The relationship between early atherosclerosis and endothelial dysfunction in type 1 diabetic patients as evidenced by measurement of carotid intima-media thickness and soluble CD146 levels: a cross sectional study
Conclusion: Our findings emphasize that sCD146 levels may be a more sensitive marker than CIMT for earlier identification of type 1 diabetic patients at high risk for atherosclerosis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 18, 2013 Category: Cardiology Authors: Sema DogansenAysen HelvaciMine AdasSuzan Onal Source Type: research

Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification
Background: Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). We studied plasma AGEs in association with T1DM and CAC, and whether or not the latter association could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: We studied 165 individuals with and 169 without T1DM. CAC was quantified in a CAC score based on CT-scanning. Plasma levels of protein-bound pentosidine, Nepsilon-(carboxymethyl)lysine (CML) and Nepsilon-(carboxyethyl)lysine (CEL) were measured with HPLC/UPLC with fluorescence detection...
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Marcelle van EupenMiranda SchramHelen ColhounJean ScheijenCoen StehouwerCasper Schalkwijk Source Type: research

Activin a is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes
Conclusions: Circulating activin A levels are associated with impaired myocardial glucose metabolism and high LVMV-ratio in patients with uncomplicated T2D, reflecting a potential detrimental role in early human diabetic cardiomyopathy.Trial registration numberCurrent Controlled Trials SRCTN53177482 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Weena ChenSabrina GreulichRutger van der MeerLuuk RijzewijkHildo LambAlbert de RoosJohannes SmitJohannes RomijnJohannes RuigeAdriaan LammertsmaMark LubberinkMichaela DiamantD Ouwens Source Type: research

Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence
Conclusions: This study provides the first evidence of crosstalk between insulin/IRS-1/PI3K signaling and RAS after acute MI, thereby adding fresh insights into the pathophysiology and treatment of acute MI. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Wei LiuXinmin ZhouFenglei YuJianguo HuWen Hu Source Type: research

Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats
Background: The combination of systemic arterial hypertension and diabetes mellitus (DM) induces greater cardiac remodeling than either condition alone. However, this association has been poorly addressed in senescent rats. Therefore, this study aimed to analyze the influence of streptozotocin-induced DM on ventricular remodeling and oxidative stress in aged spontaneously hypertensive rats (SHR). Methods: Fifty 18 month old male SHR were divided into two groups: control (SHR, n = 25) and diabetic (SHR-DM, n = 25). DM was induced by streptozotocin (40 mg/kg, i.p.). After nine weeks, the rats underwent echocardiography and m...
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Camila RosaNatasha XavierDijon Henrique CamposAna FernandesMarcelo CezarPaula MartinezAntonio CicognaCamila GimenesRodrigo GimenesMarina OkoshiKatashi Okoshi Source Type: research

Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat
In this study, we compared the effect of a long acting GLP-1 agonist, DPP-IV resistant GLP-1 (7--36, A8G) fused to an AlbudAb (GAlbudAb), with the effect of the GLP-1 mimetic, exendin-4 (short half-life GLP-1 agonist) on infarct size following acute myocardial I/R injury. Methods: Male Sprague--Dawley rats (8-week-old) were treated with vehicle, GAlbudAb or exendin-4. Myocardial ischemia was induced 2 h following the final dose for GAlbudAb and 30 min post the final dose for exendin-4. In a subgroup of animals, the final dose of exendin-4 was administered (1 mug/kg, SC, bid for 2 days) 6 h prior to myocardial ischemia when...
Source: Cardiovascular Diabetology - October 14, 2013 Category: Cardiology Authors: Weike BaoLucy HoltRob PrinceGavin JonesKarpagam AravindhanMathew SzapacsApril BarbourLarry JolivetteJohn LeporeRobert WilletteElena DeAngelisBeat Jucker Source Type: research

Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells
Conclusions: These results demonstrate that the downstream effectors of Irf-1 are cyclin E/CDK2 during the high glucose-induced proliferation of VSMCs, whereas they are cyclin D1/CDK4 in normal glucose conditions. The Irf-1 overexpression-induced proliferation of VSMCs, the up-regulation of cyclin E/CDK2 and the acceleration of cell cycle progression are associated with ROS/Erk1/2 signaling pathway under high glucose conditions. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 14, 2013 Category: Cardiology Authors: Xi ZhangLong LiuChao ChenYa-Li ChiXiang-Qun YangYan XuXiao-Tong LiShi-Lei GuoShao-Hu XiongMan-Ru ShenYu SunChuan-Sen ZhangKai-Meng Hu Source Type: research

Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus
This study measured serum electrolyte levels and examined their relationship with macrovascular complications in Chinese adults with diabetes. Methods: The three gender- and age-matched groups were enrolled into this analysis, which were 1,170 subjects with normal glucose regulation (NGR), 389 with impaired glucose regulation (IGR) and 343 with diabetes. Fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG), glycosylated hemoglobin A1c (HbA1c) and serum electrolyte levels were measured. Data collection included ankle brachial index results. Results: Serum sodium and magnesium levels in the diabetes group wer...
Source: Cardiovascular Diabetology - October 10, 2013 Category: Cardiology Authors: Shenqi WangXuhong HouYu LiuHuijuan LuLi WeiYuqian BaoWeiping Jia Source Type: research

Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study
Conclusions: ADMA is associated with diffuse but not focal coronary atherosclerosis in non-diabetic men with stable CAD irrespectively of the degree of IR. The independent relationship between ADMA and coronary atherosclerotic burden may contribute to the well-recognized prognostic effect of ADMA in CAD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 9, 2013 Category: Cardiology Authors: Olga KruszelnickaAndrzej SurdackiAlain Golay Source Type: research

The activity of circulating dipeptidyl peptidase-4 is associated with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus
Background: Patients with type 2 diabetes mellitus (T2DM) present subclinical left ventricular systolic and/or diastolic dysfunction (LVD). Dipeptidyl peptidase-4 (DPP4) inactivates peptides that possess cardioprotective actions. Our aim was to analyze whether the activity of circulating DPP4 is associated with echocardiographically defined LVD in asymptomatic patients with T2DM. Methods: In this cross-sectional study, we examined 83 T2DM patients with no coronary or valve heart disease and 59 age and gender-matched non-diabetic subjects. Plasma DPP4 activity (DPP4a) was measured by enzymatic assay and serum amino-terminal...
Source: Cardiovascular Diabetology - October 7, 2013 Category: Cardiology Authors: Susana RavassaJoaquín BarbaIsabel Coma-CanellaAna HuertaBegoña LópezArantxa GonzálezJavier Díez Source Type: research

Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC
Conclusion: Our findings highlighted a unique framework for hyperglycemia-induced endothelial dysfunction. We showed that multiple pathways are differentially affected in these endothelial cells lines in hyperglycemia. High occurrences of gene expression changes in HMVEC in this study supports the hypothesis that microvasculature precedes macrovasculature in epigenetic regulation forming vascular metabolic memory. Identifying genomic phenotype and corresponding functional changes in hyperglycemic endothelial dysfunction will provide a suitable systems biology approach for understanding underlying mechanisms and possible ef...
Source: Cardiovascular Diabetology - October 5, 2013 Category: Cardiology Authors: Hemang PatelJuan ChenKumuda DasMahendra Kavdia Source Type: research

The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs)
This study aimed to investigate the pivotal role of profilin-1 in the process of endothelial cell damage induced by AGEs. Methods: Human umbilical vein endothelial cells (HUVECs) were incubated with AGEs. The mRNA and protein expression of profilin-1 was determined using real-time PCR and western blotting analyses. The levels of intercellular adhesion molecule-1 (ICAM-1), nitric oxide (NO) and reactive oxygen species (ROS), as well as the activities of nuclear factor-kappaB (NF-kappaB) and protein kinase C (PKC), were detected using the appropriate kits. The levels of asymmetric dimethylarginine (ADMA) were determined usin...
Source: Cardiovascular Diabetology - October 4, 2013 Category: Cardiology Authors: Zhenyu LiQiaoqing ZhongTianlun YangXiumei XieMeifang Chen Source Type: research

Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines
Conclusions: In the presence of DM, neither adipokines nor MS score predicted angiographic CAD. However, in non-diabetic patients, IL-6 and adiponectin showed progressive changes according to MS score, and MS score was an independent predictor of CAD in patients without DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 2, 2013 Category: Cardiology Authors: Jong-Youn KimEui-Young ChoiHee-Sun MunPil-Ki MinYoung-Won YoonByoung LeeBum-Kee HongSe-Joong RimHyuck Kwon Source Type: research

Rationale and design of a randomized trial on the impact of aldosterone antagonism on cardiac structure and function in diabetic cardiomyopathy
: Development of cardiomyopathy in diabetes mellitus is independent of traditional risk factors, with no clinical trials targeting specific therapeutic interventions. Myocardial fibrosis is one of the key mechanisms and aldosterone is a key mediator of myocardial fibrosis. We propose that aldosterone antagonism will improve cardiac function. We aim to evaluate the efficacy of selective aldosterone receptor antagonism with eplerenone added to optimal medical treatment in improving cardiac structure and function in diabetic cardiomyopathy. We will randomize 130 patients with type 2 diabetes mellitus, stable metabolic control...
Source: Cardiovascular Diabetology - October 1, 2013 Category: Cardiology Authors: Melissa LeungVincent WongStephane HeritierAnastasia MihailidouDominic Leung Source Type: research

Lipoprotein(a) is not related to markers of insulin resistance in pregnancy
Conclusions: Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2013 Category: Cardiology Authors: Jelena TodoricAmmon HandisuryaKaroline LeitnerJuergen HarreiterGregor HoermannAlexandra Kautzky-Willer Source Type: research

Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
This study aimed to assess whether urinary adiponectin concentration is correlated with vascular complications. Methods: The study comprised 708 subjects who enrolled in the Seoul Metro City Diabetes Prevention Program and were carefully monitored from September 2008 to December 2008. Levels of urinary adiponectin were measured using an enzyme linked immunosorbent assay (ELISA) kit (AdipoGen, Korea). Urinary albumin excretion was assessed by the ratio of urinary albumin to creatinine (A/C ratio). Participants were divided into three groups based on tertiles of urinary adiponectin concentration, and we investigated whether ...
Source: Cardiovascular Diabetology - September 28, 2013 Category: Cardiology Authors: Won Seon JeonJi Woo ParkNamseok LeeSe Eun ParkEun Jung RheeWon Young LeeKi Won OhSung Woo ParkCheol-Young ParkByung-Soo Youn Source Type: research

Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin
Conclusions: High-fat feeding in combination with a low dose of STZ induced cardiac metabolic changes that mirror the decrease in glucose metabolism and increase in fat metabolism in diabetic patients. While low doses of 15--25 mg/kg STZ induced a type 2 diabetic phenotype, higher doses more closely recapitulated type 1 diabetes, demonstrating that the severity of diabetes can be easily modified according to the requirements of the study. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 24, 2013 Category: Cardiology Authors: Latt MansorEileen GonzalezMark ColeDamian TylerJessica BeesonKieran ClarkeCarolyn CarrLisa Heather Source Type: research

Cardiac implications of hypoglycaemia in patients with diabetes ¿ a systematic review
Conclusions: Emerging data suggest that there is an impact of hypoglycaemia on CV function and mechanistic link is multifactorial. Further research will be needed to ascertain the full impact of hypoglycaemia on the CV system and its complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 21, 2013 Category: Cardiology Authors: Markolf HanefeldEva DuettingPeter Bramlage Source Type: research

Cardiac implications of hypoglycaemia in patients with diabetes -- a systematic review
Conclusions: Emerging data suggest that there is an impact of hypoglycaemia on CV function and mechanistic link is multifactorial. Further research will be needed to ascertain the full impact of hypoglycaemia on the CV system and its complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 21, 2013 Category: Cardiology Authors: Markolf HanefeldEva DuettingPeter Bramlage Source Type: research

Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells
Conclusion: MG triggers eNOS uncoupling and hypophosphorylation in EA.hy926 endothelial cells associated with O2[bullet]- generation and biopterin depletion. The observed effects of the glycolysis metabolite MG presumably account, at least in part, for endothelial dysfunction in diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 19, 2013 Category: Cardiology Authors: Yang SuSyed QadriLingyun WuLixin Liu Source Type: research

Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats
Background: Large body of evidences accumulated in clinical and epidemiological studies indicate that hearts of diabetic subjects are more sensitive to ischemia reperfusion injury (IRI), which results in a higher rate of mortality at post-operation than that of non-diabetes. However, experimental results are equivocal and point to either increased or decreased susceptibility of the diabetic hearts to IRI, especially at the early stage of the disease. The present study was designed to test the hypothesis that the duration/severity of the indexed ischemia is a major determinant of the vulnerability to myocardial IRI at early...
Source: Cardiovascular Diabetology - September 17, 2013 Category: Cardiology Authors: Haobo LiZipeng LiuJunwen WangGordon WongChi-Wai CheungLiangqing ZhangCan ChenZhengyuan XiaMichael Irwin Source Type: research

Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus
Conclusions: To the best of our knowledge, this is the first report of a significant association between the ALDH2*2 allele and the incidence of DR. These findings provide additional evidence that ALDH2 protects both microvasculature and macrovasculature against reactive aldehydes generated under conditions of sustained oxidative stress, although further investigations in larger cohorts are needed to verify the results. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 13, 2013 Category: Cardiology Authors: Kazunori MoritaJunji SaruwatariHaruna MiyagawaYoshihiro UchiyashikiKentaro OnikiMisaki SakataAyami KajiwaraAkira YoshidaHideaki JinnouchiKazuko Nakagawa Source Type: research

Baseline and 1-year interim follow-up assessment of Japanese patients initiating insulin therapy who were enrolled in the cardiovascular risk evaluation in people with type 2 diabetes on insulin therapy study: an international, multicenter, observational study
Background: The Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy (CREDIT) study is an international, multicenter, observational study designed to assess metabolic parameters and cardiovascular risk of patients with type 2 diabetes mellitus (T2DM) on insulin therapy. The present report summarizes results at baseline and 1-year follow-up for the cohort of Japanese patients. Methods: Male and female patients (n = 511), aged>40 years, with T2DM for>1 year, treated with insulin therapy for>=1 month and (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 8, 2013 Category: Cardiology Authors: Ryuzo KawamoriKoichi NodeToshiaki HanafusaYoshihito AtsumiYusuke NaitoYoshitomo Oka Source Type: research

The cardiovascular safety of incretin-based therapies: a review of the evidence
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in people with diabetes and therefore managing cardiovascular (CV) risk is a critical component of diabetes care. As incretin-based therapies are effective recent additions to the glucose-lowering treatment armamentarium for type 2 diabetes mellitus (T2D), understanding their CV safety profiles is of great importance. Glucagon-like peptide-1 (GLP-1) receptor agonists have been associated with beneficial effects on CV risk factors, including weight, blood pressure and lipid profiles. Encouragingly, mechanistic studies in preclinical models and in pat...
Source: Cardiovascular Diabetology - September 6, 2013 Category: Cardiology Authors: John Petrie Source Type: research

Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control
DiscussionThis is the largest study to compare the efficacy and safety of an SGLT2 inhibitor with an SU in patients with T2DM inadequately controlled on metformin to date. In addition to determining the effects of these treatments on glycemic control over the long term, this study will investigate effects on beta-cell function, cardiovascular risk factors and markers of renal function/damage. The results will help to inform the choice of second-line treatment in patients with T2DM who have failed on metformin.Trial registrationClinicaltrials.gov NCT01167881. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 5, 2013 Category: Cardiology Authors: Martin RidderstråleRobbyna SvaerdCordula ZellerGabriel KimHans WoerleUli Broedl Source Type: research

Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart
Conclusions: These studies provide insight into the utility of MSC transplantation as a metabolic therapy that extends beyond the heart exerting beneficial systemic effects on insulin action. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 4, 2013 Category: Cardiology Authors: Curtis HugheyLianli MaFreyja JamesDeanna BracyZhizhang WangDavid WassermanJeffrey RottmanDustin HittelJane Shearer Source Type: research

Interleukin-6 and activin A are independently associated with cardiovascular events and mortality in type 2 diabetes: the prospective Asker and Bærum Cardiovascular Diabetes (ABCD) cohort study
Conclusions: IL-6 and actA may provide prognostic information on CV events and mortality in T2D beyond conventional CV risk factors.Trial registrationClinicalTrials.gov: NCT00133718 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 30, 2013 Category: Cardiology Authors: Anne Pernille OfstadLars GullestadElsa OrvikSvend AakhusKnut EndresenThor UelandPål AukrustMorten FagerlandKåre BirkelandOdd Erik Johansen Source Type: research

Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis
Background: Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an ectopic fat depot with possible paracrine or mechanical effects on myocardial function. The aim of our current study is to assess the association between EpF and Left ventricular diastolic dysfunction (LVDD) in patients undergoing PD and to clarify the relationships among EpF, inflammation, and LVDD in this population. Methods: This was a cross-sectional study of 149 patients with preserved left ventricular systolic function who were undergoing PD....
Source: Cardiovascular Diabetology - August 30, 2013 Category: Cardiology Authors: Heng-Hsu LinJen-Kuang LeeChung-Yi YangYu-Chung LienJenq-Wen HuangCho-Kai Wu Source Type: research

Interleukin-6 and activin A are independently associated with cardiovascular events and mortality in type 2 diabetes: the prospective Asker and Baerum Cardiovascular Diabetes (ABCD) cohort study
Conclusions: IL-6 and actA may provide prognostic information on CV events and mortality in T2D beyond conventional CV risk factors.Trial registrationClinicalTrials.gov: NCT00133718 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 30, 2013 Category: Cardiology Authors: Anne Pernille OfstadLars GullestadElsa OrvikSvend AakhusKnut EndresenThor UelandPål AukrustMorten FagerlandKåre BirkelandOdd Erik Johansen Source Type: research

Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
Conclusions: The present study suggests that AGE-RAGE-induced ROS generation stimulates the release of DPP-4 from ECs, which could in turn act on ECs directly via the interaction with M6P/IGF-IIR, further potentiating the deleterious effects of AGEs. The blockade by linagliptin of positive feedback loop between AGE-RAGE axis and DPP-4 might be a novel therapeutic target for vascular injury in diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2013 Category: Cardiology Authors: Yuji IshibashiTakanori MatsuiSayaka MaedaYuichiro HigashimotoSho-ichi Yamagishi Source Type: research

Correction: Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy
No description available (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2013 Category: Cardiology Authors: Joris van ArkHans-Peter HammesMarcory van DijkChris LexisIwan van der HorstClark ZeebregtsMarc VervloetBruce WolffenbuttelHarry van GoorJan-Luuk Hillebrands Source Type: research

Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease
This study was designed to investigate whether serum FGF21 level was also associated with the metabolic syndrome-related cardiovascular disease, atherosclerosis, and its clinical features in a Chinese cohort. Methods: Two-hundred-and-fifty-three subjects visiting the Cardiology Department (Sixth People's Hospital affiliated to Shanghai JiaoTong University) were examined by coronary arteriography (to diagnose coronary artery disease (CAD)) and hepatic ultrasonography (to diagnose non-alcoholic fatty liver disease (NAFLD)). Serum FGF21 level was measured by enzyme-linked immunosorbent assay and analyzed for correlation to su...
Source: Cardiovascular Diabetology - August 28, 2013 Category: Cardiology Authors: Yun ShenXiaojing MaJian ZhouXiaoping PanYaping HaoMi ZhouZhigang LuMeifang GaoYuqian BaoWeiping Jia Source Type: research

Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats
Conclusions: Diabetes causes cardiomyopathy through a copper-mediated mechanism that incorporates myocardial copper deficiency, whereas TETA treatment prevents this response and maintains the integrity of cardiac structure and myofibrillar calcium sensitivity. Altered calcium homeostasis may not be the primary defect in diabetic cardiomyopathy. Rather, a newly-described copper-mediated mechanism may cause this disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 28, 2013 Category: Cardiology Authors: Lin ZhangMarie-Louise WardAnthony PhillipsShaoping ZhangJohn KennedyBernard BarryMark CannellGarth Cooper Source Type: research

24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes ¿ a cross-sectional study
Background: Non-invasive measurements of 24 h ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes. Methods: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration ( 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average. Results: In C, SN, LN, Mi and Ma mean +/- SD...
Source: Cardiovascular Diabetology - August 27, 2013 Category: Cardiology Authors: Simone TheiladeMaria LajerTine HansenChristel JoergensenFrederik PerssonGudbjörg AndrésdottirHenrik ReinhardStine NielsenPeter LacyBryan WilliamsPeter Rossing Source Type: research

Prognostic value of coronary flow reserve assessed by transthoracic Doppler echocardiography on long-term outcome in asymptomatic patients with type 2 diabetes without overt coronary artery disease
Background: Cardiovascular risk stratification of asymptomatic diabetic patients is important and remains a difficult clinical problem. Our aim was to test the hypothesis that coronary flow reserve (CFR) assessed by noninvasive transthoracic Doppler echocardiography predicts prognosis in those patients. Methods: From February 2002 to January 2005, we evaluated 135 consecutive asymptomatic patients (74 male; mean age, 63 +/- 9 years) with type 2 diabetes without a history of coronary artery disease. Adenosine triphosphate (0.14 mg/kg/min) stress Doppler echocardiography was performed to evaluate CFR of the left anterior des...
Source: Cardiovascular Diabetology - August 27, 2013 Category: Cardiology Authors: Takayuki KawataMasao DaimonRei HasegawaTomohiko ToyodaTai SekineToshiharu HimiDaigaku UchidaSakiko MiyazakiKuniaki HiroseRyoko IchikawaMasaki MaruyamaHiromasa SuzukiHiroyuki Daida Source Type: research

24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes -- a cross-sectional study
Background: Non-invasive measurements of 24 h ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes. Methods: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration ( 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average. Results: In C, SN, LN, Mi and Ma mean +/- SD...
Source: Cardiovascular Diabetology - August 27, 2013 Category: Cardiology Authors: Simone TheiladeMaria LajerTine HansenChristel JoergensenFrederik PerssonGudbjörg AndrésdottirHenrik ReinhardStine NielsenPeter LacyBryan WilliamsPeter Rossing Source Type: research

Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects
Conclusions: Our data suggest that circulating NAMPT levels are associated with CAD in type 2 diabetic patients. NAMPT rs9770242 polymorphism may be associated with CAD in some populations. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 22, 2013 Category: Cardiology Authors: Pedro Saddi-RosaCarolina Viana de OliveiraFelipe CrispimFernando GiuffridaValter de LimaJosé VieiraAlessandro DoriaGilberto VelhoAndré Reis Source Type: research

Efficacy and safety of combination therapy with vildagliptin and metformin versus metformin up-titration in Chinese patients with type 2 diabetes mellitus: study design and rationale of the vision study
Background and aim: Limitations of the currently recommended stepwise treatment pathway for type 2 diabetes mellitus (T2DM), especially the failure of monotherapies to maintain good glycemic control, have prompted use of early, more aggressive combination therapies.The VISION study is designed to explore the efficacy and safety of vildagliptin as an add-on to metformin therapy compared with up-titration of metformin monotherapy in Chinese patients with T2DM. Methods: VISION, a 24-week, phase 4, prospective, randomized, multicenter, open-label, parallel-group study, will include 3312 Chinese T2DM patients aged>=18 years ...
Source: Cardiovascular Diabetology - August 19, 2013 Category: Cardiology Authors: Li-Nong JiChang-Yu PanJu-Ming LuHong LiQiang LiQi-Fu LiYong-De PengHao-Ming TianChen YaoZhi-Gang ZhaoRu-Ya ZhangXiang-Ling WangLei Wang Source Type: research

Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans
Conclusion: Circulating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 16, 2013 Category: Cardiology Authors: Katja PiotrowskiMelanie BeckerJulia ZugwurstIngeborg Biller-FriedmannGerald SpoettlMartin GreifAlexander LeberAlexander BeckerRüdiger LaubenderCorinna LebherzBurkhard GoekeNikolaus MarxKlaus ParhoferMichael Lehrke Source Type: research

Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy
Background: Diabetes is associated with a high incidence of macrovascular disease (MVD), including peripheral and coronary artery disease. Circulating soluble-Klotho (sKlotho) is produced in the kidney and is a putative anti-aging and vasculoprotective hormone. Reduced Klotho levels may therefore increase cardiovascular risk in diabetes. We investigated if sKlotho levels are decreased in type 2 diabetes and associate with MVD in the absence of diabetic nephropathy, and whether hyperglycemia affects renal Klotho production in vitro and in vivo. Methods: sKlotho levels were determined with ELISA in diabetic and non-diabetic ...
Source: Cardiovascular Diabetology - August 14, 2013 Category: Cardiology Authors: Joris van ArkHans-Peter HammesMarcory van DijkMarc VervloetBruce WolffenbuttelHarry van GoorJan-Luuk Hillebrands Source Type: research

Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus
Conclusions/interpretation: Skin microvascular endothelial dysfunction is already present in about 25% of paediatric type 1 diabetic patients suffering from type 1 diabetes for at least one year. Future studies are needed to assess the predictive value of endothelial dysfunction in the development of long-term (cardio)vascular comorbidity in these patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 12, 2013 Category: Cardiology Authors: Mirjam Heimhalt-El HamritiCorinna SchreiverAnja NoerenbergJulia SchefflerUlrike JacobyDieter HaffnerDagmar-C Fischer Source Type: research

The neurogenic response of cardiac resident nestin(+) cells was associated with GAP43 upregulation and abrogated in a setting of type I diabetes
Conclusion: The transient upregulation of GAP43 apparently represents a transition event during the acquisition of a neuronal-like phenotype and a type I diabetic environment attenuated the neurogenic response of cardiac nestin(+) cells to ischemia and 6-hydroxydopamine. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 12, 2013 Category: Cardiology Authors: Andreanne ChabotMarc-Andre MeusVanessa HertigNatacha DuquetteAngelino Calderone Source Type: research

Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year prospective study
The objective of this study was to determine the effect of vitamin D3 supplementation in a cohort of Saudi DMT2 population on diet, insulin and/or different oral hypoglycemic agents and compare them with a non-DMT2 control cohort. Methods: A total of 499 randomly selected Saudi subjects divided into 8 groups [Non-DMT2 Control = 151; Rosiglitazone alone = 49; Diet = 15; Insulin alone = 55; Insulin + Orals = 12; Metformin alone = 121; Oral agents combination = 37; Sulphonylurea alone = 59] were included in this 12-month interventional study. All DMT2 patients were given 2000 IU vitamin D3 daily, while the control group recei...
Source: Cardiovascular Diabetology - August 7, 2013 Category: Cardiology Authors: Khalid AlkharfyNasser Al-DaghriShaun SabicoAbdulaziz Al-OthmanOsama MoharramMajed AlokailYousef Al-SalehSudhesh KumarGeorge Chrousos Source Type: research

Impact of the LDL subfraction phenotype on Lp-PLA2 distribution, LDL modification and HDL composition in type 2 diabetes
Conclusions: The presence of LDL subfraction phenotype B is associated with increased oxidized LDL, glycated LDL and Lp-PLA2 activity associated to apoB-containing lipoproteins, as well as with abnormal HDL composition. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 5, 2013 Category: Cardiology Authors: Jose Sánchez-QuesadaIrene VinagreElena De Juan-FrancoJuan Sánchez-HernándezRosa Bonet-MarquesFrancisco Blanco-VacaJordi Ordóñez-LlanosAntonio Pérez Source Type: research

Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation
Objectives: Activation of RhoA/Rho-kinase (ROCK) is increasingly implicated in acute vasospasm and chronic vasoconstriction in major organ systems. Therefore we aimed to ascertain whether an increase in ROCK activity plays a role in the deterioration of coronary vascular function in early stage diabetes. Methods: Synchrotron radiation microangiography was used to determine in vivo coronary responses in diabetic (3 weeks post streptozotocin 65 mg/kg ip) and vehicle treated male Sprague--Dawley rats (n = 8 and 6). Changes in vessel number and calibre during vasodilator stimulation before and after blockade of nitric oxide sy...
Source: Cardiovascular Diabetology - August 1, 2013 Category: Cardiology Authors: James PearsonMathew JenkinsAmanda EdgleyTakashi SonobeMandar JoshiMark WaddinghamYutaka FujiiDaryl SchwenkeHirotsugu TsuchimochiMisa YoshimotoKeiji UmetaniDarren KellyMikiyasu Shirai Source Type: research

Low-grade albuminuria is associated with early but not late carotid atherosclerotic lesions in community-based patients with type 2 diabetes
Background: Low-grade albuminuria is associated with cardiovascular risk factors and mortality. Our aim was to investigate the association between low-grade albuminuria and carotid atherosclerotic lesions in community-based patients with type 2 diabetes. Methods: A cross-sectional study was performed in 475 community-based patients with type 2 diabetes (190 males and 285 females) with normal urinary albumin-to-creatinine ratios (UACR) (
Source: Cardiovascular Diabetology - July 24, 2013 Category: Cardiology Authors: Mei-Fang LiYin-Fang TuLian-Xi LiJun-Xi LuXue-Hong DongLi-Bo YuRong ZhangYu-Qian BaoWei-Ping JiaRen-Ming Hu Source Type: research

Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis
Conclusions: We created a resource to study genetics of left ventricular hypertrophy in diabetes and validated our left ventricular hypertrophy phenotype in replicating single nucleotide polymorphisms identified by previous genome wide association studies investigating left ventricular hypertrophy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2013 Category: Cardiology Authors: Helen ParryLouise DonnellyNatalie van ZuydamAlexander DoneyDouglas ElderAndrew MorrisAllan StruthersColin PalmerChim Lang Source Type: research

Dual renin-angiotensin system inhibition for prevention of renal and cardiovascular events: do the latest trials challenge existing evidence?
Circulatory and tissue renin-angiotensin systems (RAS) play a central role in cardiovascular (CV) and renal pathophysiology, making RAS inhibition a logical therapeutic approach in the prevention of CV and renal disease in patients with hypertension. The cardio- and renoprotective effects observed with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) monotherapy, together with the availability of a direct renin inhibitor (DRI), led to the investigation of the potential benefits of dual RAS inhibition. In small studies, ARB and ACE inhibitor combinations were shown to be beneficial i...
Source: Cardiovascular Diabetology - July 19, 2013 Category: Cardiology Authors: Samir Mallat Source Type: research

Plasma levels of the arterial wall protein fibulin-1 are associated with carotid-femoral pulse wave velocity: a cross-sectional study
Background: The arterial system in diabetic patients is characterized by generalized non-atherosclerotic alterations in the vascular extracellular matrix causing increased arterial stiffness compared with subjects without diabetes. The underlying pathophysiology remains elusive. The elastin-associated extracellular matrix protein, fibulin-1, was recently found in higher concentrations in the arterial wall and in plasma in patients with long duration type 2 diabetes. Furthermore, plasma fibulin-1 independently predicted total mortality and was associated with pulse pressure, an indirect measure of arterial stiffness. Whethe...
Source: Cardiovascular Diabetology - July 18, 2013 Category: Cardiology Authors: Esben LaugesenPernille HøyemJens ChristiansenSøren KnudsenKlavs HansenW ArgravesTroels HansenPer PoulsenLars Rasmussen Source Type: research

Inverse associations between light-to-moderate alcohol intake and lipid-related indices in patients with diabetes
Conclusions: In patients with diabetes, light-to-moderate alcohol consumption is inversely associated with lipid-related indices, and this correlates with previous findings of cardiovascular risk reduction by modest drinking in patients with diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 17, 2013 Category: Cardiology Authors: Tomoko ShimomuraIchiro Wakabayashi Source Type: research