Vildagliptin in addition to metformin improves retinal blood flow and erythrocyte deformability in patients with type 2 diabetes mellitus -- results from an exploratory study
This study investigated effects of vildagliptin in comparison to glimepiride on retinal microvascular blood flow and erythrocyte deformability in T2DM.Fourty-four patients with T2DM on metformin monotherapy were included in this randomized, exploratory study over 24 weeks. Patients were randomized to receive either vildagliptin (50 mg twice daily) or glimepiride individually titrated up to 4 mg in addition to ongoing metformin treatment. Retinal microvascular blood flow (RBF) and the arteriolar wall to lumen ratio (WLR) were assessed using a laser doppler scanner. In addition, the erythrocyte elongation index (EI) was meas...
Source: Cardiovascular Diabetology - April 8, 2013 Category: Cardiology Authors: Christine Berndt-ZipfelGeorg MichelsonMarkus DworakMichael MitryAndrea LöfflerAndreas PfütznerThomas Forst Source Type: research

The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats
This study investigated the protective effects and underlying mechanisms of metformin in balloon-injury induced stenosis in insulin resistant rats. Methods: After 4 weeks high fructose diet, rats received balloon catheter injury on carotid arteries and were sacrificed at 1 and 4 weeks post injury. Biochemical, histological, and molecular changes were investigated. Results: Plasma levels of glucose, insulin, total cholesterol, triglyceride, free fatty acids, and methylglyoxal were highly increased in fructose-induced insulin resistant rats and treatment with metformin significantly improved this metabolic profile. The neoin...
Source: Cardiovascular Diabetology - April 5, 2013 Category: Cardiology Authors: Jianxin LuJingzhang JiHoward MengDavid WangBo JiangLixin LiuEdward RandellKhosrow AdeliQing Meng Source Type: research

Metabolic disturbances and worsening of atherosclerotic lesions in ApoE-/- mice after cola beverages drinking
Background: Atherosclerosis is a major health burden. Metabolic disorders had been associated with large consumption of soft drinks. The rising incidence of atherosclerosis and metabolic alterations warrants the study of long-term soft drink consumption' effects on metabolism and atherosclerosis in genetic deficiency of apolipoprotein E which typically develops spontaneous atherosclerosis and metabolic alterations. Methods: ApoE-/- mice were randomized in 3 groups accordingly with free access to: water (W), regular cola (C) or light cola (L). After 8 weeks, 50% of the animals in each group were euthanized (Treatment: W8, C...
Source: Cardiovascular Diabetology - April 1, 2013 Category: Cardiology Authors: Matilde Otero-LosadaSantiago LoughlinGastón Rodríguez-GranilloAngélica MüllerGraciela OttavianoMarisa MoriondoJuan CutrinJosé Milei Source Type: research

Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease
Background: Pigment epithelium-derived factor (PEDF) has been proved to be closely correlated with metabolic syndrome (MetS) and its components that are all risk factors of cardiovascular disease and may play a protective role against vascular injury and atherosclerosis. The present study was designed to investigate the relationship between serum PEDF and coronary artery disease (CAD). Methods: A total of 312 consecutive in-patients (including 228 with CAD and 197 with MetS) who underwent coronary angiography were enrolled. Serum PEDF was measured by sandwich enzyme immunoassay and used to carry out multivariate stepwise r...
Source: Cardiovascular Diabetology - April 1, 2013 Category: Cardiology Authors: Feifei WangXiaojing MaMi ZhouXiaoping PanJie NiMeifang GaoZhigang LuJingyu HangYuqian BaoWeiping Jia Source Type: research

Sagittal abdominal diameter is a more independent measure compared with waist circumference to predict arterial stiffness in subjects with type 2 diabetes - a prospective observational cohort study
Conclusions: We conclude that apoB and CRP, but not LDL-cholesterol predicted subclinical atherosclerosis. Furthermore, SAD was more independent in predicting arterial stiffness over time, compared with WC, in middle-aged men and women with type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 28, 2013 Category: Cardiology Authors: Elsa DahlénNiclas BjarnegårdToste LänneFredrik NystromCarl Östgren Source Type: research

Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2
Conclusions: These results suggest that zinc supplementation provides a significant protection against diabetes-induced pathogenic changes in the aorta without gender difference in the type 1 diabetic mouse model. The aortic protection by zinc against diabetes-induced pathogenic changes is associated with the up-regulation of both MT and Nrf2 expression. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 28, 2013 Category: Cardiology Authors: Xiao MiaoYonggang WangJian SunWeixia SunYi TanLu CaiYang ZhengGuanfang SuQuan LiuYuehui Wang Source Type: research

Sitagliptin pretreatment in diabetes patients presenting with acute coronary syndrome: results from the Acute Coronary Syndrome Israeli Survey (ACSIS)
Conclusions: Our data suggests that chronic treatment with DPP4i may have cardioprotective effects in diabetes patients presenting with acute coronary syndrome. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 28, 2013 Category: Cardiology Authors: Eyal LeibovitzShmuel GottliebIlan GoldenbergNatalie Gevrielov-YusimShlomi MatetzkyDov Gavish Source Type: research

Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1ß/ErbB in response to myocardial infarction resulting in worsening heart failure
Background: Diabetes mellitus (DM) patients surviving myocardial infarction (MI) exhibit a substantially higher incidence of subsequent heart failure (HF). Neuregulin (NRG)-1 and erythroblastic leukemia viral oncogene homolog (ErbB) receptors have been shown to play a critical role in maintenance of cardiac function. However, whether myocardial NRG-1/ErbB is altered during post-MI HF associated with DM remains unknown. The aim of this study was to determine the impact of type 1 DM on the myocardial NRG-1/ErbB system following MI in relation to residual left ventricular (LV) function. Methods: Type 1 DM was induced in rats ...
Source: Cardiovascular Diabetology - March 27, 2013 Category: Cardiology Authors: Oghenerukevwe OdieteEwa KonikDouglas SawyerMichael Hill Source Type: research

Annual acknowledgement of manuscript reviewers
Contributing reviewersThe Editors of Cardiovascular Diabetology wish to thank all reviewers, both Editorial Board Members and external referees, who contributed to the journal in 2012 (Volume 11), and whose enthusiastic support in providing the essential service of peer review continues to improve the scientific quality of the journal and enable its goals to be achieved. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 27, 2013 Category: Cardiology Authors: Alexander TenenbaumEnrique FismanLucy Abel Source Type: research

Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta
Conclusion: We demonstrated that diabetes-induced vascular dysfunction can arise due to either inbition of eNOS, thereby less endothelial NO-production, either directly or indirectly, in part, due to an upregulation of ROCK2 by hyperglycemia. Additionally, our data demonstrate that high phosphorylation levels of both MLC and MLCP in endothelium-denuded rings can be due to a less endothelial NO-production dependent ROCK upregulation in the smooth muscle cells under hyperglycemia, as well. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 27, 2013 Category: Cardiology Authors: Figen CicekHilmi KandilciBelma Turan Source Type: research

Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1beta/ErbB in response to myocardial infarction resulting in worsening heart failure
Background: Diabetes mellitus (DM) patients surviving myocardial infarction (MI) exhibit a substantially higher incidence of subsequent heart failure (HF). Neuregulin (NRG)-1 and erythroblastic leukemia viral oncogene homolog (ErbB) receptors have been shown to play a critical role in maintenance of cardiac function. However, whether myocardial NRG-1/ErbB is altered during post-MI HF associated with DM remains unknown. The aim of this study was to determine the impact of type 1 DM on the myocardial NRG-1/ErbB system following MI in relation to residual left ventricular (LV) function. Methods: Type 1 DM was induced in rats ...
Source: Cardiovascular Diabetology - March 27, 2013 Category: Cardiology Authors: Oghenerukevwe OdieteEwa KonikDouglas SawyerMichael Hill Source Type: research

Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy
Conclusion: Our data demonstrate that anti-inflammatory effects of triptolide involving the NF-kappaB signaling pathway can improve left ventricular function under diabetic conditions, suggesting triptolide treatment might be beneficial in diabetic cardiomyopathy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 25, 2013 Category: Cardiology Authors: He-Ling WenZhong-Shu LiangRui ZhangKan Yang Source Type: research

Preserved endothelium-dependent dilatation of the coronary microvasculature at the early phase of diabetes mellitus despite the increased oxidative stress and depressed cardiac mechanical function ex vivo
Conclusions: The presence of diabetes, even at its beginning, significantly increased the overall oxidative stress of the organs resulting to decreased cardiac mechanical activity ex vivo. However, adaptations were adopted at this early phase of the disease regarding the preserved coronary microvascular reactivity and the associated cardiac phospholipid composition in order to provide a certain protection to the heart. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 25, 2013 Category: Cardiology Authors: Evangelia MourmouraGuillaume VialBrigitte LailletJean-Paul RigaudièreIsabelle Hininger-FavierHervé DubouchaudBeatrice MorioLuc Demaison Source Type: research

Treatment of patients with type 2 diabetes with exenatide once weekly versus oral glucose-lowering medications or insulin glargine: achievement of glycemic and cardiovascular goals
Background: Diabetes is associated with a higher risk for adverse cardiovascular outcomes. To improve the health outcomes of patients with type 2 diabetes (T2DM), the American Diabetes Association (ADA) recommended target goals for the improvement of glycemic control and the reduction of cardiovascular risk factors associated with the disease. This retrospective analysis calculated the absolute benefit increase (ABI) of using exenatide once weekly (QW), a glucagon-like peptide-1 (GLP-1) receptor agonist, vs an oral glucose-lowering medication or insulin glargine to achieve ADA-recommended goals. The number needed to treat ...
Source: Cardiovascular Diabetology - March 23, 2013 Category: Cardiology Authors: Alison MeloniMary DeYoungJenny HanJennie BestMichael Grimm Source Type: research

Co-morbidity but not dysglycaemia reduces quality of life in patients with type-2 diabetes treated with oral mono- or dual combination therapy ¿ an analysis of the DiaRegis registry
Conclusion: The present study suggests, that co-morbidity but not average glycaemic control reduces health related quality of life in type 2 diabetes mellitus. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 20, 2013 Category: Cardiology Authors: Jürgen WasemPeter BramlageAnselm GittChristiane BinzMichael KreklerEvelin DeegDiethelm Tschöpe Source Type: research

Co-morbidity but not dysglycaemia reduces quality of life in patients with type-2 diabetes treated with oral mono- or dual combination therapy -- an analysis of the DiaRegis registry
Conclusion: The present study suggests, that co-morbidity but not average glycaemic control reduces health related quality of life in type 2 diabetes mellitus. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 20, 2013 Category: Cardiology Authors: Jürgen WasemPeter BramlageAnselm GittChristiane BinzMichael KreklerEvelin DeegDiethelm Tschöpe Source Type: research

Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats
Conclusions: An antidiabetic treatment with either insulin or metformin in ZDF rats inhibits the development of hypoadiponectinemia and downregulation of APPL1 in mesenteric resistance arteries, but is not able to improve adiponectin induced vasodilation and endothelial dysfunction. This is possibly due to alterations in the expression of adiponectin receptors and eNOS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 18, 2013 Category: Cardiology Authors: Peter SchmidMarkus ReschChristian SchachChristoph BirnerGuenter RieggerAndreas LuchnerDierk Endemann Source Type: research

Structured health care for subjects with diabetic foot ulcers results in a major reduction of amputation rates
ObjectiveWe tested the effects of structured health care for the diabetic foot in one region in Germany aiming to reduce the number of major amputations.Research design and methods: In a prospective study we investigated patients with diabetic foot in a structured system of outpatient, in-patient and rehabilitative treatment. Subjects were recruited between January 1st, 2000 and December 31, 2007. All participants underwent a two-year follow-up. The modified University of Texas Wound Classification System (UT) was the basis for documentation and data analysis. We evaluated numbers of major amputations, rates of ulcer heali...
Source: Cardiovascular Diabetology - March 13, 2013 Category: Cardiology Authors: Matthias WeckTorsten SlesaczeckHartmut PaetzoldDirk MuenchThomas NanningGeorg GagernAndrej BrechowUlf DietrichMandy HolfertStefan BornsteinAndreas BarthelAntje ThomasMarkolf HanefeldCarsta Koehler Source Type: research

Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker
Background: Diabetic cardiomyopathy (DCM) is defined as structural and functional changes in the myocardium due to metabolic and cellular abnormalities induced by diabetes mellitus (DM). The impact of prediabetic conditions on the cardiac tissue remains to be elucidated. The goal of this study was to elucidate whether cardiac dysfunction is already present in a state of prediabetes, in the presence of insulin resistance, and to unravel the underlying mechanisms, in a rat model without obesity and hypertension as confounding factors. Methods: Two groups of 16-week-old Wistar rats were tested during a 9 week protocol: high s...
Source: Cardiovascular Diabetology - March 7, 2013 Category: Cardiology Authors: Sara NunesEdna SoaresJoão FernandesSofia VianaEugénia CarvalhoFrederico PereiraFlávio Reis Source Type: research

Diabetes, perioperative ischaemia and volatile anaesthetics: consequences of derangements in myocardial substrate metabolism
Volatile anaesthetics exert protective effects on the heart against perioperative ischaemic injury. However, there is growing evidence that these cardioprotective properties are reduced in case of type 2 diabetes mellitus. A strong predictor of postoperative cardiac function is myocardial substrate metabolism. In the type 2 diabetic heart, substrate metabolism is shifted from glucose utilisation to fatty acid oxidation, resulting in metabolic inflexibility and cardiac dysfunction. The ischaemic heart also loses its metabolic flexibility and can switch to glucose or fatty acid oxidation as its preferential state, which may ...
Source: Cardiovascular Diabetology - March 4, 2013 Category: Cardiology Authors: Charissa van den BromCarolien BulteStephan LoerR BouwmanChrista Boer Source Type: research

Differential impact of metabolic syndrome on subclinical atherosclerosis according to the presence of diabetes
Background: Metabolic syndrome (MS) is associated with increased risks of diabetes and atherosclerotic cardiovascular disease. However, data on the impact of MS and its individual components on subclinical atherosclerosis (SCA) according to diabetes status are scarce. Methods: Surrogate markers of SCA, brachial--ankle pulse wave velocity (baPWV), and carotid intima--medial thickness (IMT) and plaque were assessed in 2,560 subjects (60 +/- 8 years, 33% men) who participated in baseline health examinations for a community-based cohort study. Results: The participants included 2,149 non-diabetics (84%) and 411 diabetics (16%)...
Source: Cardiovascular Diabetology - March 4, 2013 Category: Cardiology Authors: Ki-Bum WonHyuk-Jae ChangHyeon-Chang KimKyewon JeonHancheol LeeSanghoon ShinIn-Jeong ChoSung-Ha ParkSang-Hak LeeYangsoo Jang Source Type: research

Impaired cardioprotective function of transplantation of mesenchymal stem cells from patients with diabetes mellitus to rats with experimentally induced myocardial infarction
Conclusions: hMSCs from patients with CAD+DM and CAD alone both have proliferative properties. Transplantation of hMSCs ameliorate heart function, but proliferative ability and myocardial protection decrease significantly in MSCs obtained from patients with CAD+DM compared with cultures from patients with CAD alone, possibly as a result of differences in Bcl-2 protein expression and reduced anti-apoptosis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 3, 2013 Category: Cardiology Authors: Yu LiuZhi LiTao LiuXiaodong XueHui JiangJianhua HuangHuishan Wang Source Type: research

Discriminant ratio and biometrical equivalence of measured vs. calculated apolipoprotein B100 in patients with T2DM
Conclusion: Both apoB100 algorithms showed biometrical equivalence, and were as effective in estimating apoB100 from routine lipids. Their use should contribute to better characterize residual cardiometabolic risk linked to the number of atherogenic particles, when direct apoB100 determination is not available. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 27, 2013 Category: Cardiology Authors: Michel HermansSylvie AhnMichel Rousseau Source Type: research

Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus
Background: We hypothesized that clinical factors other than glycemic control may influence abnormal cardiac function in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the independent factors for abnormal cardiac function among clinical factors in T2DM. Methods: We studied 148 asymptomatic patients with T2DM without overt heart disease. Echocardiographic findings were compared between diabetic patients and 68 age-matched healthy subjects. Early (E) and late (A) diastolic mitral flow velocity and early diastolic mitral annular velocity (e') were measured for assessing left ventricular (LV) diastolic ...
Source: Cardiovascular Diabetology - February 27, 2013 Category: Cardiology Authors: Ryoko IchikawaMasao DaimonTetsuro MiyazakiTakayuki KawataSakiko MiyazakiMasaki MaruyamaShuo-Ju ChiangHiromasa SuzukiChiharu ItoFumihiko SatoHirotaka WatadaHiroyuki Daida Source Type: research

Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway
Conclusions: These data indicate that AGEs-induced macrophage migration is dependent on HPA involving RAGE-HPA-PI3K/AKT pathway. The nonenzymatic activity of HPA may play a key role in AGEs-induced macrophage migration associated with inflammation in diabetic vascular complication. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 26, 2013 Category: Cardiology Authors: Qiaojing QinJianying NiuZhaoxia WangWangjie XuZhongdong QiaoYong Gu Source Type: research

Angiotensin-converting enzyme inhibition and food restriction restore delayed preconditioning in diabetic mice
Background: Classical and delayed preconditioning are powerful endogenous protection mechanisms against ischemia-reperfusion damage. However, it is still uncertain whether delayed preconditioning can effectively salvage myocardium in patients with co-morbidities, such as diabetes and the metabolic syndrome. We investigated delayed preconditioning in mice models of type II diabetes and the metabolic syndrome and investigated interventions to optimize the preconditioning potential. Methods: Hypoxic preconditioning was induced in C57Bl6-mice (WT), leptin deficient ob/ob (model for type II diabetes) and double knock-out (DKO) ...
Source: Cardiovascular Diabetology - February 23, 2013 Category: Cardiology Authors: Gerry Van der MierenInes NevelsteenAnnelies VanderperWouter OosterlinckWillem FlamengPaul Herijgers Source Type: research

Effects of sitagliptin beyond glycemic control: focus on quality of life
This study was designed as a prospective, open-label, multi-center trial. Patients with diabetes mellitus type 2 (T2DM) with poor glycemic profiles (HbA1c>= 6.2%) in spite of receiving a medical diet, therapeutic exercise, and/or medications were eligible for this study. The participants received 50 to 100 mg of the DPP-4 inhibitor sitagliptin once daily for 12 months. Results: One hundred and eighty-eight subjects were enrolled. After 12 months of sitagliptin treatment, HbA1c levels decreased (7.65% +/- 1.32% to 7.05% +/- 1.10%, p
Source: Cardiovascular Diabetology - February 21, 2013 Category: Cardiology Authors: Yoshiko SakamotoJun-ichi OyamaHideo IkedaShigetaka KurokiShigeki GondohTaketo IwamotoYasufumi UchidaKazuhisa KodamaAtsushi HiwatashiMitsuhiro ShimomuraIsao TaguchiTeruo InoueKoichi Node Source Type: research

Changes of serum angiogenic factors concentrations in patients with diabetes and unstable angina pectoris
Backgroud: Diabetic microvascular changes are considered to be influenced by angiogenic factors. As a compensatory mechanism, the expression of some angiogenic factors are elevated in ischemic myocardium. The aim of this study was to investigate the changes of serum angiogenic factors, and the association among these angiogenic factors, the severity of coronary artery stenosis and collateral vessels form in patients with diabetes and unstable angina pectoris (UAP). Methods: 42 patients with diabetes (diabetes group), 57 patients with UAP (UAP group), and 36 age-matched healthy people (control group) were selected. Serum co...
Source: Cardiovascular Diabetology - February 19, 2013 Category: Cardiology Authors: Chun GuiShi-kang LiQin-ling NongFang DuLi-guang ZhuZhi-yu Zeng Source Type: research

Prognostic value of early in-hospital glycemic excursion in elderly patients with acute myocardial infarction
Background: Acute phase hyperglycemia has been associated with increased mortality in patients with acute myocardial infarction (AMI). However, the predictive value of glycemic excursion for adverse outcome in elderly AMI patients is not clear. The aim of this study is to investigate the prognostic value of early in-hospital glycemic excursion and hemoglobin A1c (HbA1c) for one-year major adverse cardiac event (MACE) in elderly patients with AMI. Methods: We studied 186 elderly AMI patients, whose clinical data were collected and the Global Registry of Acute Coronary Events (GRACE) risk score were calculated on admission. ...
Source: Cardiovascular Diabetology - February 11, 2013 Category: Cardiology Authors: Gong SuShu-hua MiZhao LiHong TaoHong-xia YangHong Zheng Source Type: research

Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study
Conclusions: This study suggests association between the HP duplication and IMT, triglycerides, CVD mortality, and T2DM in an EA population enriched for T2DM. Lack of association with atherosclerotic calcified plaque likely reflect differences in the pathogenesis of these CVD phenotypes. HP variation may contribute to the heritable risk for CVD complications in T2DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 11, 2013 Category: Cardiology Authors: Jeremy AdamsAmanda CoxBarry FreedmanCarl LangefeldJ CarrDonald Bowden Source Type: research

Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta
Background: The aim of this study was to examine the effects of intense physical training on vascular function in streptozotocin-diabetic rats. We focused on the endothelium-dependent relaxation (EDR) induced by acetylcholine (ACh) and stable ADP adenosine-5[prime]- O -- (2-thiodiphosphate) (ADPbetaS). Methods: Control or diabetic male Wistar rats (n=44) were randomly assigned to sedentary or trained groups. The training program consisted in a regular period of running on a treadmill during 8 weeks (10[degree sign] incline and up to 25 m/min, 60 min/day). The reactivity of isolated thoracic aorta rings of healthy, diabetic...
Source: Cardiovascular Diabetology - February 11, 2013 Category: Cardiology Authors: Mohamed ZguiraSophie VincentSolène Le Douairon LahayeLudivine MalardeZouhair TabkaBernard Saïag Source Type: research

AT1-receptor-deficiency induced atheroprotection in diabetic mice is partially mediated via PPARgamma
Conclusion: Genetic disruption or pharmacological inhibition of the AT1R attenuates atherosclerosis and improves endothelial function in diabetic ApoE-/--mice via the PPARgamma pathway. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 1, 2013 Category: Cardiology Authors: Vedat TiyeriliUlrich BecherAdem AksoyDieter LütjohannSven WassmannGeorg NickenigCornelius Mueller Source Type: research

Influence of fibrinogen and C-RP on progression of peripheral arterial disease in type 2 diabetes: a preliminary report
Conclusion: Our data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 1, 2013 Category: Cardiology Authors: Marijan BosevskiGolubinka BosevskaLily Stojanovska Source Type: research

Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment
Background: Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in diabetes, wherein it also ameliorates left-ventricular (LV) hypertrophy. However, direct in vivo evidence that trientine can improve cardiac function in heart failure has hitherto been lacking. Methods: To determine whether trientine treatment could improve in vivo outcome, we measured cardiac function in groups of trientine-treated diabetic (TETA-DIA), non-drug-treated diabetic (DIA) and sham-treated con...
Source: Cardiovascular Diabetology - January 31, 2013 Category: Cardiology Authors: Jun LuBeau PontréStephen PickupSoon ChoongMingming LiHong XuGregory GambleAnthony PhillipsBrett CowanAlistair YoungGarth Cooper Source Type: research

Temporal changes in concentrations of lipids and apolipoprotein B among adults with diagnosed and undiagnosed diabetes, prediabetes, and normoglycemia: findings from the National Health and Nutrition Examination Survey 1988¿1991 to 2005¿2008
The objective of this study was to examine changes in concentrations of lipids and apolipoprotein B among participants stratified by glycemic status (diabetes, undiagnosed diabetes, prediabetes, and normoglycemia) in the United States from 1988--1991 to 2005--2008. Methods: We used data from 3202 participants aged>=20 years from the National Health and Nutrition Examination Survey (NHANES) III (1988--1991) and 3949 participants aged>=20 years from NHANES 2005--2008. Results: Among participants of all four groups, unadjusted and adjusted mean concentrations of total cholesterol, low-density lipoprotein cholesterol, no...
Source: Cardiovascular Diabetology - January 30, 2013 Category: Cardiology Authors: Earl FordChaoyang LiAllan Sniderman Source Type: research

Temporal changes in concentrations of lipids and apolipoprotein B among adults with diagnosed and undiagnosed diabetes, prediabetes, and normoglycemia: findings from the National Health and Nutrition Examination Survey 1988--1991 to 2005--2008
The objective of this study was to examine changes in concentrations of lipids and apolipoprotein B among participants stratified by glycemic status (diabetes, undiagnosed diabetes, prediabetes, and normoglycemia) in the United States from 1988--1991 to 2005--2008. Methods: We used data from 3202 participants aged>=20 years from the National Health and Nutrition Examination Survey (NHANES) III (1988--1991) and 3949 participants aged>=20 years from NHANES 2005--2008. Results: Among participants of all four groups, unadjusted and adjusted mean concentrations of total cholesterol, low-density lipoprotein cholesterol, no...
Source: Cardiovascular Diabetology - January 30, 2013 Category: Cardiology Authors: Earl FordChaoyang LiAllan Sniderman Source Type: research

High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate
Background: Dysfunctional high-density lipoprotein (HDL) may have pro-inflammatory effects on the endothelial cells,which causes atherosclerosis in type 2 diabetes mellitus (T2DM). HDL is a major carrier of sphingosine-1-phosphate (S1P) in plasma while S1P exhibits multiple biological activities. However, potential role of HDL and S1P in T2DM remains unexplored. We hypothesized that diabetic HDL with higher contents of S1P exerts beneficial effects on the vascular system. Methods: Subjects with T2DM with or without proved large arteries atherosclerosis and normal controls (n=15 for each group) were recruited in the present...
Source: Cardiovascular Diabetology - January 30, 2013 Category: Cardiology Authors: Xunliang TongHui PengDonghui LiuLiang JiChenguang NiuJun RenBing PanJianying HuLemin ZhengYining Huang Source Type: research

Changes in red blood cell membrane structure in type 2 diabetes: a scanning electron and atomic force microscopy study
Red blood cells (RBCs) are highly deformable and possess a robust membrane that can withstand shear force. Previous research showed that in diabetic patients, there is a changed RBC ultrastructure, where these cells are elongated and twist around spontaneously formed fibrin fibers. These changes may impact erythrocyte function. Ultrastructural analysis of RBCs in inflammatory and degenerative diseases can no longer be ignored and should form a fundamental research tool in clinical studies. Consequently, we investigated the membrane roughness and ultrastructural changes in type 2 diabetes. Atomic force microscopy (AFM) was ...
Source: Cardiovascular Diabetology - January 28, 2013 Category: Cardiology Authors: Antoinette BuysMia-Jean Van RooyPrashilla SomaDirk Van PapendorpBoguslaw LipinskiEtheresia Pretorius Source Type: research

Blood glucose may be an alternative to cholesterol in CVD risk prediction charts
Background: Established risk models for the prediction of cardiovascular disease (CVD) include blood pressure, smoking and cholesterol parameters. The use of total cholesterol for CVD risk prediction has been questioned, particularly for primary prevention. We evaluated whether glucose could be used instead of total cholesterol for prediction of fatal CVD using data with long follow-up. Methods: We followed-up 6,095 men and women aged>=16 years who participated 1977--79 in a community based health study and were anonymously linked with the Swiss National Cohort until the end of 2008. During follow-up, 727 participants d...
Source: Cardiovascular Diabetology - January 25, 2013 Category: Cardiology Authors: Julia BraunMatthias BoppDavid Faeh Source Type: research

Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes
ObjectiveTo investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes. Methods: We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound. Results: The crude mean of serum osteocalcin concentrations were 4.52+/-2.43 ng/ml for men and 5.75+/-2.92 ng/ml for postmenopausal women (P (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 23, 2013 Category: Cardiology Authors: Li ShengWenjie CaoBingbing ChaZhaoping ChenFang WangJun Liu Source Type: research

20/(fasting C-peptide x fasting plasma glucose) is a simple and effective index of insulin resistance in patients with type 2 diabetes mellitus: a preliminary report
Background: We developed a simple and new insulin resistance index derived from a glucose clamp and a meal tolerance test (MTT) in Japanese patients with type 2 diabetes mellitus. Methods: Fifteen patients [mean age: 53 years, fasting plasma glucose (FPG) 7.7 mmol/L, HbA1c 7.1% (54 mmol/mol), body mass index 26.8 kg/m2] underwent a MTT and a glucose clamp. Participants were given a test meal (450 kcal). Plasma glucose and insulin were measured at 0 (fasting), 30, 60, 120, and 180 min. Serum C-peptide immunoreactivity (CPR) was measured at 0 (fasting; F-CPR) and 120 min. Homeostasis model assessment of insulin resistance (H...
Source: Cardiovascular Diabetology - January 22, 2013 Category: Cardiology Authors: Tsuyoshi OhkuraHideki ShiochiYouhei FujiokaKeisuke SumiNaoya YamamotoKazuhiko MatsuzawaShoichiro IzawaHiroshi KinoshitaHiroko OhkuraMasahiko KatoShin-ichi TaniguchiKazuhiro Yamamoto Source Type: research

Macrovascular complication phenotypes in type 2 diabetic patients
Background: Macrovascular diseases (MVD) in type 2 diabetes mellitus (T2DM) are often considered all together, without discriminating the areas involved. The aim of our study was to analyse MVD prevalence in a large population of T2DM patients by dividing the cases into subgroups according to MVD sites (NMVD, no MVD; NSCS, non-significant carotid stenosis; CBVD, cerebrovascular disease; CAD, coronary artery disease; PAD, peripheral artery disease; PVD: polyvascular disease) and studying the anthropometric, clinical and laboratory parameters in each group. Methods: A diabetic outpatient cohort (n = 1199) was retrospectively...
Source: Cardiovascular Diabetology - January 18, 2013 Category: Cardiology Authors: Giuseppe PapaClaudia DeganoMaria IuratoCarmelo LicciardelloRaffaella MaioranaConcetta Finocchiaro Source Type: research

Myocardial impulse propagation is impaired in right ventricular tissue of Zucker Diabetic Fatty (ZDF) rats
Background: Diabetes increases the risk of cardiovascular complications including arrhythmias, but the underlying mechanisms remain to be established. Decreased conduction velocity (CV), which is an independent risk factor for re-entry arrhythmias, is present in models with streptozotocin (STZ) induced type 1 diabetes. Whether CV is also disturbed in models of type 2 diabetes is currently unknown. Methods: We used Zucker Diabetic Fatty (ZDF) rats, as a model of type 2 diabetes, and their lean controls Zucker Diabetic Lean (ZDL) rats to investigate CV and its response to the anti-arrhythmic peptide analogue AAP10. Gap junct...
Source: Cardiovascular Diabetology - January 17, 2013 Category: Cardiology Authors: Kristine OlsenLene AxelsenThomas BraunsteinCharlotte SørensenClaus AndersenThorkil PlougNiels-Henrik Holstein-RathlouMorten Nielsen Source Type: research

Prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study
Background: The features of carotid atherosclerosis in ketosis-onset diabetes have not been investigated. Our aim was to evaluate the prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed Chinese diabetic patients with ketosis but without islet-associated autoantibodies. Methods: In total, 423 newly diagnosed Chinese patients with diabetes including 208 ketosis-onset diabetics without islet-associated autoantibodies, 215 non-ketotic type 2 diabetics and 79 control subjects without diabetes were studied. Carotid atherosclerosis was defined as the presence of atherosclerotic plaques in any of ...
Source: Cardiovascular Diabetology - January 16, 2013 Category: Cardiology Authors: Lian-Xi LiCui-Chun ZhaoYing RenYin-Fang TuJun-Xi LuXing WuWei-Xing ZhangJia-An ZhuMei-Fang LiLi-Bo YuYu-Qian BaoWei-Ping Jia Source Type: research

Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study
The objective of the present study is to investigate the associations of LPL and 25(OH)D with IR and T2D in a Chinese population. Methods: The study cohort consisted of 2708 subjects (1326 males, 1382 females; mean age 48.5 +/- 12.6 years) in main communities of Harbin, China. Serum 25(OH)D, LPL, free fatty acids (FFAs), fasting glucose (FG), fasting insulin, lipid profile, apoA and apoB concentrations were measured. Results: Serum 25(OH)D concentration was positively associated with LPL (beta = 0.168, P
Source: Cardiovascular Diabetology - January 16, 2013 Category: Cardiology Authors: Yifan HuangXiaoxia LiMaoqing WangHua NingLima AYing LiChanghao Sun Source Type: research

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats
Conclusions: Metabolic syndrome significantly alters cardiac gene expression profile which may be involved in development of cardiac pathologies in the presence of metabolic syndrome. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 15, 2013 Category: Cardiology Authors: Márta SárközyÁgnes ZvaraNóra GyémántVeronika FeketeGabriella KocsisJudit PipisGerg¿ Sz¿csCsaba CsonkaLászló PuskásPéter FerdinandyTamás Csont Source Type: research

Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients
Conclusions: Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 15, 2013 Category: Cardiology Authors: Yifei MoJian ZhouMei LiYuwei WangYuqian BaoXiaojing MaDing LiWei LuCheng HuMinghua LiWeiping Jia Source Type: research

Propofol protects against high glucose-induced endothelial adhesion molecules expression in human umbilical vein endothelial cells
Conclusion: Propofol, via decreasing O2.- accumulation, down-regulating PKCbeta2 Ser660 phosphorylation and PKC as well as NF-kappaB activity, attenuated high glucose-induced endothelial adhesion molecules expression and mononuclear-endothelial adhesion. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 11, 2013 Category: Cardiology Authors: Minmin ZhuJiawei ChenHui JiangChanghong Miao Source Type: research

Correlation between mean platelet volume and fasting plasma glucose levels in prediabetic and normoglycemic individuals
Background: Prediabetes is an independent risk factor for cardiovascular diseases. Mean platelet volume (MPV) can reflect platelet activity, and high MPV is associated with thrombogenic activation and an increased risk of cardiovascular disease. In diabetic patients, MPV is higher when compared with normal subjects. However, the relationship between MPV and prediabetes is poorly understood. The purpose of the present study was to compare MPV in prediabetic and normoglycemic subjects, and to evaluate the relationship between MPV and fasting plasma glucose (FPG) levels in these two groups. Methods: We retrospectively studied...
Source: Cardiovascular Diabetology - January 11, 2013 Category: Cardiology Authors: Masanori ShimodairaTomohiro NiwaKoji NakajimaMutsuhiro KobayashiNorinao HanyuTomohiro Nakayama Source Type: research

Coronary aspirate TNFalpha reflects saphenous vein bypass graft restenosis risk in diabetic patients
Background: Patients with diabetes mellitus (DM) have an increased risk for periprocedural complications and adverse cardiac events after percutaneous coronary intervention. We addressed the potential for coronary microvascular obstruction and restenosis in patients with and without DM undergoing stenting for saphenous vein bypass graft (SVG) stenosis under protection with a distal occlusion/aspiration device. Methods: SVG plaque volume and composition were analyzed using intravascular ultrasound before stent implantation. Percent diameter stenosis was determined from quantitative coronary angiography before, immediately a...
Source: Cardiovascular Diabetology - January 10, 2013 Category: Cardiology Authors: Theodor BaarsThomas KonorzaPhilipp KahlertStefan MöhlenkampRaimund ErbelGerd HeuschPetra Kleinbongard Source Type: research