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Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity
ConclusionsThis work presents simulations of circle of Willis arterial flow in SCA patients and demonstrates the importance and feasibility of using a patient-specific viscosity in these simulations. Accurately characterizing cerebrovascular hemodynamics in SCA populations has potential for elucidating the pathophysiology of large-vessel occlusion, aneurysms, and tissue damage in these patients. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 20, 2021 Category: Cardiology Source Type: research

Establishing Background Pathologic Changes of Valve Replacement Surgery in Sheep
ConclusionThe sheep model for AVR and MVR requires invasive surgery and CPB, which are associated with background anatomic and pathologic changes, especially in cases with additional surgical cardiac interventions. These findings serve as a critical control for future evaluation and development of novel replacement valves in order to distinguish device-related safety issues from expected outcomes of the surgical procedure and normal background changes in sheep. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 14, 2021 Category: Cardiology Source Type: research

Importance of Preserved Tricuspid Valve Function for Effective Soft Robotic Augmentation of the Right Ventricle in Cases of Elevated Pulmonary Artery Pressure
ConclusionsShort-term augmentation of RV function using SRVAD is feasible even in cases of elevated RV afterload. Moderate or severe tricuspid regurgitation were associated with reduced device effectiveness. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 14, 2021 Category: Cardiology Source Type: research

3D-Encoded DENSE MRI with Zonal Excitation for Quantifying Biventricular Myocardial Strain During a Breath-Hold
ConclusionReproducible acquisition of 3D-encoded biventricular myocardial strain data in a breath-hold is feasible using DENSE with zonal excitation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 9, 2021 Category: Cardiology Source Type: research

Three-Dimensional Analysis of the In Vivo Motion of Implantable Cardioverter Defibrillator Leads
ConclusionOur results suggest that reconstruction of 3D ICD lead motion is feasible using biplane cine-fluoroscopy. Lead curvatures can be computed with high accuracy and the results can be implemented to improve lead design and testing. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 29, 2021 Category: Cardiology Source Type: research

A Single-opening & amp;closing Valve Tester for Direct Measurement of Closing Volume of the Heart Valve
ConclusionPulsatile flow is challenging to the flowmeter. A novel single opening&closing pulsatile flowin-vitro valve tester for the heart valve has successfully been developed and can be used to simulate and evaluate the opening and closing hemodynamics of the heart valve. The tester can be used to measure valve closing volume and time accurately with a standardized testing protocol free from effect of other components such as the resistance, compliance units and auxiliary valve in the continuous pulsatile flow valve tester. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 25, 2021 Category: Cardiology Source Type: research

Computational Modeling of Right Ventricular Motion and Intracardiac Flow in Repaired Tetralogy of Fallot
ConclusionThis CFD framework can produce intracardiac flow in rTOF patients. CFD has the potential for predicting the effects of PVR in rTOF patients and improve the clinical indications guided by cMRI. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 24, 2021 Category: Cardiology Source Type: research

Sensitivity Analysis of Single Beat Left Ventricular Elastance Estimation by Chen Method
ConclusionUnexpectedly Ees(sb) increases for higher LV end-systolic volume and decreases for higher SV. These results contrast with Ees definition, which is the ratio between the LV end-systolic pressure and the LV end-systolic volume. Moreover, Ees(sb) is influenced by cardiocirculatory parameters such as LV Eed, HR, Ras, ejection time, and pre-ejection time. Finally, Ees(sb) computed with the model output often underestimates model Ees. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 22, 2021 Category: Cardiology Source Type: research

Prosthetic Valve Monitoring via In Situ Pressure Sensors: In Silico Concept Evaluation using Supervised Learning
ConclusionsWe demonstrate that using only two discrete pressure measurements, per leaflet, on the TAV stent, individual leaflet status can be accurately predicted. Such a sensorized TAV system could enable safe and inexpensive detection of prosthetic valve dysfunction. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 18, 2021 Category: Cardiology Source Type: research

Personalized Pre- and Post-Operative Hemodynamic Assessment of Aortic Coarctation from 3D Rotational Angiography
ConclusionThe use of 3DRA for hemodynamic modelling could allow for a complete hemodynamic assessment, as well as virtual interventions or surgeries and predictive modeling. However, before such an approach can be used routinely, significant advancements are required for automating the workflow. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 18, 2021 Category: Cardiology Source Type: research

Adventures in Heart Valve Function A Personal Thank You to Dr. Ajit P. Yoganathan
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 18, 2021 Category: Cardiology Source Type: research

Failure Properties of Healthy and Diabetic Rabbit Thoracic Aortas and Their Potential Correlation with Mass Fractions of Collagen
ConclusionThe results suggest that there is a lower propensity of radial tear occurrence within the diabetic aortic wall. More importantly, time exposure to diabetic condition is not a factor that may change failure properties of the rabbit descending thoracic aortas in the circumferential and axial directions. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 17, 2021 Category: Cardiology Source Type: research

Optimization Study of the Hemodynamics of Saline Flushing in Endoscopic Imaging of Chronic Total Occlusions (CTOs)
ConclusionsA new catheter design is demonstrated to safely and effectively produce saline flushing, leading to a clear optical imaging field, and an improved technique is outlined that overcomes some practical challenges and limitations commonly encountered in angioscopy. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 15, 2021 Category: Cardiology Source Type: research

Engineering Perspective on Cardiovascular Simulations of Fontan Hemodynamics: Where Do We Stand with a Look Towards Clinical Application
This article first reviews the current state of cardiovascular simulations of Fontan hemodynamics. Then, it will discuss the technical progress of Fontan simulations with the emphasis of its clinical impact, noting that substantial improvements have been made in the considerations of patient-specific anatomy, flow, and blood rheology. The article concludes with insights into potential future directions involving clinical validation, uncertainty quantification, and computational efficiency. The advancements in these aspects could promote the clinical usage of Fontan simulations, facilitating its integration into routine cli...
Source: Cardiovascular Engineering and Technology - June 10, 2021 Category: Cardiology Source Type: research

Transcatheter Mitral Valve Repair Simulator Equipped with Eye Tracking Based Performance Assessment Capabilities: A Pilot Study
ConclusionThe functionality and objective performance assessment of the MVR simulator were demonstrated. Especially for complex procedures such as the MitraClip procedure, this simulator offers a suitable platform for risk-free training and education. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 7, 2021 Category: Cardiology Source Type: research