Design and rationale of the ODYSSEY DM-DYSLIPIDEMIA trial: lipid-lowering efficacy and safety of alirocumab in individuals with type 2 diabetes and mixed dyslipidaemia at high cardiovascular risk
Type 2 diabetes mellitus (T2DM) is often associated with mixed dyslipidaemia, where non-high-density lipoprotein cholesterol (non-HDL-C) levels may more closely align with cardiovascular risk than low-density ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 25, 2017 Category: Cardiology Authors: Dirk M üller-Wieland, Lawrence A. Leiter, Bertrand Cariou, Alexia Letierce, Helen M. Colhoun, Stefano Del Prato, Robert R. Henry, Francisco J. Tinahones, Lisa Aurand, Jaman Maroni, Kausik K. Ray and Maja Bujas-Bobanovic Source Type: research

The addition of vildagliptin to metformin prevents the elevation of interleukin 1 ß in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, open-label study
Patients with type 2 diabetes present with an accelerated atherosclerotic process. Animal evidence indicates that dipeptidyl peptidase-4 inhibitors (gliptins) have anti-inflammatory and anti-atherosclerotic ef... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 22, 2017 Category: Cardiology Authors: Arwa Younis, Dana Eskenazi, Ronen Goldkorn, Jonathan Leor, Nili Naftali-Shani, Enrique Z. Fisman, Alexander Tenenbaum, Ilan Goldenberg and Robert Klempfner Source Type: research

PRotective Effect on the coronary microcirculation of patients with DIabetes by Clopidogrel or Ticagrelor (PREDICT): study rationale and design. A randomized multicenter clinical trial using intracoronary multimodal physiology
In diabetic patients a predisposed coronary microcirculation along with a higher risk of distal particulate embolization during primary percutaneous intervention (PCI) increases the risk of peri-procedural mic... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 19, 2017 Category: Cardiology Authors: Enrico Cerrato, Alicia Quir ós, Mauro Echavarría-Pinto, Hernan Mejia-Renteria, Andres Aldazabal, Nicola Ryan, Nieves Gonzalo, Pilar Jimenez-Quevedo, Luis Nombela-Franco, Pablo Salinas, Iván J. Núñez-Gil, José Ramón Rumoroso, Antonio Fernández-Orti Source Type: research

The use of lipid-lowering therapy and effects of antihyperglycaemic therapy on lipids in subjects with type 2 diabetes with or without cardiovascular disease: a pooled analysis of data from eleven randomized trials with insulin glargine 100  U/mL
This study aimed to characterize the extent of lipid-lowering therapy use and i... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 19, 2017 Category: Cardiology Authors: Markolf Hanefeld, Louise Traylor, Ling Gao and Wolfgang Landgraf Source Type: research

Effects of exenatide on cardiac function, perfusion, and energetics in type 2 diabetic patients with cardiomyopathy: a randomized controlled trial against insulin glargine
Multiple bloodglucose-lowering agents have been linked to cardiovascular events. Preliminary studies showed improvement in left ventricular (LV) function during glucagon-like peptide-1 receptor agonist adminis... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 19, 2017 Category: Cardiology Authors: Weena J. Y. Chen, Michaela Diamant, Karin de Boer, Hendrik J. Harms, Lourens F. H. J. Robbers, Albert C. van Rossum, Mark H. H. Kramer, Adriaan A. Lammertsma and Paul Knaapen Source Type: research

SGLT2 inhibitors: a novel choice for the combination therapy in diabetic kidney disease
Diabetic kidney disease (DKD) is the most common cause of end stage renal disease. The comprehensive management of DKD depends on combined target-therapies for hyperglycemia, hypertension, albuminuria, and hyp... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 16, 2017 Category: Cardiology Authors: Honghong Zou, Baoqin Zhou and Gaosi Xu Source Type: research

Target organ damage and incident type 2 diabetes mellitus: the Strong Heart Study
Recent analyses in a registry of hypertensive patients suggested that preceding left ventricular (LV) hypertrophy (LVH) and/or carotid atherosclerosis are associated with incident type 2 diabetes, independent ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 12, 2017 Category: Cardiology Authors: Giovanni de Simone, Wenyu Wang, Lyle G. Best, Fawn Yeh, Raffaele Izzo, Costantino Mancusi, Mary J. Roman, Elisa T. Lee, Barbara V. Howard and Richard B. Devereux Source Type: research

Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study
Diabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuab... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 11, 2017 Category: Cardiology Authors: Hirotsugu Yamada, Atsushi Tanaka, Kenya Kusunose, Rie Amano, Munehide Matsuhisa, Hiroyuki Daida, Masaaki Ito, Hiroyuki Tsutsui, Mamoru Nanasato, Haruo Kamiya, Yasuko K. Bando, Masato Odawara, Hisako Yoshida, Toyoaki Murohara, Masataka Sata and Koichi Node Source Type: research

Lipopolysaccharide-binding protein is associated with arterial stiffness in patients with type 2 diabetes: a cross-sectional study
Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by LPS. Recent evidence indicates the association of circulating LBP levels with obesity, diab... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 10, 2017 Category: Cardiology Authors: Takeshi Sakura, Tomoaki Morioka, Atsushi Shioi, Yoshinori Kakutani, Yuya Miki, Yuko Yamazaki, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Tetsuo Shoji, Masanori Emoto and Masaaki Inaba Source Type: research

Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice
Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart failure with preserved ejection fraction, is a predictor of future cardiovascular events. We previously reported that linagliptin, ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 5, 2017 Category: Cardiology Authors: Annayya R. Aroor, Javad Habibi, Hemanth Kumar Kandikattu, Mona Garro-Kacher, Brady Barron, Dongqing Chen, Melvin R. Hayden, Adam Whaley-Connell, Shawn B. Bender, Thomas Klein, Jaume Padilla, James R. Sowers, Bysani Chandrasekar and Vincent G. DeMarco Source Type: research

Erratum to: Inhibition of dynamin-related protein 1 protects against myocardial ischemia –reperfusion injury in diabetic mice
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 4, 2017 Category: Cardiology Authors: Mingge Ding, Qianqian Dong, Zhenhua Liu, Zheng Liu, Yinxian Qu, Xing Li, Cong Huo, Xin Jia, Feng Fu and Xiaoming Wang Source Type: research

Erratum to: Third generation drug eluting stent (DES) with biodegradable polymer in diabetic patients: 5  years follow-up
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 4, 2017 Category: Cardiology Authors: Marcus Wiemer, Sinisa Stojkovic, Alexander Samol, Zisis Dimitriadis, Juan M. Ruiz-Nodar, Ralf Birkemeyer, Jacques Monsegu, G érard Finet, David Hildick-Smith, Damras Tresukosol, Enrique Garcia Novo, Jacques J. Koolen, Emanuele Barbato and Gian Battista D Source Type: research

Erratum to: Inhibition of dynamin-related protein 1 protects against myocardial ischemia –reperfusion injury in diabetic mice
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 4, 2017 Category: Cardiology Authors: Mingge Ding, Qianqian Dong, Zhenhua Liu, Zheng Liu, Yinxian Qu, Xing Li, Cong Huo, Xin Jia, Feng Fu and Xiaoming Wang Source Type: research

Erratum to: Third generation drug eluting stent (DES) with biodegradable polymer in diabetic patients: 5  years follow-up
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 4, 2017 Category: Cardiology Authors: Marcus Wiemer, Sinisa Stojkovic, Alexander Samol, Zisis Dimitriadis, Juan M. Ruiz-Nodar, Ralf Birkemeyer, Jacques Monsegu, G érard Finet, David Hildick-Smith, Damras Tresukosol, Enrique Garcia Novo, Jacques J. Koolen, Emanuele Barbato and Gian Battista D Source Type: research

Erratum to: Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 26, 2017 Category: Cardiology Authors: Chang-Chiang Chen, Hendra Susanto, Wen-Han Chuang, Ta-Yu Liu, Arivajiagane Arundhathi and Chih-Hong Wang Source Type: research

Retinal vessel diameters and reactivity in diabetes mellitus and/or cardiovascular disease
Retinal vessel calibre and vascular dilation/constriction in response to flicker light provocation may provide a measure distinguishing patients suffering from diabetes mellitus and/or cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 26, 2017 Category: Cardiology Authors: R. Heitmar, G. Y. H. Lip, R. E. Ryder and A. D. Blann Source Type: research

Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats
Sudden cardiac death (SCD), a leading cause of global mortality, most commonly arises from a substrate of cardiac ischemia, but requires an additional trigger. Diabetes mellitus (DM) predisposes to SCD even af... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 26, 2017 Category: Cardiology Authors: Zhaoyang Hu, Mou Chen, Ping Zhang, Jin Liu and Geoffrey W. Abbott Source Type: research

Erratum to: Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 26, 2017 Category: Cardiology Authors: Chang-Chiang Chen, Hendra Susanto, Wen-Han Chuang, Ta-Yu Liu, Arivajiagane Arundhathi and Chih-Hong Wang Source Type: research

Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study
Altered regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in type 1 diabetes. We invest... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 26, 2017 Category: Cardiology Authors: S. A. Peeters, L. Engelen, J. Buijs, A. Jorsal, H.-H. Parving, L. Tarnow, P. Rossing, C. G. Schalkwijk and C. D. A. Stehouwer Source Type: research

Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008 –2011)
Although central fat is a well-known risk factor for cardiovascular disease (CVD) and cardiometabolic disorders, the effect of other regional fats or muscle distribution on CVD risk has not been fully investig... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 26, 2017 Category: Cardiology Authors: Eugene Han, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee and Bong-Soo Cha Source Type: research

Erratum to: Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 20, 2017 Category: Cardiology Authors: Kirstie A. De Jong, Juliane K. Czeczor, Smithamol Sithara, Kevin McEwen, Gary D. Lopaschuk, Alan Appelbe, Kimberly Cukier, Mark Kotowicz and Sean L. McGee Source Type: research

Advanced glycation end-products decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells
Advanced glycation end-products (AGEs) are elevated under diabetic conditions and associated with insulin resistance, endothelial dysfunction and vascular inflammation in humans. It has been demonstrated that ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 20, 2017 Category: Cardiology Authors: Xiaomei Ren, Liqun Ren, Qin Wei, Hua Shao, Long Chen and Naifeng Liu Source Type: research

Is ischemia the only factor predicting cardiovascular outcomes in all diabetes mellitus patients?
Diabetes mellitus (DM) is associated with an excess in cardiovascular morbidity and mortality, and is characterized by increased rates of coronary artery disease. Furthermore, once atherosclerosis is establish... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 20, 2017 Category: Cardiology Authors: Mark W. Kennedy, Enrico Fabris, Harry Suryapranata and Elvin Kedhi Source Type: research

Treatment with high-dose n-3 PUFAs has no effect on platelet function, coagulation, metabolic status or inflammation in patients with atherosclerosis and type 2 diabetes
Despite numerous studies on cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), there is limited evidence for n-3 PUFA-mediated effects, especially at its higher dose, on cardiovascula... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 14, 2017 Category: Cardiology Authors: Malgorzata Poreba, Magdalena Mostowik, Aleksander Siniarski, Renata Golebiowska-Wiatrak, Krzysztof Piotr Malinowski, Maciej Haberka, Ewa Konduracka, Jadwiga Nessler, Anetta Undas and Grzegorz Gajos Source Type: research

Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study
Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 13, 2017 Category: Cardiology Authors: Tiina Vilmi-Ker älä, Anneli Lauhio, Taina Tervahartiala, Outi Palomäki, Jukka Uotila, Timo Sorsa and Ari Palomäki Source Type: research

Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial
Type 2 diabetes mellitus (T2DM) is characterized by systemic metabolic abnormalities and the development of micro- and macrovascular complications, resulting in a shortened life expectancy. A recent cardiovasc... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 12, 2017 Category: Cardiology Authors: Atsushi Tanaka, Michio Shimabukuro, Yosuke Okada, Isao Taguchi, Minako Yamaoka-Tojo, Hirofumi Tomiyama, Hiroki Teragawa, Seigo Sugiyama, Hisako Yoshida, Yasunori Sato, Atsushi Kawaguchi, Yumi Ikehara, Noritaka Machii, Tatsuya Maruhashi, Kosuke R. Shima, T Source Type: research

Human serum RNase-L level is inversely associated with metabolic syndrome and age
Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents. Here, we develo... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 11, 2017 Category: Cardiology Authors: Yi-Ting Wang, Ping-Huei Tseng, Chi-Ling Chen, Der-Sheng Han, Yu-Chiao Chi, Fen-Yu Tseng and Wei-Shiung Yang Source Type: research

Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats
Disturbances in coronary microcirculatory function, such as the endothelial glycocalyx, are early hallmarks in the development of obesity and insulin resistance. Accordingly, in the present study myocardial mi... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 11, 2017 Category: Cardiology Authors: Judith van Haare, M. Eline Kooi, Jurgen W. G. E. van Teeffelen, Hans Vink, Jos Slenter, Hanneke Cobelens, Gustav J. Strijkers, Dennis Koehn, Mark J. Post and Marc van Bilsen Source Type: research

Pregnancy-associated plasma protein-A is a stronger predictor for adverse cardiovascular outcomes after acute coronary syndrome in type-2 diabetes mellitus
The risk prediction of pregnancy-associated plasma protein-A (PAPP-A) for future cardiovascular (CV) events post acute coronary syndrome (ACS) in patients with type-2 diabetes mellitus (T2DM) was investigated ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 5, 2017 Category: Cardiology Authors: Wei-Ping Li, Moni B. Neradilek, Fu-Sheng Gu, Daniel A. Isquith, Zhi-Jun Sun, Xing Wu, Hong-Wei Li and Xue-Qiao Zhao Source Type: research

Impact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis
Patients with diabetes concomitant to critical limb ischemia (CLI) represent a sub-group at particular risk. Objective of this analysis is to evaluate the actual impact of diabetes on treatment, outcome, and c... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2017 Category: Cardiology Authors: Eva Freisinger, Nasser M. Malyar, Holger Reinecke and Holger Lawall Source Type: research

Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial
Sodium-glucose co-transporter-2 inhibitors (SGLT2i) reduce glucose levels, body weight, and blood pressure, possibly resulting in cardiovascular protection. In phase III trials, SGLT2i were shown to increase H... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2017 Category: Cardiology Authors: Gian Paolo Fadini, Benedetta Maria Bonora, Giancarlo Zatti, Nicola Vitturi, Elisabetta Iori, Maria Cristina Marescotti, Mattia Albiero and Angelo Avogaro Source Type: research

Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes
Nowadays, obesity is seriously increasing in most of the populations all over the world, and is associated with the development and progression of high-mortality diseases such as type-2 diabetes mellitus (T2DM) a... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2017 Category: Cardiology Authors: N. Gonz ález, Z. Moreno-Villegas, A. González-Bris, J. Egido and Ó. Lorenzo Source Type: research

Glycemia and the cardioprotective effects of insulin pre-conditioning in the isolated rat heart
While acute hyperglycemia has been shown to mitigate the beneficial effects of ischemic preconditioning, its effect on insulin-induced preconditioning remains unclear. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 4, 2017 Category: Cardiology Authors: Yosuke Nakadate, Hiroaki Sato, Takeshi Oguchi, Tamaki Sato, Akiko Kawakami, Tadahiko Ishiyama, Takashi Matsukawa and Thomas Schricker Source Type: research

Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes
Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are associated with endothelial dysfunction a main predictor of late cardiovascular (CV) events. Despite the high prevalence of OSA in patients with T2D,... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 21, 2017 Category: Cardiology Authors: Vanessa Bironneau, Fran çois Goupil, Pierre Henri Ducluzeau, Marc Le Vaillant, Pierre Abraham, Samir Henni, Séverine Dubois, Audrey Paris, Pascaline Priou, Nicole Meslier, Claire Sanguin, Wojciech Trzépizur, Ramaroson Andriantsitohaina, Maria Carmen Ma Source Type: research

Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature
We aimed to (1) assess the association between lipoprotein(a) [Lp(a)] concentration and incident type-2 diabetes in the Bruneck study, a prospective population-based study, and (2) combine findings with eviden... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 21, 2017 Category: Cardiology Authors: Ellie Paige, Katya L. Masconi, Sotirios Tsimikas, Florian Kronenberg, Peter Santer, Siegfried Weger, Johann Willeit, Stefan Kiechl and Peter Willeit Source Type: research

Efficacy and safety of canagliflozin in patients with type 2 diabetes based on history of cardiovascular disease or cardiovascular risk factors: a post hoc analysis of pooled data
Treatment of patients with type 2 diabetes mellitus (T2DM) and a history of cardiovascular (CV) disease or CV risk factors may present clinical challenges due to the presence of comorbid conditions and the use... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 21, 2017 Category: Cardiology Authors: Michael J. Davies, Katherine Merton, Ujjwala Vijapurkar, Jacqueline Yee and Rong Qiu Source Type: research

Subclinical left ventricular diastolic dysfunction and incident type 2 diabetes risk: the Korean Genome and Epidemiology Study
Subclinical left ventricular (LV) diastolic dysfunction in type 2 diabetes (T2D) is a common finding and represents an early sign of diabetic cardiomyopathy. However, the relationship between LV diastolic dysf... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 14, 2017 Category: Cardiology Authors: Juri Park, Jin-Seok Kim, Seong Hwan Kim, Sunwon Kim, Sang Yup Lim, Hong-Euy Lim, Goo-Yeong Cho, Ki-Chul Sung, Jang-Young Kim, Inkyung Baik, Kwang Kon Koh, Jung Bok Lee, Seung Ku Lee and Chol Shin Source Type: research

Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis
To establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 14, 2017 Category: Cardiology Authors: Aimee Grace, Erick Chan, Francesco Giallauria, Petra L. Graham and Neil A. Smart Source Type: research

Report from the 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D & CVD) EASD Study Group
The 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group was held on the 20th –21st October 2016 in Munich. This second Summit was organized in ligh... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 11, 2017 Category: Cardiology Authors: Oliver Schnell, Eberhard Standl, Doina Catrinoiu, Stefano Genovese, Nebojsa Lalic, Jan Skra, Paul Valensi, Dario Rahelic and Antonio Ceriello Source Type: research

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk
An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between pla... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 9, 2017 Category: Cardiology Authors: Katherine Kearney, Darren Tomlinson, Kerrie Smith and Ramzi Ajjan Source Type: research

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
Vascular dysfunction is a pivotal event in the development of diabetes-associated vascular disease. Increased inflammation and oxidative stress are major contributors to vascular dysfunction. Nrf2, a master re... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 3, 2017 Category: Cardiology Authors: Arpeeta Sharma, Luddwi Rizky, Nada Stefanovic, Mitchel Tate, Rebecca H. Ritchie, Keith W. Ward and Judy B. de Haan Source Type: research

Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes: a pilot study
Accumulation of epicardial fat (EF) is associated with increased cardio-metabolic risks and coronary events, independently of traditional cardiovascular risk factors. Therefore, the reduction of EF volume (EFV... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 3, 2017 Category: Cardiology Authors: Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto and Yoshihiro Ogawa Source Type: research

Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study
Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 1, 2017 Category: Cardiology Authors: Ming Zhang, Bingyuan Wang, Yu Liu, Xizhuo Sun, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Yang Zhao, Junmei Zhou, Chengyi Han, Jingzhi Zhao and Dongsheng Hu Source Type: research

Incretin-based agents in type 2 diabetic patients at cardiovascular risk: compare the effect of GLP-1 agonists and DPP-4 inhibitors on cardiovascular and pancreatic outcomes
Incretin-based agents, including dipeptidyl peptidase-4 inhibitors (DPP-4Is) and glucagon-like peptide-1 agonists (GLP-1As), work via GLP-1 receptor for hyperglycemic control directly or indirectly, but have d... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 1, 2017 Category: Cardiology Authors: Zeqing Zhang, Xi Chen, Puhan Lu, Jianhua Zhang, Yongping Xu, Wentao He, Mengni Li, Shujun Zhang, Jing Jia, Shiying Shao, Junhui Xie, Yan Yang and Xuefeng Yu Source Type: research

Effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure and markers of arterial stiffness in patients with type 2 diabetes mellitus: a post hoc analysis
Physiologic determinants, such as pulse pressure [difference between systolic blood pressure (SBP) and diastolic BP (DBP)], mean arterial pressure (2/3 DBP  + 1/3 SBP), and double product [beats per minute (bpm... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 27, 2017 Category: Cardiology Authors: Michael Pfeifer, Raymond R. Townsend, Michael J. Davies, Ujjwala Vijapurkar and Jimmy Ren Source Type: research

Diagnostic approaches for diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a cardiac dysfunction which affects approximately 12% of diabetic patients, leading to overt heart failure and death. However, there is not an efficient and specific methodolog... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 23, 2017 Category: Cardiology Authors: A. Lorenzo-Almor ós, J. Tuñón, M. Orejas, M. Cortés, J. Egido and Ó. Lorenzo Source Type: research

A randomised study of the impact of the SGLT2 inhibitor dapagliflozin on microvascular and macrovascular circulation
The sodium –glucose cotransporter 2 inhibitor, dapagliflozin, has been shown to improve diabetic control and reduce blood pressure in patients with type 2 diabetes mellitus. Its effects on micro- and macrovascu... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 23, 2017 Category: Cardiology Authors: Christian Ott, Agnes Jumar, Kristina Striepe, Stefanie Friedrich, Marina V. Karg, Peter Bramlage and Roland E. Schmieder Source Type: research

Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes
Fewer circulating endothelial progenitor cells (EPCs) and increased plasma (C-term) stromal cell-derived factor 1 α (SDF-1α), a substrate of DPP-4, are biomarkers, and perhaps mediators, of cardiovascular risk ... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 23, 2017 Category: Cardiology Authors: Alessandra Dei Cas, Valentina Spigoni, Monia Cito, Raffaella Aldigeri, Valentina Ridolfi, Elisabetta Marchesi, Michela Marina, Eleonora Derlindati, Rosalia Aloe, Riccardo C. Bonadonna and Ivana Zavaroni Source Type: research

Erratum to: Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
(Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 16, 2017 Category: Cardiology Authors: Concepci ón Peiró, Tania Romacho, Verónica Azcutia, Laura Villalobos, Emilio Fernández, Juan P. Bolaños, Salvador Moncada and Carlos F. Sánchez-Ferrer Source Type: research