A Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations
ConclusionThe study demonstrates that the haemodynamic effects of the embolisation procedure can be simulated from routinely acquired clinical data via a porous medium with varying permeability as evidenced by the good qualitative agreement between numerical predictions and bothin vivo andin vitro data. It provides a fundamental building block towards a computational treatment-planning framework for AVM embolisation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 5, 2021 Category: Cardiology Source Type: research

A 1D –3D Hybrid Model of Patient-Specific Coronary Hemodynamics
ConclusionSavings in computational cost may be significant in situations with changing geometry, such as growing thrombosis. Also, this approach would allow quantifying the time-dependent effect of thrombotic growth and occlusion on the global coronary circulation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 30, 2021 Category: Cardiology Source Type: research

Validation of Central Pressure Estimation in Patients with an Aortic Aneurysm Before and After Endovascular Repair
ConclusionIn untreated AAA ’s the accuracy of non-invasive central pressure estimation was acceptable (mean difference between 5 and 10 mmHg) when compared to invasive pressures, but dependent of AAA characteristics. After EVAR the accuracy of central pressure estimation improved (reduction of 75% of the mean difference bet ween pre and post measurements)Trial Registration NumberNCT03469388; 3-5-2018. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 28, 2021 Category: Cardiology Source Type: research

Establishment of a Modular Hemodynamic Simulator for Accurate In Vitro Simulation of Physiological and Pathological Pressure Waveforms in Native and Bioartificial Blood Vessels
ConclusionThe MHS serves as a variablein vitro platform for accurate emulation of physiological and pathological pressure environments in biological probes. Potential applications of the system include bioartificial vessel maturation in cardiovascular tissue engineering approaches as well as etiopathogenetic investigations of various cardiovascular pathologies. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 23, 2021 Category: Cardiology Source Type: research

In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study
ConclusionWe showed the feasibility of a newin-vitro method for real-time thrombus growth visualization by means of phase contrast X-ray imaging. In addition, with more blood parameters that are clinically relevant, this approach might contribute to improved oxygenator exchange protocols in the clinical routine. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 16, 2021 Category: Cardiology Source Type: research

Development of Inspired Therapeutics Pediatric VAD: Benchtop Evaluation of Impeller Performance and Torques for MagLev Motor Design
ConclusionsThe empirically determined performance and torque values establish the requirements for the magnetically levitated motor design to be used in the Inspired Universal MagLev System. This next step in our research and development is to fabricate a fully integrated and functional magnetically levitated pump, motor and controller system that meets the product requirement specifications and achieves a state of readiness for acute ovine animal studies to verify safety and performance of the system. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 13, 2021 Category: Cardiology Source Type: research

Simulating Radial Pressure Waveforms with a Mock Circulatory Flow Loop to Characterize Hemodynamic Monitoring Systems
ConclusionOverall, the development of robust analysis methods in conjunction with modified MCLs can expand device testing applications to hemodynamic monitoring systems. Properly validated MCLs can create a stable and reproducible environment for testing patient monitoring systems over their entire operating ranges prior to clinical use. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 1, 2021 Category: Cardiology Source Type: research

Alterations in Intracardiac Flow Patterns Affect Mitral Leaflets Dynamics in a Model of Ischemic Mitral Regurgitation
ConclusionIn conclusion, this study shows the effects that altered vortex formation, due to IMR, can have on ventricular filling and leaflet dynamics. These findings have important implications for understanding blood flow through the dilated heart and how ring annuloplasty and volume reduction interventions may influence mitral valve dynamics. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - August 31, 2021 Category: Cardiology Source Type: research

Cycle Length Evaluation in Persistent Atrial Fibrillation Using Kernel Density Estimation to Identify Transient and Stable Rapid Atrial Activity
ConclusionDCL identifies rapid atrial activity that may represent psAF drivers. This study uses DCL as a tool to evaluate the dynamic, patient specific properties of psAF by identifying rapid and regular activity. If automated, this technique could rapidly identify areas for ablation in psAF. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - August 27, 2021 Category: Cardiology Source Type: research

Numerical Analysis for Non-Uniformity of Balloon-Expandable Stent Deployment Driven by Dogboning and Foreshortening
ConclusionImproved positional accuracies, uniform balloon wall thickness, and selection of the appropriate length of a balloon for selected stent configuration will help to minimize dogboning, asymmetry, and foreshortening during non-uniform stent expansion, thereby reducing the risk of restenosis. The stated numerical approach will be helpful to optimize stent catheter assembly parameters thus minimizing in-vitro tests and product development time. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - August 24, 2021 Category: Cardiology Source Type: research

Influences of Stent Design on In-Stent Restenosis and Major Cardiac Outcomes: A Scoping Review and Meta-Analysis
AbstractThanks to the developments in implantable biomaterial technologies, invasive operating procedures, and widespread applications especially in vascular disease treatment, a milestone for interventional surgery was achieved with the introduction of vascular stents. Despite vascular stents providing a solution for embolisms, this technology includes various challenges, such as mechanical, electro-chemical complications, or in-stent restenosis (ISR) risks with long-term usage. Therefore, further development of biomaterial technologies is vital to overcome such risks and problems. For this purpose, recent research has fo...
Source: Cardiovascular Engineering and Technology - August 18, 2021 Category: Cardiology Source Type: research

A Robot Mimicking Heart Motions: An Ex-Vivo Test Approach for Cardiac Devices
ConclusionThe novel robotic approach allows reproducing heart motions with high accuracy and repeatability. This may benefit the device development process and allows re-using previously acquired heart motion data repeatedly, thus avoiding animal trials. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - August 18, 2021 Category: Cardiology Source Type: research

Artificial Intelligence Based Framework to Quantify the Cardiomyocyte Structural Integrity in Heart Slices
ConclusionThis technology could be widely applied to perform unbiased quantification of the structural effect of the cardiotoxins on heart slices. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - August 16, 2021 Category: Cardiology Source Type: research

Preparation of Cell-Seeded Heart Patch In Vitro; Co-Culture of Adipose-Derived Mesenchymal Stem Cell and Cardiomyocytes in Amnion Bilayer Patch
ConclusionCardiomyogenesis capacity of hAdSC co-cultured with hCardio in a 3-D scaffold taken from the 30 –40yo donor showed better morphology and viability than the 60-70yo group, but maintained less than 5 days in this system. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 28, 2021 Category: Cardiology Source Type: research

Correction to: Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 26, 2021 Category: Cardiology Source Type: research