Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus
Circulating microRNAs (miRs) are differentially regulated and selectively packaged into microparticles (MPs). We evaluated whether diabetes mellitus alters circulating vascular and endothelial MP-incorporated ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Felix Jansen, Han Wang, David Przybilla, Bernardo S. Franklin, Andreas Dolf, Philipp Pfeifer, Theresa Schmitz, Anna Flender, Elmar Endl, Georg Nickenig and Nikos Werner Source Type: research

Cost-effectiveness of screening strategies to detect heart failure in patients with type 2 diabetes
Heart failure (HF), especially with preserved ejection fraction (HFpEF) is common in older patients with type 2 diabetes (T2DM), but often not recognized. Early HF detection in older T2DM patients may be worth... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Anoukh van Giessen, Leandra J. M. Boonman-de Winter, Frans H. Rutten, Maarten J. Cramer, Marcel J. Landman, Anho H. Liem, Arno W. Hoes and Hendrik Koffijberg Source Type: research

Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension
Questions remain as to the association between essential hypertension and increased incidence of type 2 diabetes (T2DM). The premise of this analysis is that insulin resistance/compensatory hyperinsulinemia is... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 22, 2016 Category: Cardiology Authors: Ki-Chul Sung, Hyun-Young Park, Min-Ju Kim and Gerald Reaven Source Type: research

Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum
Hyperglycemia and increased levels of methylglyoxal (MGO) can trigger the development of vascular complications in diabetes. Resveratrol and quercetin are red wine polyphenols with known beneficial cardiovascu... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 18, 2016 Category: Cardiology Authors: Charlotte Boydens, Bart Pauwels, Laura Vanden Daele and Johan Van de Voorde Source Type: research

Association of glucose homeostasis measures with heart rate variability among Hispanic/Latino adults without diabetes: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Reduced heart rate variability (HRV), a measure of cardiac autonomic function, is associated with an increased risk of cardiovascular disease (CVD) and mortality. Glucose homeostasis measures are associated wi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 16, 2016 Category: Cardiology Authors: Michelle L. Meyer, Nathan M. Gotman, Elsayed Z. Soliman, Eric A. Whitsel, Raanan Arens, Jianwen Cai, Martha L. Daviglus, Pablo Denes, Hector M. González, Juan Moreiras, Gregory A. Talavera and Gerardo Heiss Source Type: research

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understoo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 8, 2016 Category: Cardiology Authors: Vidya Kandula, Ramoji Kosuru, Haobo Li, Dan Yan, Qiqi Zhu, Qingquan Lian, Ren-shan Ge, Zhengyuan Xia and Michael G. Irwin Source Type: research

The coexistence of carotid and lower extremity atherosclerosis further increases cardio-cerebrovascular risk in type 2 diabetes
Both carotid and lower limb atherosclerosis are associated with increased cardiovascular and cerebrovascular risks. However, it is still unclear whether the concomitant presence of carotid and lower extremity ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 5, 2016 Category: Cardiology Authors: Mei-Fang Li, Cui-Chun Zhao, Ting-Ting Li, Yin-Fang Tu, Jun-Xi Lu, Rong Zhang, Ming-Yun Chen, Yu-Qian Bao, Lian-Xi Li and Wei-Ping Jia Source Type: research

Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells
Previous studies have shown that high glucose (HG) induced endothelial cell (EC) damage via a phenotypic transition of EC. There is increasing evidence suggesting the role of inflammatory cytokines in mediated... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 5, 2016 Category: Cardiology Authors: Dong-Dong Zhu, Ri-Ning Tang, Lin-Li Lv, Yi Wen, Hong Liu, Xiao-Liang Zhang, Kun-Ling Ma and Bi-Cheng Liu Source Type: research

Risks of cardiovascular diseases associated with dipeptidyl peptidase-4 inhibitors and other antidiabetic drugs in patients with type 2 diabetes: a nation-wide longitudinal study
Several antidiabetic drugs (i.e., sulfonylureas; SU, rosiglitazone) have been reported to be associated with increased risks of cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). D... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 1, 2016 Category: Cardiology Authors: Huang-Tz Ou, Kai-Cheng Chang, Chung-Yi Li and Jin-Shang Wu Source Type: research

Association of soluble tumor necrosis factor receptors 1 and 2 with nephropathy, cardiovascular events, and total mortality in type 2 diabetes
Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2) contribute to experimental diabetic kidney disease, a condition with substantially increased cardiovascular risk when present in patients. Th... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 29, 2016 Category: Cardiology Authors: Axel C. Carlsson, Carl Johan Östgren, Fredrik H. Nystrom, Toste Länne, Pär Jennersjö, Anders Larsson and Johan Ärnlöv Source Type: research

Long-term mortality and incidence of cardiovascular diseases and type 2 diabetes in diabetic and nondiabetic obese patients undergoing gastric banding: a controlled study
Aim of this retrospective study was to compare long-term mortality and incidence of new diseases [diabetes and cardiovascular (CV) disease] in morbidly obese diabetic and nondiabetic patients, undergoing gastr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 27, 2016 Category: Cardiology Authors: Antonio E. Pontiroli, Ahmed S. Zakaria, Ermanno Mantegazza, Alberto Morabito, Alessandro Saibene, Enrico Mozzi and Giancarlo Micheletto Source Type: research

Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events
Patients with type 2 diabetes (T2D) have a substantial increased risk for cardiovascular (CV) disease and associated mortality than those without diabetes. Dulaglutide is a once-weekly glucagon-like peptide-1 ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 24, 2016 Category: Cardiology Authors: Keith C. Ferdinand, Fady T. Botros, Charles M. Atisso and Philip T. Sager Source Type: research

Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects
Patients with angina-like symptoms without myocardial perfusion scintigram (MPS)-verified abnormality may still be at risk for cardiovascular events. We hypothesized that insulin resistance could play a role i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 19, 2016 Category: Cardiology Authors: Helena U. Westergren, Sara Svedlund, Remi A. Momo, Juuso I. Blomster, Karin Wåhlander, Erika Rehnström, Peter J. Greasley, Regina Fritsche-Danielson, Jan Oscarsson and Li-Ming Gan Source Type: research

Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis
A pre-specified meta-analysis of cardiovascular (CV) events from 21 phase 2b/3 dapagliflozin clinical trials was undertaken to characterise the CV profile of dapagliflozin. This showed no increase in CV risk w... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 19, 2016 Category: Cardiology Authors: Christian Sonesson, Peter A. Johansson, Eva Johnsson and Ingrid Gause-Nilsson Source Type: research

Report from the 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group
The 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group was held during the annual meeting on 30 October 2015 in Munich. This summit was organized i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 18, 2016 Category: Cardiology Authors: Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi and Antonio Ceriello Source Type: research

Erratum to: Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 18, 2016 Category: Cardiology Authors: Dalia El-Lebedy, Hala M. Raslan and Asmaa M. Mohammed Source Type: research

Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism
Conclusion: We found GLP-1 secretion to be increased in response to inflammatory stimuli in humans, which was associated to parameters of glucose metabolism and best predicted by IL6. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 3, 2016 Category: Cardiology Authors: Corinna LebherzFlorian KahlesKatja PiotrowskiMichael VogeserAnn FoldenauerKirsten NassauErich KilgerNikolaus MarxKlaus ParhoferMichael Lehrke Source Type: research

Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus
Background: Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients. Methods: A total of 247 T2DM patients without history of cardiovascular complications and participated in the CDATS study were prospectively enrolled. Left ventricular (LV) systolic function was assessed by LV ejection fraction and speckle tracking derived LV systolic GLS. Diastolic function was assessed by E/E′ ratio defined as the passive trans-mitral LV inflow velocity to tissue Doppler imaging ...
Source: Cardiovascular Diabetology - February 3, 2016 Category: Cardiology Authors: Ju-Hua LiuYan ChenMichele YuenZhe ZhenCarmen ChanKaren LamHung-Fat TseKai-Hang Yiu Source Type: research

Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study
Conclusions: Our results show that low plasma concentration of PTX3 in early pregnancy is associated with subsequent development of GDM and with an enhanced risk for CVD as estimated by an elevated apoB/apoA ratio at 5 years postpartum. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 3, 2016 Category: Cardiology Authors: Tove LekvaAnnika MichelsenJens BollerslevErrol NorwitzPål AukrustTore HenriksenThor Ueland Source Type: research

Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)
Conclusions: Our study indicates that polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 1, 2016 Category: Cardiology Authors: Yu WangJiantao YeJie LiCheng ChenJunying HuangPeiqing LiuHeqing Huang Source Type: research

Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population
Background: The genetic contribution to complex diseases or traits, including cardio-metabolic traits, has been elucidated recently by large-scale genome-wide association studies. These genome-wide association studies have indicated that most pleiotropic loci contain genes associated with lipids. Clinically, lipid related abnormalities are strongly associated with other diseases such as type 2 diabetes, coronary artery disease and hypertension. The aim of this study was to evaluate the shared genetic background of lipids and other cardio-metabolic traits. Methods: We conducted meta-analyses of the association between 157 p...
Source: Cardiovascular Diabetology - February 1, 2016 Category: Cardiology Authors: Yun KimMi HwangYoung KimSanghoon MoonSohee HanBong-Jo Kim Source Type: research

High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy
Conclusions: Glucose-related hyperosmolarity seems to be able to promote angiogenesis and retinopathy through activation of TonEBP and possibly increasing expression of AQP1 and COX-2. Osmolarity signaling may be a target for therapy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 29, 2016 Category: Cardiology Authors: Rosalinda MadonnaGaia GiovannelliPamela ConfaloneFrancesca RennaYong-Jian GengRaffaele De Caterina Source Type: research

Early cardiovascular events in women with a history of gestational diabetes mellitus
Conclusions: A history of GDM was identified as a risk factor of CVD, especially coronary vascular diseases, within the 7 years postpartum. A lifestyle changes from postpartum onwards can be recommended and supported. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 27, 2016 Category: Cardiology Authors: Karine GoueslardJonathan CottenetAnne-Sophie MarietMaurice GiroudYves CottinJean-Michel PetitCatherine Quantin Source Type: research

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes
Conclusions: Our data suggest that the paradoxical association between high serum adiponectin levels and increased cardiovascular mortality rate is based on a cause-effect relationship, thus pointing to an unexpected deleterious role of adiponectin action/metabolism on atherosclerotic processes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 27, 2016 Category: Cardiology Authors: Lorena Ortega MorenoMassimiliano CopettiAndrea FontanaConcetta De BonisLucia SalveminiVincenzo TrischittaClaudia Menzaghi Source Type: research

Cardiovascular disease guideline adherence and self-reported statin use in longstanding type 1 diabetes: results from the Canadian study of longevity in diabetes cohort
Conclusion: Despite good self-reported adherence to general CVD prevention guidelines, against the principles of these guidelines we found that statin use was substantially lower in those without CVD history. Interventions are needed to improve statin use in older type 1 diabetes patients without a history of CVD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 25, 2016 Category: Cardiology Authors: Johnny BaiGeneviève BouletElise HalpernLeif LovblomDevrim EldelekliHillary KeenanMichael BrentNarinder PaulVera BrilDavid CherneyAlanna WeismanBruce Perkins Source Type: research

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease
Conclusions: ApoE gene polymorphisms associate with CVD and affect the lipid profile. The ε4 allele is an independent risk factor for both T2DM and CVD. Further genetic studies to add information beyond the traditional cardiovascular risk factors in T2DM and to identify risk genotypes will help in early prediction and identification of at risk patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2016 Category: Cardiology Authors: Dalia El-LebedyHala RaslanAsmaa Mohammed Source Type: research

Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques
Conclusion: One year of exercise training in patients with type 2 diabetes and CAD did not significantly change cIMT progression. However, in patients without identified carotid plaques, beneficial effect of exercise training on cIMT progression was demonstrated. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2016 Category: Cardiology Authors: Rune ByrkjelandKnut-Haakon StensæthSigmund AnderssenIda NjerveHarald ArnesenIngebjørg SeljeflotSvein Solheim Source Type: research

Bezafibrate for the treatment of dyslipidemia in patients with coronary artery disease: 20-year mortality follow-up of the BIP randomized control trial
Conclusions: During long-term follow-up bezafibrate-allocated patients experienced a modest but significant 10 % reduction in the adjusted risk of mortality. This effect of bezafibrate was more prominent among patients with baseline hypertriglyceridemia (25 % mortality risk reduction). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2016 Category: Cardiology Authors: Yaron ArbelRobert KlempfnerAharon ErezIlan GoldenbergSagit BenzekryNir ShlomoEnrique FismanAlexander Tenenbaumfor the BIP Study Group Source Type: research

Is visceral adiposity a modifier for the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes?
Background: We aimed to investigate whether visceral adiposity could modify the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes. Methods: This cross-sectional study examines the interaction of visceral adiposity with increased blood pressure on arterial stiffness and albuminuria. 638 patients with type 2 diabetes (mean age 64 ± 12 years; 40 % female) were enrolled. Visceral fat area (VFA, cm 2 ) was assessed by a dual-impedance analyzer, whereby patients were divided into those with VFA  (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 21, 2016 Category: Cardiology Authors: Ryotaro BouchiNorihiko OharaMasahiro AsakawaYujiro NakanoTakato TakeuchiMasanori MurakamiYuriko SasaharaMitsuyuki NumasawaIsao MinamiHajime IzumiyamaKoshi HashimotoTakanobu YoshimotoYoshihiro Ogawa Source Type: research

The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype
Conclusions: The compositions of skeletal muscle and visceral fat play key roles in the association between circulating irisin and a patient’s metabolic phenotype. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 20, 2016 Category: Cardiology Authors: You-Cheol HwangWon JeonCheol-Young ParkByung-Soo Youn Source Type: research

Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study
Conclusions: MDI with AI results in better postmeal glucose control compared to HI. The treatment with AI is associated with improved diastolic cardiac function.ClinicalTrials.gov (NTC00747409) (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2016 Category: Cardiology Authors: Helene von BibraThorsten SiegmundIris KingreenMarkus RiemerTibor SchusterPetra-Maria Schumm-Draeger Source Type: research

Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression
Conclusions: CD59 and AAT proteins are significantly altered in hypertensive patients developing albuminuria. Interestingly, CD59 and AAT are able to predict, in normoalbuminuric individuals, who will develop albuminuria in the future, being potential predictors of vascular damage and CV risk. These findings contribute to early identify patients at risk of developing albuminuria even when this classical predictor is still in the normal range, constituting a novel strategy towards a prompt and more efficient therapeutic intervention with better outcome. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2016 Category: Cardiology Authors: Laura Gonzalez-CaleroMarta Martin-LorenzoFernando de la CuestaAroa MarotoMontserrat Baldan-MartinGema Ruiz-HurtadoHelena Pulido-OlmoJulian SeguraMaria BarderasLuis RuilopeFernando VivancoGloria Alvarez-Llamas Source Type: research

Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals
Platelet hyper-reactivity is a crucial cause of accelerated atherosclerosis increasing risk of thrombotic vascular events in diabetic patients. The mechanisms leading to abnormal platelet activity during diabetes are complex and not fully defined. The current study attempted to clarify the role of CTRP9, a novel adiponectin paralog, in enhanced platelet activity and determined whether CTRP9 may inhibit platelet activity. Adult male C57BL/6 J mice were randomized to receive high-fat diet (HFD) or normal diet (ND). 8 weeks after HFD, animals were sacrificed, and both plasma CTRP9 and platelet aggregation were det...
Source: Cardiovascular Diabetology - January 11, 2016 Category: Cardiology Authors: Wenqing WangWayne LauYajing WangXinliang MaRong Li Source Type: research

Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
Background: Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. Methods: Based on albumin/creatinine ratio (ACR), 109 T2DM patients were divided into normoalbuminuria (ACR 300 mg/g). Serum betatrophin levels of 109 T2DM patients and 32 healthy subjects were determined by enzyme-linked immunosorbent assay (ELIS...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Chang-Chiang ChenHendra SusantoWen-Han ChuangTa-Yu LiuChih-Hong Wang Source Type: research

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
Background: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However,...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Dolores CorellaEva. AsensioOscar ColtellJosé SorlíRamón EstruchMiguel Martínez-GonzálezJordi Salas-SalvadóOlga CastañerFernando ArósJosé LapetraLluís Serra-MajemEnrique Gómez-GraciaCarolina Ortega-AzorínMiquel FiolJavier EspinoAndrés Díaz-L Source Type: research

Lower-extremity amputation as a marker for renal and cardiovascular events and mortality in patients with long standing type 1 diabetes
Background: We evaluated the risks of renal and cardiovascular complications, and mortality associated with lower extremity amputation (LEA) in patients with type 1 diabetes. Methods: We studied two cohorts of people with long standing type 1 diabetes: GENEDIAB (n = 456) and GENESIS (n = 611). Subsets of the cohorts (n = 260, n = 544) were followed for 9 and 5 years, respectively. Outcomes were the incidence of end stage renal disease (ESRD), myocardial infarction, stroke and mortality during follow-up. Analyses were performed in pooled cohorts. Results: The prevalence of LEA at...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Kamel MohammediLouis PotierNarimène BelhatemNadia MatallahSamy HadjadjRonan RousselMichel MarreGilberto Velho Source Type: research

Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study
Background: Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells and induces insulin secretion. However, there are no previous longitudinal studies in humans. Methods: We analyzed the age- and sex-matched data of 240 normal weight and overweight Korean children from the Korean Metabolic disorders and Obesity Study in Elementary School children (K-MOSES), a prospective observational cohort study. Results: At bas...
Source: Cardiovascular Diabetology - January 6, 2016 Category: Cardiology Authors: Hye ChungMin LeeSoon HwangHyun LeeHye YooJi-A SeoSin KimNan KimSei BaikDong ChoiSeon KimKyung Choi Source Type: research

Coronary artery bypass surgery compared with percutaneous coronary interventions in patients with insulin-treated type 2 diabetes mellitus: a systematic review and meta-analysis of 6 randomized controlled trials
Background: Data regarding the long-term clinical outcomes in patients with insulin-treated type 2 diabetes mellitus (ITDM) revascularized by either coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI) are still controversial. We sought to compare the long-term (≥1 year) adverse clinical outcomes in patients with ITDM who underwent revascularization by either CABG or PCI. Methods: Randomized Controlled Trials (RCTs) comparing the long-term clinical outcomes in patients with ITDM and non-ITDM revascularized by either CABG or PCI were searched from electronic databases. Data for patients ...
Source: Cardiovascular Diabetology - January 6, 2016 Category: Cardiology Authors: Pravesh BundhunZi WuMeng-Hua Chen Source Type: research

Safety, tolerability and effects on cardiometabolic risk factors of empagliflozin monotherapy in drug-naïve patients with type 2 diabetes: a double-blind extension of a Phase III randomized controlled trial
Background: To investigate the long-term efficacy and safety of empagliflozin monotherapy compared with placebo and sitagliptin in drug-naïve patients with type 2 diabetes mellitus. Methods: Of 899 patients randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, placebo, or sitagliptin 100 mg once daily for 24 weeks, 615 continued in a double-blind extension trial for ≥52 weeks. Exploratory endpoints included changes from baseline in HbA1c, weight and blood pressure at week 76. Results: Compared with placebo, adjusted mean changes from baseline in HbA1c at week 76 were −0.78&n...
Source: Cardiovascular Diabetology - December 23, 2015 Category: Cardiology Authors: Michael RodenLudwig MerkerAnita ChristiansenFlavien RouxAfshin SalsaliGabriel KimPeter StellaHans WoerleUli BroedlOn behalf of the EMPA-REG EXTEND¿ MONO investigators Source Type: research

Temporal changes in the prevalence and associates of diabetes-related lower extremity amputations in patients with type 2 diabetes: the Fremantle Diabetes Study
Background: To determine temporal changes in the prevalence and associates of lower extremity amputation (LEA) complicating type 2 diabetes. Methods: Baseline data from the longitudinal observational Fremantle Diabetes Study (FDS) relating to LEA and its risk factors collected from 1296 patients recruited to FDS Phase 1 (FDS1) from 1993 to 1996 and from 1509 patients recruited to FDS Phase 2 (FDS2) from 2008 to 2011 were analysed. Multiple logistic regression was used to determine associates of prevalent LEA in individual and pooled phases. Generalised linear modelling was used to examine whether diabetes related LEA preva...
Source: Cardiovascular Diabetology - December 18, 2015 Category: Cardiology Authors: Mendel BabaWendy DavisPaul NormanTimothy Davis Source Type: research

Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function
Conclusions: Collectively, these observations have two implications. First, they indicate a pathological role of insulin in heart complications stemming from mitochondrial disruption. Second, they identify ceramide as a possible mediator of insulin-related heart disorders. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 18, 2015 Category: Cardiology Authors: Aimee HodsonTrevor TippettsBenjamin Bikman Source Type: research

Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning
Background: Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been studied so far. Therefore, here we investigated the effect of acute hyperglycemia on cardioprotection by RIPerC. Methods: Wistar rats were divided into normoglycemic (NG) and acute hyperglycemic (AHG) groups. Acute hyperglycemia wa...
Source: Cardiovascular Diabetology - November 18, 2015 Category: Cardiology Authors: Tamás BaranyaiCsilla NagyGábor KoncsosZsófia OnódiMelinda Károlyi-SzabóAndrás MakkosZoltán VargaPéter FerdinandyZoltán Giricz Source Type: research

Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet
Background: It remains to be established if, and to what extent, the coronary microcirculation becomes compromised during the development of obesity and insulin resistance. Recent studies suggest that changes in endothelial glycocalyx properties contribute to microvascular dysfunction under (pre-)diabetic conditions. Accordingly, early effects of diet-induced obesity on myocardial perfusion and function were studied in rats under baseline and hyperaemic conditions. Methods: Rats were fed a high fat diet (HFD) for 6 weeks and myocardial microvascular perfusion was determined using first-pass perfusion MRI before and af...
Source: Cardiovascular Diabetology - November 17, 2015 Category: Cardiology Authors: Judith van HaareM. KooiHans VinkMark PostJurgen van TeeffelenJos SlenterChantal MuntsHanneke CobelensGustav StrijkersDennis KoehnMarc van Bilsen Source Type: research

Glucose and fatty acid metabolism in infarcted heart from streptozotocin-induced diabetic rats after 2 weeks of tissue remodeling
Background: The effects of streptozotocin (STZ)-induced diabetes on heart metabolism and function after myocardial infarction (MI) remodelling were investigated in rats. Methods: Fifteen days after STZ (50 mg/kg b.w. i.v.) injection, MI was induced by surgical occlusion of the left coronary artery. Two weeks after MI induction, contents of glycogen, ATP, free fatty acids and triacylglycerols (TG) and enzyme activities of glycolysis and Krebs cycle (hexokinase, glucose-6-phosphate dehydrogenase, phosphofructokinase, citrate synthase) and expression of carnitine palmitoyl-CoA transferase I (a key enzyme of mitochondrial...
Source: Cardiovascular Diabetology - November 9, 2015 Category: Cardiology Authors: Christiane MalfitanoAlcione de Souza JuniorMariana CarbonaroAndressa Bolsoni-LopesDiego FigueroaLeandro de SouzaKleiton SilvaFernanda Consolim-ColomboRui CuriMaria Irigoyen Source Type: research

Visceral adiposity is associated with altered myocardial glucose uptake measured by 18 FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes
Background: The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptake in hearts of subjects with normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) using [ 18 F]-fluorodeoxyglucose-positron emission tomography ( 18 FDG-PET) in association with visceral and subcutaneous adiposity, and metabolic laboratory parameters....
Source: Cardiovascular Diabetology - November 4, 2015 Category: Cardiology Authors: Gyuri KimKwanhyeong JoKwang KimYong-ho LeeEugene HanHye-jin YoonHye WangEun KangMijin Yun Source Type: research

Association between brachial-ankle pulse wave velocity and progression of coronary artery calcium: a prospective cohort study
Conclusions: Higher arterial stiffness measured by baPWV could be significantly associated with CAC progression. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2015 Category: Cardiology Authors: Jong-Young LeeSeungho RyuSung LeeByung KimBum-Soo KimJin-Ho KangEun CheongJang-Young KimJeong ParkKi-Chul Sung Source Type: research

The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus
Background: Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects of elevated intracellular cGMP-levels have been described in different heart diseases. In the current study we aimed at investigating the effects of pharmacological activation of sGC in diabetic cardiomyopathy. Methods: Type-1 DM was induced in rats by streptozotocin. Animals were treated either with the sGC activator cinaciguat (10 mg/kg/day) or with placebo orall...
Source: Cardiovascular Diabetology - October 31, 2015 Category: Cardiology Authors: Csaba MátyásBalázs NémethAttila OláhLászló HidiEde BirtalanDalma KellermayerMihály RuppertSevil Korkmaz-IcözGábor KökényEszter HorváthGábor SzabóBéla MerkelyTamás Radovits Source Type: research

Factors associated with no apparent coronary artery disease in patients with type 2 diabetes mellitus for more than 10 years of duration: a case control study
Background: Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain free of CAD even after many years of treatment for diabetes. The present study was aimed to identify the factors that are associated with a favorable CAD profile. Methods: A case–control study of 76 patients with type 2 diabetes mellitus who were on treatment for more than 10 years duration and undergoing a coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospita...
Source: Cardiovascular Diabetology - October 31, 2015 Category: Cardiology Authors: Mukund SrinivasanPadmanabh KamathNarayan BhatNarasimha PaiPoornima ManjrekarChakrapani Mahabala Source Type: research

Combined influence of nonalcoholic fatty liver and body size phenotypes on diabetes risk
Background: We aimed to determine the association between nonalcoholic fatty liver disease (NAFLD) and diabetes risk among body size phenotypes which was based on cross-classification of body mass index (BMI) categories (normal or overweight/obesity) and metabolic status (metabolically health or metabolically at-risk). Methods: We conducted a cross-sectional analysis using a cohort of 10,761 apparently healthy Chinese adults who underwent comprehensive health checkups including abdominal ultrasonography. Subjects were classified as metabolically at-risk by having any two of the following, consistent with the Adult Treatmen...
Source: Cardiovascular Diabetology - October 29, 2015 Category: Cardiology Authors: Tingting DuXuefeng YuGang YuanJianhua ZhangXingxing Sun Source Type: research

SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
Conclusions: Overexpression of SIRT1 reduces diabetes-exacerbated MI/R injury and oxidative stress via activating eNOS in diabetic rats. The findings suggest SIRT1 may be a promising novel therapeutic target for diabetic cardiac complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 21, 2015 Category: Cardiology Authors: Mingge DingJingyi LeiHongcheng HanWeibo LiYinxian QuEnqing FuFeng FuXiaoming Wang Source Type: research