Peroxiredoxin II regulates exosome secretion from dermal mesenchymal stem cells through the ISGylation signaling pathway
Exosomes are small extracellular vesicles that play important roles in intercellular communication and have potential therapeutic applications in regenerative medicine. Dermal mesenchymal stem cells (DMSCs) ar... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 20, 2023 Category: Molecular Biology Authors: Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun and Taeho Kwon Tags: Research Source Type: research
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
E. coli O83 (Colinfant Newborn) is a Gram-negative (G-) probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration offer... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 20, 2023 Category: Molecular Biology Authors: Anna Marlene Schmid, Agnieszka Razim, Magdalena Wysmo łek, Daniela Kerekes, Melissa Haunstetter, Paul Kohl, Georgii Brazhnikov, Nora Geissler, Michael Thaler, Eliška Krčmářová, Martin Šindelář, Tamara Weinmayer, Jiří Hrdý, Katy Schmidt, Peter Tags: Research Source Type: research
NF- κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF- κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant number of cancers and dri... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Amy Oh, Makayla Pardo, Anaelena Rodriguez, Connie Yu, Lisa Nguyen, Olin Liang, Anna Chorzalska and Patrycja M. Dubielecka Tags: Review Source Type: research
Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma
Hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis among all head-and-neck cancers, and treatment options are limited. Tumor microenvironment (TME) analysis can help identify new therapeuti... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Zhimou Cai, Lin Chen, Siyu Chen, Ruihua Fang, Xiaolin Chen and Wenbin Lei Tags: Research Source Type: research
Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation
Macrophage filopodia, which are dynamic nanotube-like protrusions, have mainly been studied in the context of pathogen clearance. The mechanisms by which they facilitate intercellular communication and mediate... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Xiaodong Zhu, Yu Zhao, Yuqiu Liu, Wen Shi, Junlan Yang, Zhihong Liu and Xiaoliang Zhang Tags: Research Source Type: research
Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism
Adrenal gland is the synthesis and secretion organ of glucocorticoid, which is crucial to fetal development and postnatal fate. Recently, we found that prenatal dexamethasone exposure (PDE) could cause adrenal... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 18, 2023 Category: Molecular Biology Authors: Zheng He, Jinzhi Zhang, Yawen Chen, Can Ai, Xiaohan Gong, Dan Xu and Hui Wang Tags: Research Source Type: research
Insights into the diverse mechanisms and effects of variant CUL3-induced familial hyperkalemic hypertension
Familial hyperkalemic hypertension (FHHt), also known as Pseudohypoaldosteronism type II (PHAII) or Gordon syndrome is a rare Mendelian disease classically characterized by hyperkalemia, hyperchloremic metabol... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 16, 2023 Category: Molecular Biology Authors: Prashant Sharma and Harish E. Chatrathi Tags: Review Source Type: research
A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways
As a member of the Janus kinase (JAK) family, which includes JAK1, JAK2 and JAK3, tyrosine kinase 2 (TYK2) plays an important role in signal transduction and immune system regulation. Moreover, it is also invo... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 16, 2023 Category: Molecular Biology Authors: Celia X.-J. Chen, Wei Zhang, Shulan Qu, Fucan Xia, Yidong Zhu and Bo Chen Tags: Research Source Type: research
Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease
Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and imposes a heavy global economic burden; however, little is known about its complicated pathophysiology. Investigating the cellular ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 16, 2023 Category: Molecular Biology Authors: Shan Jiang and Hua Su Tags: Review Source Type: research
Cellular signaling modulated by miRNA-3652 in ovarian cancer: unveiling mechanistic pathways for future therapeutic strategies
MicroRNAs (miRNAs) are small non-coding RNA molecules that play pivotal roles in regulating gene expression and have been implicated in the pathogenesis of numerous cancers. miRNA-3652, though relatively less ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 16, 2023 Category: Molecular Biology Authors: Komal Imran, Muhammad Javed Iqbal, Rameesha Abid, Muhammad Mushtaq Ahmad, Daniela Calina, Javad Sharifi-Rad and William C. Cho Tags: Review Source Type: research
Fibroblast growth factor signaling in axons: from development to disease
The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting funct... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 16, 2023 Category: Molecular Biology Authors: Diogo Tom é, Marta S. Dias, Joana Correia and Ramiro D. Almeida Tags: Review Source Type: research
Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-I κBα axis in liver inflammation
Caspase 6 is an essential regulator in innate immunity, inflammasome activation and host defense. We aimed to characterize the causal mechanism of Caspase 6 in liver sterile inflammatory injury. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 12, 2023 Category: Molecular Biology Authors: Yuanbang Lin, Mingwei Sheng, Hua Qin, Peng Zhang, Chunli Wang, Wei Fu, Xiangjun Meng, Duowei Wang and Yachao Hou Tags: Research Source Type: research
Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by an accumulation of immature leukemic myeloblasts initiating from leukemic stem cells (LSCs) —the subpopulation that is also ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 12, 2023 Category: Molecular Biology Authors: Jirarat Poohadsuan, George A. O ’Doherty, Weerapat Owattanapanich, Smith Kungwankiattichai, Yon Rojanasakul, Surapol Issaragrisil and Sudjit Luanpitpong Tags: Research Source Type: research
AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling
Gonadotropin-releasing hormone (GnRH) receptors are essential for reproduction and are expressed in numerous urogenital, reproductive, and non-reproductive cancers. In addition to canonical G protein-coupled r... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 12, 2023 Category: Molecular Biology Authors: Pardis Mohammadzadeh, Mina Roueinfar and Gregory C. Amberg Tags: Research Source Type: research
Correction: Intrinsic disorder in PRAME and its role in uveal melanoma
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 12, 2023 Category: Molecular Biology Authors: Michael Antonietti, David J. Taylor Gonzalez, Mak Djulbegovic, Guy W. Dayhoff II, Vladimir N. Uversky, Carol L. Shields and Carol L. Karp Tags: Correction Source Type: research
