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Similar but Distinct Roles of Membrane and Interior Fluid Viscosities in Capsule Dynamics in Shear Flows
ConclusionsOur results and analysis show that the dissipation ratio is a system and process dependent variable and it cannot be treated as a constant even for the same capsule. This research is valuable for a better understanding of the complex capsule dynamics in flows and also suggests that the membrane viscosity needs to be considered explicitly for accurate and reliable results in future studies. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 22, 2021 Category: Cardiology Source Type: research

Delivery of siRNA to Endothelial Cells In Vivo Using Lysine/Histidine Oligopeptide-Modified Poly( β -amino ester) Nanoparticles
ConclusionsWe demonstrate that C6-KH pBAE can used for delivery of siRNAs to the artery endothelium and lung, while minimizing potential side or toxic effects in the liver and heart. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 20, 2021 Category: Cardiology Source Type: research

Coupled Hemodynamics and Oxygen Diffusion in Abdominal Aortic Aneurysm: A Computational Sensitivity Study
ConclusionThe presence of an ILT significantly impairs oxygen transport from the lumen to the wall. This study confirms that consideration of ILT size and anatomy may be important in considering the severity of a AAA, however, other parameters can also affect thrombus-mediated oxygen delivery within the aneurysmal wall. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 19, 2021 Category: Cardiology Source Type: research

Proper Orthogonal Decomposition Analysis of the Flow Downstream of a Dysfunctional Bileaflet Mechanical Aortic Valve
ConclusionConsidering these results, proper orthogonal decomposition can provide a rapid binary classifier to evaluate if the bileaflet mechanical valve deviates from its normal operating conditions. Moreover, the study shows that the size of the reduced-order model depends on which flow parameter is required to be reconstructed. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 19, 2021 Category: Cardiology Source Type: research

In Vitro Assessment of Right Ventricular Outflow Tract Anatomy and Valve Orientation Effects on Bioprosthetic Pulmonary Valve Hemodynamics
ConclusionsThe compound effects of geometry and orientation on bioprosthetic valve hemodynamics illustrated in this study could have a crucial impact on long-term valve performance. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 15, 2021 Category: Cardiology Source Type: research

Testing a Patient-Specific In-Silico Model to Noninvasively Estimate Central Blood Pressure
ConclusionThe proposed modeling approach shows a good patient-specific response and appears to be potentially useful in clinical practice. However, this approach needs to be evaluated in a larger cohort of patients and could possibly be improved through more accurate oscillometric BP measurement methods. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 12, 2021 Category: Cardiology Source Type: research

Cell-Laden Bioactive Poly(ethylene glycol) Hydrogels for Studying Mesenchymal Stem Cell Behavior in Myocardial Infarct-Stiffness Microenvironments
ConclusionsThese findings suggest that a 3D microenvironment hinders two key mechanisms by which MSCs could improve cardiac function after post-MI scar formation, namely cardiac transdifferentiation and secreted factor production. Future studies incorporating MSCs other cell types should broaden understanding of the post-MI scar microenvironment. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 11, 2021 Category: Cardiology Source Type: research

A Model for Studying the Biomechanical Effects of Varying Ratios of Collagen Types I and III on Cardiomyocytes
ConclusionThis study model can be adopted to simulate various biomechanical environments in which cells crosstalk with the Collagen-matrix in diseased pathologies to generate insights on strategies for prevention of fibrosis. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 11, 2021 Category: Cardiology Source Type: research

Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study
ConclusionsThe mechanical interactions between AV leaflets and LVOT steepening/DSS hemodynamic derangements do not cause AR. However, the leaflet WSS abnormalities predicted in those anatomies provide new support to a mechanobiological etiology of AR secondary to DSS. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 11, 2021 Category: Cardiology Source Type: research

Special Issue on Professor John M. Tarbell ’s Contribution to Cardiovascular Engineering
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 7, 2021 Category: Cardiology Source Type: research

Modeling and Reducing the Effect of Geometric Uncertainties in Intracranial Aneurysms with Polynomial Chaos Expansion, Data Decomposition, and 4D-Flow MRI
ConclusionPolynomial chaos expansion is an effective approach to propagate the effect of the uncertainty variable in the blood flow velocities of intracranial aneurysms. Merging 4D-Flow MRI and uncertainty propagated fluid velocities leads to more realistic flow trends relative to ignoring the uncertainty in the vessel radius. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 7, 2021 Category: Cardiology Source Type: research

John M. Tarbell: Artificial Heart and Mechanical Heart Valve Research Contributions
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 6, 2021 Category: Cardiology Source Type: research

Farewell Editorial
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 23, 2020 Category: Cardiology Source Type: research

Transcatheter Aortic Valve Thrombogenesis: A Foreign Materials Perspective
ConclusionStent-with-skirt was found to impart the most prominent thrombogenic effect, indicating the significance of blood-stent and blood-skirt interactions in TAV thrombosis. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 4, 2020 Category: Cardiology Source Type: research

Transpericardial 3D Echocardiography in the Sheep Model, Facilitating Real Time Anatomical Assessment for Planning and Guiding Transcatheter Mitral Valve Replacement and Repair
ConclusionThe value of TEE in the sheep model is limited and could not be reliable for complete assessment of the LV and mitral valve apparatus. Whereas, TPE produce reliable and similar imaging to TEE in the human patients which could allow animal testing of devices designed to be delivered in humans. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 2, 2020 Category: Cardiology Source Type: research