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Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment
Conclusion: This study identified novel miRNA in the field of diabetic vasculopathy and might provide new information about the effect of vitamin D on gene regulation induced by a diabetic-like environment. New gene targets that are part of the molecular mechanism and the therapeutic treatment in diabetic vasculopathy are highlighted. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2014 Category: Cardiology Authors: Tali Zitman-GalJanice GreenMetsada Pasmanik-ChorEliezer GolanJacques BernheimSydney Benchetrit Source Type: research

Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
Conclusions: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2014 Category: Cardiology Authors: Dolores CorellaJose SorlíJosé GonzálezCarolina OrtegaMontserrat FitóMonica BullóMiguel Martínez-GonzálezEmilio RosFernando ArósJosé LapetraEnrique Gómez-GraciaLluís Serra-MajemValentina Ruiz-GutierrezMiquel FiolOscar ColtellErnest VinyolesXavie Source Type: research

Exercise increases serum endostatin levels in female and male patients with diabetes and controls
Conclusion: Middle-aged healthy female individuals as well as female T2DM-patients showed higher circulating serum endostatin levels compared to males, suggesting a hormonal influence on baseline circulating endostatin amounts. Exercise-induced increase in endostatin is also observable in patients suffering from T2DM. Concerning vascularisation, lower endostatin levels in T2DM might be advantageous. Concerning plaque stability, lower levels might be prejudicial.Trial registration: Clinical Trial Registration-URL: http://clinicaltrials.gov/ct2/results?term=NCT01165515 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2014 Category: Cardiology Authors: Michael SponderDaniela DanglStephanie KampfMonika Fritzer-SzekeresJeanette Strametz-Juranek Source Type: research

Step Monitoring to improve ARTERial health (SMARTER) through step count prescription in type 2 diabetes and hypertension: trial design and methods
Background: With increasing numbers of type 2 diabetes (DM2) and hypertension patients, there is a pressing need for effective, time-efficient and sustainable strategies to help physicians support their patients to achieve higher physical activity levels. SMARTER will determine whether physician-delivered step count prescriptions reduce arterial stiffness over a one-year period, compared with usual care, in sedentary overweight/obese adults with DM2/hypertension.DesignRandomized, allocation-concealed, assessor-blind, multisite clinical trial. The primary outcome is change in arterial stiffness over one year. The secondary ...
Source: Cardiovascular Diabetology - January 6, 2014 Category: Cardiology Authors: Kaberi DasguptaEllen RosenbergStella Daskalopouloufor the SMARTER collaborators Source Type: research

The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes
Conclusions: Diabetes reduces the ability of the heart to pump at high afterloads and, consequently, reduces the afterload at which peak efficiency occurs. However, the peak efficiency of the isolated working rat heart remains unaffected by STZ-induced diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 5, 2014 Category: Cardiology Authors: June-Chiew HanSoyeon GooCarolyn BarrettKimberley MellorAndrew TabernerDenis Loiselle Source Type: research

Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease
Conclusion: In conclusion, from the present study it appears that transition from T2DM or CAD to T2DM-CAD co-morbidity is associated with strong down regulation of Th2 cytokines and enhancement of Th1 responses. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Haridoss MadhumithaViswanathan MohanMohan DeepaSubash BabuVivekanandhan Aravindhan Source Type: research

Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study
Conclusions: We found a diminished vasomotor reactivity in individuals with obesity which was not explained by the presence of insulin resistance. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Marcela Rodríguez-FloresCarlos Cantú-BritoEduardo García-GarcíaClaudia Cano-Nigenda Source Type: research

National trends in utilization and outcomes of coronary revascularization procedures among people with and without type 2 diabetes in Spain (2001-2011)
Conclusions: The annual percent change in PCI procedures increased in diabetic and non-diabetic patients. Higher comorbidity and the female gender are associated with a higher IHM in PCI procedures. In diabetic and non-diabetic patients, we found a decrease in the use of CABG procedures. IHM was higher in patients without diabetes than in those with diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Ana Lopez-de-AndresRodrigo Jimenez-GarcíaValentin Hernandez-BarreraNapoleon Perez-FarinosJose de Miguel-YanesManuel Mendez-BailonIsabel Jimenez-TrujilloAngel de MiguelCarmen PinoPilar Carrasco-Garrido Source Type: research

Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes
Background: An increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been determined. We therefore investigated the correlation between leukocyte subtype counts and intima-media thickness of the common carotid artery (CCA-IMT) in subjects with type 2 diabetes. Methods: This cross-sectional study involved 484 in-patients with type 2 diabetes (282 males and 202 females), who were hospitalized for glycemic control and underwent carotid ultrasonography at Kumamoto University Hospital b...
Source: Cardiovascular Diabetology - December 27, 2013 Category: Cardiology Authors: Takeshi MatsumuraKayo TaketaHiroyuki MotoshimaTakafumi SenokuchiNorio IshiiHiroyuki KinoshitaKazuki FukudaSarie YamadaDaisuke KukidomeTatsuya KondoAya HisadaTakahiko KatohSeiya ShimodaTakeshi NishikawaEiichi Araki Source Type: research

Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome
This study was designed to evaluate the relationship between serum LCN2 levels and coronary artery disease (CAD). Methods: Serum LCN2 levels of 261 in-patients who underwent coronary angiography were measured by sandwich enzyme immunoassay. Demographic (169 men and 92 postmenopausal women) and clinical (metabolic syndrome (MS), triglyceride (TG) and C-reactive protein (CRP) levels) characteristics were collected to assess independent factors of CAD (CAD: 188 and non-CAD: 73) and serum LCN2 levels by multiple logistic regression and multivariate stepwise regression analyses, respectively. Results: Serum LCN2 levels were sig...
Source: Cardiovascular Diabetology - December 21, 2013 Category: Cardiology Authors: Jie NiXiaojing MaMi ZhouXiaoping PanJunling TangYaping HaoZhigang LuMeifang GaoYuqian BaoWeiping Jia Source Type: research

Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice
Background: The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has been indicated to have important vasculoprotective properties and to be vulnerable to degradation by hyperglycemic conditions, we evaluated in the current study the effect of short-term metformin treatment on whole-body glycocalyx barrier properties in a mouse model of non-insulin dependent diabetes mellitus (db/db mouse). Methods: Glycocalyx barrier properties were measured in an acute experiment in three ...
Source: Cardiovascular Diabetology - December 5, 2013 Category: Cardiology Authors: Bart EskensCoert ZuurbierJudith van HaareHans VinkJurgen van Teeffelen Source Type: research

Do patients with type 1 and type 2 diabetes really have an impaired endothelial function? A population-based propensity score matching analysis
Conclusions: In this population-based study comparing adjusted FMD values of diabetic individuals with adequately matched controls, propensity score analyses revealed no association between diabetes and endothelial function. Since these findings are in discordance with the majority of previous reports, we suggest performing similar analyses using data from other population-based studies. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 5, 2013 Category: Cardiology Authors: Klaus EmpenRoberto LorbeerHenry VölzkeThorsten ReffelmannSabine SchipfMatthias NauckWolfgang KernerHenri WallaschofskiStephan FelixMarcus Dörr Source Type: research

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects
Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 22, 2013 Category: Cardiology Authors: Camila LeançaValéria NunesNatália PanzoldoVanessa ZagoEliane ParraPatrícia CazitaMatti JauhiainenMarisa PassarelliEdna NakandakareEliana de FariaEder Quintão Source Type: research

Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes
Conclusions: By blocking mineralocorticoid receptors, eplerenone may attenuate cardiac steatosis and apoptosis, and subsequent remodelling and diastolic dysfunction in obese/type-II diabetic rats. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 21, 2013 Category: Cardiology Authors: Elisa RamírezMercedes Klett-MingoSara Ares-CarrascoBelén PicatosteAlessia FerrariniFrancisco RupérezAlicia Caro-VadilloCoral BarbasJesús EgidoJosé TuñónÓscar Lorenzo Source Type: research

High admission glucose levels increase Fas apoptosis and mortality in patients with acute ST-elevation myocardial infarction: a prospective cohort study
This study explored the relative associations among admission plasma glucose level, soluble Fas (sFas) concentration, and long-term survival in patients with acute ST-elevation myocardial infarction (STEMI). Methods: This prospective cohort study include 83 patients with acute STEMI. Based on their admission plasma glucose levels (7.8 and 11.1 mmol/L as the limits for low and high levels, respectively), patients were allocated into one of three groups: normal glucose (n = 33), median glucose (n = 24), and high glucose (n = 26). The admission plasma level of sFas was measured with a sandwich enzyme-linked immunosorbent assa...
Source: Cardiovascular Diabetology - November 15, 2013 Category: Cardiology Authors: Jing ChangGong ZhangLi ZhangYuan-Ping HouXiu-Lan LiuLin Zhang Source Type: research

Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study
The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR. Methods: Healthy Canadian Aboriginal, Chinese, European, and South Asian adults (N = 634) were assessed for sociodemographics; lifestyle; fasting plasma insulin, glucose, and total and HMW adiponectin; and adiposity measures [BMI, waist circumference, waist-to-hip ratio, percent body fat, and subcutaneous and visceral adipose tissue (quantified by computed tomography)]. The homeostasis model assessment-insulin resistance (HOMA-IR) assessed IR. Results: South Asians had the greatest HOMA...
Source: Cardiovascular Diabetology - November 13, 2013 Category: Cardiology Authors: Dian SulistyoningrumDanijela GasevicScott LearJoe HoAndrew MenteAngela Devlin Source Type: research

Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors
Conclusions: These data indicated that the AT1a receptor, thus extracellular ANG II, are not required for the development of diabetic cardiomyopathy. The KKS might contribute to the beneficial effects of benazeprilat and valsartan in diabetic cardiomyopathy. A role of intracellular ANG II is suggested by the inhibitory effects of aliskiren, which needs confirmation in future studies. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 12, 2013 Category: Cardiology Authors: Qian Chen YongCandice ThomasRachid SeqqatNiketa ChandelKenneth BakerRajesh Kumar Source Type: research

Plasma Copeptin levels are inversely associated with Intima-Media-Thickness in Men: the Population-based KORA F4 Study
Conclusions: Plasma copeptin was not associated with an increased IMT in our study cohort. In contrast, copeptin levels were related to a lower IMT in men and subjects with prediabetes, suggesting that elevated copeptin concentrations do not exert proatherogenic effects on carotid arteries. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 11, 2013 Category: Cardiology Authors: Cornelia ThenBernd KowallAndreas LechnerChrista MeisingerMargit HeierWolfgang KoenigAnnette PetersJoachim ThieryWolfgang RathmannJochen Seissler Source Type: research

Obesity and high waist circumference are associated with low circulating pentraxin-3 in acute coronary syndrome
Background: Long pentraxin 3 (PTX3) is a component of the pentraxin superfamily and a potential marker of vascular damage and inflammation, associated with negative outcome in patients with acute coronary syndromes (ACS). Obesity is a risk factor for cardiovascular disease and PTX3 production is reported in abdominal adipose tissue. Low PTX3 is however reported in the obese population, and obesity per se may be associated with less negative ACS outcome. Methods: We investigated the potential impact of obesity and high waist circumference (reflecting abdominal fat accumulation) on plasma PTX3 concentration in ACS patients (...
Source: Cardiovascular Diabetology - November 11, 2013 Category: Cardiology Authors: Rocco BarazzoniAneta AleksovaCosimo CarriereMaria CattinMichela ZanettiPierandrea VinciDavide StolfoGianfranco GuarnieriGianfranco Sinagra Source Type: research

High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome
Background: Bilirubin has been implicated in cardiovascular protection by virtue of its anti-inflammatory and anti-oxidative properties. The metabolic syndrome is featured by enhanced low-grade systemic inflammation and oxidative stress. Serum amyloid A (SAA) impairs anti-oxidative properties of high-density lipoprotein (HDL). We determined relationships of high sensitive C-reactive protein (hs-CRP) and SAA with bilirubin in subjects with and without metabolic syndrome (MetS). Methods: Serum total bilirubin, hs-CRP, SAA and homeostasis model assessment- insulin resistance (HOMA-IR) were documented in 94 subjects with and i...
Source: Cardiovascular Diabetology - November 9, 2013 Category: Cardiology Authors: Petronella DeetmanStephan BakkerRobin Dullaart Source Type: research

Association of increased serum glycated albumin levels with low coronary collateralization in type 2 diabetic patients with stable angina and chronic total occlusion
Conclusions: Increased GA levels in serum are associated with impaired collateral growth in type 2 diabetic patients with stable angina and chronic total occlusion. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 8, 2013 Category: Cardiology Authors: Ying ShenLin LuFeng DingZhen SunRui ZhangQi ZhangZheng YangJian HuQiu ChenWei Shen Source Type: research

Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study
Conclusions: Our findings suggest that elevated HbA1c levels are an independent risk factor for CVD, especially CHD and ischaemic stroke, and that the addition of HbA1c to the model with traditional risk factors significantly improves the predictive ability of CVD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 7, 2013 Category: Cardiology Authors: Fumie IkedaYasufumi DoiToshiharu NinomiyaYoichiro HirakawaNaoko MukaiJun HataKentaro ShikataDaigo YoshidaTakayuki MatsumotoTakanari KitazonoYutaka Kiyohara Source Type: research

Safety and efficacy of long-term combination therapy with bezafibrate and ezetimibe in patients with dyslipidemia in the prospective, observational J-COMPATIBLE study
In this study, we examined the safety, including the risk of gallstone formation, and the efficacy of long-term combination therapy with bezafibrate and ezetimibe for treating dyslipidemia. Methods: Dyslipidemic patients treated with 400 mg/day bezafibrate in combination with 10 mg/day ezetimibe for the first time were eligible. We selected 157 institutions in Japan and conducted a 12-month prospective observational study, with patients enrolled on the day they started combination therapy. Safety of the combination was examined in terms of the type, onset, and severity of adverse drug reactions (ADRs). Efficacy was evaluat...
Source: Cardiovascular Diabetology - November 6, 2013 Category: Cardiology Authors: Tamio TeramotoKazunori AbeTakehiko Taneyama Source Type: research

Arterial stiffness, fatty liver and the presence of coronary artery calcium in a large population cohort
Conclusion: We showed that both fatty liver and baPWV are independently associated with the presence of CAC, a marker of preclinical atherosclerosis. These associations are independent of conventional risk factors and medical history. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 5, 2013 Category: Cardiology Authors: Ki-Chul SungYoung-Hyo LimSungha ParkSeok-Min KangJeong ParkByung-Jin KimJin-Ho Shin Source Type: research

Coronary calcium in patients with and without diabetes: first manifestation of acute or chronic coronary events is characterized by different calcification patterns
Background: Coronary artery calcification (CAC) is closely related to coronary atherosclerosis. However, less is known about the clinical significance of extensive CAC (ECAC) in regard to types of first coronary events (acute vs. chronic). Diabetes mellitus (DM) represents a strong risk factor for CAD although its association with CAC is controversial. Aiming to elucidate these controversies we investigated the long-term outcome of coronary artery disease (CAD) in relation to degree of CAC in patients with and without DM from our annual cheek-up outpatient clinic. Methods: Coronary artery computed tomography (CT) was perfo...
Source: Cardiovascular Diabetology - November 5, 2013 Category: Cardiology Authors: Joseph ShemeshAlexander TenenbaumEnrique FismanNira Koren-MoragEhud Grossman Source Type: research

Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes
Conclusions: The combination therapy of ViL and VaL improves both pancreatic beta-cell function and insulin sensitivity, with a reduction of the inflammatory and cell stress milieu in mouse models of T2DM. Our results suggest that this combination therapy exerts additive or even synergistic benefits to treat T2DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2013 Category: Cardiology Authors: Katsutoshi MiyagawaTatsuya KondoRieko GotoRina MatsuyamaKaoru OnoSayaka KitanoShuji KawasakiMotoyuki IgataJunji KawashimaTakeshi MatsumuraHiroyuki MotoshimaEiichi Araki Source Type: research

Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study
Conclusions: Our study showed that losartan had the most beneficial effect on SUA level among five ARBs, and that there was no significant difference in the unfavorable effects on SUA level among four ARBs other than losartan, at least during one year. These findings provide evidence of an effect of ARBs on SUA level, and support the benefit of the use of losartan in hypertensive patients with type 2 DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2013 Category: Cardiology Authors: Yayoi NishidaYasuo TakahashiNorio SusaNobukazu KanouTomohiro NakayamaSatoshi Asai Source Type: research

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy
This study identifies the PERK signalling pathway as the mediator of cardiomyocyte cell death due to oxidative stress caused by diabetes, leading to diabetes-associated heart disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 2, 2013 Category: Cardiology Authors: Zhong-Wei LiuHai-Tao ZhuKun-Lun ChenXin DongJin WeiChuan QiuJia-Hong Xue Source Type: research

Long-term prognostic impact of cystatin c on acute coronary syndrome octogenarians with diabetes mellitus
ObjectiveCystatin C (Cys C) is a marker of renal dysfunction. Prior studies have shown that blood Cys C is related to the prognosis of coronary heart disease. The aim of the present study was to evaluate the long-term prognostic impact of Cys C on acute coronary syndrome (ACS) octogenarians with diabetes mellitus (DM). Methods: We enrolled 660 consecutive ACS octogenarians who underwent coronary angiography and were classified into two groups based on diabetes. The baseline characters and Cys C level were measured on admission. Survival curve was calculated using the Kaplan-Meier method. Multivariate Cox regression was use...
Source: Cardiovascular Diabetology - November 1, 2013 Category: Cardiology Authors: Zhenhong FuHao XueJun GuoLian ChenWei DongLuyue GaiHongbin LiuZhijun SunYundai Chen Source Type: research

Correction: The metabolic syndrome and progression of carotid atherosclerosis over 13 years: the Tromsø study
No description available (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 31, 2013 Category: Cardiology Authors: Marit HerderKjell ArntzenStein JohnsenEllisiv Mathiesen Source Type: research

Type 1 diabetes and cardiovascular disease
The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications. In Type 1 diabetes, the presence of coronary calcifications is also related to coronary artery disease. Cardiac autonomic neuropathy, which significantly impairs myocardial function and blood flow, also enhances cardiac abnormalities. Also hypoglycemic episodes are considered to adversely influence cardiac performance. Intensive insulin therapy has been demonstrated to re...
Source: Cardiovascular Diabetology - October 28, 2013 Category: Cardiology Authors: Oliver SchnellFrancesco CappuccioStefano GenoveseEberhard StandlPaul ValensiAntonio Ceriello Source Type: research

Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up
Background: Intima-media thickness (IMT) is a validated marker of preclinical atherosclerosis and a predictor of cardiovascular events.Patients: We studied a population of 529 asymptomatic patients (age 62 +/- 12.8 years), divided into two groups of subjects with and without Metabolic Syndrome (MetS). Methods: All patients, at baseline, have had a carotid ultrasound evaluation and classified in two subgroups: the first one without atherosclerotic lesions and the second one with preclinical atherosclerosis (increased IMT or asymptomatic carotid plaque). Cardiovascular endpoints were investigated in a 20-years follow-up. Res...
Source: Cardiovascular Diabetology - October 23, 2013 Category: Cardiology Authors: Salvatore NovoAngelica PeritoreRosaria TrovatoFrancesco GuarneriDaniela Di LisiIda MuratoriGiuseppina Novo Source Type: research

Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner
Conclusions: We find that chronic treatment with DPP-4 inhibitors reduced MI size, via the GLP-1 receptor-PKA pathway, in a glucose-dependent manner. Glucose-sensitive cardioprotection of endogenous GLP-1 in diabetic patients may in part explain why intensive control of serum glucose levels has been associated with increased cardiovascular risk. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 22, 2013 Category: Cardiology Authors: Derek HausenloyHannah WhittingtonAbigail WynneShah BegumLouise TheodorouNiels RiksenMihaela MocanuDerek Yellon Source Type: research

The relationship between early atherosclerosis and endothelial dysfunction in type 1 diabetic patients as evidenced by measurement of carotid intima-media thickness and soluble CD146 levels: a cross sectional study
Conclusion: Our findings emphasize that sCD146 levels may be a more sensitive marker than CIMT for earlier identification of type 1 diabetic patients at high risk for atherosclerosis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 18, 2013 Category: Cardiology Authors: Sema DogansenAysen HelvaciMine AdasSuzan Onal Source Type: research

Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification
Background: Advanced glycation endproducts (AGEs) may play a role in the development of coronary artery calcification (CAC) in type 1 diabetes (T1DM). We studied plasma AGEs in association with T1DM and CAC, and whether or not the latter association could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: We studied 165 individuals with and 169 without T1DM. CAC was quantified in a CAC score based on CT-scanning. Plasma levels of protein-bound pentosidine, Nepsilon-(carboxymethyl)lysine (CML) and Nepsilon-(carboxyethyl)lysine (CEL) were measured with HPLC/UPLC with fluorescence detection...
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Marcelle van EupenMiranda SchramHelen ColhounJean ScheijenCoen StehouwerCasper Schalkwijk Source Type: research

Activin a is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes
Conclusions: Circulating activin A levels are associated with impaired myocardial glucose metabolism and high LVMV-ratio in patients with uncomplicated T2D, reflecting a potential detrimental role in early human diabetic cardiomyopathy.Trial registration numberCurrent Controlled Trials SRCTN53177482 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Weena ChenSabrina GreulichRutger van der MeerLuuk RijzewijkHildo LambAlbert de RoosJohannes SmitJohannes RomijnJohannes RuigeAdriaan LammertsmaMark LubberinkMichaela DiamantD Ouwens Source Type: research

Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence
Conclusions: This study provides the first evidence of crosstalk between insulin/IRS-1/PI3K signaling and RAS after acute MI, thereby adding fresh insights into the pathophysiology and treatment of acute MI. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Wei LiuXinmin ZhouFenglei YuJianguo HuWen Hu Source Type: research

Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats
Background: The combination of systemic arterial hypertension and diabetes mellitus (DM) induces greater cardiac remodeling than either condition alone. However, this association has been poorly addressed in senescent rats. Therefore, this study aimed to analyze the influence of streptozotocin-induced DM on ventricular remodeling and oxidative stress in aged spontaneously hypertensive rats (SHR). Methods: Fifty 18 month old male SHR were divided into two groups: control (SHR, n = 25) and diabetic (SHR-DM, n = 25). DM was induced by streptozotocin (40 mg/kg, i.p.). After nine weeks, the rats underwent echocardiography and m...
Source: Cardiovascular Diabetology - October 17, 2013 Category: Cardiology Authors: Camila RosaNatasha XavierDijon Henrique CamposAna FernandesMarcelo CezarPaula MartinezAntonio CicognaCamila GimenesRodrigo GimenesMarina OkoshiKatashi Okoshi Source Type: research

Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat
In this study, we compared the effect of a long acting GLP-1 agonist, DPP-IV resistant GLP-1 (7--36, A8G) fused to an AlbudAb (GAlbudAb), with the effect of the GLP-1 mimetic, exendin-4 (short half-life GLP-1 agonist) on infarct size following acute myocardial I/R injury. Methods: Male Sprague--Dawley rats (8-week-old) were treated with vehicle, GAlbudAb or exendin-4. Myocardial ischemia was induced 2 h following the final dose for GAlbudAb and 30 min post the final dose for exendin-4. In a subgroup of animals, the final dose of exendin-4 was administered (1 mug/kg, SC, bid for 2 days) 6 h prior to myocardial ischemia when...
Source: Cardiovascular Diabetology - October 14, 2013 Category: Cardiology Authors: Weike BaoLucy HoltRob PrinceGavin JonesKarpagam AravindhanMathew SzapacsApril BarbourLarry JolivetteJohn LeporeRobert WilletteElena DeAngelisBeat Jucker Source Type: research

Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells
Conclusions: These results demonstrate that the downstream effectors of Irf-1 are cyclin E/CDK2 during the high glucose-induced proliferation of VSMCs, whereas they are cyclin D1/CDK4 in normal glucose conditions. The Irf-1 overexpression-induced proliferation of VSMCs, the up-regulation of cyclin E/CDK2 and the acceleration of cell cycle progression are associated with ROS/Erk1/2 signaling pathway under high glucose conditions. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 14, 2013 Category: Cardiology Authors: Xi ZhangLong LiuChao ChenYa-Li ChiXiang-Qun YangYan XuXiao-Tong LiShi-Lei GuoShao-Hu XiongMan-Ru ShenYu SunChuan-Sen ZhangKai-Meng Hu Source Type: research

Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus
This study measured serum electrolyte levels and examined their relationship with macrovascular complications in Chinese adults with diabetes. Methods: The three gender- and age-matched groups were enrolled into this analysis, which were 1,170 subjects with normal glucose regulation (NGR), 389 with impaired glucose regulation (IGR) and 343 with diabetes. Fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG), glycosylated hemoglobin A1c (HbA1c) and serum electrolyte levels were measured. Data collection included ankle brachial index results. Results: Serum sodium and magnesium levels in the diabetes group wer...
Source: Cardiovascular Diabetology - October 10, 2013 Category: Cardiology Authors: Shenqi WangXuhong HouYu LiuHuijuan LuLi WeiYuqian BaoWeiping Jia Source Type: research

Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study
Conclusions: ADMA is associated with diffuse but not focal coronary atherosclerosis in non-diabetic men with stable CAD irrespectively of the degree of IR. The independent relationship between ADMA and coronary atherosclerotic burden may contribute to the well-recognized prognostic effect of ADMA in CAD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 9, 2013 Category: Cardiology Authors: Olga KruszelnickaAndrzej SurdackiAlain Golay Source Type: research

The activity of circulating dipeptidyl peptidase-4 is associated with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus
Background: Patients with type 2 diabetes mellitus (T2DM) present subclinical left ventricular systolic and/or diastolic dysfunction (LVD). Dipeptidyl peptidase-4 (DPP4) inactivates peptides that possess cardioprotective actions. Our aim was to analyze whether the activity of circulating DPP4 is associated with echocardiographically defined LVD in asymptomatic patients with T2DM. Methods: In this cross-sectional study, we examined 83 T2DM patients with no coronary or valve heart disease and 59 age and gender-matched non-diabetic subjects. Plasma DPP4 activity (DPP4a) was measured by enzymatic assay and serum amino-terminal...
Source: Cardiovascular Diabetology - October 7, 2013 Category: Cardiology Authors: Susana RavassaJoaquín BarbaIsabel Coma-CanellaAna HuertaBegoña LópezArantxa GonzálezJavier Díez Source Type: research

Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC
Conclusion: Our findings highlighted a unique framework for hyperglycemia-induced endothelial dysfunction. We showed that multiple pathways are differentially affected in these endothelial cells lines in hyperglycemia. High occurrences of gene expression changes in HMVEC in this study supports the hypothesis that microvasculature precedes macrovasculature in epigenetic regulation forming vascular metabolic memory. Identifying genomic phenotype and corresponding functional changes in hyperglycemic endothelial dysfunction will provide a suitable systems biology approach for understanding underlying mechanisms and possible ef...
Source: Cardiovascular Diabetology - October 5, 2013 Category: Cardiology Authors: Hemang PatelJuan ChenKumuda DasMahendra Kavdia Source Type: research

The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs)
This study aimed to investigate the pivotal role of profilin-1 in the process of endothelial cell damage induced by AGEs. Methods: Human umbilical vein endothelial cells (HUVECs) were incubated with AGEs. The mRNA and protein expression of profilin-1 was determined using real-time PCR and western blotting analyses. The levels of intercellular adhesion molecule-1 (ICAM-1), nitric oxide (NO) and reactive oxygen species (ROS), as well as the activities of nuclear factor-kappaB (NF-kappaB) and protein kinase C (PKC), were detected using the appropriate kits. The levels of asymmetric dimethylarginine (ADMA) were determined usin...
Source: Cardiovascular Diabetology - October 4, 2013 Category: Cardiology Authors: Zhenyu LiQiaoqing ZhongTianlun YangXiumei XieMeifang Chen Source Type: research

Usefulness of metabolic syndrome score in the prediction of angiographic coronary artery disease severity according to the presence of diabetes mellitus: relation with inflammatory markers and adipokines
Conclusions: In the presence of DM, neither adipokines nor MS score predicted angiographic CAD. However, in non-diabetic patients, IL-6 and adiponectin showed progressive changes according to MS score, and MS score was an independent predictor of CAD in patients without DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 2, 2013 Category: Cardiology Authors: Jong-Youn KimEui-Young ChoiHee-Sun MunPil-Ki MinYoung-Won YoonByoung LeeBum-Kee HongSe-Joong RimHyuck Kwon Source Type: research

Rationale and design of a randomized trial on the impact of aldosterone antagonism on cardiac structure and function in diabetic cardiomyopathy
: Development of cardiomyopathy in diabetes mellitus is independent of traditional risk factors, with no clinical trials targeting specific therapeutic interventions. Myocardial fibrosis is one of the key mechanisms and aldosterone is a key mediator of myocardial fibrosis. We propose that aldosterone antagonism will improve cardiac function. We aim to evaluate the efficacy of selective aldosterone receptor antagonism with eplerenone added to optimal medical treatment in improving cardiac structure and function in diabetic cardiomyopathy. We will randomize 130 patients with type 2 diabetes mellitus, stable metabolic control...
Source: Cardiovascular Diabetology - October 1, 2013 Category: Cardiology Authors: Melissa LeungVincent WongStephane HeritierAnastasia MihailidouDominic Leung Source Type: research

Lipoprotein(a) is not related to markers of insulin resistance in pregnancy
Conclusions: Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2013 Category: Cardiology Authors: Jelena TodoricAmmon HandisuryaKaroline LeitnerJuergen HarreiterGregor HoermannAlexandra Kautzky-Willer Source Type: research

Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
This study aimed to assess whether urinary adiponectin concentration is correlated with vascular complications. Methods: The study comprised 708 subjects who enrolled in the Seoul Metro City Diabetes Prevention Program and were carefully monitored from September 2008 to December 2008. Levels of urinary adiponectin were measured using an enzyme linked immunosorbent assay (ELISA) kit (AdipoGen, Korea). Urinary albumin excretion was assessed by the ratio of urinary albumin to creatinine (A/C ratio). Participants were divided into three groups based on tertiles of urinary adiponectin concentration, and we investigated whether ...
Source: Cardiovascular Diabetology - September 28, 2013 Category: Cardiology Authors: Won Seon JeonJi Woo ParkNamseok LeeSe Eun ParkEun Jung RheeWon Young LeeKi Won OhSung Woo ParkCheol-Young ParkByung-Soo Youn Source Type: research

Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin
Conclusions: High-fat feeding in combination with a low dose of STZ induced cardiac metabolic changes that mirror the decrease in glucose metabolism and increase in fat metabolism in diabetic patients. While low doses of 15--25 mg/kg STZ induced a type 2 diabetic phenotype, higher doses more closely recapitulated type 1 diabetes, demonstrating that the severity of diabetes can be easily modified according to the requirements of the study. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 24, 2013 Category: Cardiology Authors: Latt MansorEileen GonzalezMark ColeDamian TylerJessica BeesonKieran ClarkeCarolyn CarrLisa Heather Source Type: research