Nonalcoholic fatty pancreatic disease and cardio-metabolic risk: is there is a place for obstructive sleep apnea?
Background: Obstructive sleep apnea is a common disorder acting as a risk factor for the development and progression of cardiometabolic derangements including non-alcoholic fatty liver disease. Recent research data suggest that non-alcoholic fatty pancreatic disease may be a more sensitive marker than non-alcoholic fatty liver disease for early subclinical metabolic risk and may contribute to the progression of subclinical disease to overt type 2 diabetes mellitus.Presentation of the hypothesisWe postulate that obstructive sleep apnea may be a risk factor for non-alcoholic fatty pancreatic disease. It is well known that in...
Source: Cardiovascular Diabetology - January 30, 2014 Category: Cardiology Authors: Aibek Mirrakhimov Source Type: research

Annual acknowledgement of manuscript reviewers
Contributing reviewersThe Editors of Cardiovascular Diabetology wish to thank all reviewers, both Editorial Board Members and external referees, who contributed to the journal in 2013 (Volume 12), and whose enthusiastic support in providing the essential service of peer review continues to improve the scientific quality of the journal and enable its goals to be achieved. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 30, 2014 Category: Cardiology Authors: Alexander TenenbaumEnrique Fisman Source Type: research

The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
Background: Individuals with type 1 diabetes mellitus are at high risk for the development of hypertension, contributing to cardiovascular complications. Hyperglycaemia-mediated neurohormonal activation increases arterial stiffness, and is an important contributing factor for hypertension. Since the sodium glucose cotransport-2 (SGLT2) inhibitor empagliflozin lowers blood pressure and HbA1c in type 1 diabetes mellitus, we hypothesized that this agent would also reduce arterial stiffness and markers of sympathetic nervous system activity. Methods: Blood pressure, arterial stiffness, heart rate variability (HRV) and circulat...
Source: Cardiovascular Diabetology - January 29, 2014 Category: Cardiology Authors: David CherneyBruce PerkinsNima SoleymanlouRonnie HarNora FaganOdd JohansenHans-Juergen WoerleMaximilian von EynattenUli Broedl Source Type: research

CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models
Conclusions: CNX-012-570 has the potential to control hyperglycemia and hyperlipidemia. It also reduces body weight gain with an additional benefit of minimizing cardiovascular risks in diabetics. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 25, 2014 Category: Cardiology Authors: Tharappel AnilChandrashekaran HarishMudigere LakshmiKrishnaReddy HarshaMallappa OnkaramurthyVenkatesh Sathish KumarNitya ShreeVenkatachalaiah GeethaGundalmandikal BalamuraliAralakuppe GopalaBobbili Madhusudhan ReddyMadabosse GovindMammen AnupYoganand Mool Source Type: research

Residual macrovascular risk in 2013: what have we learned?
In conclusion, the R3i believes that ongoing trials with these novel treatments may help to define the optimal management of atherogenic dyslipidaemia to reduce the clinical and socioeconomic burden of residual cardiovascular risk. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 24, 2014 Category: Cardiology Authors: Jean-Charles FruchartJean DavignonMichel HermansKhalid Al-RubeaanPierre AmarencoGerd AssmannPhilip BarterJohn BetteridgeEric BruckertAda CuevasMichel FarnierEle FerranniniPaola FiorettoJacques GenestHenry GinsbergAntonio GottoDayi HuTakashi KadowakiTatsuh Source Type: research

Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK
Conclusions: Our results indicate that changes in the myocardium occur in the liver-specific glucokinase knockout mouse and suggest that reduced glucokinase expression in the liver may induce diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK protein levels. Rosiglitazone treatment may protect against diabetic cardiomyopathy by altering the levels of a set of proteins involved in cardiac damage. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2014 Category: Cardiology Authors: Hui LiXi WangYiqing MaoRuobi HuWei XuZhen LeiNa ZhouLing JinTingting GuoZhixin LiDavid IrwinGang NiuHuanran Tan Source Type: research

Associations of metabolic syndrome and diabetes mellitus with 16-year survival after CABG
Background: The associations of metabolic syndrome (MetS) or diabetes mellitus (DM) on long-term survival after coronary artery bypass grafting (CABG) have not been extensively evaluated. The aim of the present study was to assess the impact of MetS and DM on the 16-year survival after CABG. Methods: Diabetic and metabolic status together with relevant cardiovascular data was established in 910 CABG patients operated in 1993-94. They were divided in three groups as follows: neither DM nor MetS (375 patients), MetS alone (279 patients) and DM with or without MetS (256 patients). The 16-year follow-up of patient survival was...
Source: Cardiovascular Diabetology - January 22, 2014 Category: Cardiology Authors: Ville HällbergAri PalomäkiJorma LahtelaSeppo VoutilainenMatti TarkkaMatti Kataja Source Type: research

Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Objectives: Early menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have different life courses, is unknown. We tested the hypothesis that earlier menarche is associated with higher diabetes risk in Brazilian adults. Methods: We used data from 8,075 women aged 35-74 years in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who had complete information on age at menarche, diabetes status, and covariates. Diabetes was defined based on self-reported physician diagnosis...
Source: Cardiovascular Diabetology - January 16, 2014 Category: Cardiology Authors: Noel MuellerBruce DuncanSandhi BarretoDora ChorMarina BesselEstela AquinoMark PereiraMaria Schmidt Source Type: research

Flow-mediated-paradoxical vasoconstriction is independently associated with asymptomatic myocardial ischemia and coronary artery disease in type 2 diabetic patients
Background: To investigate whether flow-mediated dilation (FMD) impairment, which precedes overt atherosclerosis, is associated with silent myocardial ischemia (SMI) and asymptomatic coronary artery disease (CAD) in type 2 diabetes. Methods: Forearm FMD was measured by ultrasonography in 25 healthy control, 30 non-diabetic overweight or obese patients and 118 asymptomatic type 2 diabetic patients with a high cardiovascular risk profile. SMI (abnormal stress myocardial scintiscan and/or stress dobutamine echocardiogram) and CAD (coronary angiography in the patients with SMI) were assessed in the diabetic cohort. Results: FM...
Source: Cardiovascular Diabetology - January 15, 2014 Category: Cardiology Authors: Minh Tuan NguyenIsabelle PhamPaul ValensiHélène RousseauEric VicautChristelle Laguillier-MorizotAlain NitenbergEmmanuel Cosson Source Type: research

Do incretins improve endothelial function?
An impaired endothelial function has been recognized in the early stage of atherosclerosis, and is a major factor affecting the future development of cardiovascular events. Type 2 diabetes mellitus (T2DM) is widely prevalent, and is one of the most important risk factors for cardiovascular disease. T2DM is associated with increases in both morbidity and mortality, particularly from cardiovascular disease.New therapies based on the incretin hormone and its actions are now becoming widely used, and appear to offer advantages over conventional therapies by keeping the body weight steady and limiting hypoglycemia, while also a...
Source: Cardiovascular Diabetology - January 15, 2014 Category: Cardiology Authors: Jun-ichi OyamaYukihito HigashiKoichi Node Source Type: research

Possible effects of glimepiride beyond glycemic control in patients with type 2 diabetes: a preliminary report
Conclusions: Glimepiride may have potent anti-oxidative, anti-inflammatory and angiogenic properties and it may potentially repair tissue damage by decreasing the levels of toxic AGE and increasing colony-stimulating factors. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 14, 2014 Category: Cardiology Authors: Ikuko NakamuraJun-ichi OyamaHiroshi KomodaAya ShirakiYoshiko SakamotoIsao TaguchiAtsushi HiwatashiAiko KomatsuMasayoshi TakeuchiSho-ichi YamagishiTeruo InoueKoichi Node Source Type: research

A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes
Conclusion: To our knowledge, this is the first study in subjects with T2D to demonstrate that increased F&V intake augmented the carotenoid content and influenced enzymes associated with the antioxidant properties of HDL. We suggest that these changes would enhance the cardioprotective properties of this lipoprotein.Clinical trial registration: ISRCTN21676269 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 14, 2014 Category: Cardiology Authors: Jane-Ann DanielsCiara MulliganDavid McCanceJayne WoodsideChristopher PattersonIan YoungJane McEneny Source Type: research

Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes
Background: Patients with diabetes mellitus are at increased risk for microvascular complications. Early changes in microcirculation are characterized by hyperperfusion (e.g. in the retina and kidney) and increased pulse wave reflection leading to increased aortic pressure. We investigated the effects of the DPP-4-inhibitor saxagliptin on early retinal microvascular changes. Methods: In this double-blind, controlled, cross-over trial 50 patients (without clinical signs of microvascular alterations) with type-2 diabetes (mean duration of 4 years) were randomized to receive placebo or 5 mg saxagliptin for 6 weeks. Retinal ar...
Source: Cardiovascular Diabetology - January 14, 2014 Category: Cardiology Authors: Christian OttUlrike RaffStephanie SchmidtIris KistnerStefanie FriedrichPeter BramlageJoanna HaraznyRoland Schmieder Source Type: research

Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris
Background: C1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. We analyzed the relationship between CTRP-3, progranulin and coronary artery disease (CAD) in Korean men and women. Methods: Circulating CTRP-3 and progranulin levels were examined in 362 Korean adults with acute coronary syndrome (ACS, n = 69), stable angina pectoris (SAP, n = 85), and control subjects (n = 208) along with various kinds of cardiometabolic risk factors. Results: CTRP-3 concentrations were signific...
Source: Cardiovascular Diabetology - January 13, 2014 Category: Cardiology Authors: Kyung ChoiSoon HwangHo HongHae ChoiHye YooByung-Soo YounSei BaikHong Seo Source Type: research

Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study
Conclusions: Low serum DHA is associated with progression of coronary atherosclerosis in statin-treated patients with DM.Trial registration: UMIN Clinical Trials Registry, UMIN ID: C000000311. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2014 Category: Cardiology Authors: Tsuyoshi NozueShingo YamamotoShinichi TohyamaKazuki FukuiShigeo UmezawaYuko OnishiTomoyuki KunishimaAkira SatoToshihiro NozatoShogo MiyakeYouichi TakeyamaYoshihiro MorinoTakao YamauchiToshiya MuramatsuKiyoshi HibiMitsuyasu TerashimaIchiro Michishita Source Type: research

The co-occurrence of myocardial dysfunction and peripheral insensate neuropathy in a streptozotocin-induced rat model of diabetes
Conclusions: Cardiovascular structural and functional changes developed early in the course of DM and in combination with insensate neuropathy. In parallel, signs of cardiac autonomic dysfunction were also found and included decreased myocardial NE levels and altered CGRP levels. These results may indicate the need for early cardiovascular evaluation in DM patients with insensate neuropathy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2014 Category: Cardiology Authors: Maria MarangoniScott BradyShamim ChowdhuryMariann Piano Source Type: research

Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes
In this study, we investigated the association of plasma leptin levels with vascular endothelial function in lean and overweight patients with type 2 diabetes. Methods: One hundred seventy-one type 2 diabetic patients, of which 85 were overweight (body mass index (BMI)>= 25 kg/m2), were enrolled in this cross-sectional study. Plasma leptin concentrations were measured by enzyme-linked immunosorbent assay. Flow-mediated dilatation (FMD) of the brachial artery was measured to evaluate vascular endothelial function using ultrasound. Results: No significant difference in FMD was found between the lean and overweight groups ...
Source: Cardiovascular Diabetology - January 10, 2014 Category: Cardiology Authors: Tomoaki MoriokaMasanori EmotoYuko YamazakiNaoya KawanoSatoshi ImamuraRyutaro NumaguchiHiromi UrataKoka MotoyamaKatsuhito MoriShinya FukumotoHidenori KoyamaTetsuo ShojiMasaaki Inaba Source Type: research

High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome
Conclusions: Patients with ACS had higher serum C1q-APN levels.Trial RegistrationUMIN000002997 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 9, 2014 Category: Cardiology Authors: Ken KishidaYasuhiko NakagawaHironori KobayashiToru MazakiHiroyoshi YokoiKoji YanagiTohru FunahashiIichiro Shimomura Source Type: research

Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment
Conclusion: This study identified novel miRNA in the field of diabetic vasculopathy and might provide new information about the effect of vitamin D on gene regulation induced by a diabetic-like environment. New gene targets that are part of the molecular mechanism and the therapeutic treatment in diabetic vasculopathy are highlighted. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2014 Category: Cardiology Authors: Tali Zitman-GalJanice GreenMetsada Pasmanik-ChorEliezer GolanJacques BernheimSydney Benchetrit Source Type: research

Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
Conclusions: We confirmed the FAIM2-rs7138803 relationship with obesity and identified novel and consistent associations with heart rate in particular in type 2 diabetic subjects. Furthermore, our results suggest a possible association of this polymorphism with higher myocardial infarction risk in type-2 diabetic subjects, although this result needs to be replicated as it could represent a false positive. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2014 Category: Cardiology Authors: Dolores CorellaJose SorlíJosé GonzálezCarolina OrtegaMontserrat FitóMonica BullóMiguel Martínez-GonzálezEmilio RosFernando ArósJosé LapetraEnrique Gómez-GraciaLluís Serra-MajemValentina Ruiz-GutierrezMiquel FiolOscar ColtellErnest VinyolesXavie Source Type: research

Exercise increases serum endostatin levels in female and male patients with diabetes and controls
Conclusion: Middle-aged healthy female individuals as well as female T2DM-patients showed higher circulating serum endostatin levels compared to males, suggesting a hormonal influence on baseline circulating endostatin amounts. Exercise-induced increase in endostatin is also observable in patients suffering from T2DM. Concerning vascularisation, lower endostatin levels in T2DM might be advantageous. Concerning plaque stability, lower levels might be prejudicial.Trial registration: Clinical Trial Registration-URL: http://clinicaltrials.gov/ct2/results?term=NCT01165515 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2014 Category: Cardiology Authors: Michael SponderDaniela DanglStephanie KampfMonika Fritzer-SzekeresJeanette Strametz-Juranek Source Type: research

Step Monitoring to improve ARTERial health (SMARTER) through step count prescription in type 2 diabetes and hypertension: trial design and methods
Background: With increasing numbers of type 2 diabetes (DM2) and hypertension patients, there is a pressing need for effective, time-efficient and sustainable strategies to help physicians support their patients to achieve higher physical activity levels. SMARTER will determine whether physician-delivered step count prescriptions reduce arterial stiffness over a one-year period, compared with usual care, in sedentary overweight/obese adults with DM2/hypertension.DesignRandomized, allocation-concealed, assessor-blind, multisite clinical trial. The primary outcome is change in arterial stiffness over one year. The secondary ...
Source: Cardiovascular Diabetology - January 6, 2014 Category: Cardiology Authors: Kaberi DasguptaEllen RosenbergStella Daskalopouloufor the SMARTER collaborators Source Type: research

The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes
Conclusions: Diabetes reduces the ability of the heart to pump at high afterloads and, consequently, reduces the afterload at which peak efficiency occurs. However, the peak efficiency of the isolated working rat heart remains unaffected by STZ-induced diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 5, 2014 Category: Cardiology Authors: June-Chiew HanSoyeon GooCarolyn BarrettKimberley MellorAndrew TabernerDenis Loiselle Source Type: research

Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease
Conclusion: In conclusion, from the present study it appears that transition from T2DM or CAD to T2DM-CAD co-morbidity is associated with strong down regulation of Th2 cytokines and enhancement of Th1 responses. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Haridoss MadhumithaViswanathan MohanMohan DeepaSubash BabuVivekanandhan Aravindhan Source Type: research

Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study
Conclusions: We found a diminished vasomotor reactivity in individuals with obesity which was not explained by the presence of insulin resistance. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Marcela Rodríguez-FloresCarlos Cantú-BritoEduardo García-GarcíaClaudia Cano-Nigenda Source Type: research

National trends in utilization and outcomes of coronary revascularization procedures among people with and without type 2 diabetes in Spain (2001-2011)
Conclusions: The annual percent change in PCI procedures increased in diabetic and non-diabetic patients. Higher comorbidity and the female gender are associated with a higher IHM in PCI procedures. In diabetic and non-diabetic patients, we found a decrease in the use of CABG procedures. IHM was higher in patients without diabetes than in those with diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Ana Lopez-de-AndresRodrigo Jimenez-GarcíaValentin Hernandez-BarreraNapoleon Perez-FarinosJose de Miguel-YanesManuel Mendez-BailonIsabel Jimenez-TrujilloAngel de MiguelCarmen PinoPilar Carrasco-Garrido Source Type: research

Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes
Background: An increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been determined. We therefore investigated the correlation between leukocyte subtype counts and intima-media thickness of the common carotid artery (CCA-IMT) in subjects with type 2 diabetes. Methods: This cross-sectional study involved 484 in-patients with type 2 diabetes (282 males and 202 females), who were hospitalized for glycemic control and underwent carotid ultrasonography at Kumamoto University Hospital b...
Source: Cardiovascular Diabetology - December 27, 2013 Category: Cardiology Authors: Takeshi MatsumuraKayo TaketaHiroyuki MotoshimaTakafumi SenokuchiNorio IshiiHiroyuki KinoshitaKazuki FukudaSarie YamadaDaisuke KukidomeTatsuya KondoAya HisadaTakahiko KatohSeiya ShimodaTakeshi NishikawaEiichi Araki Source Type: research

Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome
This study was designed to evaluate the relationship between serum LCN2 levels and coronary artery disease (CAD). Methods: Serum LCN2 levels of 261 in-patients who underwent coronary angiography were measured by sandwich enzyme immunoassay. Demographic (169 men and 92 postmenopausal women) and clinical (metabolic syndrome (MS), triglyceride (TG) and C-reactive protein (CRP) levels) characteristics were collected to assess independent factors of CAD (CAD: 188 and non-CAD: 73) and serum LCN2 levels by multiple logistic regression and multivariate stepwise regression analyses, respectively. Results: Serum LCN2 levels were sig...
Source: Cardiovascular Diabetology - December 21, 2013 Category: Cardiology Authors: Jie NiXiaojing MaMi ZhouXiaoping PanJunling TangYaping HaoZhigang LuMeifang GaoYuqian BaoWeiping Jia Source Type: research

Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice
Background: The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has been indicated to have important vasculoprotective properties and to be vulnerable to degradation by hyperglycemic conditions, we evaluated in the current study the effect of short-term metformin treatment on whole-body glycocalyx barrier properties in a mouse model of non-insulin dependent diabetes mellitus (db/db mouse). Methods: Glycocalyx barrier properties were measured in an acute experiment in three ...
Source: Cardiovascular Diabetology - December 5, 2013 Category: Cardiology Authors: Bart EskensCoert ZuurbierJudith van HaareHans VinkJurgen van Teeffelen Source Type: research

Do patients with type 1 and type 2 diabetes really have an impaired endothelial function? A population-based propensity score matching analysis
Conclusions: In this population-based study comparing adjusted FMD values of diabetic individuals with adequately matched controls, propensity score analyses revealed no association between diabetes and endothelial function. Since these findings are in discordance with the majority of previous reports, we suggest performing similar analyses using data from other population-based studies. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 5, 2013 Category: Cardiology Authors: Klaus EmpenRoberto LorbeerHenry VölzkeThorsten ReffelmannSabine SchipfMatthias NauckWolfgang KernerHenri WallaschofskiStephan FelixMarcus Dörr Source Type: research

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects
Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 22, 2013 Category: Cardiology Authors: Camila LeançaValéria NunesNatália PanzoldoVanessa ZagoEliane ParraPatrícia CazitaMatti JauhiainenMarisa PassarelliEdna NakandakareEliana de FariaEder Quintão Source Type: research

Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes
Conclusions: By blocking mineralocorticoid receptors, eplerenone may attenuate cardiac steatosis and apoptosis, and subsequent remodelling and diastolic dysfunction in obese/type-II diabetic rats. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 21, 2013 Category: Cardiology Authors: Elisa RamírezMercedes Klett-MingoSara Ares-CarrascoBelén PicatosteAlessia FerrariniFrancisco RupérezAlicia Caro-VadilloCoral BarbasJesús EgidoJosé TuñónÓscar Lorenzo Source Type: research

High admission glucose levels increase Fas apoptosis and mortality in patients with acute ST-elevation myocardial infarction: a prospective cohort study
This study explored the relative associations among admission plasma glucose level, soluble Fas (sFas) concentration, and long-term survival in patients with acute ST-elevation myocardial infarction (STEMI). Methods: This prospective cohort study include 83 patients with acute STEMI. Based on their admission plasma glucose levels (7.8 and 11.1 mmol/L as the limits for low and high levels, respectively), patients were allocated into one of three groups: normal glucose (n = 33), median glucose (n = 24), and high glucose (n = 26). The admission plasma level of sFas was measured with a sandwich enzyme-linked immunosorbent assa...
Source: Cardiovascular Diabetology - November 15, 2013 Category: Cardiology Authors: Jing ChangGong ZhangLi ZhangYuan-Ping HouXiu-Lan LiuLin Zhang Source Type: research

Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study
The objective of this study is to determine if plasma total and HMW adiponectin concentrations underlie ethnic-specific differences in IR. Methods: Healthy Canadian Aboriginal, Chinese, European, and South Asian adults (N = 634) were assessed for sociodemographics; lifestyle; fasting plasma insulin, glucose, and total and HMW adiponectin; and adiposity measures [BMI, waist circumference, waist-to-hip ratio, percent body fat, and subcutaneous and visceral adipose tissue (quantified by computed tomography)]. The homeostasis model assessment-insulin resistance (HOMA-IR) assessed IR. Results: South Asians had the greatest HOMA...
Source: Cardiovascular Diabetology - November 13, 2013 Category: Cardiology Authors: Dian SulistyoningrumDanijela GasevicScott LearJoe HoAndrew MenteAngela Devlin Source Type: research

Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors
Conclusions: These data indicated that the AT1a receptor, thus extracellular ANG II, are not required for the development of diabetic cardiomyopathy. The KKS might contribute to the beneficial effects of benazeprilat and valsartan in diabetic cardiomyopathy. A role of intracellular ANG II is suggested by the inhibitory effects of aliskiren, which needs confirmation in future studies. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 12, 2013 Category: Cardiology Authors: Qian Chen YongCandice ThomasRachid SeqqatNiketa ChandelKenneth BakerRajesh Kumar Source Type: research

Plasma Copeptin levels are inversely associated with Intima-Media-Thickness in Men: the Population-based KORA F4 Study
Conclusions: Plasma copeptin was not associated with an increased IMT in our study cohort. In contrast, copeptin levels were related to a lower IMT in men and subjects with prediabetes, suggesting that elevated copeptin concentrations do not exert proatherogenic effects on carotid arteries. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 11, 2013 Category: Cardiology Authors: Cornelia ThenBernd KowallAndreas LechnerChrista MeisingerMargit HeierWolfgang KoenigAnnette PetersJoachim ThieryWolfgang RathmannJochen Seissler Source Type: research

Obesity and high waist circumference are associated with low circulating pentraxin-3 in acute coronary syndrome
Background: Long pentraxin 3 (PTX3) is a component of the pentraxin superfamily and a potential marker of vascular damage and inflammation, associated with negative outcome in patients with acute coronary syndromes (ACS). Obesity is a risk factor for cardiovascular disease and PTX3 production is reported in abdominal adipose tissue. Low PTX3 is however reported in the obese population, and obesity per se may be associated with less negative ACS outcome. Methods: We investigated the potential impact of obesity and high waist circumference (reflecting abdominal fat accumulation) on plasma PTX3 concentration in ACS patients (...
Source: Cardiovascular Diabetology - November 11, 2013 Category: Cardiology Authors: Rocco BarazzoniAneta AleksovaCosimo CarriereMaria CattinMichela ZanettiPierandrea VinciDavide StolfoGianfranco GuarnieriGianfranco Sinagra Source Type: research

High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome
Background: Bilirubin has been implicated in cardiovascular protection by virtue of its anti-inflammatory and anti-oxidative properties. The metabolic syndrome is featured by enhanced low-grade systemic inflammation and oxidative stress. Serum amyloid A (SAA) impairs anti-oxidative properties of high-density lipoprotein (HDL). We determined relationships of high sensitive C-reactive protein (hs-CRP) and SAA with bilirubin in subjects with and without metabolic syndrome (MetS). Methods: Serum total bilirubin, hs-CRP, SAA and homeostasis model assessment- insulin resistance (HOMA-IR) were documented in 94 subjects with and i...
Source: Cardiovascular Diabetology - November 9, 2013 Category: Cardiology Authors: Petronella DeetmanStephan BakkerRobin Dullaart Source Type: research

Association of increased serum glycated albumin levels with low coronary collateralization in type 2 diabetic patients with stable angina and chronic total occlusion
Conclusions: Increased GA levels in serum are associated with impaired collateral growth in type 2 diabetic patients with stable angina and chronic total occlusion. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 8, 2013 Category: Cardiology Authors: Ying ShenLin LuFeng DingZhen SunRui ZhangQi ZhangZheng YangJian HuQiu ChenWei Shen Source Type: research

Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study
Conclusions: Our findings suggest that elevated HbA1c levels are an independent risk factor for CVD, especially CHD and ischaemic stroke, and that the addition of HbA1c to the model with traditional risk factors significantly improves the predictive ability of CVD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 7, 2013 Category: Cardiology Authors: Fumie IkedaYasufumi DoiToshiharu NinomiyaYoichiro HirakawaNaoko MukaiJun HataKentaro ShikataDaigo YoshidaTakayuki MatsumotoTakanari KitazonoYutaka Kiyohara Source Type: research

Safety and efficacy of long-term combination therapy with bezafibrate and ezetimibe in patients with dyslipidemia in the prospective, observational J-COMPATIBLE study
In this study, we examined the safety, including the risk of gallstone formation, and the efficacy of long-term combination therapy with bezafibrate and ezetimibe for treating dyslipidemia. Methods: Dyslipidemic patients treated with 400 mg/day bezafibrate in combination with 10 mg/day ezetimibe for the first time were eligible. We selected 157 institutions in Japan and conducted a 12-month prospective observational study, with patients enrolled on the day they started combination therapy. Safety of the combination was examined in terms of the type, onset, and severity of adverse drug reactions (ADRs). Efficacy was evaluat...
Source: Cardiovascular Diabetology - November 6, 2013 Category: Cardiology Authors: Tamio TeramotoKazunori AbeTakehiko Taneyama Source Type: research

Arterial stiffness, fatty liver and the presence of coronary artery calcium in a large population cohort
Conclusion: We showed that both fatty liver and baPWV are independently associated with the presence of CAC, a marker of preclinical atherosclerosis. These associations are independent of conventional risk factors and medical history. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 5, 2013 Category: Cardiology Authors: Ki-Chul SungYoung-Hyo LimSungha ParkSeok-Min KangJeong ParkByung-Jin KimJin-Ho Shin Source Type: research

Coronary calcium in patients with and without diabetes: first manifestation of acute or chronic coronary events is characterized by different calcification patterns
Background: Coronary artery calcification (CAC) is closely related to coronary atherosclerosis. However, less is known about the clinical significance of extensive CAC (ECAC) in regard to types of first coronary events (acute vs. chronic). Diabetes mellitus (DM) represents a strong risk factor for CAD although its association with CAC is controversial. Aiming to elucidate these controversies we investigated the long-term outcome of coronary artery disease (CAD) in relation to degree of CAC in patients with and without DM from our annual cheek-up outpatient clinic. Methods: Coronary artery computed tomography (CT) was perfo...
Source: Cardiovascular Diabetology - November 5, 2013 Category: Cardiology Authors: Joseph ShemeshAlexander TenenbaumEnrique FismanNira Koren-MoragEhud Grossman Source Type: research

Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes
Conclusions: The combination therapy of ViL and VaL improves both pancreatic beta-cell function and insulin sensitivity, with a reduction of the inflammatory and cell stress milieu in mouse models of T2DM. Our results suggest that this combination therapy exerts additive or even synergistic benefits to treat T2DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2013 Category: Cardiology Authors: Katsutoshi MiyagawaTatsuya KondoRieko GotoRina MatsuyamaKaoru OnoSayaka KitanoShuji KawasakiMotoyuki IgataJunji KawashimaTakeshi MatsumuraHiroyuki MotoshimaEiichi Araki Source Type: research

Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study
Conclusions: Our study showed that losartan had the most beneficial effect on SUA level among five ARBs, and that there was no significant difference in the unfavorable effects on SUA level among four ARBs other than losartan, at least during one year. These findings provide evidence of an effect of ARBs on SUA level, and support the benefit of the use of losartan in hypertensive patients with type 2 DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2013 Category: Cardiology Authors: Yayoi NishidaYasuo TakahashiNorio SusaNobukazu KanouTomohiro NakayamaSatoshi Asai Source Type: research

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy
This study identifies the PERK signalling pathway as the mediator of cardiomyocyte cell death due to oxidative stress caused by diabetes, leading to diabetes-associated heart disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 2, 2013 Category: Cardiology Authors: Zhong-Wei LiuHai-Tao ZhuKun-Lun ChenXin DongJin WeiChuan QiuJia-Hong Xue Source Type: research

Long-term prognostic impact of cystatin c on acute coronary syndrome octogenarians with diabetes mellitus
ObjectiveCystatin C (Cys C) is a marker of renal dysfunction. Prior studies have shown that blood Cys C is related to the prognosis of coronary heart disease. The aim of the present study was to evaluate the long-term prognostic impact of Cys C on acute coronary syndrome (ACS) octogenarians with diabetes mellitus (DM). Methods: We enrolled 660 consecutive ACS octogenarians who underwent coronary angiography and were classified into two groups based on diabetes. The baseline characters and Cys C level were measured on admission. Survival curve was calculated using the Kaplan-Meier method. Multivariate Cox regression was use...
Source: Cardiovascular Diabetology - November 1, 2013 Category: Cardiology Authors: Zhenhong FuHao XueJun GuoLian ChenWei DongLuyue GaiHongbin LiuZhijun SunYundai Chen Source Type: research

Correction: The metabolic syndrome and progression of carotid atherosclerosis over 13 years: the Tromsø study
No description available (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 31, 2013 Category: Cardiology Authors: Marit HerderKjell ArntzenStein JohnsenEllisiv Mathiesen Source Type: research

Type 1 diabetes and cardiovascular disease
The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the key pathophysiological factor of both micro- and macrovascular complications. In Type 1 diabetes, the presence of coronary calcifications is also related to coronary artery disease. Cardiac autonomic neuropathy, which significantly impairs myocardial function and blood flow, also enhances cardiac abnormalities. Also hypoglycemic episodes are considered to adversely influence cardiac performance. Intensive insulin therapy has been demonstrated to re...
Source: Cardiovascular Diabetology - October 28, 2013 Category: Cardiology Authors: Oliver SchnellFrancesco CappuccioStefano GenoveseEberhard StandlPaul ValensiAntonio Ceriello Source Type: research

Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up
Background: Intima-media thickness (IMT) is a validated marker of preclinical atherosclerosis and a predictor of cardiovascular events.Patients: We studied a population of 529 asymptomatic patients (age 62 +/- 12.8 years), divided into two groups of subjects with and without Metabolic Syndrome (MetS). Methods: All patients, at baseline, have had a carotid ultrasound evaluation and classified in two subgroups: the first one without atherosclerotic lesions and the second one with preclinical atherosclerosis (increased IMT or asymptomatic carotid plaque). Cardiovascular endpoints were investigated in a 20-years follow-up. Res...
Source: Cardiovascular Diabetology - October 23, 2013 Category: Cardiology Authors: Salvatore NovoAngelica PeritoreRosaria TrovatoFrancesco GuarneriDaniela Di LisiIda MuratoriGiuseppina Novo Source Type: research