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Enhanced Embolization Efficacy with the Embolic Microspheres Guided by the Aggregate Gradation Theory Through In Vitro and Simulation Evaluation
ConclusionsThe graded embolic microspheres have a larger drag coefficient compared with the narrow size distribution groups bothin vitro experiment and FEA. These findings can be used to formulate the embolic agents with optimal size distributions and are significant for the improvement of clinical embolization therapy. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 12, 2021 Category: Cardiology Source Type: research

Analysis of Turbulence Effects in a Patient-Specific Aorta with Aortic Valve Stenosis
ConclusionsThis study demonstrates the importance of turbulence in assessing aortic haemodynamics in a patient with AVS. Neglecting the turbulent contribution to WSS could potentially result in a significant underestimation of the total WSS. Further work is warranted to extend the analysis to more AVS cases and patients with other aortic valve diseases. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 7, 2021 Category: Cardiology Source Type: research

Influence of Distal Re-entry Tears on False Lumen Thrombosis After Thoracic Endovascular Aortic Repair in Type B Aortic Dissection Patients: A Computational Fluid Dynamics Simulation
ConclusionThe different morphology of the re-entry tears had different effects on the thrombosis-related hemodynamic parameters in FL following TEVAR. and the number of re-entry tears was most crucial to the potential thrombosis in the post-TEVAR FL of TBAD patients. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 25, 2021 Category: Cardiology Source Type: research

Validated Guidelines for Simulating Centrifugal Blood Pumps
ConclusionThe findings of the study strongly suggest that SBES can be used to better predict RBP performance in the early development phase. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 25, 2021 Category: Cardiology Source Type: research

Relationship of Catheter Contact Angle and Contact Force with Contact Area on the Surface of Heart Muscle Tissue in Cardiac Catheter Ablation
ConclusionBoth the catheter contact angle and contact force substantially impact the contact area and morphology in catheter ablation procedures. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 15, 2021 Category: Cardiology Source Type: research

Design, Development, In Vitro and Preliminary In Vivo Evaluation of a Novel Photo-Angioplasty Device: Lumi - Solve
ConclusionsLumi-Solve, a novel DEBc device developed utilizing a combination of chemical, fibre-optic and catheter based technology platforms, demonstrated potential for targeted delivery of bioactive HDACi to the blood vessel wall supporting direct application to the management of NIH and warranting additionalin vivo studies. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 11, 2021 Category: Cardiology Source Type: research

In Vitro Clot Trapping Efficiency of the FDA Generic Inferior Vena Cava Filter in an Anatomical Model: An Experimental Fluid –Structure Interaction Benchmark
ConclusionOverall, this data set provides a benchmark for validating simulations predicting IVC filter clot trapping efficiency and, more generally, low-Reynolds number FSI modeling. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 8, 2021 Category: Cardiology Source Type: research

Manual Carotid Compression is a Viable Alternative for Reduction of Cerebral Microemboli
ConclusionBrief compression of the common carotid arteries during cardiovascular interventions has the potential to dramatically reduce the number of cerebral emboli and should be investigated further. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 8, 2021 Category: Cardiology Source Type: research

Equivalent Scalar Stress Formulation Taking into Account Non-Resolved Turbulent Scales
ConclusionWith the used scalar stress formulation, it is possible to include information about the turbulence of the flow into the mechanical stress calculation even when the used simulation method does not resolve any turbulence. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 5, 2021 Category: Cardiology Source Type: research

PIV Analysis of Haemodynamics Distal to the Frozen Elephant Trunk Stent Surrogate
ConclusionsThe identification of the Type 1B endoleak proved thatin-vitro modelling can be used to investigate complex compliance changes and wall motions. The recirculation may indicate the potential for long term intimal layer inflammatory issues such as atherosclerosis. These results may aid future remediation techniques or stent design. Further development of the methods used in this experiment may assist with the future testing of stents prior to animal or human trial. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 5, 2021 Category: Cardiology Source Type: research

Left Atrial Remodeling Mechanisms Associated with Atrial Fibrillation
AbstractHeart disease has always been one of the important diseases that endanger health and cause death. Therefore, it is particularly important to understand left atrium reconstruction and atrial fibrillation before heart image processing. The purpose of this paper is to provide an important review of the mechanisms of left atrial remodeling (LAR) associated with atrial fibrillation (AF). LAR refers to the spectrum of pathophysiological changes in (i) atrial structure and physiological function, and (ii) electric, ionic, and molecular milieu of the LA, in response to stresses imposed by conditions such as hypertension, m...
Source: Cardiovascular Engineering and Technology - March 1, 2021 Category: Cardiology Source Type: research

Correction to: A Brush –Spin–Coating Method for Fabricating In Vitro Patient-Specific Vascular Models by Coupling 3D-Printing
This Erratum is to add additional funding information to the article. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 16, 2021 Category: Cardiology Source Type: research

The Fluid-Dynamics of Endo Vascular Aneurysm Sealing (EVAS) System failure
ConclusionsIn this paper, the migration of one or both endobags is supposed to be related to the existing differential pressures acting in the gap formed between the two, which could go on pushing the two branches one away from the other, thus causing aneurysm re-activation and endoleaks. Regions of flow recirculation and low-pressure drops are revealed only in case of endobag migration and in presence of an aneurysm. These regions are supposed to lead to possible plaque formation and atherosclerosis. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 9, 2021 Category: Cardiology Source Type: research

Chemokine-Induced PBMC and Subsequent MSC Migration Toward Decellularized Heart Valve Tissue
ConclusionThe results of this study provide evidence for the inflammation-mediated recellularization mechanism. Furthermore, the results support the use of such an approach for enhancing the recellularization of a decellularized heart valve. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 9, 2021 Category: Cardiology Source Type: research

On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology
AbstractHeart valves function in one of the most mechanically demanding environments in the body to ensure unidirectional blood flow. The resident valve interstitial cells respond to this mechanical environment and maintain the structure and integrity of the heart valve tissues to preserve homeostasis. While the mechanics of organ-tissue-cell heart valve function has progressed, the intracellular signaling network downstream of mechanical stimuli has not been fully elucidated. This has hindered efforts to both understand heart valve mechanobiology and rationally identify drug targets for treating valve disease. In the pres...
Source: Cardiovascular Engineering and Technology - February 1, 2021 Category: Cardiology Source Type: research