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Intraventricular Flow Simulations in Singular Right Ventricles Reveal Deteriorated Washout and Low Vortex Formation
ConclusionsThe study pinpoints the intriguing role of intraventricular flows to characterize performance of SRVs that goes beyond standard clinical metrics such as ejection fraction. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 30, 2021 Category: Cardiology Source Type: research

A Computational Framework Examining the Mechanical Behaviour of Bare and Polymer-Covered Self-Expanding Laser-Cut Stents
ConclusionThis study demonstrates that stent covering has a substantial effect on the overall stent mechanical performance and highlights the importance of considering the mechanical properties of the combined cover and stent. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 30, 2021 Category: Cardiology Source Type: research

Spectral-Clustering of Lagrangian Trajectory Graphs: Application to Abdominal Aortic Aneurysms
ConclusionIdentifying coherent sets enables tracking their transport during the cardiac cycle and identify their role in the flow dynamics. Moreover, the size and the transport of the long residing coherent sets inside the AAA bulges can be deduced which may aid in predicting thrombus formation at such location. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 29, 2021 Category: Cardiology Source Type: research

Biological Equivalence of GGTA-1 Glycosyltransferase Knockout and Standard Porcine Pericardial Tissue Using 90-Day Mitral Valve Implantation in Adolescent Sheep
ConclusionsThis is the first demonstration of biological equivalence between GalKO and standard pig pericardium. The GalKO mutation causes neither intrinsic detrimental biological nor functional impact on BHV performance. Commercial adaptation of GalKO tissue for surgical or transcatheter BHVs would remove the clinical disparity between patients producing anti-Gal antibody and BHVs containing the Gal antigen. GalKO BHVs may reduce accelerated tissue calcification and SVD, enhancing patient choices, especially for younger patients.Graphical Abstract (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 24, 2021 Category: Cardiology Source Type: research

During Early VF in Rabbit Hearts, His Bundle Pacing is Less Effective Than Working Myocardial Pacing in Modulating Left Ventricular Activation Rates
ConclusionThis study provides evidence that during early VF in rabbit hearts, the HPS cannot be driven to effectively modulate the LV activation rates. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 23, 2021 Category: Cardiology Source Type: research

The Individual and Combined Effects of Shear, Tension, and Flexure on Aortic Heart Valve Endothelial Cells in Culture
ConclusionsWhen VECs face a single mechanical stimuli, they undergo transdifferentiation and transform into mesenchymal cells. However, when these cells face a combination of mechanical stimuli, the rate of transformation decreases compared to single stimuli applications. This indicates that a single stimulus induces endothelial to mesenchymal transition in VECs while the process is slower under the combination of multiple mechanical stimuli. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 22, 2021 Category: Cardiology Source Type: research

Light-Weight Localization and Scale-Independent Multi-gate UNET Segmentation of Left and Right Ventricles in MRI Images
ConclusionAdding the Multi-Gate Dilated Inception Block has boosted the performance of UNet architecture and has shown generalization ability when tested on noisy and deformed cardiac magnetic resonance images. The proposed method has proven its wide applicability and reliability for heart detection when tested on different datasets. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 12, 2021 Category: Cardiology Source Type: research

Computational Fluid –Structure Interaction Study of a New Wave Membrane Blood Pump
ConclusionA new design of WMBP was computationally studied. The proposed FSI model with contact was employed to predict the new pump hydraulic performance and it could help to properly select an operating point for the upcoming first-in-human trials. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 12, 2021 Category: Cardiology Source Type: research

Hemodynamic Study of a Patient-Specific Intracranial Aneurysm: Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics
ConclusionsOur results indicated that the differences in spatial resolution could be the main contributor to the discrepancies between each modality. The findings of this study suggest that with current techniques, care should be taken when using absolute WSS values to perform a quantitative risk analysis of aneurysm rupture. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 8, 2021 Category: Cardiology Source Type: research

Association of Left Atrial Sphericity with Risk of Stroke in Patients with Atrial Fibrillation. Sub-Analysis of the ASSAM Study
ConclusionLASP is associated with prior stroke in AF patients. The proposed new formula for identification of AF patients who are at risk of stroke, based on geometrical measurements of LA, is superior to the basic LASP in identification of AF patients with a history of stroke. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 8, 2021 Category: Cardiology Source Type: research

Chondroitin Sulfate Promotes Interstitial Cell Activation and Calcification in an In Vitro Model of the Aortic Valve
ConclusionThis study demonstrates a more complete model of aortic valve disease, including endothelial cells, interstitial cells, and a stiff and disease-like ECM.In vitro models of both healthy and diseased valves can be useful for understanding the mechanisms of CAVD pathogenesis and provide a model for testing novel therapeutics. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 4, 2021 Category: Cardiology Source Type: research

Segmentation of Coronary Arteries Images Using Spatio-temporal Feature Fusion Network with Combo Loss
ConclusionsOur method can intelligently capture coronary artery structure and achieve accurate flow reserve fraction (FFR) analysis. Through a series of steps such as CPR curved reconstruction, the detection of coronary heart disease can be achieved without affecting the patient ’s body. In addition, our work can be used as an effective means to assist in the detection of stenosis. In the screening of coronary heart disease among high-risk cardiovascular factors, automatic detection of luminal stenosis can be performed based on the application of later algorithm transform ation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 3, 2021 Category: Cardiology Source Type: research

Correction to: Influence of Tissue Technology on Pannus Formation on Bioprosthetic Heart Valves
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 25, 2021 Category: Cardiology Source Type: research

Systematic Review and Regression Modeling of the Effects of Age, Body Size, and Exercise on Cardiovascular Parameters in Healthy Adults
ConclusionAlthough other studies observe exponential predictor-output relations, the linear regression algorithms performed the best for the data in this study. The use of subject-level data and more predictors may provide regression models with higher fidelity.SignificanceModels developed in this study can be useful to clinicians for personalized patient assessment and to researchers for tuning computational models. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 19, 2021 Category: Cardiology Source Type: research

Shaping the field of Cardiovascular Fluid Mechanics: The 40th Anniversary of Ajit Yoganathan ’s Research Laboratory
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 8, 2021 Category: Cardiology Source Type: research