Combined optical coherence tomography morphologic and fractional flow reserve hemodynamic assessment of non- culprit lesions to better predict adverse event outcomes in diabetes mellitus patients: COMBINE (OCT –FFR) prospective study. Rationale and design
Fractional flow reserve (FFR) is a widely used tool for the identification of ischaemia-generating stenoses and to guide decisions on coronary revascularisation. However, the safety of FFR-based decisions in h... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 10, 2016 Category: Cardiology Authors: Mark W. Kennedy, Enrico Fabris, Alexander J. Ijsselmuiden, Holger Nef, Sebastian Reith, Javier Escaned, Fernando Alfonso, Niels van Royen, Wojtek Wojakowski, Adam Witkowski, Ciro Indolfi, Jan Paul Ottervanger, Harry Suryapranata and Elvin Kedhi Source Type: research

Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome
Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 6, 2016 Category: Cardiology Authors: Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao and Ming Li Source Type: research

Serum bicarbonate concentration and the risk of cardiovascular disease and death in type 2 diabetes: the Fremantle Diabetes Study
Serum bicarbonate is associated with mortality, heart failure (HF) and progression of renal failure in studies of healthy people and patients with chronic kidney disease, but the significance of these observat... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 6, 2016 Category: Cardiology Authors: S. A. Paul Chubb, Wendy A. Davis, Kirsten E. Peters and Timothy M. E. Davis Source Type: research

Association of serum calcium and heart failure with preserved ejection fraction in patients with type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a recognized trigger factor for heart failure with preserved ejection fraction (HFpEF). Recent studies show that higher serum calcium level is associated with greater risk of... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 3, 2016 Category: Cardiology Authors: Junfeng Li, Nan Wu, Wenling Dai, Liu Jiang, Yintao Li, Shibao Li and Zhongyuan Wen Source Type: research

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics
The coronary risk in diabetes (CoRDia) trial (n  = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including gen... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 3, 2016 Category: Cardiology Authors: Katherine E. Beaney, Claire E. Ward, Dauda A. S. Bappa, Nadine McGale, Anna K. Davies, Shashivadan P. Hirani, KaWah Li, Philip Howard, Dwaine R. Vance, Martin A. Crockard, John V. Lamont, Stanton Newman and Steve E. Humphries Source Type: research

Current perspectives on cardiovascular outcome trials in diabetes
Cardiovascular disease (CVD) is one of the most common diabetes-associated complications, as well as a leading cause for death in type 2 diabetes patients (T2D). Despite the well-known correlation between the ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2016 Category: Cardiology Authors: Oliver Schnell, Lars Ryd én, Eberhard Standl and Antonio Ceriello Source Type: research

Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes
In patients with type 2 diabetes (T2D), responsiveness of serum lipid concentrations to dietary patterns may vary by genotype. The aims of the present study were to identify explorative dietary patterns and to... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 27, 2016 Category: Cardiology Authors: Katharina S. Weber, Birgit Knebel, Klaus Strassburger, J örg Kotzka, Peter Stehle, Julia Szendroedi, Karsten Müssig, Anette E. Buyken and Michael Roden Source Type: research

Acute hyperglycemia suppresses left ventricular diastolic function and inhibits autophagic flux in mice under prohypertrophic stimulation
Left ventricular (LV) dysfunction is closely associated with LV hypertrophy or diabetes, as well as insufficient autophagic flux. Acute or chronic hyperglycemia is a prognostic factor for patients with myocard... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 22, 2016 Category: Cardiology Authors: Jiahe Xie, Kai Cui, Huixin Hao, Yingxue Zhang, Hairuo Lin, Zhenhuan Chen, Xiaobo Huang, Shiping Cao, Wangjun Liao, Jianping Bin, Masafumi Kitakaze and Yulin Liao Source Type: research

Cholesterol remnants and triglycerides are associated with decreased myocardial function in patients with type 2 diabetes
Recently, genetic studies have suggested a causal relationship between cholesterol remnants and ischemic heart disease. We aimed to determine whether cholesterol remnants and its marker, triglyceride levels, a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 22, 2016 Category: Cardiology Authors: Peter Godsk J ørgensen, Magnus Thorsten Jensen, Tor Biering-Sørensen, Rasmus Mogelvang, Søren Galatius, Thomas Fritz-Hansen, Peter Rossing, Tina Vilsbøll and Jan Skov Jensen Source Type: research

The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice
While most studies focus on cardiovascular morbidity following anesthesia and surgery in excessive obesity, it is unknown whether these intraoperative cardiovascular alterations also occur in milder forms of a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 20, 2016 Category: Cardiology Authors: Chantal A. Boly, Etto C. Eringa, R. Arthur Bouwman, Rob F. P. van den Akker, Frances S. de Man, Ingrid Schalij, Stephan A. Loer, Christa Boer and Charissa E. van den Brom Source Type: research

Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients
Angiopoietin-like protein 3 (ANGPTL3) is a major lipoprotein regulator and shows positive correlation with high-density lipoprotein-cholesterol (HDL-c) in population studies and ANGPTL3 mutated subjects. Howev... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 13, 2016 Category: Cardiology Authors: Dong Zhao, Long-Yan Yang, Xu-Hong Wang, Sha-Sha Yuan, Cai-Guo Yu, Zong-Wei Wang, Jia-Nan Lang and Ying-Mei Feng Source Type: research

Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study
Type 2 diabetes mellitus is associated strongly with an increased risk of micro- and macro-vascular complications, leading to impaired quality of life and shortened life expectancy. In addition to appropriate ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 13, 2016 Category: Cardiology Authors: Atsushi Tanaka, Toyoaki Murohara, Isao Taguchi, Kazuo Eguchi, Makoto Suzuki, Masafumi Kitakaze, Yasunori Sato, Tomoko Ishizu, Yukihito Higashi, Hirotsugu Yamada, Mamoru Nanasato, Michio Shimabukuro, Hiroki Teragawa, Shinichiro Ueda, Satoshi Kodera, Munehi Source Type: research

Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study
As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 dia... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 13, 2016 Category: Cardiology Authors: Tatsuya Maruhashi, Yukihito Higashi, Yasuki Kihara, Hirotsugu Yamada, Masataka Sata, Shinichiro Ueda, Masato Odawara, Yasuo Terauchi, Kazuoki Dai, Jun Ohno, Masato Iida, Hiroaki Sano, Hirofumi Tomiyama, Teruo Inoue, Atsushi Tanaka, Toyoaki Murohara & hell Source Type: research

Mortality and causes of death in a national sample of type 2 diabetic patients in Korea from 2002 to 2013
We aimed to investigate the mortality rate (MR), causes of death and standardized mortality ratio (SMR) in Korean type 2 diabetic patients from 2002 to 2013 using data from the Korean National Health Insurance... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 13, 2016 Category: Cardiology Authors: Yu Mi Kang, Ye-Jee Kim, Joong-Yeol Park, Woo Je Lee and Chang Hee Jung Source Type: research

Remote ischaemic conditioning in the context of type 2 diabetes and neuropathy: the case for repeat application as a novel therapy for lower extremity ulceration
An emerging treatment modality for reducing damage caused by ischaemia –reperfusion injury is ischaemic conditioning. This technique induces short periods of ischaemia that have been found to protect against a ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 9, 2016 Category: Cardiology Authors: J. A. Epps and N. A. Smart Source Type: research

Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study
Peripheral arterial disease (PAD) is known to be associated with high cardiovascular risk, but the individual impact of PAD presentations on risk of macrovascular and microvascular events has not been reliably... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 2, 2016 Category: Cardiology Authors: Kamel Mohammedi, Mark Woodward, Yoichiro Hirakawa, Sophia Zoungas, Stephen Colagiuri, Pavel Hamet, Stephen Harrap, Neil Poulter, David R. Matthews, Michel Marre and John Chalmers Source Type: research

Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus
Although increased oxidative stress is a major component of diabetic hypertensive cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains scarce. The actions of antioxidant apoc... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 1, 2016 Category: Cardiology Authors: C. M. Rosa, R. Gimenes, D. H. S. Campos, G. N. Guirado, C. Gimenes, A. A. H. Fernandes, A. C. Cicogna, R. M. Queiroz, I. Falc ão-Pires, D. Miranda-Silva, P. Rodrigues, F. R. Laurindo, D. C. Fernandes, C. R. Correa, M. P. Okoshi and K. Okoshi Source Type: research

Association between use of oral-antidiabetic drugs and the risk of aortic aneurysm: a nested case –control analysis
Pleiotropic effects on cardiovascular protection have been suggested in several oral antidiabetic drugs (OAD). The impacts of OADs on aortic aneurysm (AA) growth have been found in animal studies, but the evid... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 1, 2016 Category: Cardiology Authors: Chien-Yi Hsu, Yu-Wen Su, Yung-Tai Chen, Shih-Hung Tsai, Chun-Chin Chang, Szu-Yuan Li, Po-Hsun Huang, Jaw-Wen Chen and Shing-Jong Lin Source Type: research

Adequate vitamin D status is associated with the reduced odds of prevalent diabetic retinopathy in African Americans and Caucasians
Vitamin D status has been hypothesized to protect against development of diabetic retinopathy via its anti-inflammatory and anti-angiogenic properties. Additionally, in vitro and in vivo studies suggest vitami... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 1, 2016 Category: Cardiology Authors: Amy E. Millen, Michelle W. Sahli, Jing Nie, Michael J. LaMonte, Pamela L. Lutsey, Barbara E. K. Klein, Julie A. Mares, Kirstin J. Meyers, Christopher A. Andrews and Ronald Klein Source Type: research

Five-year clinical outcomes in patients with diabetes mellitus treated with polymer-free sirolimus- and probucol-eluting stents versus second-generation zotarolimus-eluting stents: a subgroup analysis of a randomized controlled trial
Improved outcomes in patients with diabetes mellitus undergoing percutaneous coronary intervention remain an unmet clinical need. We assessed the long-term efficacy and safety of novel polymer-free sirolimus- ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 1, 2016 Category: Cardiology Authors: Yukinori Harada, Roisin Colleran, Sebastian Kufner, Daniele Giacoppo, Tobias Rheude, Jonathan Michel, Salvatore Cassese, Tareq Ibrahim, Karl-Ludwig Laugwitz, Adnan Kastrati and Robert A. Byrne Source Type: research

Skin autofluorescence predicts cardio-renal outcome in type 1 diabetes: a longitudinal study
We aimed to analyze the relationships between skin autofluorescence (SAF) and incident macrovascular events and renal impairment after 4  years of follow-up in patients with type 1 diabetes (T1D). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 1, 2016 Category: Cardiology Authors: Fritz-Line V élayoudom-Céphise, Kalina Rajaobelina, Catherine Helmer, Sovanndany Nov, Emilie Pupier, Laurence Blanco, Marie Hugo, Blandine Farges, Cyril Astrugue, Henri Gin and Vincent Rigalleau Source Type: research

Glucagon and heart in type 2 diabetes: new perspectives
Increased levels of glucagon in type 2 diabetes are well known and, until now, have been considered deleterious. However, glucagon has an important role in the maintenance of both heart and kidney function. Mo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 27, 2016 Category: Cardiology Authors: Antonio Ceriello, Stefano Genovese, Edoardo Mannucci and Edoardo Gronda Source Type: research

Association between dietary acid load and the risk of cardiovascular disease: nationwide surveys (KNHANES 2008 –2011)
Acid –base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load and cardiovascular disease (CVD) risk in the general population... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 26, 2016 Category: Cardiology Authors: Eugene Han, Gyuri Kim, Namki Hong, Yong-ho Lee, Dong Woo Kim, Hyun Joon Shin, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee and Bong-Soo Cha Source Type: research

Effects of 6-month eicosapentaenoic acid treatment on postprandial hyperglycemia, hyperlipidemia, insulin secretion ability, and concomitant endothelial dysfunction among newly-diagnosed impaired glucose metabolism patients with coronary artery disease. An open label, single blinded, prospective randomized controlled trial
Recent experimental studies have revealed that n-3 fatty acids, such as eicosapentaenoic acid (EPA) regulate postprandial insulin secretion, and correct postprandial glucose and lipid abnormalities. However, t... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 26, 2016 Category: Cardiology Authors: Takahiro Sawada, Hideo Tsubata, Naoko Hashimoto, Michinori Takabe, Taishi Miyata, Kosuke Aoki, Soichiro Yamashita, Shogo Oishi, Tsuyoshi Osue, Kiminobu Yokoi, Yasue Tsukishiro, Tetsuari Onishi, Akira Shimane, Yasuyo Taniguchi, Yoshinori Yasaka, Takeshi Oh Source Type: research

Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study
Type 1 diabetes is associated with increased cardiovascular disease (CVD). Decreased endothelial progenitor cells (EPCs) number plays a pivotal role in reduced endothelial repair and development of CVD. We aim... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 26, 2016 Category: Cardiology Authors: Fahad W. Ahmed, Rachel Rider, Michael Glanville, Kilimangalam Narayanan, Salman Razvi and Jolanta U. Weaver Source Type: research

Common dysregulated pathways in obese adipose tissue and atherosclerosis
The metabolic syndrome is becoming increasingly prevalent in the general population that is at simultaneous risk for both type 2 diabetes and cardiovascular disease. The critical pathogenic mechanisms underlyi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 26, 2016 Category: Cardiology Authors: V. Moreno-Viedma, M. Amor, A. Sarabi, M. Bilban, G. Staffler, M. Zeyda and T. M. Stulnig Source Type: research

TNF- α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice
High fat diet (HFD) induces insulin resistance in various tissues, including the vasculature. HFD also increases plasma levels of TNF- α, a cytokine that contributes to insulin resistance and vascular dysfuncti... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 25, 2016 Category: Cardiology Authors: Rafael Menezes da Costa, Karla Bianca Neves, Fab íola Leslie Mestriner, Paulo Louzada-Junior, Thiago Bruder-Nascimento and Rita C. Tostes Source Type: research

Associations between blood glucose level and outcomes of adult in-hospital cardiac arrest: a retrospective cohort study
We intended to analyse the associations between blood glucose (BG) level and clinical outcomes of in-hospital cardiac arrest (IHCA). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 24, 2016 Category: Cardiology Authors: Chih-Hung Wang, Chien-Hua Huang, Wei-Tien Chang, Min-Shan Tsai, Ping-Hsun Yu, Yen-Wen Wu and Wen-Jone Chen Source Type: research

Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?
Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 24, 2016 Category: Cardiology Authors: Ting-Ting Chang and Jaw-Wen Chen Source Type: research

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids
An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relation... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 22, 2016 Category: Cardiology Authors: Katherine E. Beaney, Jackie A. Cooper, Stela McLachlan, S. Goya Wannamethee, Barbara J. Jefferis, Peter Whincup, Yoav Ben-Shlomo, Jacqueline F. Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Mika Kivimaki, Antti J. Kangas, Pasi Soini Source Type: research

Glucose intolerance after chronic stress is related with downregulated PPAR- γ in adipose tissue
Chronic stress is associated with increased risk of glucose intolerance and cardiovascular diseases, albeit through undefined mechanisms. With the aim of gaining insights into the latter, this study examined t... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 19, 2016 Category: Cardiology Authors: Vitor H. Pereira, Fernanda Marques, V ânia Lages, Filipa G. Pereira, Alexandre Patchev, Osborne F. X. Almeida, Joana Almeida-Palha, Nuno Sousa and João J. Cerqueira Source Type: research

Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): from bedside to bench
Despite the known risk of diabetes-induced cardiac fibrosis, less is known about whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Peroxisome proliferator-activated ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 12, 2016 Category: Cardiology Authors: Wei-Ting Chang, Juei-Tang Cheng and Zhih-Cherng Chen Source Type: research

High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men
There are conflicting results for relationships between serum vitamin D levels and metabolic diseases. The aim of this study was to investigate whether serum vitamin D levels were associated with various metab... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 12, 2016 Category: Cardiology Authors: Ki-Chul Sung, Yoosoo Chang, Seungho Ryu and Hye-Kyung Chung Source Type: research

Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice
Diabetic patients suffer from a high rate of cardiovascular events and such risk increases with HbA1c. However, lowering HbA1c does not appear to yield the same benefit on macrovascular endpoints, as observed ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 11, 2016 Category: Cardiology Authors: Angelo Avogaro, Gian Paolo Fadini, Giorgio Sesti, Enzo Bonora and Stefano Del Prato Source Type: research

Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats
There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also hav... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 5, 2016 Category: Cardiology Authors: M árta Sárközy, Gergő Szűcs, Veronika Fekete, Márton Pipicz, Katalin Éder, Renáta Gáspár, Andrea Sója, Judit Pipis, Péter Ferdinandy, Csaba Csonka and Tamás Csont Source Type: research

Serum gamma-glutamyltransferase is not associated with subclinical atherosclerosis in patients with type 2 diabetes
This study investigated the association between serum gamma-glutamyltransferase (GGT) level and subclinical atherosclerosis in patients with type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 5, 2016 Category: Cardiology Authors: Hye Eun Yoon, Eun Young Mo, Seok Joon Shin, Sung Dae Moon, Je Ho Han and Eun Sook Kim Source Type: research

Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo
Complications of diabetes mellitus (DM) are related not only to elevated plasma glucose, but also plasma glucose fluctuations. However, the specific mechanism underlying the role of plasma glucose fluctuation ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 5, 2016 Category: Cardiology Authors: Na Wu, Haitao Shen, Henan Liu, Yanjun Wang, Yu Bai and Ping Han Source Type: research

Circulating PCSK9 levels and CETP plasma activity are independently associated in patients with metabolic diseases
PCSK9 inhibition is a new powerful cholesterol-lowering strategy. Recently, it was reported that CETP inhibitors influence PCSK9 levels as an off-target effect. We explored the relationship between circulating... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 4, 2016 Category: Cardiology Authors: Josefa Girona, Daiana Ibarretxe, Nuria Plana, Sandra Guaita-Esteruelas, Nuria Amigo, Mercedes Heras and Luis Masana Source Type: research

The influence of body composition on renal function in patients with coronary artery disease and its prognostic significance: a retrospective cohort study
We try to analyse the effect of renal functions on death in CAD patients with different body compositions. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 2, 2016 Category: Cardiology Authors: Yong Peng, Hua Wang, Fei Chen, Fang-yang Huang, Tian-li Xia, Yan-biao Liao, Hua Chai, Peng-ju Wang, Zhi-liang Zuo, Wei Liu, Chen Zhang, Yi-jian Li, Yi-yue Gui, Mao Chen and De-jia Huang Source Type: research

Effects of the glucagon-like peptide-1 receptor agonist liraglutide on systolic function in patients with coronary artery disease and type 2 diabetes: a randomized double-blind placebo-controlled crossover study
Patients with type 2 diabetes (T2D) and coronary artery disease (CAD) have increased risk of cardiac dysfunction. The diabetic heart is characterized by increased fatty acid oxidation and reduced glucose uptak... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 26, 2016 Category: Cardiology Authors: Preman Kumarathurai, Christian Anholm, Olav W. Nielsen, Ole P. Kristiansen, Jens M ølvig, Sten Madsbad, Steen B. Haugaard and Ahmad Sajadieh Source Type: research

Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study
To investigate whether atherogenic dyslipidemia, a dyslipidemic profile combining elevated triglycerides and low high-density lipoprotein (HDL) cholesterol, is predictive of risk of silent myocardial ischemia ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 22, 2016 Category: Cardiology Authors: Paul Valensi, Antoine Avignon, Ariane Sultan, Bernard Chanu, Minh Tuan Nguyen and Emmanuel Cosson Source Type: research

Erratum to: National trends in incidence and outcomes of abdominal aortic aneurysm among elderly type 2 diabetic and non-diabetic patients in Spain (2003 –2012)
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 21, 2016 Category: Cardiology Authors: Ana Lopez-de-Andr és, Isabel Jiménez-Trujillo, Rodrigo Jiménez-García, Valentín Hernández-Barrera, José Mª de Miguel-Yanes, Manuel Méndez-Bailón, Napoleón Perez-Farinos, Miguel Ángel Salinero-Fort and Pilar Carrasco-Garrido Source Type: research

Rationale and design of the randomised controlled trial to assess the impact of liraglutide on cardiac function and structure in young adults with type 2 diabetes (the LYDIA study)
The prevalence of type 2 diabetes (T2DM) in younger adults is growing. Compared to the late onset T2DM, it is well recognized that the disease tends to behave more aggressively in the younger age group with ev... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 21, 2016 Category: Cardiology Authors: Z. Z. Htike, T. Yates, E. M. Brady, D. Webb, L. J. Gray, D. Swarbrick, G. P. McCann, K. Khunti and M. J. Davies Source Type: research

Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies
Glucagon-like peptide-1 (7–36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP ch... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 19, 2016 Category: Cardiology Authors: Joel P. Giblett, Richard G. Axell, Paul A. White, Sophie J. Clarke, Liam McCormick, Philip A. Read, Johannes Reinhold, Adam J. Brown, Michael O’Sullivan, Nick E. J. West, David P. Dutka and Stephen P. Hoole Source Type: research

The relationship between HbA1c and ultrasound plaque textures in atherosclerotic patients
Diabetes mellitus (DM) is associated to the morphological and componential characteristics of atheromatous plaques. It has proven that plaque textures are related to plaque components and beneficial for athero... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 19, 2016 Category: Cardiology Authors: Xiao-Wei Huang, Yan-Ling Zhang, Long Meng, Ming Qian, Wei Zhou, Rong-Qin Zheng, Hai-Rong Zheng and Li–Li Niu Source Type: research

Clinical outcomes of deferred revascularisation using fractional flow reserve in patients with and without diabetes mellitus
Deferred revascularisation based upon fractional flow reserve (FFR >0.80) is associated with a low incidence of target lesion failure (TLF). Whether deferred revascularisation is also as safe in diabetes melli... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 19, 2016 Category: Cardiology Authors: Mark W. Kennedy, Eliza Kaplan, Rik S. Hermanides, Enrico Fabris, Veemal Hemradj, Petra C. Koopmans, Jan-Hank E. Dambrink, A. T. Marcel Gosselink, Arnoud W. J. van‘t Hof, Jan Paul Ottervanger, Vincent Roolvink, Wouter S. Remkes, Aize van der Sluis, Harry Source Type: research

The influence of baseline risk on the relation between HbA1c and risk for new cardiovascular events and mortality in patients with type 2 diabetes and symptomatic cardiovascular disease
Strict glycaemic control in patients with type 2 diabetes has proven to have microvascular benefits while the effects on CVD and mortality are less clear, especially in high risk patients. Whether strict glyca... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 19, 2016 Category: Cardiology Authors: Sophie H. Bots, Yolanda van der Graaf, Hendrik M. W. Nathoe, Gert Jan de Borst, Jaap L. Kappelle, Frank L. J. Visseren and Jan Westerink Source Type: research

Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design
Heart failure (HF) and diabetes (DM) are a lethal combination. The current armamentarium of anti-diabetic agents has been shown to be less efficacious and sometimes even harmful in diabetic patients with conco... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2016 Category: Cardiology Authors: Jagdeep S. S. Singh, Amir Fathi, Keeran Vickneson, Ify Mordi, Mohapradeep Mohan, J. Graeme Houston, Ewan R. Pearson, Allan D. Struthers and Chim C. Lang Source Type: research

Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function
The effects of insulin on cardiomyocytes, such as positive inotropic action and glucose uptake are well described. However, in vitro studies comparing long-acting insulin analogues with regard to cardiomyocyte... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2016 Category: Cardiology Authors: Thorsten Hartmann, Sabrina Overhagen, D. Margriet Ouwens, Silja Raschke, Paulus Wohlfart, Norbert Tennagels, Nina Wronkowitz and Jürgen Eckel Source Type: research

Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile?
Dyslipidemia is the most fundamental risk factor for atherosclerotic cardiovascular disease (ASCVD). In clinical practice, many commonly prescribed medications can alter the patient’s lipid profile and, potent... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 14, 2016 Category: Cardiology Authors: Paul D. Rosenblit Source Type: research