Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF- β signaling responses in ovarian cancer

In pathologies including cancer, aberrant Transforming Growth Factor- β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathw...

Source: Cell Communication and Signaling - February 15, 2024 Category: Molecular Biology Authors: Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee & hellip; Tags: Research Source Type: research