Establishing Background Pathologic Changes of Valve Replacement Surgery in Sheep

ConclusionThe sheep model for AVR and MVR requires invasive surgery and CPB, which are associated with background anatomic and pathologic changes, especially in cases with additional surgical cardiac interventions. These findings serve as a critical control for future evaluation and development of novel replacement valves in order to distinguish device-related safety issues from expected outcomes of the surgical procedure and normal background changes in sheep.
Source: Cardiovascular Engineering and Technology - Category: Cardiology Source Type: research