The EMPA-REG outcome study: critical appraisal and potential clinical implications
Diabetes health care professionals have to face a study with results of incomparable success in secondary and tertiary cardiovascular disease prevention. In the past, no studies in patients with type 2 diabete... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 4, 2016 Category: Cardiology Authors: Gianluca Perseghin and Anna Solini Source Type: research

The nine-year changes of the incidence and characteristics of metabolic syndrome in China: longitudinal comparisons of the two cross-sectional surveys in a newly formed urban community
To assess the 9-year changes of the incidence and characteristics of metabolic syndrome (MetS) in Chinese community under the background of dramatically changed environment. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 3, 2016 Category: Cardiology Authors: Boren Jiang, Bin Li, Yongbin Wang, Bing Han, Ningjian Wang, Qin Li, Weihong Yang, Guolan Huang, Jinhua Wang, Yi Chen, Yingchao Chen, Chunfang Zhu, Dongping Lin and Yingli Lu Source Type: research

Diastolic orthostatic hypertension and cardiovascular prognosis in type 2 diabetes: a prospective cohort study
In patients with type 2 diabetes, the prognostic impact of an orthostatic rise in blood pressure is not known. Therefore, the aim of this study was to determine the prognostic implications of the diastolic ort... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 2, 2016 Category: Cardiology Authors: Magnus Wijkman, Toste Länne, Carl Johan Östgren and Fredrik H. Nystrom Source Type: research

Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
Hyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cel... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 1, 2016 Category: Cardiology Authors: Concepción Peiró, Tania Romacho, Verónica Azcutia, Laura Villalobos, Emilio Fernández, Juan P. Bolaños, Salvador Moncada and Carlos F. Sánchez-Ferrer Source Type: research

Statin use and cardiovascular risk factors in diabetic patients developing a first myocardial infarction
The risk for a first myocardial infarction (MI) in people with diabetes has been shown to be as high as the risk for a new MI in non-diabetic patients with a prior MI. Consequently, risk-reducing statin therap... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 27, 2016 Category: Cardiology Authors: Martin Bødtker Mortensen, Imra Kulenovic and Erling Falk Source Type: research

Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial
We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control comp... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 23, 2016 Category: Cardiology Authors: Maelán Fontes-Villalba, Staffan Lindeberg, Yvonne Granfeldt, Filip K. Knop, Ashfaque A. Memon, Pedro Carrera-Bastos, Óscar Picazo, Madhvi Chanrai, Jan Sunquist, Kristina Sundquist and Tommy Jönsson Source Type: research

Effects of daily glucose fluctuations on the healing response to everolimus-eluting stent implantation as assessed using continuous glucose monitoring and optical coherence tomography
Several studies have revealed that glucose fluctuations provoke oxidative stress that leads to endothelial cell dysfunction, progression of coronary atherosclerosis, and plaque vulnerability. However, little i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 21, 2016 Category: Cardiology Authors: Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Daisuke Sugiyama, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Yoshinori Nagasawa, Kazuhiko Sakaguchi, Yushi Hirota, Wataru O Source Type: research

Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men
Impaired vasoreactivity is often observed in subjects with metabolic syndrome, a condition that includes the presence of a specific cluster of risk factors for obesity and cardiovascular disease. However, hier... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 17, 2016 Category: Cardiology Authors: Michio Shimabukuro, Namio Higa, Hiroaki Masuzaki, Masataka Sata and Shinichiro Ueda Source Type: research

Major adverse cardiovascular events with basal insulin peglispro versus comparator insulins in patients with type 1 or type 2 diabetes: a meta-analysis
To identify possible differences in cardiovascular (CV) risk among different insulin therapies, we performed pre-specified meta-analyses across the clinical program for basal insulin peglispro (BIL), in patien... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 17, 2016 Category: Cardiology Authors: Byron J. Hoogwerf, A. Michael Lincoff, Angel Rodriguez, Lei Chen and Yongming Qu Source Type: research

Impact of teneligliptin on oxidative stress and endothelial function in type 2 diabetes patients with chronic kidney disease: a case–control study
The aim of the present study was to elucidate the effect of teneligliptin on oxidative stress and endothelial function in Japanese patients with type 2 diabetes and chronic kidney disease (CKD). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 17, 2016 Category: Cardiology Authors: Masaaki Sagara, Kunihiro Suzuki, Chie Aoki, Seiichi Tanaka, Isao Taguchi, Teruo Inoue and Yoshimasa Aso Source Type: research

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway
Type-2 diabetics have an increased risk of cardiomyopathy, and heart failure is a major cause of death among these patients. Growing evidence indicates that proinflammatory cytokines may induce the development... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 6, 2016 Category: Cardiology Authors: Sevil Korkmaz-Icöz, Samer Al Said, Tamás Radovits, Shiliang Li, Maik Brune, Péter Hegedűs, Ayhan Atmanli, Mihály Ruppert, Paige Brlecic, Lorenz Heyne Lehmann, Bernd Lahrmann, Niels Grabe, Yutaka Yoshikawa, Hiroyuki Yasui, Patrick Most and Matthias Ka Source Type: research

The prevalence of diabetes, hypertension and obesity among immigrants from East Africa and the former Soviet Union: a retrospective comparative 30-year cohort study
Previous studies have reported an increasing prevalence of metabolic abnormalities in immigrants who moved from low-cardiovascular-risk regions to Western countries, but little is known about time trends follo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 5, 2016 Category: Cardiology Authors: Yonatan Reuven, Jacob Dreiher and Pesach Shvartzman Source Type: research

Achievement of treatment goals for secondary prevention of myocardial infarction or stroke in 29,325 patients with type 2 diabetes: a German/Austrian DPV-multicenter analysis
To analyze whether medical care is in accordance with guidelines for secondary prevention of myocardial infarction (MI), or stroke in patients with type 2 diabetes from Germany and Austria. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 3, 2016 Category: Cardiology Authors: Barbara Bohn, Christof Schöfl, Vincent Zimmer, Michael Hummel, Nikolai Heise, Erhard Siegel, Wolfram Karges, Michaela Riedl and Reinhard W. Holl Source Type: research

Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study
Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess the relationships betw... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 3, 2016 Category: Cardiology Authors: François R. Jornayvaz, Peter Vollenweider, Murielle Bochud, Vincent Mooser, Gérard Waeber and Pedro Marques-Vidal Source Type: research

Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells
Intracellular antioxidant response to high glucose is mediated by Cu/Mn-superoxide dismutases (SOD-1/SOD-2), catalase (CAT) and glutathione peroxidases (GPx), particularly glutathione peroxidase-1 (GPx-1). Alt... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 30, 2016 Category: Cardiology Authors: Lucia La Sala, Monica Cattaneo, Valeria De Nigris, Gemma Pujadas, Roberto Testa, Anna R. Bonfigli, Stefano Genovese and Antonio Ceriello Source Type: research

The source of circulating selenoprotein S and its association with type 2 diabetes mellitus and atherosclerosis: a preliminary study
Selenoprotein S (SelS) is a transmembrane protein that is expressed in the liver, skeletal muscle, adipose tissue, pancreatic islets, kidney, and blood vessels. In addition to its transmembrane localization, S... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 28, 2016 Category: Cardiology Authors: Shan-shan Yu, Li–li Men, Jia-ling Wu, Li-wei Huang, Qian Xing, Jun-jie Yao, Yong-bo Wang, Gui-rong Song, Hui-shu Guo, Guo-hua Sun, Yu-hong Zhang, Hua Li and Jian-ling Du Source Type: research

The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study
To evaluate the clinical value of metabolic syndrome based on different definitions [American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF) and... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 27, 2016 Category: Cardiology Authors: Thijs T. W. van Herpt, Abbas Dehghan, Mandy van Hoek, M. Arfan Ikram, Albert Hofman, Eric J. G. Sijbrands and Oscar H. Franco Source Type: research

Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome
Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 20, 2016 Category: Cardiology Authors: Nikolaos Östlund Papadogeorgos, Gun Jörneskog, Mattias Bengtsson, Thomas Kahan and Majid Kalani Source Type: research

Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R+ T cells
Low-grade systemic inflammation is considered to participate in the progression of type 2 diabetes (T2D) and in diabetic complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 19, 2016 Category: Cardiology Authors: Bernt Johan von Scholten, Alexander Rosendahl, Philip Hasbak, Regine Bergholdt, Andreas Kjaer, Peter Rossing and Tine W. Hansen Source Type: research

Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
Previous evidences have shown the presence of a prolonged and exaggerated postprandial response in type 2 diabetes mellitus (T2DM) and its relation with an increase of cardiovascular risk. However, the respons... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 19, 2016 Category: Cardiology Authors: A. Leon-Acuña, J. F. Alcala-Diaz, J. Delgado-Lista, J. D. Torres-Peña, J. Lopez-Moreno, A. Camargo, A. Garcia-Rios, C. Marin, F. Gomez-Delgado, J. Caballero, B. Van-Ommen, M. M. Malagon, P. Perez-Martinez and J. Lopez-Miranda Source Type: research

Clinical relevance of dual-energy X-ray absorptiometry (DXA) as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetes
Whole body dual-energy X-ray absorptiometry (DXA) can simultaneously measure both regional fat and non-fat mass. Android-to-gynoid (A/G) ratio measured by DXA has been reported to be associated with cardiovasc... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 14, 2016 Category: Cardiology Authors: Ryotaro Bouchi, Yujiro Nakano, Norihiko Ohara, Takato Takeuchi, Masanori Murakami, Masahiro Asakawa, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa Source Type: research

Metabolically-inactive glucagon-like peptide-1(9–36)amide confers selective protective actions against post-myocardial infarction remodelling
Glucagon-like peptide-1 (GLP-1) therapies are routinely used for glycaemic control in diabetes and their emerging cardiovascular actions have been a major recent research focus. In addition to GLP-1 receptor a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 14, 2016 Category: Cardiology Authors: Emma Robinson, Mitchel Tate, Samuel Lockhart, Claire McPeake, Karla M. O’Neill, Kevin S. Edgar, Danielle Calderwood, Brian D. Green, Barbara J. McDermott and David J. Grieve Source Type: research

Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells
Vascular dysfunction is a distinctive phenotype in diabetes mellitus. Current treatments mostly focus on the tight glycemic control and few of these treatments have been designed to directly recover the vascul... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 12, 2016 Category: Cardiology Authors: Yu-Guang Ma, Yin-Bin Zhang, Yun-Gang Bai, Zhi-Jun Dai, Liang Liang, Mei Liu, Man-Jiang Xie and Hai-Tao Guan Source Type: research

Nicorandil attenuates carotid intimal hyperplasia after balloon catheter injury in diabetic rats
Diabetic patients suffer from undesired intimal hyperplasia after angioplasty. Nicorandil has a trend to reduce the rate of target lesion revascularization. However, whether nicorandil inhibits intimal hyperpl... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 8, 2016 Category: Cardiology Authors: Ying Qian Zhang, Feng Tian, Ying Zhou, Yun Dai Chen, Bo Li, Qiang Ma and Ying Zhang Source Type: research

Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor ß family and has been associated with inflammation, cancer, aging, diabetes mellitus (DM) and atherosclerosis. Determinan... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 8, 2016 Category: Cardiology Authors: Serdar Farhan, Matthias K. Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber and Alexandra Kautzky-Willer Source Type: research

Cohort profile: the German Diabetes Study (GDS)
The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on the course of the disease. GDS aims at identifying prognostic factors and mechanisms underly... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 7, 2016 Category: Cardiology Authors: Julia Szendroedi, Aaruni Saxena, Katharina S. Weber, Klaus Strassburger, Christian Herder, Volker Burkart, Bettina Nowotny, Andrea Icks, Oliver Kuss, Dan Ziegler, Hadi Al-Hasani, Karsten Müssig and Michael Roden Source Type: research

The influence of body composition on the N-terminal pro-B-type natriuretic peptide level and its prognostic performance in patients with acute coronary syndrome: a cohort study
Whether body composition is associated with the N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and its prognostic performance in acute coronary syndrome (ACS) remains unknown. We aimed to investig... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 6, 2016 Category: Cardiology Authors: Fang-Yang Huang, Hua Wang, Bao-Tao Huang, Wei Liu, Yong Peng, Chen Zhang, Tian-Li Xia, Peng-Ju Wang, Zhi-Liang Zuo, Yue Heng, Rui-Shuang Liu, Xiao-Bo Pu, Yi-Yue Gui, Shi-Jian Chen, Ye Zhu and Mao Chen Source Type: research

Association between socioeconomic status and metabolic control and diabetes complications: a cross-sectional nationwide study in Chinese adults with type 2 diabetes mellitus
Low socioeconomic status (SES) is associated with adverse cardiovascular risk factor patterns and poor outcomes in patients with diabetes. The aim of this study was to determine whether SES is associated with ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 5, 2016 Category: Cardiology Authors: Xiaoming Tao, Jihu Li, Xiaolin Zhu, Bin Zhao, Jiao Sun, Linong Ji, Dayi Hu, Changyu Pan, Yuxin Huang, Suyuan Jiang, Qiang Feng and Cuiping Jiang Source Type: research

Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial
Because type 2 diabetes mellitus is associated strongly with an increased risk of cardiovascular diseases, the number of patients with diabetes with chronic heart failure is increasing steadily. However, clini... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2016 Category: Cardiology Authors: Atsushi Tanaka, Teruo Inoue, Masafumi Kitakaze, Jun-ichi Oyama, Masataka Sata, Isao Taguchi, Wataru Shimizu, Hirotaka Watada, Hirofumi Tomiyama, Junya Ako, Yasushi Sakata, Toshihisa Anzai, Masaaki Uematsu, Makoto Suzuki, Kazuo Eguchi, Akira Yamashina&hell Source Type: research

A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients: a population-based dynamic cohort study in Taiwan
Contemporary guidelines recommend angiotensin-converting-enzyme inhibitors (ACEi) or angiotensin-receptor blockers (ARB) for hypertensive patients with diabetes. However, there is limited data to evaluate the ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 2, 2016 Category: Cardiology Authors: Lung-Sheng Wu, Shang-Hung Chang, Gwo-Jyh Chang, Jia-Rou Liu, Yi-Hsin Chan, Hsin-Fu Lee, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh, Chi-Tai Kuo and Lai-Chu See Source Type: research

Need for streamlined use of DPP-4 inhibitors in the treatment of type 2 diabetes
Regulatory agencies request an assessment of cardiovascular safety for all “new” oral anti-diabetic drugs in order to avoid possible negative effects on cardiovascular events. Dipeptidyl peptidase 4 inhibitors... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 2, 2016 Category: Cardiology Authors: Cristiana Vitale, Giuseppe M. C. Rosano and Krishna Prasad Source Type: research

Cardiovascular efficacy of sitagliptin in patients with diabetes at high risk of cardiovascular disease: a 12-month follow-up
Gliptins should have beneficial effects beyond glycemic control, potentially on the pathophysiology of cardiovascular (CV) diseases, with some basic studies demonstrating this possibility. However, we are yet ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 31, 2016 Category: Cardiology Authors: Takashi Nakamura, Yoshitaka Iwanaga, Yuki Miyaji, Ryuji Nohara, Takao Ishimura and Shunichi Miyazaki Source Type: research

Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease
Prior studies demonstrate mitochondrial dysfunction with increased reactive oxygen species generation in peripheral blood mononuclear cells in diabetes mellitus. Oxidative stress-mediated damage to mitochondri... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 31, 2016 Category: Cardiology Authors: Jessica L. Fetterman, Monica Holbrook, David G. Westbrook, Jamelle A. Brown, Kyle P. Feeley, Rosa Bretón-Romero, Erika A. Linder, Brittany D. Berk, Robert M. Weisbrod, Michael E. Widlansky, Noyan Gokce, Scott W. Ballinger and Naomi M. Hamburg Source Type: research

Flow cytometric analysis of platelets type 2 diabetes mellitus reveals ‘angry’ platelets
The function of platelets have extended way beyond the horizon of haemostasis and thrombosis, and are recognised as active participants in vascular inflammation, as well as in prothrombotic complications of ca... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 31, 2016 Category: Cardiology Authors: Prashilla Soma, Albe Carina Swanepoel, Jeanette Noel du Plooy, Thandi Mqoco and Etheresia Pretorius Source Type: research

Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes
We examined the association of... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 24, 2016 Category: Cardiology Authors: Andrew O. Odegaard, David R. Jacobs, Otto A. Sanchez, David C. Goff, Alexander P. Reiner and Myron D. Gross Source Type: research

Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
The mechanisms leading to the high on-treatment platelet reactivity in diabetes patients are not fully elucidated. The genetic factors may be associated with the diminished antiplatelet efficacy of dual antipl... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Dingyu Zhang, Xiaolin Zhang, Dan Liu, Tengfei Liu, Wenzhi Cai, Chenghui Yan and Yaling Han Source Type: research

Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus
Circulating microRNAs (miRs) are differentially regulated and selectively packaged into microparticles (MPs). We evaluated whether diabetes mellitus alters circulating vascular and endothelial MP-incorporated ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Felix Jansen, Han Wang, David Przybilla, Bernardo S. Franklin, Andreas Dolf, Philipp Pfeifer, Theresa Schmitz, Anna Flender, Elmar Endl, Georg Nickenig and Nikos Werner Source Type: research

Cost-effectiveness of screening strategies to detect heart failure in patients with type 2 diabetes
Heart failure (HF), especially with preserved ejection fraction (HFpEF) is common in older patients with type 2 diabetes (T2DM), but often not recognized. Early HF detection in older T2DM patients may be worth... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Anoukh van Giessen, Leandra J. M. Boonman-de Winter, Frans H. Rutten, Maarten J. Cramer, Marcel J. Landman, Anho H. Liem, Arno W. Hoes and Hendrik Koffijberg Source Type: research

Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension
Questions remain as to the association between essential hypertension and increased incidence of type 2 diabetes (T2DM). The premise of this analysis is that insulin resistance/compensatory hyperinsulinemia is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Ki-Chul Sung, Hyun-Young Park, Min-Ju Kim and Gerald Reaven Source Type: research

Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum
Hyperglycemia and increased levels of methylglyoxal (MGO) can trigger the development of vascular complications in diabetes. Resveratrol and quercetin are red wine polyphenols with known beneficial cardiovascu... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 18, 2016 Category: Cardiology Authors: Charlotte Boydens, Bart Pauwels, Laura Vanden Daele and Johan Van de Voorde Source Type: research

Association of glucose homeostasis measures with heart rate variability among Hispanic/Latino adults without diabetes: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Reduced heart rate variability (HRV), a measure of cardiac autonomic function, is associated with an increased risk of cardiovascular disease (CVD) and mortality. Glucose homeostasis measures are associated wi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 16, 2016 Category: Cardiology Authors: Michelle L. Meyer, Nathan M. Gotman, Elsayed Z. Soliman, Eric A. Whitsel, Raanan Arens, Jianwen Cai, Martha L. Daviglus, Pablo Denes, Hector M. González, Juan Moreiras, Gregory A. Talavera and Gerardo Heiss Source Type: research

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understoo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 8, 2016 Category: Cardiology Authors: Vidya Kandula, Ramoji Kosuru, Haobo Li, Dan Yan, Qiqi Zhu, Qingquan Lian, Ren-shan Ge, Zhengyuan Xia and Michael G. Irwin Source Type: research

The coexistence of carotid and lower extremity atherosclerosis further increases cardio-cerebrovascular risk in type 2 diabetes
Both carotid and lower limb atherosclerosis are associated with increased cardiovascular and cerebrovascular risks. However, it is still unclear whether the concomitant presence of carotid and lower extremity ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 5, 2016 Category: Cardiology Authors: Mei-Fang Li, Cui-Chun Zhao, Ting-Ting Li, Yin-Fang Tu, Jun-Xi Lu, Rong Zhang, Ming-Yun Chen, Yu-Qian Bao, Lian-Xi Li and Wei-Ping Jia Source Type: research

Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells
Previous studies have shown that high glucose (HG) induced endothelial cell (EC) damage via a phenotypic transition of EC. There is increasing evidence suggesting the role of inflammatory cytokines in mediated... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 5, 2016 Category: Cardiology Authors: Dong-Dong Zhu, Ri-Ning Tang, Lin-Li Lv, Yi Wen, Hong Liu, Xiao-Liang Zhang, Kun-Ling Ma and Bi-Cheng Liu Source Type: research

Risks of cardiovascular diseases associated with dipeptidyl peptidase-4 inhibitors and other antidiabetic drugs in patients with type 2 diabetes: a nation-wide longitudinal study
Several antidiabetic drugs (i.e., sulfonylureas; SU, rosiglitazone) have been reported to be associated with increased risks of cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). D... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 1, 2016 Category: Cardiology Authors: Huang-Tz Ou, Kai-Cheng Chang, Chung-Yi Li and Jin-Shang Wu Source Type: research

Association of soluble tumor necrosis factor receptors 1 and 2 with nephropathy, cardiovascular events, and total mortality in type 2 diabetes
Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2) contribute to experimental diabetic kidney disease, a condition with substantially increased cardiovascular risk when present in patients. Th... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 29, 2016 Category: Cardiology Authors: Axel C. Carlsson, Carl Johan Östgren, Fredrik H. Nystrom, Toste Länne, Pär Jennersjö, Anders Larsson and Johan Ärnlöv Source Type: research

Long-term mortality and incidence of cardiovascular diseases and type 2 diabetes in diabetic and nondiabetic obese patients undergoing gastric banding: a controlled study
Aim of this retrospective study was to compare long-term mortality and incidence of new diseases [diabetes and cardiovascular (CV) disease] in morbidly obese diabetic and nondiabetic patients, undergoing gastr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 27, 2016 Category: Cardiology Authors: Antonio E. Pontiroli, Ahmed S. Zakaria, Ermanno Mantegazza, Alberto Morabito, Alessandro Saibene, Enrico Mozzi and Giancarlo Micheletto Source Type: research

Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events
Patients with type 2 diabetes (T2D) have a substantial increased risk for cardiovascular (CV) disease and associated mortality than those without diabetes. Dulaglutide is a once-weekly glucagon-like peptide-1 ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 24, 2016 Category: Cardiology Authors: Keith C. Ferdinand, Fady T. Botros, Charles M. Atisso and Philip T. Sager Source Type: research

Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects
Patients with angina-like symptoms without myocardial perfusion scintigram (MPS)-verified abnormality may still be at risk for cardiovascular events. We hypothesized that insulin resistance could play a role i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 19, 2016 Category: Cardiology Authors: Helena U. Westergren, Sara Svedlund, Remi A. Momo, Juuso I. Blomster, Karin Wåhlander, Erika Rehnström, Peter J. Greasley, Regina Fritsche-Danielson, Jan Oscarsson and Li-Ming Gan Source Type: research

Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis
A pre-specified meta-analysis of cardiovascular (CV) events from 21 phase 2b/3 dapagliflozin clinical trials was undertaken to characterise the CV profile of dapagliflozin. This showed no increase in CV risk w... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 19, 2016 Category: Cardiology Authors: Christian Sonesson, Peter A. Johansson, Eva Johnsson and Ingrid Gause-Nilsson Source Type: research