Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet
Conclusions: These data suggest that HFC-fed Tibetan minipigs develop IR and AS and that PPARs are involved in cardiovascular remodeling and impaired function. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2015 Category: Cardiology Authors: Pan YongmingCai ZhaoweiMa YichaoZhu KeyanChen LiangChen FangmingXu XiaopingMa QuanxinChen Minli Source Type: research

Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study: a case series report
Background: The cardio ankle vascular index (CAVI) is a new index of the overall stiffness of the artery from the origin of the aorta to the ankle. This index can estimate the risk of atherosclerosis. We aimed to find the relationship between CAVI and target organ damage (TOD), vascular structure and function, and cardiovascular risk factors in Caucasian patients with type 2 diabetes mellitus or metabolic syndrome. Methods: We included 110 subjects from the LOD-Diabetes study, whose mean age was 61???11?years, and 37.3% were women. Measurements of CAVI, brachial ankle pulse wave velocity (ba-PWV), and ankle brachial index ...
Source: Cardiovascular Diabetology - January 16, 2015 Category: Cardiology Authors: Manuel Gómez-MarcosJosé Recio-RodríguezMaría Patino-AlonsoCristina Agudo-CondeLeticia Gómez-SánchezMarta Gomez-SanchezEmiliano Rodríguez-SanchezJose Maderuelo-FernandezLuís García-OrtizLOD-DIABETES Group Source Type: research

Systemic arteriosclerosis and eating behavior in Japanese type 2 diabetic patients with visceral fat accumulation
We described previously visceral fat accumulation and multiple cardiovascular risk factors in a considerable number of Japanese non-obese subjects (BMI (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2015 Category: Cardiology Authors: Shiro FukudaAyumu HirataHitoshi NishizawaHirofumi NagaoSusumu KashineTakekazu KimuraKana InoueYuya FujishimaMasaya YamaokaJunji KozawaTetsuhiro KitamuraTetsuyuki YasudaNorikazu MaedaAkihisa ImagawaTohru FunahashiIichiro Shimomura Source Type: research

Body weight and risk of atrial fibrillation in 7,169 patients with newly diagnosed type 2 diabetes; an observational study
Background: Obesity, type 2 diabetes and atrial fibrillation (AF) are closely associated, but the underlying mechanisms are not fully understood. We aimed to explore associations between body mass index (BMI) or weight change with risk of AF in patients with type 2 diabetes. Methods: A total of 7,169 participations with newly diagnosed type 2 diabetes were stratified according to baseline BMI, and after a second BMI measurement within 18?months, further grouped according to relative weight change as ?weight gain? (>1 BMI unit), ?stable weight? (+/? 1 BMI unit) and ?weight loss? ( (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 15, 2015 Category: Cardiology Authors: Irene GrundvoldJohan BodegardPeter NilssonBodil SvennbladGunnar JohanssonCarl ÖstgrenJohan Sundström Source Type: research

Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications
This article summarizes the crosstalk between AGEs-RAGE axis and DPP-4-incretin system in the development and progression of diabetes-associated disorders and its therapeutic intervention, especially focusing on diabetic vascular complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2015 Category: Cardiology Authors: Sho-ichi YamagishiKei FukamiTakanori Matsui Source Type: research

Higher blood aldosterone level in metabolic syndrome is independently related to adiposity and fasting plasma glucose
In this study, we investigate the association of aldosterone with MetS and IR, and compare it with that of adiponectin. Methods: In this cross-sectional study, we recruited 556 women receiving physical examinations at a general hospital in central Taiwan. At the time of examination, we collected data on various demographic and physical characteristics and measured blood levels of aldosterone, adiponectin and a variety of metabolic factors. Multiple linear regression analysis was performed using adiponectin or aldosterone as the dependent variables. Results: We found an inverse correlation between blood adiponectin and aldo...
Source: Cardiovascular Diabetology - January 13, 2015 Category: Cardiology Authors: Jui-Kun ChiangChi-Ling ChenFeng-Yu TsengYu-Chiao ChiKuo-Chin HuangWei-Shiung Yang Source Type: research

Diastolic dysfunction in the diabetic continuum : association with insulin resistance, metabolic syndrome and type 2 diabetes
Background: Diabetes increases the risk of heart failure but the underlying mechanisms leading to diabetic cardiomyopathy are poorly understood. Left ventricle diastolic dysfunction (LVDD) is one of the earliest cardiac changes in these patients. We aimed to evaluate the association between LVDD with insulin resistance, metabolic syndrome (MS) and diabetes, across the diabetic continuum. Methods: Within a population-based study (EPIPorto), a total of 1063 individuals aged ?45?years (38% male, 61.2???9.6?years) were evaluated. Diastolic function was assessed by echocardiography, using tissue Doppler analysis (E? velocity an...
Source: Cardiovascular Diabetology - January 13, 2015 Category: Cardiology Authors: Ricardo Fontes-CarvalhoRicardo Ladeiras-LopesPaulo BettencourtAdelino Leite-MoreiraAna Azevedo Source Type: research

Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE
Conclusions: The present study suggests that GLAP might be a main glyceraldehyde-related AGE structure in Gly-AGEs that bound to RAGE and subsequently elicited ROS generation and inflammatory and thrombogenic reactions in HUVECs. Blockade of the GLAP-RAGE interaction by AGE-aptamer or GLAP-aptamer might be a novel therapeutic strategy for preventing vascular injury in diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 8, 2015 Category: Cardiology Authors: Takanori MatsuiEriko OdaYuichiro HigashimotoSho-ichi Yamagishi Source Type: research

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats
Conclusions: In this short-term model of type 1 diabetes, endothelial dysfunction is associated to an IL-1 receptor-mediated activation of vascular NADPH oxidase and NF-?B, as well as to vascular inflammation. Moreover, endothelial dysfunction, vascular oxidative stress and inflammation were reduced after anakinra treatment. Whether this mechanism can be extrapolated to a chronic situation or whether it may apply to diabetic patients remain to be established. However, it may provide new insights to further investigate the therapeutic use of IL-1 receptor antagonists to obtain vascular benefits in patients with diabetes mel...
Source: Cardiovascular Diabetology - December 18, 2014 Category: Cardiology Authors: Susana VallejoErika PalaciosTania RomachoLaura VillalobosConcepción PeiróCarlos Sánchez-Ferrer Source Type: research

Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study
Background: Vascular calcified plaque, a measure of subclinical cardiovascular disease (CVD), is unlikely to be limited to a single vascular bed in patients with multiple risk factors. Consideration of vascular calcified plaque as a global phenomenon may allow for a more accurate assessment of the CVD burden. The aim of this study was to examine the utility of a combined vascular calcified plaque score in the prediction of mortality. Methods: Vascular calcified plaque scores from the coronary, carotid, and abdominal aortic vascular beds and a derived multi-bed score were examined for associations with all-cause and CVD-mor...
Source: Cardiovascular Diabetology - December 12, 2014 Category: Cardiology Authors: Amanda CoxFang-Chi HsuSubhashish AgarwalBarry FreedmanDavid HerringtonJ CarrDonald Bowden Source Type: research

Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo
Background: Increasing numbers of type 2 diabetic and obese patients with enhanced rates of cardiovascular complications require surgical interventions, however they have a higher incidence of perioperative haemodynamic complications, which has been linked to adrenergic dysfunction. Therefore, we aimed to determine how α- and β-adrenoceptor (AR)-mediated haemodynamic responses are affected by isoflurane anaesthesia in experimental type 2 diabetes and obesity in vivo. Methods: Sixteen-week old male Zucker type 2 Diabetic Fatty (ZDF) rats, Zucker Obese rats and their lean counterparts (n = 7-9 per gr...
Source: Cardiovascular Diabetology - December 10, 2014 Category: Cardiology Authors: Carol BusseyAnne de LeeuwRegis Lamberts Source Type: research

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor
In conclusion, the classical clinical paradigm of lipids-modifying treatment should be changed and high TG should be recognized as an important target for therapy in their own right. Hypertriglyceridemia should be treated. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 4, 2014 Category: Cardiology Authors: Alexander TenenbaumRobert KlempfnerEnrique Fisman Source Type: research

Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control
Conclusions: In patients with type 2 diabetes, ADMA might be an independent risk factor for long-term adverse cardiovascular events. However, ADMA was not correlated with serum HbA1c level, and in diabetic patients with HbA1c ?6.5%, elevated ADMA level was no longer associated with increased risk of long-term prognosis. Our findings suggested that the prognosis predictive value of ADMA in type 2 diabetes might be modified by the glycemic control. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 3, 2014 Category: Cardiology Authors: Chiao-Po HsuPai-Feng HsuMing-Yi ChungShing-Jong LinTse-Min Lu Source Type: research

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure
Conclusions: Our results provided the experimental evidence that linagliptin treatment initiated after the appearance of hypertension and cardiac hypertrophy protected against cardiovascular injury induced by salt-sensitive hypertension, independently of blood pressure and blood glucose. These beneficial effects of linagliptin seem to be attributed to the reduction of oxidative stress and ACE. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 29, 2014 Category: Cardiology Authors: Nobutaka KoibuchiYu HasegawaTetsuji KatayamaKensuke ToyamaKen UekawaDaisuke SuetaHiroaki KusakaMingJie MaTakashi NakagawaBowen LinShokei Kim-Mitsuyama Source Type: research

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice
Conclusions: Our data demonstrate that GW3965 exerts a cardioprotective effect against DCM by (at least in part) attenuating insulin resistance, modulating Akt and MAP kinases pathways, and reducing oxidative/nitrative stress and inflammatory response. These findings strongly suggest that LXR agonist may have therapeutic potential in treating DCM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 22, 2014 Category: Cardiology Authors: Qing HeJun PuAncai YuanTianbao YaoXiaoying YingYichao ZhaoLongwei XuHuan TongBen He Source Type: research

Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway
Conclusion: GLP-1RA exenatide can inhibit human VSMCs calcification through NF-κB/RANKL signaling. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Jun-Kun ZhanPan TanYan-Jiao WangYi WangJie-Yu HeZhi-Yong TangWu HuangYou-Shuo Liu Source Type: research

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury
In this study, we investigated the vascular-protective effect of the DPP-4 inhibitor, linagliptin, using vascular smooth muscle cells (VSMCs). Methods: Six-week-old male C57BL/6 mice were divided into control (n =19) and linagliptin (3 mg/kg/day, n =20) treated groups. Endothelial denudation injuries were induced in the femoral artery at 8 weeks of age, followed by evaluation of neointima formation at 12 weeks. To evaluate cell proliferation of rat aortic smooth muscle cells, a bromodeoxyuridine (BrdU) incorporation assay was performed. Results: Linagliptin treatment reduced vascular injury-induced neointima...
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Yuichi TerawakiTakashi NomiyamaTakako KawanamiYuriko HamaguchiHiroyuki TakahashiTomoko TanakaKunitaka MuraseRyoko NagaishiMakito TanabeToshihiko Yanase Source Type: research

The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report
Conclusions: These data suggest that the Mediterranean diet, using olive oil, prevents the acute hyperglycemia effect on endothelial function, inflammation and oxidative stress, and improves the action of GLP-1, which may have a favorable effect on the management of type 2 diabetes, particularly for the prevention of cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Antonio CerielloKatherine EspositoLucia La SalaGemma PujadasValeria De NigrisRoberto TestaLoredana BucciarelliMaurizio RondinelliStefano Genovese Source Type: research

Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway
Conclusion: GLP-1RA exenatide can inhibit human VSMCs calcification through NF-?B/ RANKL signaling. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Jun-Kun ZhanPan TanYan-Jiao WangYi WangJieyu HeZhi-Yong TangWu HuangYou-Shuo Liu Source Type: research

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury
In this study, we investigated the vascular-protective effect of the DPP-4 inhibitor, linagliptin, using vascular smooth muscle cells (VSMCs). Methods: Six-week-old male C57BL/6 mice were divided into control (n =19) and linagliptin (3?mg/kg/day, n =20) treated groups. Endothelial denudation injuries were induced in the femoral artery at 8?weeks of age, followed by evaluation of neointima formation at 12?weeks. To evaluate cell proliferation of rat aortic smooth muscle cells, a bromodeoxyuridine (BrdU) incorporation assay was performed. Results: Linagliptin treatment reduced vascular injury-induced neointima formation, com...
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Yuichi TerawakiTakashi NomiyamaTakako KawanamiYuriko HamaguchiHiroyuki TakahashiTomoko TanakaKunitaka MuraseRyoko NagaishiMakito TanabeToshihiko Yanase Source Type: research

Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease
Background: Secreted frizzled-related proteins (SFRP) are regulators of Wnt-signalling. SFRP4 has been shown to regulate insulin exocytosis and is overexpressed in type 2 diabetes mellitus.Here we characterized the relation of SFRP4 to glucose and triglyceride metabolism and outcomes in patients with stable coronary artery disease on statin treatment in the prospective Homburg Cream & Sugar Study (NCT00628524). Methods: Fasting SFRP4 concentrations were measured by ELISA in 504 consecutive patients with stable CAD confirmed by angiography. Results: The median age was 68?years and 83% of patients were male. Oral glucose...
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Michael HoffmannChristian WernerMichael BöhmUlrich LaufsKarl Winkler Source Type: research

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice
Conclusions: Subcutaneous immunization with AGE-LDL significantly inhibits atherosclerosis progression in hyperlipidemic diabetic mice possibly through activation of specific humoral and cell mediated immune responses and metabolic control improvement. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Lin ZhuZhiqing HeFeng WuRu DingQixia JiangJiayou ZhangMin FanXing WangBengtsson EvaNilsson JanChun LiangZonggui Wu Source Type: research

Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis
Conclusion: The protective effect of metformin against free fatty acid induced apoptosis is potentially clinically relevant as metformin is first line treatment for patients with T2D, a patient group which is rapidly increasing and carries a high burden of cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Linnéa ErikssonThomas Nyström Source Type: research

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice
Conclusions: Subcutaneous immunization with AGE-LDL significantly inhibits atherosclerosis progression in hyperlipidemic diabetic mice possibly through activation of specific humoral and cell mediated immune responses and metabolic control improvement. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Lin ZhuZhiqing HeFeng WuRu DingQixia JiangJiayou ZhangMin FanXing WangBengtsson EvaNilsson JanChun LiangZonggui Wu Source Type: research

Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis
Conclusion: The protective effect of metformin against free fatty acid induced apoptosis is potentially clinically relevant as metformin is first line treatment for patients with T2D, a patient group which is rapidly increasing and carries a high burden of cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Linnéa ErikssonThomas Nyström Source Type: research

PPAR¿ activation but not PPAR¿ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors
Conclusions: In summary, activation of PPARγ by rosiglitazone improves angiogenic potential of diabetic ECs and PACs, but decreased expression of PPARγ in diabetes does not impair angiogenesis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Jerzy KotlinowskiAnna Grochot-PrzeczekHevidar TahaMagdalena KozakowskaBartosz PileckiKlaudia SkrzypekAleksandra BartelikRafal DerlaczAnton HorrevoetsAttila PapLaszlo NagyJozef DulakAlicja Jozkowicz Source Type: research

Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris
Background: Recent evidence demonstrated that the circulating adipokines were associated with the onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and acute myocardial infarction (AMI). As a novel adipokine, chemerin has been related to atherosclerosis and the presence of coronary artery disease. However, the plasma levels of chemerin in patients with ACS have yet to be investigated. Methods: Plasma levels of chemerin and adiponectin were measured by an enzyme-linked immunosorbent assay (ELISA) in 60 patients with stable angina pectoris (SAP), 60 patients with UAP, 60 patients with AMI and 40...
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Qingwei JiYingzhong LinZhishan LiangKunwu YuYuyang LiuZhe FangLing LiuYing ShiQiutang ZengChao ChangMeng ChaiYujie Zhou Source Type: research

Association of impaired fasting glucose, diabetes and their management with the presentation and outcome of peripheral artery disease: a cohort study
Conclusions: Non-medicated diabetes is common in peripheral artery disease patients and associated with poor outcomes. Impaired fasting glucose is also common but does not increase intermediate term complications. Peripheral artery disease patients with diabetes requiring insulin are at high risk of intermediate term mortality. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Jonathan GolledgeFrank QuigleyRamesh VeluPhillip WalkerJoseph Moxon Source Type: research

PPAR¿ activation but not PPAR¿ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors
Conclusions: In summary, activation of PPAR? by rosiglitazone improves angiogenic potential of diabetic ECs and PACs, but decreased expression of PPAR? in diabetes does not impair angiogenesis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Jerzy KotlinowskiAnna Grochot-PrzeczekHevidar TahaMagdalena KozakowskaBartosz PileckiKlaudia SkrzypekAleksandra BartelikRafal DerlaczAnton HorrevoetsAttila PapLaszlo NagyJozef DulakAlicja Jozkowicz Source Type: research

Association between carotid intima-media thickness and index of central fat distribution in middle-aged and elderly Chinese
Background: Evidence has demonstrated that central fat distribution produces the most profound metabolic abnormalities and is associated with an increased risk of atherosclerotic cardiovascular diseases. We aimed to investigate whether the indexes of central fat distribution, including waist-to-height ratio (WHtR) and visceral fat area (VFA), were stronger risk factors of subclinical atherosclerosis than body mass index (BMI) in Chinese adults. Methods: A total of 3381 participants aged 40?years or older without history of cardiovascular diseases (CVD) were enrolled in the present cross-sectional study from the Songnan com...
Source: Cardiovascular Diabetology - October 30, 2014 Category: Cardiology Authors: Chenxi RenJie ZhangYu XuBaihui XuWanwan SunJichao SunTiange WangMin XuJieli LuWeiqing WangYufang BiYuhong Chen Source Type: research

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
Conclusions: Glycemic control with empagliflozin significantly ameliorated cardiovascular injury and remodeling, vascular dysfunction, and cognitive decline in obese and type 2 diabetic mice. Thus, empagliflozin seems to be potentially a promising therapeutic agent for diabetic macrovascular disease and cognitive decline. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 26, 2014 Category: Cardiology Authors: Bowen LinNobutaka KoibuchiYu HasegawaDaisuke SuetaKensuke ToyamaKen UekawaMingJie MaTakashi NakagawaHiroaki KusakaShokei Kim-Mitsuyama Source Type: research

Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study
Conclusions: Brain atrophy is associated with resting aortic stiffness in T2DM, and resting Pexcess in healthy individuals. Central vascular mechanisms underlying structural brain changes may differ between healthy individuals and T2DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 23, 2014 Category: Cardiology Authors: Rachel ClimieVelandai SrikanthRichard BeareLaura KeithJames FellJustin DaviesJames Sharman Source Type: research

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
Patients with type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and stroke are responsible for 75% of all death in patients with diabetes, who present a 2-4x increased incidence of death from coronary artery disease. Patients with diabetes are considered for cardiovascular disease secondary prevention because their risk level is similar to that reported in patients without diabetes who have already suffered a myocardial infarction. More recently, with a better risk factors control, mainly in intensive LDL cholesterol target...
Source: Cardiovascular Diabetology - October 22, 2014 Category: Cardiology Authors: Francisco SaraivaAndrei Sposito Source Type: research

Normal weight diabetic patients versus obese diabetics: relation of overall and abdominal adiposity to vascular health
Conclusions: Abdominal obesity defined by WC was associated with significantly higher AI and PWV in in both diabetic men and women; whereas overall obesity defined by BMI did not predict adverse vascular changes in this study population. Abdominal obesity was associated with an adverse effect on blood vessels, independently of age, sex, blood pressure, fasting glucose and BMI. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 22, 2014 Category: Cardiology Authors: Alla LukichDov GavishMarina Shargorodsky Source Type: research

Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance
Conclusion: The apoB/apoA-I performs no better than any of the traditional lipid ratios in correlating with IR. The TG/HDL-C, VAI and TyG are better markers for early identification of IR individuals. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 20, 2014 Category: Cardiology Authors: Tingting DuGang YuanMuxun ZhangXinrong ZhouXingxing SunXuefeng Yu Source Type: research

Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study
Conclusions: This finding suggests that more attention should be given to the management of cardiovascular risk in type 2 diabetic patients with high triglycerides levels. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2014 Category: Cardiology Authors: Maria-Agata MiselliEdoardo NoraAngelina PassaroFranco TomasiGiovanni Zuliani Source Type: research

Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study
Conclusion: The study shows that a 4-month treatment with add-on insulin significantly increases the outgrowth of EPC in patients with type 2 diabetes mellitus.Trial registration(Clinical Trials Identifier: NCT00523393). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2014 Category: Cardiology Authors: Dimitrios OikonomouStefan KopfRüdiger von BauerZdenka DjuricRita CebolaAnja SanderStefan EnglertSpiros VittasAsa HidmarkMichael MorcosGrigorios KorosoglouPeter NawrothPer Humpert Source Type: research

Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50?mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15?days after STZ. Thirty days after streptozocin-ind...
Source: Cardiovascular Diabetology - October 10, 2014 Category: Cardiology Authors: Christiane MalfitanoCatarina BarbozaCristiano MostardaRenata da PalmaCamila dos SantosBruno RodriguesSarah FreitasAdriane Belló-KleinSusana LlesuyMaria-Cláudia IrigoyenKátia De Angelis Source Type: research

Visceral adiposity index and risks of cardiovascular events and mortality in prevalent hemodialysis patients
Conclusion: VAI is an optimal method to measure visceral adiposity to assess long-term CV outcomes and all-cause mortality in prevalent hemodialysis patients. VAI may provide a superior predictive power of CV outcomes to WC and WHtR.Trial registrationClinicalTrials.gov NCT01457625 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 4, 2014 Category: Cardiology Authors: Hung-Yuan ChenYen-Ling ChiuYi-Fang ChuangShih-Ping HsuMei-Fen PaiJu-Yeh YangYu-Sen Peng Source Type: research

Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus
Conclusions: Elevated circulating markers of endothelial dysfunction in young females with GDM history might reflect an early stage on the pathway to the manifestation of future cardiometabolic disorders. Timely identification of women at high risk and optimization of follow-up management might provide an opportunity to prevent disease progression. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 4, 2014 Category: Cardiology Authors: Christian GöblLatife BozkurtRajashri YarragudiThomas PrikoszovichAndrea TuraGiovanni PaciniRenate KoppensteinerAlexandra Kautzky-Willer Source Type: research

Endothelial Na + /H + exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal
Conclusion: MG elicits SGK1-dependent activation of endothelial Na+/H+ exchanger NHE1 which participates in MG-induced ROS production, upregulation of endothelial ICAM-1, leukocyte recruitment and microvascular hyperpermeability. Pharmacological inhibition of NHE1 attenuates the proinflammatory effects of excessive MG and may, thus, be beneficial in diabetes-associated inflammation. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 30, 2014 Category: Cardiology Authors: Syed QadriYang SuFrancisco CayabyabLixin Liu Source Type: research

Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes
Background: Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India. Methods: Type 2 diabetes patients from two secondary care diabetic centres (Europ...
Source: Cardiovascular Diabetology - September 26, 2014 Category: Cardiology Authors: Antonysunil AdaikalakoteswariRamamurthy JayashriNithya SukumarHema VenkataramanRajendra PradeepaKuppan GokulakrishnanRanjit AnjanaPhilip McTernanGyanendra TripathiVinod PatelSudhesh KumarViswanathan MohanPonnusamy Saravanan Source Type: research

A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy
Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. Howev...
Source: Cardiovascular Diabetology - September 13, 2014 Category: Cardiology Authors: Ren ZhangAbdul Abou-Samra Source Type: research

A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy
Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. Howev...
Source: Cardiovascular Diabetology - September 13, 2014 Category: Cardiology Authors: Ren ZhangAbdul Abou-Samra Source Type: research

Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism
Conclusions: This is the first report showing that high circulating adiponectin predicts increased CV mortality in men, but not in women with type 2 diabetes. Further studies are necessary to unravel the mechanisms through which adiponectin influences CV mortality in a sex-specific manner. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 10, 2014 Category: Cardiology Authors: Claudia MenzaghiMin XuLucia SalveminiConcetta De BonisGiuseppe PalladinoTao HuangMassimiliano CopettiYan ZhengYanping LiGrazia FiniFrank HuSimonetta BacciLu QiVincenzo Trischitta Source Type: research

Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3
Background: Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury. However, the mechanisms for this protection are poorly understood. Caveolae, sarcolemmal invaginations, and caveolins, scaffolding proteins in caveolae, localize molecules involved in cardiac protection. We tested the hypothesis that caveolae and caveolins are essential for exendin-4 induced cardiac protection using in vitro and in vivo studies in control and caveolin-3 (Cav-3) knockout mice (Cav-3 KO). Methods: Myocytes were treated with exendin-4 and then incubated with methyl-β...
Source: Cardiovascular Diabetology - September 7, 2014 Category: Cardiology Authors: Yasuo TsutsumiRie TsutsumiEisuke HamaguchiYoko SakaiAsuka KasaiYoshihiro IshikawaUtako YokoyamaKatsuya Tanaka Source Type: research