: Research Source Type: research
Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review
Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwide. It is characterized by proteinuria, glomerular damage, and renal fibrosis, leading t... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Shiwan Hu, Xing Hang, Yu Wei, Han Wang, Lili Zhang and Linhua Zhao Tags: Review Source Type: research
A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
Protein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes, and is mediated by over 520 protein kinases in humans and other mammals... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Brian G. Poll, Kirby T. Leo, Venky Deshpande, Nipun Jayatissa, Trairak Pisitkun, Euijung Park, Chin-Rang Yang, Viswanathan Raghuram and Mark A. Knepper Tags: Research Source Type: research
Liquid plasma promotes angiogenesis through upregulation of endothelial nitric oxide synthase-induced extracellular matrix metabolism: potential applications of liquid plasma for vascular injuries
Applications of nonthermal plasma have expanded beyond the biomedical field to include antibacterial, anti-inflammatory, wound healing, and tissue regeneration. Plasma enhances epithelial cell repair; however,... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 19, 2024 Category: Molecular Biology Authors: Sung Un Kang, Haeng Jun Kim, Sukhwal Ma, Doo-Yi Oh, Jeon Yeob Jang, Chorong Seo, Yun Sang Lee and Chul-Ho Kim Tags: Research Source Type: research
Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the e... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 17, 2024 Category: Molecular Biology Authors: Xiaotong Xu, Yi Han, Binlong Zhang, Quanzhong Ren, Juan Ma and Sijin Liu Tags: Review Source Type: research
Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines
Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments. A better understanding of PDAC biology will he... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 17, 2024 Category: Molecular Biology Authors: Sandy Anania, Martin Farnir, Rapha ël Peiffer, Yasmine Boumahd, Marc Thiry, Ferman Agirman, Naima Maloujahmoum, Akeila Bellahcène and Olivier Peulen Tags: Research Source Type: research
The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy
Malignant tumours seriously threaten human life and health, and effective treatments for cancer are still being explored. The ability of SHC SH2 domain-binding protein 1 (SHCBP1) to induce cell cycle disturban... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 16, 2024 Category: Molecular Biology Authors: Mei Zhou, Limin Duan, Jiangbin Chen, Yumei Li, Zhengrong Yin, Siwei Song, Yaqi Cao, Ping Luo, Fan Hu, Guanghai Yang, Juanjuan Xu, Tingting Liao and Yang Jin Tags: Research Source Type: research
TGF β1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli
Meningitic Escherichia coli (E. coli) is the major etiological agent of bacterial meningitis, a life-threatening infectious disease with severe neurological sequelae and high mortality. The major cause of central... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2024 Category: Molecular Biology Authors: Jinrui Sun, Ruicheng Yang, Jiyang Fu, Dong Huo, Xinyi Qu, Chen Tan, Huanchun Chen and Xiangru Wang Tags: Research Source Type: research
Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration
Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative stress and promoting cell differentiation. The interaction be... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2024 Category: Molecular Biology Authors: Yan Wu, Luxin Li, Zuojun Ning, Changrong Li, Yongkui Yin, Kaiyuan Chen, Lu Li, Fei Xu and Jie Gao Tags: Review Source Type: research
COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches
Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated with more severe outcomes among patients living w... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2024 Category: Molecular Biology Authors: Sareh Kakavandi, Bahareh Hajikhani, Paniz Azizi, Fatemeh Aziziyan, Mohsen Nabi-Afjadi, Marzieh Ramezani Farani, Hamidreza Zalpoor, Maryam Azarian, Mahdiyar Iravani Saadi, Behrouz Gharesi-Fard, Evangelos Terpos, Iman Zare and Mohammad Motamedifar Tags: Review Source Type: research
Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF- β signaling responses in ovarian cancer
In pathologies including cancer, aberrant Transforming Growth Factor- β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathw... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2024 Category: Molecular Biology Authors: Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee & hellip; Tags: Research Source Type: research
