From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy

Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge. Currently, there is no effective treatm...

Source: Cell Communication and Signaling - March 27, 2024 Category: Molecular Biology Authors: R. J. A. Veltrop, M. M. Kukk, K. Topouzidou, L. Didden, A. Muchir, F. G. van Steenbeek, L. J. Schurgers and M. Harakalova Tags: Review Source Type: research