Effects of the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) on biomedical outcomes, observed cardiovascular events and cardiovascular risks in primary care: a longitudinal comparative study
Background: To assess whether the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) led to improvements in biomedical outcomes, observed cardiovascular events and predicted cardiovascular risks after 12-month intervention in the primary care setting. Methods: A random sample of 1,248 people with diabetes enrolled to RAMP-DM for at least 12?months was selected and 1,248 people with diabetes under the usual primary care were matched by age, sex, and HbA1c level at baseline as the usual care group. Biomedical and cardiovascular outcomes were measured at baseline and at 12-m...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Fang JiaoColman FungCarlos WongYuk WanDaisy DaiRuby KwokCindy Lam Source Type: research

Nestin downregulation in rat vascular smooth muscle cells represents an early marker of vascular disease in experimental type I diabetes
Conclusions: Hyperglycaemia-mediated nestin downregulation and the concomitant reduction of cycling vascular smooth muscle cells represent early markers of vascular disease in experimental type I diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Kim TardifVanessa HertigCamille DumaisLouis VilleneuveLouis PerraultJean-François TanguayAngelino Calderone Source Type: research

Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease
Background: Although no receptor has yet been identified, changes in circulating levels of the adipokine designated as Omentin have been demonstrated in obesity and related comorbidities such as cardiovascular disease, insulin resistance, metabolic syndrome and chronic inflammation. Methods: Changes in Omentin levels at 1 and 5?days and 6 and 12?months in response to biliopancreatic diversion with duodenal switch bariatric surgery were evaluated, specifically to investigate if changes preceded gain of insulin sensitivity. Results: Pre-operative plasma Omentin was not different between men (n?=?18) vs women (n?=?48), or dia...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Marc LapointePaul PoirierJulie MartinMarjorie BastienAudrey AuclairKatherine Cianflone Source Type: research

Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B
Conclusions: These results suggest that in DM2, the most important predictor of HAPR is younger age. Younger DM2 patients may therefore require total daily ASA doses higher than 75 mg, preferably as a twice-daily regimen, to achieve full therapeutic effect. Higher BMI and lower HMW adiponectin concentration were also associated with less potent ASA effect. This is the first study to demonstrate an association of lower adiponectin concentration with higher serum TXB2 level in patients treated with ASA. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 15, 2014 Category: Cardiology Authors: Agnieszka Kaplon-CieslickaMarek PostulaMarek RosiakMichal PellerAgnieszka KondrackaAgnieszka SerafinEwa TrzeplaGrzegorz OpolskiKrzysztof Filipiak Source Type: research

EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice
Background: We have previously shown that EphrinA1/EphA expression profile changes in response to myocardial infarction (MI), exogenous EphrinA1-Fc administration following MI positively influences wound healing, and that deletion of the EphA2 Receptor (EphA2-R) exacerbates injury and remodeling. To determine whether or not ephrinA1-Fc would be of therapeutic value in the hyperglycemic infarcted heart, it is critical to evaluate how ephrinA1/EphA signaling changes in the hyperglycemic myocardium in response to MI. Methods: Streptozotocin (STZ)-induced hyperglycemia in wild type (WT) and EphA2-receptor mutant (EphA2-R-M) mi...
Source: Cardiovascular Diabetology - August 13, 2014 Category: Cardiology Authors: Augustin DuSablonSusan KentAnita CoburnJitka Virag Source Type: research

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice
Conclusions: Enhanced systolic function and reduced diastolic function indicates early ventricular remodeling in obese and diabetic mice. They have SAN dysfunction, and adrenoreceptor stimulation triggers cardiac arrhythmia originating in the SAN. Thus, dysfunction of the intrinsic cardiac pacemaker and remodeling of the autonomic nervous system may conspire to increase cardiac mortality in diabetic patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 12, 2014 Category: Cardiology Authors: Ewa SoltysinskaTobias SpeerschneiderSine WintherMorten Thomsen Source Type: research

Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies
Background: Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the most commonly used medication for patients with DM, on AF has not been investigated. The primary aim of this study was to examine whether metformin prevented the occurrence of AF in type 2 DM patients by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated the effect of metformin on tachycardia-induced myolysis and oxidative stress in atrial cells. Methods: The study popu...
Source: Cardiovascular Diabetology - August 10, 2014 Category: Cardiology Authors: Shang-Hung ChangLung-Sheng WuMeng-Jiun ChiouJia-Rou LiuKuang-Hui YuChang-Fu KuoMing-Shien WenWei-Jan ChenYung-Hsin YehLai-Chu See Source Type: research

Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program
Background: Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today. Methods: Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physic...
Source: Cardiovascular Diabetology - August 3, 2014 Category: Cardiology Authors: Juan Serrano-FerrerGuillaume WaltherEdward CrendalAgnès VinetFrédéric DutheilGeraldine NaughtonBruno LesourdRobert ChapierDaniel CourteixPhilippe Obert Source Type: research

High or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes
Background: We investigated the effects of dietary calcium (Ca) and magnesium (Mg) intakes on cardiovascular disease risks in older patients with diabetes. Methods: In this cross-sectional study, 197 patients with type 2 diabetes aged 65?years and above were recruited. The 24-h dietary recalls and 1-week self-reported typical dietary intake patterns were collected. The Ca and Mg intakes of 100% of RDA were defined as low, moderate, and high Ca and Mg intakes, respectively. Anthropometric measurements were determined and biochemical analysis of blood and urine was performed. Results: Our data indicated that 60.9% and 87.3% ...
Source: Cardiovascular Diabetology - August 1, 2014 Category: Cardiology Authors: Jui-Hua HuangLeih-Ching TsaiYu-Chen ChangFu-Chou Cheng Source Type: research

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage
Conclusions: Our data suggest that moderate hyperinsulinemia in response to insulin resistance or lowering of TNF-α levels within the aorta attenuates vascular damage, this protective effect being mediated by UCP-2 expression levels through iNOS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2014 Category: Cardiology Authors: Almudena Gómez-HernándezLiliana PerdomoNatalia de las HerasNuria BeneitÓscar EscribanoYolanda OteroCarlos GuillénSabela Díaz-CastroverdeBeatriz Gozalbo-LópezVictoria CachofeiroVicente LaheraManuel Benito Source Type: research

Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice
Conclusions: We conclude that glibenclamide could attenuate myocardial injury induced by LPS challenge in STZ-mice, which was possibly related to inhibiting inflammation through Nalp3 inflammasomes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2014 Category: Cardiology Authors: Jian CaiShuai LuZheng YaoYa-Ping DengLing-Di ZhangJia-Wen YuGuo-Fei RenFu-Ming ShenGuo-Jun Jiang Source Type: research

Antagonistic effect of TNF-¿ and insulin on UCP-2 expression and vascular damage
Conclusions: Our data suggest that moderate hyperinsulinemia in response to insulin resistance or lowering of TNF-? levels within the aorta attenuates vascular damage, this protective effect being mediated by UCP-2 expression levels through iNOS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2014 Category: Cardiology Authors: Almudena Gómez-HernándezLiliana PerdomoNatalia de las HerasNuria BeneitÓscar EscribanoYolanda OteroCarlos GuillénSabela Díaz-CastroverdeBeatriz Gozalbo-LópezVictoria CachofeiroVicente LaheraManuel Benito Source Type: research

GLP-1 (7¿36) amide restores myocardial insulin sensitivity and prevents the progression of heart failure in senescent beagles
Background: We previously demonstrated that older beagles have impaired whole body and myocardial insulin responsiveness (MIR), and that glucagon-like peptide-1 (GLP-1 [7?36] amide) improves MIR in young beagles with dilated cardiomyopathy (DCM). Here, we sought to determine if aging alone predisposes to an accelerated course of DCM, and if GLP-1 [7?36] amide would restore MIR and impact the course of DCM in older beagles. Methods: Eight young beagles (Young-Control) and sixteen old beagles underwent chronic left ventricle (LV) instrumentation. Seven old beagles were treated with GLP-1 (7?36) amide (2.5pmol/kg/min) for 2?w...
Source: Cardiovascular Diabetology - July 31, 2014 Category: Cardiology Authors: Melissa ChenFranca AngeliYou-tang ShenRichard Shannon Source Type: research

DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study
Conclusions: Sitagliptin improved endothelial dysfunction just as well as voglibose in patients with type 2 diabetes. Sitagliptin had protective effects on endothelial function without adverse events.Trial registrationregistered at http://www.umin.ac.jp/ctrj/ under UMIN000003951 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 30, 2014 Category: Cardiology Authors: Kazufumi NakamuraHiroki OeHajime KiharaKenei ShimadaShota FukudaKyoko WatanabeTsutomu TakagiKei YunokiToru MiyoshiKumiko HirataJunichi YoshikawaHiroshi Ito Source Type: research

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity
Conclusions: Taking together, we demonstrate here for the first time that Arg-II causes eNOS-uncoupling through activation of p38 mapk in HFD-induced obesity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 18, 2014 Category: Cardiology Authors: Yi YuAngana RajapakseJean-Pierre MontaniZhihong YangXiu-Fen Ming Source Type: research

High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury
Conclusions: Relatively long-term administration of the two obesity-inducing diets resulted in cardioprotection against ischaemia/reperfusion damage. Further protection by preconditioning was, however, without effect on infarct size, while an improvement in functional recovery was observed. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 18, 2014 Category: Cardiology Authors: Ruduwaan SalieBarbara HuisamenAmanda Lochner Source Type: research

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity
Conclusions: Taking together, we demonstrate here for the first time that Arg-II causes eNOS-uncoupling through activation of p38 mapk in HFD-induced obesity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 18, 2014 Category: Cardiology Authors: Yi YuAngana RajapakseJean-Pierre MontaniZhihong YangXiu-Fen Ming Source Type: research

Effects of pitavastatin versus atorvastatin on the peripheral endothelial progenitor cells and vascular endothelial growth factor in high-risk patients: a pilot prospective, double-blind, randomized study
This study aimed to investigate the potential class effects of different statin treatment including pitavastatin and atorvastatin on circulating EPCs in clinical setting. Methods: A pilot prospective, double-blind, randomized study was conducted to evaluate the ordinary dose of pitavastatin (2?mg daily) or atorvastatin (10?mg daily) treatment for 12?weeks on circulating EPCs in patients with cardiovascular risk such as hypercholesterolemia and type 2 diabetes mellitus (T2DM). Additional in vitro study was conducted to clarify the direct effects of both statins on EPCs from the patients. Results: A total of 26 patients (19 ...
Source: Cardiovascular Diabetology - July 16, 2014 Category: Cardiology Authors: Liang-Yu LinChin-Chou HuangJia-Shiong ChenTao-Cheng WuHsin-Bang LeuPo-Hsun HuangTing-Ting ChangShing-Jong LinJaw-Wen Chen Source Type: research

Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-ß¿dependent vascular endothelial cadherin tyrosine phosphorylation
Conclusions: Our findings show that the high-concentration glucose-induced disruption of endothelial adherens junctions is mediated by tyrosine phosphorylation of VE-cad through PKC-β and MLC phosphorylation. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2014 Category: Cardiology Authors: Mehran HaidariWei ZhangJames WillersonRichard Dixon Source Type: research

Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-beta-dependent vascular endothelial cadherin tyrosine phosphorylation
Conclusions: Our findings show that the high-concentration glucose-induced disruption of endothelial adherens junctions is mediated by tyrosine phosphorylation of VE-cad through PKC-beta and MLC phosphorylation. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2014 Category: Cardiology Authors: Mehran HaidariWei ZhangJames WillersonRichard Dixon Source Type: research

Neck circumference and early stage atherosclerosis: the cardiometabolic risk in Chinese (CRC) study
Conclusions: Our data showed that high NC was associated with an increased risk of early stage atherosclerosis in Chinese adults, independent of other metabolic risk factors. Hypertension might modify the association between NC and cfPWV. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 8, 2014 Category: Cardiology Authors: Jun LiangYu WangHongyan LiXuekui LiuQinqin QiuLu Qi Source Type: research

Group-based activities with on-site childcare and online support improve glucose tolerance in women within 5 years of gestational diabetes pregnancy
Conclusions: A tailored group intervention appears to lead to improvements in health behaviours and cardiometabolic risk factors despite unchanged body mass index and body composition. This approach merits further study.Clinical trial registration: ClinicalTrials.gov (NCT01814995). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 30, 2014 Category: Cardiology Authors: Anne-Sophie BrazeauAaron LeongSara MeltzerRani CruzDeborah DaCostaMary Hendrickson-NelsonLawrence JosephKaberi Dasgupta Source Type: research

Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
Adiponectin is the most abundant peptide secreted by adipocytes, being a key component in the interrelationship between adiposity, insulin resistance and inflammation. Central obesity accompanied by insulin resistance is a key factor in the development of metabolic syndrome (MS) and future macrovascular complications. Moreover, the remarkable correlation between coronary artery disease (CAD) and alterations in glucose metabolism has raised the likelihood that atherosclerosis and type 2 diabetes mellitus (T2DM) may share a common biological background. We summarize here the current knowledge about the influence of adiponect...
Source: Cardiovascular Diabetology - June 23, 2014 Category: Cardiology Authors: Enrique FismanAlexander Tenenbaum Source Type: research

Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOMETM)
Background: Evidence concerning the importance of glucose lowering in the prevention of cardiovascular (CV) outcomes remains controversial. Given the multi-faceted pathogenesis of atherosclerosis in diabetes, it is likely that any intervention to mitigate this risk must address CV risk factors beyond glycemia alone. The SGLT-2 inhibitor empagliflozin improves glucose control, body weight and blood pressure when used as monotherapy or add-on to other antihyperglycemic agents in patients with type 2 diabetes. The aim of the ongoing EMPA-REG OUTCOMETM trial is to determine the long-term CV safety of empagliflozin, as well as ...
Source: Cardiovascular Diabetology - June 19, 2014 Category: Cardiology Authors: Bernard ZinmanSilvio InzucchiJohn LachinChristoph WannerRoberto FerrariDavid FitchettErich BluhmkiStefan HantelJoan Kempthorne-RawsonJennifer NewmanOdd JohansenHans WoerleUli Broedl Source Type: research

Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: accompanying the glycemic continuum
Background: Diabetic patients have a significantly worse prognosis after an acute myocardial infarction (AMI) than their counterparts. Previous studies have shown that the number of circulating endothelial progenitor cells (EPCs) significantly increase early after an AMI in normoglycemic patients. However, it is well known that type 2 diabetes mellitus (DM) is associated with impaired function and reduced circulating EPCs levels. Nonetheless, few studies have analyzed EPCs response of diabetics to an AMI and the EPC response of pre-diabetic patients has not been reported yet. Therefore, we hypothesized that in the acute ph...
Source: Cardiovascular Diabetology - June 16, 2014 Category: Cardiology Authors: Natália AntónioRosa FernandesAna SoaresFrancisco SoaresAna LopesTiago CarvalheiroArtur PaivaGuilherme PêgoLuís ProvidênciaLino GonçalvesCarlos Ribeiro Source Type: research

Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation
Background: Heart disease is the leading cause of death in diabetic patients, and defective copper metabolism may play important roles in the pathogenesis of diabetic cardiomyopathy (DCM). The present study sought to determine how myocardial copper status and key copper- proteins might become impaired by diabetes, and how they respond to treatment with the Cu (II)-selective chelator triethylenetetramine (TETA) in DCM. Methods: Experiments were performed in Wistar rats with streptozotocin (STZ)-induced diabetes with or without TETA treatment. Cardiac function was analysed in isolated-perfused working hearts, and myocardial ...
Source: Cardiovascular Diabetology - June 14, 2014 Category: Cardiology Authors: Shaoping ZhangHong LiuGreeshma AmarsinghCarlos CheungSebastian HoglUmayal NarayananLin ZhangSelina McHargJingshu XuDeming GongJohn KennedyBernard BarryYee ChoongAnthony PhillipsGarth Cooper Source Type: research

Low levels of 1,5-anhydro-D-glucitol are associated with vascular endothelial dysfunction in type 2 diabetes
Conclusions: In T2DM with HbA1c (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 13, 2014 Category: Cardiology Authors: Keiichi TorimotoYosuke OkadaHiroko MoriYoshiya Tanaka Source Type: research

Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats
Conclusions: CAPA, which is structurally similar to CAPE, exerts cardioprotective activity in I/R injury through its antioxidant property and by preserving nitric oxide levels. On the other hand, chronic CAPA treatment could also ameliorate cardiac dysfunction in diabetic animals. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 12, 2014 Category: Cardiology Authors: Yi-Jin HoAn-Sheng LeeWen-Pin ChenWei-Lung ChangYing-Kang TsaiHsi-Lin ChiuYueh-Hsiung KuoMing-Jai Su Source Type: research

Dopamine D4 receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression
This study suggests that activation of the D4 receptor suppresses the proliferation and migration of VSMCs, therefore, inhibit atherosclerosis. The D4 receptor may be a potential therapeutic target to reduce the effects of insulin on artery remodeling. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 2, 2014 Category: Cardiology Authors: Changqing YuZhen WangYu HanYukai LiuWei Eric WangCaiyu ChenHongyong WangPedro A JoseChunyu Zeng Source Type: research

A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus- a randomized controlled trial START-J study
Conclusion: In Japanese T2DM patients, serum adiponectin level was elevated by three-month treatment with sitagliptin without change of body weight.Trial registration: UMIN000004721 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 24, 2014 Category: Cardiology Authors: Toshiyuki HibuseNorikazu MaedaKen KishidaTakekazu KimuraTomoko MinamiEriko TakeshitaAyumu HirataYasuhiko NakagawaSusumu KashineAkemi OkaMasumi HayashiHitoshi NishizawaTohru FunahashiIichiro Shimomura Source Type: research

Multiple risk factor intervention reduces carotid atherosclerosis in patients with type 2 diabetes
Conclusions: Intensification of risk factor intervention in type 2 diabetes results in CIMT regression over a period of 2 years. None of the biomarkers used including endothelial function parameters or endothelial progenitor cells turned out to be useful to predict CIMT changes.Trial registration: Clinical Trial Registration - URL: http://clinicaltrials.gov/show/NCT00660790 Unique identifier: NCT00660790 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 23, 2014 Category: Cardiology Authors: Norbert TripoltSophie NarathMichaela EderThomas PieberThomas WascherHarald Sourij Source Type: research

Safety and tolerability of canakinumab, an IL-1ß inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studies
Background: We aimed to assess the safety and tolerability of different doses of canakinumab versus placebo in patients with type 2 diabetes mellitus (T2DM). Methods: Data were pooled from three studies in 1026 T2DM patients with different routes of administration, treatment regimens and follow-up duration. Canakinumab groups were categorised as low (0.03 mg/kg i.v. once; N = 20), intermediate (0.1 and 0.3 mg/kg i.v. once, 5 and 15 mg s.c. monthly; N = 247), medium (1.5 mg/kg i.v. once, 50 mg s.c. monthly and 150 mg s.c. once; N = 268), and high doses (10 mg/kg i.v. once and 150 mg s.c. monthly; N = 137) and compared with ...
Source: Cardiovascular Diabetology - May 17, 2014 Category: Cardiology Authors: Campbell HowardAdele NoeAndrej SkerjanecBjörn HolzhauerMargaret WernsingMonica Ligueros-SaylanTom Thuren Source Type: research

Effects of metformin and exercise training, alone or in association, on cardio-pulmonary performance and quality of life in insulin resistance patients
Background: Metformin (MET) therapy exerts positive effects improving glucose tolerance and preventing the evolution toward diabetes in insulin resistant patients. It has been shown that adding MET to exercise training does not improve insulin sensitivity. The aim of this study was to determine the effect of MET and exercise training alone or in combination on maximal aerobic capacity and, as a secondary end-point on quality of life indexes in individuals with insulin resistance. Methods: 75 insulin resistant patients were enrolled and subsequently assigned to MET (M), MET with exercise training (MEx), and ET alone (Ex). 1...
Source: Cardiovascular Diabetology - May 15, 2014 Category: Cardiology Authors: Christian CadedduSilvio NoccoCugusi LuciaMartino DeiddaAlessandro BinaOrru FabioStefano BandinuEfisio CossuMarco BaroniGiuseppe Mercuro Source Type: research

The dipeptidyl peptidase-4 inhibitor Saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients
Conclusions: Saxagliptin reverses PACs dysfunction associated with T2D in vitro and improves inducible angiogenesis by circulating cells in vivo. These data add knowledge to the potential pleiotropic cardiovascular effects of DPP-4 inhibition. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 14, 2014 Category: Cardiology Authors: Nicol PoncinaMattia AlbieroLisa MenegazzoRoberta CappellariAngelo AvogaroGian Fadini Source Type: research

PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort
Conclusion: PLA1A2 polymorphism is associated with mortality in participants with HbA1c ranging from 5.5% (37 mmol/mol) to 6.5% (48 mmol/mol). Maintenance of euglycemic control and antiplatelet therapy are therefore regarded as effective primary prevention in this group. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 5, 2014 Category: Cardiology Authors: Bernd StratmannTao XuChrista MeisingerBarbara MenartMichael RodenChristian HerderHarald GrallertAnnette PetersWolfgang KoenigThomas IlligHeinz Erich WichmannRui Wang-SattlerWolfgang RathmannDiethelm Tschoepe Source Type: research

High glucose induces smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy
Background: Despite advances in the treatment of heart failure, mortality remains high, particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-beta) contributes to the pathogenesis of the fibrotic interstitium observed in diabetic cardiomyopathy. We hypothesized that high glucose enhances the activity of the transcriptional co-activator p300, leading to the activation of TGF-beta via acetylation of Smad2; and that by inhibiting p300, TGF-beta activity will be reduced and heart failure prevented in a clinically relevant animal model of diabetic cardiomyopathy. Methods: p300 activity was as...
Source: Cardiovascular Diabetology - May 5, 2014 Category: Cardiology Authors: Antoinette Bugyei-TwumAndrew AdvaniSuzanne AdvaniYuan ZhangKerri ThaiDarren KellyKim Connelly Source Type: research

Influence of a family history of type 2 diabetes, demographic and clinical data on carotid intima-media thickness in patients with type 1 diabetes: a cross-sectional study
Background: Intima-media thickness (IMT) of the common carotid artery is a surrogate end point of cardiovascular disease (CVD). Identifying the factors associated with a higher IMT may contribute to the identification of subjects with higher CVD risk. Our objective was to compare the common carotid IMT of type 1 diabetes patients to healthy control subjects. The secondary objective was to determine factors associated with a higher carotid IMT. Methods: We conducted a cross-sectional study between March 2009 and October 2013, comprising 127 type 1 diabetes patients and 125 control subjects matched by age, gender and body ma...
Source: Cardiovascular Diabetology - May 3, 2014 Category: Cardiology Authors: Carlos de JuniorEliete SilvaMaria da MattaMarcia CastierMaria RosaMarília Gomes Source Type: research

Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis
Background: Insulin resistance, as a key mediator of metabolic syndrome, is thought to be associated with pathogenesis of calcific aortic valve disease and altered left ventricular (LV) function and structure. However, in patients with aortic valve sclerosis (AVS), the association between insulin resistance and subclinical impairment of LV function is not fully elucidated. Methods: We studied 57 patients (mean age 70 +/- 8 years, 22 women) with asymptomatic AVS but normal LV ejection fraction in echocardiography. LV longitudinal and circumferential strain and strain rate was analyzed using two-dimensional speckle tracking ...
Source: Cardiovascular Diabetology - April 27, 2014 Category: Cardiology Authors: Hiroto UtsunomiyaHideya YamamotoEiji KunitaTakayuki HidakaYasuki Kihara Source Type: research

Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein
Conclusions: High dp-ucMGP levels were independently associated with below-knee arterial calcification score in patients with type 2 diabetes and normal or slightly altered kidney function. The reversibility of the elevation of dp-ucMGP levels and the latter's relationship with clinical events merit further investigation. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 24, 2014 Category: Cardiology Authors: Sophie LiabeufBourron OlivierCees VemeerElke TheuwissenElke MagdeleynsCarole AubertMichel BrazierRomuald MentaverriAgnes HartemannZiad Massy Source Type: research

Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure
Background: Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. Omentin-1 is a novel adipokine and is associated with incident coronary artery disease. However, it remains unclear whether serum omentin-1 levels are associated with cardiac prognosis in patients with HF. Methods: We measured serum omentin-1 levels at admission in 136 consecutive patients with HF, and 20 control subjects without signs of significant heart disease. We prospectively followed patients with HF to endpoints of cardiac death or re-hospitalization for worsen...
Source: Cardiovascular Diabetology - April 23, 2014 Category: Cardiology Authors: Taro NarumiTetsu WatanabeShinpei KadowakiDaisuke KinoshitaMiyuki YokoyamaYuki HondaYoichiro OtakiSatoshi NishiyamaHiroki TakahashiTakanori ArimotoTetsuro ShishidoTakuya MiyamotoIsao Kubota Source Type: research

Low sensitivity of the metabolic syndrome to identify adolescents with impaired glucose tolerance: An analysis of NHANES 1999-2010
Conclusion: This lack of overlap between MetS and IGT may indicate that assessment of MetS is not likely to be a good indicator of which adolescents to screen using OGTT. These data further underscore the importance of other potential contributors to IGT, including Type 1 diabetes and genetic causes of poor beta-cell function. Practitioners should keep these potential causes of IGT in mind, even when evaluating obese adolescents with IGT. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 23, 2014 Category: Cardiology Authors: Mark DeBoerMatthew Gurka Source Type: research

The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus
Background: Glycation of high-density lipoprotein (HDL) decreases its ability to induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells. Whether lipid content of HDL, especially sphingosine-1-phosphate (S1P), plays any specific role in restoring the protective function of HDL in type 2 diabetes mellitus (T2DM) is still unknown.Methods and results: Immunochemical techniques demonstrated that glycated HDL loses its protective function of regulating COX-2 expression compared with diabetic HDL. We proved that the lipid content differed between diabetic HDL and glycated HDL, especia...
Source: Cardiovascular Diabetology - April 21, 2014 Category: Cardiology Authors: Xunliang TongPu LvAnna MathewDonghui LiuChenguang NiuYan WangLiang JiJizhao LiZhiwei FuBing PanSubramaniam PennathurLemin ZhengYining Huang Source Type: research

On the potential of acarbose to reduce cardiovascular disease
In the emerging landscape of cardiovascular (CV) outcome trials evaluating the effects of blood glucose lowering drugs in individuals with type 2 diabetes, it is becoming increasingly apparent that since the promising signals coming from the United Kingdom Prospective Diabetes Study (UKPDS) no unequivocal benefits have been established for any single therapy thus far. There is an unmet need for introducing an effective pharmacological agent which could target both correlates of glycaemic regulation and CV risk factors, to ameliorate the enormous burden of fatal and non-fatal CV events in diabetic patients. Acarbose, like o...
Source: Cardiovascular Diabetology - April 16, 2014 Category: Cardiology Authors: Eberhard StandlMichael TheodorakisMichael ErbachOliver SchnellJaakko Tuomilehto Source Type: research

Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae
Conclusions: Diabetes prolongs twitch duration without having an effect on work output or heat production, and hence efficiency, of isolated ventricular trabeculae. Collectively, our results, arising from isolated trabeculae, reconcile the discrepancy between the mechanical performance of the whole heart and its tissues. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 15, 2014 Category: Cardiology Authors: June-Chiew HanKenneth TranPoul NielsenAndrew TabernerDenis Loiselle Source Type: research

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle
Conclusions: GKA RO-28-1675 did not increase glucose consumption in endothelial cells indicating the absence of GK in those cells. No direct deleterious actions, in terms of atherogenic changes or excessive vasoactive effects were seen on cells or vessels of the cardiovascular system in response to GKAs. If reflected in vivo, these drugs are unlikely to have their use compromised by direct cardiovascular toxicity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 15, 2014 Category: Cardiology Authors: Sefaa Al-aryahiDanielle KamatoRobel GetachewWenhua ZhengSimon PotocnikNeale CohenDaniel GuidoneNarin OsmanPeter Little Source Type: research

Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
Conclusion: This study provides evidence that AGEs induces cardiomyocyte autophagy by, at least in part, inhibiting the PI3K/Akt/mTOR pathway via RAGE. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 14, 2014 Category: Cardiology Authors: Xuwei HouZhaohui HuHanying XuJian XuShunrong ZhangYigang ZhongXiuying HeNingfu Wang Source Type: research

Analysis of common and coding variants with cardiovascular disease in the diabetes heart study
Background: Type 2 diabetes mellitus (T2DM) is a major cardiovascular disease (CVD) risk factor. Identification of genetic risk factors for CVD is important to understand disease risk. Two recent genome-wide association study (GWAS) meta-analyses in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium detected CVD-associated loci. Methods: Variants identified in CHARGE were tested for association with CVD phenotypes, including vascular calcification, and conventional CVD risk factors, in the Diabetes Heart Study (DHS) (n = 1208;>80% T2DM affected). This included 36 genotyped or imputed si...
Source: Cardiovascular Diabetology - April 12, 2014 Category: Cardiology Authors: Jeremy AdamsLaura RaffieldBarry FreedmanCarl LangefeldMaggie NgJ CarrAmanda CoxDonald Bowden Source Type: research

Comprehensive analysis of circulating adipokines and HsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs
In this study, for the first time, the relationship between traditional cardiovascular risk factors, Metabolic Syndrome (MetS) and circulating level of adipokines in Arab ethnicity was investigated. Methods: We conducted a population-based cross-sectional survey on 379 adult Arab participants living in Kuwait. Traditional cardiovascular risk factors such as blood pressure (BP), low density lipoprotein (LDL) and triglyceride (TG) were measured. Plasma levels of circulating Leptin, Plasminogen Activator Inhibitor (PAI-1) leptin, visfatin, adiponectin, resistin and adipsin were assessed using the multiplexing immunobead-based...
Source: Cardiovascular Diabetology - April 9, 2014 Category: Cardiology Authors: Mohamed Abu-FarhaKazem BehbehaniNaser Elkum Source Type: research

Progressive decay of Ca2+ homeostasis in the development of diabetic cardiomyopathy
Conclusions: Ca2+ sparks exhibited a time-dependent decay with progression of diabetic cardiomyopathy, which may partly contribute to cardiac dysfunction. This abnormality may be attributable to alterations in the expressions of some Ca2+-associated proteins. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 9, 2014 Category: Cardiology Authors: Shu-Mei ZhaoYong-Liang WangChun-Yan GuoJin-Ling ChenYong-Quan Wu Source Type: research

Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway
Conclusions: Our study demonstrates that OCN has an endothelial-protective effect in atherosclerosis through mediating the PI3K/Akt/eNOS signaling pathway. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 7, 2014 Category: Cardiology Authors: Jianxin DouHuating LiXiaojing MaMingliang ZhangQichen FangMeiyun NieYuqian BaoWeiping Jia Source Type: research