Respiration and Heat Shock Protein After Short-Term Heating/Stretch-Fixing on Smooth Muscle Cells
ConclusionsSMCs heated at 60  °C with stretching would have high recovery ability and low respiratory activity related to SMC migration. These results may be important evidence in determining the treatment condition in PTDBA. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 2, 2020 Category: Cardiology Source Type: research

Post-exercise Response of Arterial Parameters for Arterial Health Assessment Using a Microfluidic Tactile Sensor and Vibration-Model-Based Analysis: A Proof-of-Concept Study
The objective of this study is to propose a novel method that can measure post-exercise response of arterial parameters and is also suitable for routine use.ApproachA microfluidic tactile sensor with a location-insensitive configuration was used for arterial pulse signal measurements on six asymptomatic male subjects, offering measurement reliability, ease use by a layperson, and affordability. By treating the arterial pulse signal as a vibration signal of the arterial wall, vibration-model-based analysis of only one measured pulse signal with no calibration was conducted for simultaneous estimation of three arterial param...
Source: Cardiovascular Engineering and Technology - January 29, 2020 Category: Cardiology Source Type: research

A Metabolic Intravascular Platform to Study FDG Uptake in Vascular Injury
ConclusionIn this study, we validated a tunable very sensitive metabolic sensor platform that can be used for the detection of vascular metabolism, such as inflammation. This sensor can be used not only for the detection of macrophage activity but, with alternative probes, it could allow the detection of other pathophysiological processes. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 29, 2020 Category: Cardiology Source Type: research

Speckle-Tracking Echocardiography Enables Model-Based Identification of Regional Stiffness Indices in the Left Ventricular Myocardium
ConclusionOur findings suggest that STE-integrated computational modeling can be used to track indices of LV myocardial stiffness and, thus, is a potential tool for HF diagnosis and prognosis. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 28, 2020 Category: Cardiology Source Type: research

Correlation Between Doppler Derived Carotid Artery Corrected Flow Time and Pressure Transducer Derived Radial Artery Corrected Flow Time: A Prospective Observational Study
ConclusionPressure transducer derived radial artery cFT correlated with Doppler derived carotid artery cFT and may be a reasonable predictor of volume responsiveness. Further studies are required to confirm its role in various clinical scenario for prediction of volume responsiveness. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 15, 2020 Category: Cardiology Source Type: research

A Highly Conductive 3D Cardiac Patch Fabricated Using Cardiac Myocytes Reprogrammed from Human Adipogenic Mesenchymal Stem Cells
ConclusionBased on the results of this study, there is evidence to support the successful fabrication of a highly functional 3D patches with measurable electrical activity using cardiac myocytes reprogrammed from hADMSCs. 3D patches fabricated using optimal conductions described in this study can be used to improve the functional properties of failing hearts. Predominantly, in case of the infarcted hearts with partial loss of electrical activity, the electrical properties of the 3D patches may restore the electrical activity of the heart. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 7, 2020 Category: Cardiology Source Type: research

Inhibition of miR-217 Protects Against Myocardial Ischemia –Reperfusion Injury Through Inactivating NF-κB and MAPK Pathways
ConclusionsMiR-217 inhibition protected against MIRI through inactivating NF- κB and MAPK pathways by targeting DUSP14. This study may provide valuable diagnostic and factors and therapeutic agents for MIRI. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 7, 2020 Category: Cardiology Source Type: research

Effect of Aortic Wall Deformation with Healthy and Calcified Annulus on Hemodynamic Performance of Implanted On-X Valve
ConclusionsIn this study, the complex flow field characteristics in the new generation of BMHVs considering aorta flexibility with healthy and calcified annulus were investigated. It was found that the blood flow around the hinges region is in the danger of hemolysis and platelet activation and subsequently thromboembolism. Furthermore, the results show that similar to vessel wall deformation, considering the probable annulus calcification after valve replacement is also essential. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 6, 2020 Category: Cardiology Source Type: research

Influence of Configuration on Stress Distribution of Pulmonary Monocusp Leaflet
ConclusionsThe leaflet of model (1.2_min) had the most even stress distribution and lowest peak principal stress, which was the optimal choice among all the models. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 17, 2019 Category: Cardiology Source Type: research

Numerical Simulation of Magnetic Drug Targeting to the Stenosis Vessel Using Fe 3 O 4 Magnetic Nanoparticles Under the Effect of Magnetic Field of Wire
AbstractPurposeIn the present paper, the magnetic drug targeting using drug coated Fe3O4 nanoparticles to the stenosis region of the vessel was investigated. The problem was solved for various magnetic numbers. Moreover, the effect of the location of the wire, as a magnetic source, on the MDT was studied.MethodsThe governing equations of continuity, momentum and volume fraction were solved by taking into account the effects of kelvin force and magnetophoresis. Finite volume method is used for discretization of unsteady two-phase flow equations.ResultsIn low magnetic numbers, the most important phenomenon is the gradual for...
Source: Cardiovascular Engineering and Technology - December 17, 2019 Category: Cardiology Source Type: research

Future Balloon-Expandable Stents: High or Low-Strength Materials?
ConclusionUsing high-strength materials has a double-edged sword effect on the stent performance and existing uncertainty in the precise estimate of stent mechanical properties adversely affects the reliability of numerical models ’ predictions. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 12, 2019 Category: Cardiology Source Type: research

A Systematic Review for the Design of In Vitro Flow Studies of the Carotid Artery Bifurcation
ConclusionsA simplified three-step design process is proposed for better fitting and adequate match with the pertinent research question at hand and as guidance for less experienced flow study researchers. The three consecutive selection steps are: flow parameters, image modality, and model materials and designs. Model materials depend on the chosen imaging technique, whereas choice of flow parameters is independent from imaging technique and is therefore only determined by the goal of the study. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 9, 2019 Category: Cardiology Source Type: research

Hemodynamic Effects of Multiple Overlapping Uncovered Stents on Aortic Dissection: Surgical Strategies and Implications for False Lumen Thrombosis
ConclusionsMOUS helps to generate a favored hemodynamic environment for thrombus formation in the false lumen. Application of MOUS along with covered stent grafts may represent a more effective treatment for AD than utilizing MOUS or stent graft alone. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 8, 2019 Category: Cardiology Source Type: research

Evaluation of a Desktop 3D Printed Rigid Refractive-Indexed-Matched Flow Phantom for PIV Measurements on Cerebral Aneurysms
ConclusionsThis study presents an alternative low-cost option for 3D printing of a flow phantom suitable  for flow visualization simulations. The use of 3D printed flow phantoms reduces the complexity, time and effort required compared to conventional investment casting methods by removing the necessity of a multi-part process required with investment casting techniques. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 8, 2019 Category: Cardiology Source Type: research

The Implementation of an Adjustable Afterload Module for Ex Situ Heart Perfusion
ConclusionsWe conclude that due to the demonstrable control of our afterload module, we can maintain physiological aortic pressures in a passive afterload working mode across prolonged perfusion periods, enabling effective perfusion regardless of contractile performance. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 2, 2019 Category: Cardiology Source Type: research