Evaluation of the Effect of Crosslinking Method of Poly(Vinyl Alcohol) Hydrogels on Thrombogenicity
ConclusionThis work supports crosslinker dependent thrombogenicity of PVA hydrogels and advances our understanding of how the manufacturing of a PVA hydrogel affects its hemocompatibility. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 29, 2020 Category: Cardiology Source Type: research

Mitral Valve Posterior Leaflet Reconstruction Using Extracellular Matrix: In Vitro Evaluation
ConclusionsIn thisin vitro model, mitral valve anatomy and function were comparable between the native mitral valve and our new surgical technique for complete reconstruction of the posterior mitral leaflet and associated chordae tendineae. These promising results warrant furtherin vivo evaluation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 25, 2020 Category: Cardiology Source Type: research

Haemodynamic Effect of Left Atrial and Left Ventricular Cannulation with a Rapid Speed Modulated Rotary Blood Pump During Rest and Exercise: Investigation in a Numerical Cardiorespiratory Model
ConclusionFor a simulated heart failure patient intending to complete exercise, LVC seems to assure a better hemodynamic performance in terms of pressure-volume area unloading and increasing RBP flow. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 15, 2020 Category: Cardiology Source Type: research

Influence of the Adopted Balloon Modeling Strategies in the Stent Deployment Procedure: An In-Silico Analysis
ConclusionThe hyperelastic taper-ended balloon suggests being the model that better correlates with both experimental and clinical results regarding the expanded balloon profile during the procedure. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 14, 2020 Category: Cardiology Source Type: research

Residual Stress Estimates from Multi-cut Opening Angles of the Left Ventricle
ConclusionWe conclude that both radial and circumferential cuts are required to release the residual stress in the left ventricle; using multiple radial cuts alone is not sufficient. A multiple-cut model gives a marked increase of residual stress in a left ventricle ring compared to that of the commonly used single-cut model. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 14, 2020 Category: Cardiology Source Type: research

Biomechanical Assessment of Bicuspid Aortic Valve Phenotypes: A Fluid –Structure Interaction Modelling Approach
ConclusionThe findings of this proof-of-concept work suggest that there are specific differences across haemodynamics and valve mechanics associated with BAV phenotypes, which may be critical to subsequent processes associated with their pathophysiology processes. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 8, 2020 Category: Cardiology Source Type: research

Role of Occlusion Position in Coronary Artery Fistulas with Terminal Aneurysms: A Hemodynamic Perspective
ConclusionsA proximal occlusion, namely, removing the aneurysm of the CAF, may help in reducing the risk of thrombosis after surgery. However, follow-up studies with a larger cohort should be carried out to test and verify this speculation in the future. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 31, 2020 Category: Cardiology Source Type: research

An Insight to the Role of Thermal Effects on the Onset of Atrioesophageal Fistula: A Computer Model of Open-Irrigated Radiofrequency Ablation
ConclusionStudies such as the present work may provide more convenient platforms for investigating the effect of the many factors involved in the RF procedure and how they may link to the development of AEF. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 13, 2020 Category: Cardiology Source Type: research

Effect of the Center Post Establishment and Its Design Variations on the Performance of a Centrifugal Rotary Blood Pump
ConclusionsThe center post can greatly reduce the stagnation zone occurring in the center post free pump. The diameter of center post makes a difference to the flow field in the gap between the impeller and the center post. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 13, 2020 Category: Cardiology Source Type: research

Long-Term Venovenous Connection for Extracorporeal Carbon Dioxide Removal (ECCO 2 R) –Numerical Investigation of the Connection to the Common Iliac Veins
ConclusionIn conclusion, a connection without recirculation could be feasible and therefore provides a promising option for a long-term ECCO2R connection. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 12, 2020 Category: Cardiology Source Type: research

The Ryanodine Receptor Contributes to the Lysophosphatidylcholine-Induced Mineralization in Valvular Interstitial Cells
ConclusionsOur findings suggest blocking the activity of the ryanodine receptor can attenuate the valvular mineralization caused by LPC. We conclude that oxidized lipids, such as LPC, play an important role in the development and progression of CAVD and that the ryanodine receptor is a promising target for pharmacological intervention. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 29, 2020 Category: Cardiology Source Type: research

Non-Invasive Quantification of Ventricular Contractility, Arterial Elastic Function and Ventriculo-Arterial Coupling from a Single Diagnostic Encounter Using Simultaneous Arterial Tonometry and Magnetic Resonance Imaging
ConclusionNon-invasive assessment of LV pressure –volume and aortic pressure-flow relationships are both feasible and reproducible using simultaneous AT and CMRI. Methods permit assessment of load independent LV contractility, arterial function and LV/arterial coupling from a single non-invasive diagnostic encounter. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 19, 2020 Category: Cardiology Source Type: research

Large-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis
ConclusionThe ICTVSS framework of generalizing laminar power-law models to turbulent flows shows promise, but would benefit from further numerical validation and carefully designed experiments. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 14, 2020 Category: Cardiology Source Type: research

Transcatheter Mitral Valve Replacement: State of the Art
AbstractThe emergence of transcatheter aortic valve replacement (TAVR) has segued the development of transcatheter mitral valve (MV) repair devices. Transcatheter mitral valve repair has become a well-established alternative for patients with severe primary and secondary mitral regurgitation (MR) and with a perceived surgical risk. Transcatheter mitral valve replacement (TMVR) could become a more complete form of reduction of severe MR compared to MV repair devices, albeit with significant engineering challenges and all the risks associated with a bioprosthetic heart valve. The development of TMVR devices has become promin...
Source: Cardiovascular Engineering and Technology - March 3, 2020 Category: Cardiology Source Type: research

Hemodynamic Effects of Additional Pulmonary Blood Flow on Glenn and Fontan Circulation
ConclusionsModerate APBF is not only a measure to promote pulmonary artery growth and systemic arterial oxygen saturation but also an effective method against endothelial dysfunction and thrombosis. However, moderate APBF is patient-specific and should be determined based on hemodynamic preference that leads to desired patient outcomes, and care should be taken to preventPRSVC and heart load from being too high as well as an imbalance in HFD. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 17, 2020 Category: Cardiology Source Type: research