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Redo Transcatheter Aortic Valve Implantation with the ALLEGRA Transcatheter Heart Valve: Insights from Bench Testing
ConclusionThe ALLEGRA THV had favorable hydrodynamic performance, stability and pinwheeling in all redo TAVI samples except the Evolut Pro at low implantation depth with compromised function. The choice of initial THV may have late implications on new THV choice and function. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 3, 2022 Category: Cardiology Source Type: research

Effect of Cyclic Uniaxial Mechanical Strain on Endothelial Progenitor Cell Differentiation
ConclusionOverall, we show that EPCs lose their endothelial progenitor phenotype, and have the potential to be differentiated into mesenchymal-like cells through cyclic mechanical stimulation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 2, 2022 Category: Cardiology Source Type: research

Micromechanical Force Measurement of Clotted Blood Particle Cohesion: Understanding Thromboembolic Aggregation Mechanisms
ConclusionThese results provide new insight to potential mechanisms of macroscopic thromboembolic aggregation via particles cohering in the vascular system —data that can be directly applied to computational simulations to predict particle fate, better informing the mechanistic developments of embolic occlusion. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 13, 2022 Category: Cardiology Source Type: research

Multi-Objective Optimization of Bioresorbable Magnesium Alloy Stent by Kriging Surrogate Model
ConclusionStent expansion behavior are highly dependent on design parameters, i.e. thickness, U-bend and link strut width. The purposed Multi-objective optimization approach based on Kriging surrogate model and finite element analysis is efficient in stent design optimization problem. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 12, 2022 Category: Cardiology Source Type: research

Reproducibility of Systolic Strain in Mice Using Cardiac Magnetic Resonance Feature Tracking of Black-Blood Cine Images
ConclusionThe results of this preliminary study showed excellent reproducibility for all ES strain parameters, with good to excellent reproducibility for the peak strain parameters. Moreover, all ES strain parameters had larger ICC values than the peak strain. In general, these results imply that feature-tracking with CMR42 software and black-blood cine images can be reliably used to assess strain patterns in mice. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 8, 2022 Category: Cardiology Source Type: research

Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure
ConclusionThe current framework illustrates the potential of using simulations and 3D printed models for pre-TAVR planning and assessing post-TAVR complications in BAV patients. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 7, 2022 Category: Cardiology Source Type: research

Deep Learning Forecasts the Occurrence of Sleep Apnea from Single-Lead ECG
ConclusionsThe proposed deep learning approach was successful in forecasting the occurrence of sleep apnea from single-lead ECG. It can therefore be adopted in wearable sleep monitors for the management of sleep apnea. Our developed algorithms are publicly available on GitHub. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 17, 2022 Category: Cardiology Source Type: research

Colocalization of Coronary Plaque with Wall Shear Stress in Myocardial Bridge Patients
ConclusionWSS may be obtained non-invasively in MB patients and provides a surrogate marker of plaque area. Using CFD, it may be possible to non-invasively assess the extent of plaque area, and identify patients who could benefit from frequent monitoring or medical management. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 16, 2022 Category: Cardiology Source Type: research

Embedded Computational Heart Model for External Ventricular Assist Device Investigations
ConclusionWe demonstrate that the devised computational modeling framework is capable of predicting characteristic trends (e.g. apex shortening, wall thickening and apex twisting) of a healthy heart, and that it can be used to study pathological hearts and external activation thereof. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 15, 2022 Category: Cardiology Source Type: research

ECG Signal Quality Assessments of a Small Bipolar Single-Lead Wearable Patch Sensor
ConclusionThis study demonstrates the diagnostic capability with similar morphological representation and reasonable timing accuracy of ECG signal from a patch sensor compared to 12-lead ECG. The advantages and limitations of small bipolar single-lead wearable patch sensor compared to 12-lead ECG are discussed in the context of relevant differences in ECG signal for clinical applications. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 15, 2022 Category: Cardiology Source Type: research

Characterization of Surgical Tools for Specific Endovascular Navigation
ConclusionThe Young moduli of the shaft and the distal tip of the guidewire were determined. We defined a suitable current intensity to activate the guidewire related to an optimal curvature. Then, the time of activation/deactivation was measured at 1.7 s. On the flip side, parts of the catheters were considered either elastic or viscoelastic. In all cases, the rigidity gradients along the various catheters were highlighted. The characterization of the aforementioned surgical tools provides the opportunity to simulate the endovascular nagivation process. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 2, 2022 Category: Cardiology Source Type: research

Fluid-Structure Interaction Model for Predicting Surgical Result of Total Anomalous Pulmonary Venous Connection and Estimating Pulmonary Venous Properties
ConclusionsThe FSI model has high potential to predict the result of surgery for TAPVC and to estimate the physical properties of pulmonary vein. This model also has potential to guide the strategy for surgical treatment. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 1, 2022 Category: Cardiology Source Type: research

Leaflet Stresses During Full Device Simulation of Crimping to 6 mm in Transcatheter Aortic Valve Implantation, TAVI
ConclusionSuccessful simulation of crimping requires a finely resolved skirt mesh. Leaflet stresses during crimping are dependent on leaflet thickness, material properties and the ratio of leaflet volume to the available volume inside the crimped valve. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 1, 2022 Category: Cardiology Source Type: research

Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children
ConclusionThe simulation results show the potential of patient-specific lumped parameter modelling to simulate clinical cases. Modelling patient specific cardiac function and blood flow in the paediatric patients would allow us to evaluate a variety of physiological scenarios and treatment options. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 22, 2022 Category: Cardiology Source Type: research

Morphological and Dynamic Analysis of the Right Atrioventricular Junction in Healthy Subjects with 4D Computed Tomography
ConclusionsCardiac-volume CT improves physiological knowledge of the relationships between the RAVJ components in healthy subjects. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 15, 2022 Category: Cardiology Source Type: research