The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
Vascular dysfunction is a pivotal event in the development of diabetes-associated vascular disease. Increased inflammation and oxidative stress are major contributors to vascular dysfunction. Nrf2, a master re... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 3, 2017 Category: Cardiology Authors: Arpeeta Sharma, Luddwi Rizky, Nada Stefanovic, Mitchel Tate, Rebecca H. Ritchie, Keith W. Ward and Judy B. de Haan Source Type: research

Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes: a pilot study
Accumulation of epicardial fat (EF) is associated with increased cardio-metabolic risks and coronary events, independently of traditional cardiovascular risk factors. Therefore, the reduction of EF volume (EFV... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 3, 2017 Category: Cardiology Authors: Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa Source Type: research

Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 1, 2017 Category: Cardiology Authors: Ming Zhang, Bingyuan Wang, Yu Liu, Xizhuo Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Yang Zhao, Junmei Zhou, Chengyi Han, Jingzhi Zhao and Dongsheng Hu Source Type: research

Incretin-based agents in type 2 diabetic patients at cardiovascular risk: compare the effect of GLP-1 agonists and DPP-4 inhibitors on cardiovascular and pancreatic outcomes
Incretin-based agents, including dipeptidyl peptidase-4 inhibitors (DPP-4Is) and glucagon-like peptide-1 agonists (GLP-1As), work via GLP-1 receptor for hyperglycemic control directly or indirectly, but have d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 1, 2017 Category: Cardiology Authors: Zeqing Zhang, Xi Chen, Puhan Lu, Jianhua Zhang, Yongping Xu, Wentao He, Mengni Li, Shujun Zhang, Jing Jia, Shiying Shao, Junhui Xie, Yan Yang and Xuefeng Yu Source Type: research

Effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure and markers of arterial stiffness in patients with type 2 diabetes mellitus: a post hoc analysis
Physiologic determinants, such as pulse pressure [difference between systolic blood pressure (SBP) and diastolic BP (DBP)], mean arterial pressure (2/3 DBP  + 1/3 SBP), and double product [beats per minute (bpm... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 27, 2017 Category: Cardiology Authors: Michael Pfeifer, Raymond R. Townsend, Michael J. Davies, Ujjwala Vijapurkar and Jimmy Ren Source Type: research

Diagnostic approaches for diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a cardiac dysfunction which affects approximately 12% of diabetic patients, leading to overt heart failure and death. However, there is not an efficient and specific methodolog... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 23, 2017 Category: Cardiology Authors: A. Lorenzo-Almor ós, J. Tuñón, M. Orejas, M. Cortés, J. Egido and Ó. Lorenzo Source Type: research

A randomised study of the impact of the SGLT2 inhibitor dapagliflozin on microvascular and macrovascular circulation
The sodium –glucose cotransporter 2 inhibitor, dapagliflozin, has been shown to improve diabetic control and reduce blood pressure in patients with type 2 diabetes mellitus. Its effects on micro- and macrovascu... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 23, 2017 Category: Cardiology Authors: Christian Ott, Agnes Jumar, Kristina Striepe, Stefanie Friedrich, Marina V. Karg, Peter Bramlage and Roland E. Schmieder Source Type: research

Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes
Fewer circulating endothelial progenitor cells (EPCs) and increased plasma (C-term) stromal cell-derived factor 1 α (SDF-1α), a substrate of DPP-4, are biomarkers, and perhaps mediators, of cardiovascular risk ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 23, 2017 Category: Cardiology Authors: Alessandra Dei Cas, Valentina Spigoni, Monia Cito, Raffaella Aldigeri, Valentina Ridolfi, Elisabetta Marchesi, Michela Marina, Eleonora Derlindati, Rosalia Aloe, Riccardo C. Bonadonna and Ivana Zavaroni Source Type: research

Erratum to: Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 16, 2017 Category: Cardiology Authors: Concepci ón Peiró, Tania Romacho, Verónica Azcutia, Laura Villalobos, Emilio Fernández, Juan P. Bolaños, Salvador Moncada and Carlos F. Sánchez-Ferrer Source Type: research

Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients
Vascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. How... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 15, 2017 Category: Cardiology Authors: Aur élien Mary, Agnes Hartemann, Sophie Liabeuf, Carole Elodie Aubert, Salim Kemel, Joe Elie Salem, Philippe Cluzel, Aurélie Lenglet, Ziad A. Massy, Jean-Daniel Lalau, Romuald Mentaverri, Olivier Bourron and Saïd Kamel Source Type: research

DPP-4 inhibition has no acute effect on BNP and its N-terminal pro-hormone measured by commercial immune-assays. A randomized cross-over trial in patients with type 2 diabetes
Use of dipeptidyl peptidase-4 inhibitors (DPP4-i) for the treatment of type 2 diabetes (T2D) has been associated with a possible increase in the risk for heart failure (HF). B-type natriuretic peptide (BNP), w... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 10, 2017 Category: Cardiology Authors: Gian Paolo Fadini, Benedetta Maria Bonora, Mattia Albiero, Martina Zaninotto, Mario Plebani and Angelo Avogaro Source Type: research

Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study
It is unclear whether obesity and type 2 diabetes (T2D), either alone or in combination, induce left ventricular hypertrophy (LVH) independent of hypertension. In the current study, we provide clarity on this ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 8, 2017 Category: Cardiology Authors: Kirstie A. De Jong, Juliane K. Czeczor, Smithamol Sithara, Kevin McEwen, Gary D. Loopaschuk, Alan Appelbe, Kimberly Cukier, Mark Kotowicz and Sean L. McGee Source Type: research

Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation
Brain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with dia... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 8, 2017 Category: Cardiology Authors: Kazuo Furukawa, Ichiro Fuse, Yuriko Iwakura, Hidekazu Sotoyama, Osamu Hanyu, Hiroyuki Nawa, Hirohito Sone and Nobuyuki Takei Source Type: research

Inhibition of dynamin-related protein 1 protects against myocardial ischemia –reperfusion injury in diabetic mice
Many cardioprotective pharmacological agents failed to exert their protective effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the molecular basis linking diabetes with ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 7, 2017 Category: Cardiology Authors: Mingge Ding, Qianqian Dong, Zhenghua Liu, Zheng Liu, Yinxian Qu, Xing Li, Cong Huo, Xin Jia, Feng Fu and Xiaoming Wang Source Type: research

Cardiovascular safety of non-insulin pharmacotherapy for type 2 diabetes
Patients with type 2 diabetes mellitus have a twofold increased risk of cardiovascular mortality compared with non-diabetic individuals. There is a growing awareness that glycemic efficacy of anti-diabetic dru... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 2, 2017 Category: Cardiology Authors: James Xu and Rohan Rajaratnam Source Type: research

Serum levels of interleukin-22, cardiometabolic risk factors and incident type 2 diabetes: KORA F4/FF4 study
Interleukin-22 (IL-22) has beneficial effects on body weight, insulin resistance and inflammation in different mouse models, but its relevance for the development of type 2 diabetes in humans is unknown. We ai... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 31, 2017 Category: Cardiology Authors: Christian Herder, Julia M. Kannenberg, Maren Carstensen-Kirberg, Cornelia Huth, Christa Meisinger, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann, Michael Roden and Barbara Thorand Source Type: research

The renal tubular damage marker urinary N-acetyl- β-d-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes
To determine the association between urinary N-acetyl- β-d-glucosaminidase (NAG), a marker of renal tubulopathy, and carotid intima-media thickness (IMT) and plaques in patients with type 2 diabetes mellitus (T2D)... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 26, 2017 Category: Cardiology Authors: So Ra Kim, Yong-ho Lee, Sang-Guk Lee, Eun Seok Kang, Bong-Soo Cha and Byung-Wan Lee Source Type: research

Skin autofluorescence is associated with inappropriate left ventricular mass and diastolic dysfunction in subjects at risk for cardiovascular disease
Enhanced advanced glycation end products deposition within myocardial tissue may cause diastolic dysfunction. However, whether this is related to left ventricular hypertrophy or inappropriate left ventricular ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 25, 2017 Category: Cardiology Authors: Chun-Cheng Wang, Yao-Chang Wang, Guei-Jane Wang, Ming-Yi Shen, Yen-Lin Chang, Show-Yih Liou, Hung-Chih Chen, An-Sheng Lee, Kuan-Cheng Chang, Wei-Yu Chen and Chiz-Tzung Chang Source Type: research

Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry
To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 25, 2017 Category: Cardiology Authors: Edward A. Hulten, Marcio Sommer Bittencourt, Ryan Preston, Avinainder Singh, Carla Romagnolli, Brian Ghoshhajra, Ravi Shah, Siddique Abbasi, Suhny Abbara, Khurram Nasir, Michael Blaha, Udo Hoffmann, Marcelo F. Di Carli and Ron Blankstein Source Type: research

A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes
This study assessed the effects of the DPP-4 inhibitor linaglipti... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 21, 2017 Category: Cardiology Authors: Thomas Jax, Alin Stirban, Arne Terjung, Habib Esmaeili, Andreas Berk, Sandra Thiemann, Robert Chilton, Maximilian von Eynatten and Nikolaus Marx Source Type: research

The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis
Diabetes and cardiovascular disease develop in concert with metabolic abnormalities mirroring and causing changes in the vasculature, particularly the microcirculation. The microcirculation can be affected in ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 19, 2017 Category: Cardiology Authors: Dagmar Fuchs, Pepijn P. Dupon, Laura A. Schaap and Richard Draijer Source Type: research

T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity
Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function. The present study examine... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 19, 2017 Category: Cardiology Authors: Han Wang, Ling Tao, Anastasia Ambrosio, Wenjun Yan, Ross Summer, Wayne Bond Lau, Yajing Wang and Xinliang Ma Source Type: research

Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
This study aimed to determine how S... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2017 Category: Cardiology Authors: Toshiyuki Hayashi, Tomoyasu Fukui, Noriko Nakanishi, Saki Yamamoto, Masako Tomoyasu, Anna Osamura, Makoto Ohara, Takeshi Yamamoto, Yasuki Ito and Tsutomu Hirano Source Type: research

Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes
Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation and heart failure with preserved ejection fraction. The impairments in diastolic relaxation are especially pronounce... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2017 Category: Cardiology Authors: Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Brady Barron, Eric Mayoux, R. Scott Rector, Adam Whaley-Connell and Vincent G. DeMarco Source Type: research

Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways
Hyperglycaemia, hypertension, dyslipidemia and insulin resistance collectively impact on the myocardium of people with diabetes, triggering molecular, structural and myocardial abnormalities. These have been s... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2017 Category: Cardiology Authors: Jason Kar Sheng Lew, James T. Pearson, Daryl O. Schwenke and Rajesh Katare Source Type: research

Differential effects of glucagon-like peptide-1 receptor agonists on heart rate
While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various agonists and is affected by... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2017 Category: Cardiology Authors: Martin Lorenz, Francesca Lawson, David Owens, Denis Raccah, Christine Roy-Duval, Anne Lehmann, Riccardo Perfetti and Lawrence Blonde Source Type: research

Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study
Adenosine-free coronary pressure wire metrics have been proposed to test the functional significance of coronary artery lesions, but it is unexplored whether their diagnostic performance might be altered in pa... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 13, 2017 Category: Cardiology Authors: Giuseppe Gargiulo, Eugenio Stabile, Marco Ferrone, Emanuele Barbato, Frederik M. Zimmermann, Julien Adjedj, Barry Hennigan, Mitsuaki Matsumura, Nils P. Johnson, William F. Fearon, Allen Jeremias, Bruno Trimarco and Giovanni Esposito Source Type: research

Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a significant risk factor for  cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 10, 2017 Category: Cardiology Authors: Tove Lekva, Annika Elisabet Michelsen, P ål Aukrust, Tore Henriksen, Jens Bollerslev and Thor Ueland Source Type: research

Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy
To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 7, 2017 Category: Cardiology Authors: Yoo-Ri Chung, Sung Wook Park, Shin-Young Choi, Seung Woo Kim, Ka Young Moon, Jeong Hun Kim and Kihwang Lee Source Type: research

Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome
Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic fo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2017 Category: Cardiology Authors: Antonino Tuttolomondo, Alessandra Casuccio, Giovanni Guercio, Carlo Maida, Alessandro Del Cuore, Domenico Di Raimondo, Irene Simonetta, Danilo Di Bona, Rosaria Pecoraro, Vittoriano Della Corte, Eliana Gulotta, Gaspare Gulotta and Antonio Pinto Source Type: research

Blood pressure control in type 2 diabetic patients
Diabetes mellitus (DM) and essential hypertension are common conditions that are frequently present together. Both are considered risk factors for cardiovascular disease and microvascular complications and the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2017 Category: Cardiology Authors: Alon Grossman and Ehud Grossman Source Type: research

Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006 –2013)
Representative data on the secular trends in cardiovascular disease (CVD) are limited in Asian populations with diabetes. We aimed to estimate the temporal trends in cardiovascular complications using Korean n... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 6, 2017 Category: Cardiology Authors: Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko and Joong-Yeol Park Source Type: research

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis
Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunctio... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 22, 2016 Category: Cardiology Authors: Morgane Evin, Kathryn M. Broadhouse, Fraser M. Callaghan, Rachel T. McGrath, Sarah Glastras, Rebecca Kozor, Samantha L. Hocking, J érôme Lamy, Alban Redheuil, Nadjia Kachenoura, Greg R. Fulcher, Gemma A. Figtree and Stuart M. Grieve Source Type: research

Ankle-brachial index and incident diabetes mellitus: the atherosclerosis risk in communities (ARIC) study
Individuals with peripheral artery disease (PAD) often have reduced physical activity, which may increase the future risk of diabetes mellitus. Although diabetes is a risk factor for PAD, whether low ankle-bra... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 7, 2016 Category: Cardiology Authors: Simin Hua, Laura R. Loehr, Hirofumi Tanaka, Gerardo Heiss, Josef Coresh, Elizabeth Selvin and Kunihiro Matsushita Source Type: research

Liraglutide improves metabolic parameters and carotid intima-media thickness in diabetic patients with the metabolic syndrome: an 18-month prospective study
Liraglutide, a GLP-1 analogue, exerts several beneficial non-glycemic effects in patients with type-2 diabetes (T2DM), such as those on body weight, blood pressure, plasma lipids and inflammation markers. Howe... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 3, 2016 Category: Cardiology Authors: Manfredi Rizzo, Ali A. Rizvi, Angelo Maria Patti, Dragana Nikolic, Rosaria Vincenza Giglio, Giuseppa Castellino, Giovanni Li Volti, Massimiliano Caprio, Giuseppe Montalto, Vincenzo Provenzano, Stefano Genovese and Antonio Ceriello Source Type: research

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is a major contributor to the development of atherosclerotic process. In a previous work, we demonstrated that the insulin receptor ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 1, 2016 Category: Cardiology Authors: N. Beneit, C. E. Fern ández-García, J. L. Martín-Ventura, L. Perdomo, Ó. Escribano, J. B. Michel, G. García-Gómez, S. Fernández, S. Díaz-Castroverde, J. Egido, A. Gómez-Hernández and M. Benito Source Type: research

Characteristics and outcomes of diabetic patients with an implantable cardioverter defibrillator in a real world setting: results from the Israeli ICD registry
There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 1, 2016 Category: Cardiology Authors: Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z. Fisman, Gregory Golovchiner, Boris Strasberg and Alon Barsheshet Source Type: research

Relationship of cardiometabolic parameters in non-smokers, current smokers, and quitters in diabetes: a systematic review and meta-analysis
Smoking is associated with increased macrovascular and microvascular complications in people with diabetes. In addition to other concomitant vascular perturbations, it also seems to influence the cardiometabol... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 24, 2016 Category: Cardiology Authors: Debasish Kar, Clare Gillies, Francesco Zaccardi, David Webb, Samuel Seidu, Solomon Tesfaye, Melanie Davies and Kamlesh Khunti Source Type: research

Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome
The potential benefit of SGLT2 inhibitors in metabolic syndrome is with prediabetic stage unclear. This work was undertaken to investigate the non-glycemic effect of empagliflozin on metabolic syndrome rats wi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 11, 2016 Category: Cardiology Authors: Hiroaki Kusaka, Nobutaka Koibuchi, Yu Hasegawa, Hisao Ogawa and Shokei Kim-Mitsuyama Source Type: research

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels
The leading cause of death among the obese population is heart failure and stroke prompted by structural and functional changes in the heart. The molecular mechanisms that underlie obesity-related cardiac remo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 10, 2016 Category: Cardiology Authors: Elisa Lucas, Rocio Vila-Bedmar, Alba C. Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor and Cristina Murga Source Type: research

Correlation between insulin-induced estrogen receptor methylation and atherosclerosis
Hyperinsulinemia and insulin resistance have been recently recognized as an important cause of atherosclerosis. Clinical studies have also found that expression of the estrogen receptor is closely related to t... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 10, 2016 Category: Cardiology Authors: Jia Min, Zhong Weitian, Cai Peng, Peng Yan, Zhang Bo, Wang Yan, Bai Yun and Wang Xukai Source Type: research

Effect of trelagliptin on vascular endothelial functions and serum adiponectin level in patients with type 2 diabetes: a preliminary single-arm prospective pilot study
Trelagliptin, an oral DPP-4 inhibitor, which is administered once per week and characterized by a long half-life in blood. The effects of trelagliptin on vascular endothelial functions have not been clarified ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2016 Category: Cardiology Authors: Satoshi Ida, Kazuya Murata, Katunori Betou, Chiaki Kobayashi, Yuki Ishihara, Kanako Imataka, Akihiro Uchida, Kou Monguchi, Ryutaro Kaneko, Ryoko Fujiwara and Hiroka Takahashi Source Type: research

Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study
This study assessed temporal relationships of blood lipids with IR and ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2016 Category: Cardiology Authors: Tianshu Han, Yu Cheng, Shuang Tian, Li Wang, Xi Liang, Wei Duan, Lixin Na and Changhao Sun Source Type: research

Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 3, 2016 Category: Cardiology Authors: Hirofumi Tomiyama, Takashi Miwa, Kenshi Kan, Munehide Matsuhisa, Haruo Kamiya, Mamoru Nanasato, Tomoki Kitano, Hiroaki Sano, Jun Ohno, Masato Iida, Masataka Sata, Hirotsugu Yamada, Koji Maemura, Atsushi Tanaka, Toyoaki Murohara and Koichi Node Source Type: research

Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus
Vascular disease in diabetes is initiated by monocyte adhesion to vascular endothelium, transmigration and formation of foam cells. Increasing clinical evidence supports a role for the secretory protein, cyclo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 3, 2016 Category: Cardiology Authors: Surya Ramachandran, Anandan Vinitha and Cheranellore Chandrasekharan Kartha Source Type: research

Impact of diabetes on the predictive value of heart failure biomarkers
Patients with diabetes mellitus (DM) have an increased risk of developing heart failure (HF). Further, DM is associated with poor prognosis in patients with HF. Our aim was to determine whether DM has any impa... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 3, 2016 Category: Cardiology Authors: Nuria Alonso, Josep Lup ón, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Pedro Moliner, Amparo Galán, Javier Santesmases, Cruz Pastor, Dídac Mauricio and Antoni Bayes-Genis Source Type: research

Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease
Data regarding long-term association of metabolic syndrome (MetS) with adverse outcomes are conflicting. We aim to determine the independent association of MetS (based on its different definitions) with 20  yea... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 28, 2016 Category: Cardiology Authors: Arwa Younis, Anan Younis, Boaz Tzur, Yael Peled, Nir Shlomo, Ilan Goldenberg, Enrique Z. Fisman, Alexander Tenenbaum and Robert Klempfner Source Type: research

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial
The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arter... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 24, 2016 Category: Cardiology Authors: Leticia Gomez-Sanchez, Luis Garcia-Ortiz, M. Carmen Patino-Alonso, Jose I. Recio-Rodriguez, Rigo Fernando, Ruth Marti, Cristina Agudo-Conde, Emiliano Rodriguez-Sanchez, Jose A. Maderuelo-Fernandez, Rafel Ramos and Manuel A. Gomez-Marcos Source Type: research

Moderate-intensity statin therapy seems ineffective in primary cardiovascular prevention in patients with type 2 diabetes complicated by nephropathy. A multicenter prospective 8  years follow up study
Although numerous studies and metanalysis have shown the beneficial effect of statin therapy in CVD secondary prevention, there is still controversy such the use of statins for primary CVD prevention in patien... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 13, 2016 Category: Cardiology Authors: Ferdinando Carlo Sasso, Nadia Lascar, Antonella Ascione, Ornella Carbonara, Luca De Nicola, Roberto Minutolo, Teresa Salvatore, Maria Rosaria Rizzo, Plinio Cirillo, Giuseppe Paolisso and Raffaele Marfella Source Type: research

N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats
Patients with diabetes are prone to develop cardiac hypertrophy and more susceptible to myocardial ischemia –reperfusion (I/R) injury, which are concomitant with hyperglycemia-induced oxidative stress and impai... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 12, 2016 Category: Cardiology Authors: Wating Su, Yuan Zhang, Qiongxia Zhang, Jinjin Xu, Liying Zhan, Qiqi Zhu, Qingquan Lian, Huimin Liu, Zhong-yuan Xia, Zhengyuan Xia and Shaoqing Lei Source Type: research