VICTORIA: VIrtual neck Curve and True Ostium Reconstruction of Intracranial Aneurysms
ConclusionsVICTORIAs findings reveal the complexity of aneurysm neck curve definition, especially for bifurcation aneurysms. Standardization appears to be mandatory for future sac-vessel-separations. For hemodynamic simulations a careful neck curve definition is crucial to avoid inaccuracies during the quantitative flow analysis. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 7, 2021 Category: Cardiology Source Type: research

Development of Custom Wall-Less Cardiovascular Flow Phantoms with Tissue-Mimicking Gel
ConclusionCustom, tissue-mimicking flow phantoms can be fabricated using the developed methodology and have potential for use in a variety of applications, including ultrasound-based imaging methods. This is the first reported use of BSI with anin vitro flow phantom. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 2, 2021 Category: Cardiology Source Type: research

Cell Cycle Withdrawal Limit the Regenerative Potential of Neonatal Cardiomyocytes
ConclusionThe neonatal heart at P4 harbors a robust but incomplete capacity for cardiac regeneration. Endothelial overexpression of Ccm2l has no effect on cardiac regeneration. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 27, 2021 Category: Cardiology Source Type: research

An Overview of Chemical and Biological Materials lead to Damage and Repair of Heart Tissue
ConclusionThis mini-review tried to explain some methods which can induce cardiac damage and repair of heart cells by use chemical and biological materials. We considered that various molecular pathways play a role in restoration and that most of these pathways are connected in a complex network and, to this end, different chemicals and drugs have been studied to date. Nonetheless, more studies are needed to ensure the performance and safety of the drugs and chemicals produced. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 27, 2021 Category: Cardiology Source Type: research

A New Semi-automated Algorithm for Volumetric Segmentation of the Left Ventricle in Temporal 3D Echocardiography Sequences
ConclusionThe method performed well compared to the four other registration algorithms. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 27, 2021 Category: Cardiology Source Type: research

Ineffective Orifice Area: Practical Limitations of Accurate EOA Assessment for Low-Gradient Heart Valve Prostheses
ConclusionsThe volatility of the standard EOA formulation at low mean gradients combined with the difficulty in accurately measuring such small differentials with industry-standard fluid pressure transducers results in a performance metric which is very sensitive to test execution, particularly for low-gradient prostheses. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 24, 2021 Category: Cardiology Source Type: research

A Tribute to Ajit Yoganathan's Cardiovascular Fluid Mechanics Lab: A Survey of Its Contributions to Our Understanding of the Physiology and Management of Single-Ventricle Patients
ConclusionsAmong many contributions in this field, work from the Cardiovascular Fluid Mechanics Lab has led to novel medical devices and patient-specific computational modeling workflows and software tools. These key contributions from this group have enhanced our understanding of the physiology and management of single-ventricle patients. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 20, 2021 Category: Cardiology Source Type: research

Toward an Electrical Analog of the Cardiovascular System in Hemorrhage
AbstractCurrent quantitative descriptions of the cardiovascular system in hemorrhagic shock focus on pressure based metrics. This approach is often incomplete; overlooking the important role of tissue perfusion. Electrical analogs to the cardiovascular system may offer a more complete description of hemorrhage. Application of fundamental concepts in electrical circuit theory (i.e.; Kirchhoff ’s Voltage Law and Ohm’s Law) to analogs of the cardiovascular system offers a more refined description of this complex process. This manuscript hopes to serve as a starting point for a more mathematically robust, and clinically re...
Source: Cardiovascular Engineering and Technology - May 20, 2021 Category: Cardiology Source Type: research

Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept and Experimental Validation in Swine
ConclusionWhile there was only weak to moderate agreement between predicted and measured changes in PA pressures and pulmonary blood flow distributions, hemodynamic simulations did show good diagnostic value for predicting successful versus unsuccessful catheter based interventions to relieve bPAS. The results of this proof of concept study are promising and should encourage future development for using hemodynamic models in planning interventions for patients with bPAS. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 18, 2021 Category: Cardiology Source Type: research

eG Coated Stents Exhibit Enhanced Endothelial Wound Healing Characteristics
ConclusionThe PBMA eG Coating ™ has the effect of promoting endothelial wound healing. Future studies will focus on elucidating the mechanistic basis of this observation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 18, 2021 Category: Cardiology Source Type: research

Observation of Skin Color Change by Carotenosis in Hyperlipidemia Patient
ConclusionIn the future, increasing the number of subjects and doses of carotenoids will be considered for more reliable verification. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 17, 2021 Category: Cardiology Source Type: research

Is Doppler Echocardiography Adequate for Surgical Planning of Single Ventricle Patients?
ConclusionDoppler echocardiography is an adequate alternative approach to acquire flow data for SV surgical planning. This finding encourages broader usage of SV surgical planning with echo-Doppler when MRI may present artifacts or is not available, especially in low and lower-middle-income countries. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 30, 2021 Category: Cardiology Source Type: research

Prevention of Ischemic Myocardial Contracture Through Hemodynamically Controlled DCD
ConclusionAutomatic dosing of hemodynamic drugs in the controlled DCD context has the potential to prevent onset of IMC up to\({1}{\text { h}}\), enabling ethical and medically safe organ procurement. This has the potential to increase the use of DCD heart transplantation, which has been widely recognized as a means of meeting the growing demand for donor hearts. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 29, 2021 Category: Cardiology Source Type: research

Influence of Tissue Technology on Pannus Formation on Bioprosthetic Heart Valves
ConclusionThe new tissue technology leads to less pannus formation. This may beneficially influence both short- and long-term valve behavior of bioprosthetic valvesGraphic Abstract (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 20, 2021 Category: Cardiology Source Type: research

Establishing the Biofidelity of a Multiphysics Finite Element Model of the Human Heart
ConclusionsThis conservative simulated use environment for heart-based medical devices, and its judicious application in the evaluation of medical devices is justified, but careful interpretation of the results is encouraged. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 13, 2021 Category: Cardiology Source Type: research