Incremental prognostic value of global longitudinal strain in patients with type 2 diabetes mellitus
Background: Patients with type 2 diabetes mellitus (T2DM) are at high risk for cardiovascular events. The aim of the study was to assess whether global longitudinal strain (GLS) provides prognostic value in these patients. Methods: A total of 247 T2DM patients without history of cardiovascular complications and participated in the CDATS study were prospectively enrolled. Left ventricular (LV) systolic function was assessed by LV ejection fraction and speckle tracking derived LV systolic GLS. Diastolic function was assessed by E/E′ ratio defined as the passive trans-mitral LV inflow velocity to tissue Doppler imaging ...
Source: Cardiovascular Diabetology - February 3, 2016 Category: Cardiology Authors: Ju-Hua LiuYan ChenMichele YuenZhe ZhenCarmen ChanKaren LamHung-Fat TseKai-Hang Yiu Source Type: research

Low circulating pentraxin 3 levels in pregnancy is associated with gestational diabetes and increased apoB/apoA ratio: a 5-year follow-up study
Conclusions: Our results show that low plasma concentration of PTX3 in early pregnancy is associated with subsequent development of GDM and with an enhanced risk for CVD as estimated by an elevated apoB/apoA ratio at 5 years postpartum. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 3, 2016 Category: Cardiology Authors: Tove LekvaAnnika MichelsenJens BollerslevErrol NorwitzPål AukrustTore HenriksenThor Ueland Source Type: research

Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)
Conclusions: Our study indicates that polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 1, 2016 Category: Cardiology Authors: Yu WangJiantao YeJie LiCheng ChenJunying HuangPeiqing LiuHeqing Huang Source Type: research

Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population
Background: The genetic contribution to complex diseases or traits, including cardio-metabolic traits, has been elucidated recently by large-scale genome-wide association studies. These genome-wide association studies have indicated that most pleiotropic loci contain genes associated with lipids. Clinically, lipid related abnormalities are strongly associated with other diseases such as type 2 diabetes, coronary artery disease and hypertension. The aim of this study was to evaluate the shared genetic background of lipids and other cardio-metabolic traits. Methods: We conducted meta-analyses of the association between 157 p...
Source: Cardiovascular Diabetology - February 1, 2016 Category: Cardiology Authors: Yun KimMi HwangYoung KimSanghoon MoonSohee HanBong-Jo Kim Source Type: research

High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy
Conclusions: Glucose-related hyperosmolarity seems to be able to promote angiogenesis and retinopathy through activation of TonEBP and possibly increasing expression of AQP1 and COX-2. Osmolarity signaling may be a target for therapy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 29, 2016 Category: Cardiology Authors: Rosalinda MadonnaGaia GiovannelliPamela ConfaloneFrancesca RennaYong-Jian GengRaffaele De Caterina Source Type: research

Early cardiovascular events in women with a history of gestational diabetes mellitus
Conclusions: A history of GDM was identified as a risk factor of CVD, especially coronary vascular diseases, within the 7 years postpartum. A lifestyle changes from postpartum onwards can be recommended and supported. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 27, 2016 Category: Cardiology Authors: Karine GoueslardJonathan CottenetAnne-Sophie MarietMaurice GiroudYves CottinJean-Michel PetitCatherine Quantin Source Type: research

Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes
Conclusions: Our data suggest that the paradoxical association between high serum adiponectin levels and increased cardiovascular mortality rate is based on a cause-effect relationship, thus pointing to an unexpected deleterious role of adiponectin action/metabolism on atherosclerotic processes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 27, 2016 Category: Cardiology Authors: Lorena Ortega MorenoMassimiliano CopettiAndrea FontanaConcetta De BonisLucia SalveminiVincenzo TrischittaClaudia Menzaghi Source Type: research

Cardiovascular disease guideline adherence and self-reported statin use in longstanding type 1 diabetes: results from the Canadian study of longevity in diabetes cohort
Conclusion: Despite good self-reported adherence to general CVD prevention guidelines, against the principles of these guidelines we found that statin use was substantially lower in those without CVD history. Interventions are needed to improve statin use in older type 1 diabetes patients without a history of CVD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 25, 2016 Category: Cardiology Authors: Johnny BaiGeneviève BouletElise HalpernLeif LovblomDevrim EldelekliHillary KeenanMichael BrentNarinder PaulVera BrilDavid CherneyAlanna WeismanBruce Perkins Source Type: research

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease
Conclusions: ApoE gene polymorphisms associate with CVD and affect the lipid profile. The ε4 allele is an independent risk factor for both T2DM and CVD. Further genetic studies to add information beyond the traditional cardiovascular risk factors in T2DM and to identify risk genotypes will help in early prediction and identification of at risk patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2016 Category: Cardiology Authors: Dalia El-LebedyHala RaslanAsmaa Mohammed Source Type: research

Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques
Conclusion: One year of exercise training in patients with type 2 diabetes and CAD did not significantly change cIMT progression. However, in patients without identified carotid plaques, beneficial effect of exercise training on cIMT progression was demonstrated. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2016 Category: Cardiology Authors: Rune ByrkjelandKnut-Haakon StensæthSigmund AnderssenIda NjerveHarald ArnesenIngebjørg SeljeflotSvein Solheim Source Type: research

Bezafibrate for the treatment of dyslipidemia in patients with coronary artery disease: 20-year mortality follow-up of the BIP randomized control trial
Conclusions: During long-term follow-up bezafibrate-allocated patients experienced a modest but significant 10 % reduction in the adjusted risk of mortality. This effect of bezafibrate was more prominent among patients with baseline hypertriglyceridemia (25 % mortality risk reduction). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 22, 2016 Category: Cardiology Authors: Yaron ArbelRobert KlempfnerAharon ErezIlan GoldenbergSagit BenzekryNir ShlomoEnrique FismanAlexander Tenenbaumfor the BIP Study Group Source Type: research

Is visceral adiposity a modifier for the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes?
Background: We aimed to investigate whether visceral adiposity could modify the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes. Methods: This cross-sectional study examines the interaction of visceral adiposity with increased blood pressure on arterial stiffness and albuminuria. 638 patients with type 2 diabetes (mean age 64 ± 12 years; 40 % female) were enrolled. Visceral fat area (VFA, cm 2 ) was assessed by a dual-impedance analyzer, whereby patients were divided into those with VFA  (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 21, 2016 Category: Cardiology Authors: Ryotaro BouchiNorihiko OharaMasahiro AsakawaYujiro NakanoTakato TakeuchiMasanori MurakamiYuriko SasaharaMitsuyuki NumasawaIsao MinamiHajime IzumiyamaKoshi HashimotoTakanobu YoshimotoYoshihiro Ogawa Source Type: research

The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype
Conclusions: The compositions of skeletal muscle and visceral fat play key roles in the association between circulating irisin and a patient’s metabolic phenotype. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 20, 2016 Category: Cardiology Authors: You-Cheol HwangWon JeonCheol-Young ParkByung-Soo Youn Source Type: research

Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study
Conclusions: MDI with AI results in better postmeal glucose control compared to HI. The treatment with AI is associated with improved diastolic cardiac function.ClinicalTrials.gov (NTC00747409) (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2016 Category: Cardiology Authors: Helene von BibraThorsten SiegmundIris KingreenMarkus RiemerTibor SchusterPetra-Maria Schumm-Draeger Source Type: research

Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression
Conclusions: CD59 and AAT proteins are significantly altered in hypertensive patients developing albuminuria. Interestingly, CD59 and AAT are able to predict, in normoalbuminuric individuals, who will develop albuminuria in the future, being potential predictors of vascular damage and CV risk. These findings contribute to early identify patients at risk of developing albuminuria even when this classical predictor is still in the normal range, constituting a novel strategy towards a prompt and more efficient therapeutic intervention with better outcome. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - January 16, 2016 Category: Cardiology Authors: Laura Gonzalez-CaleroMarta Martin-LorenzoFernando de la CuestaAroa MarotoMontserrat Baldan-MartinGema Ruiz-HurtadoHelena Pulido-OlmoJulian SeguraMaria BarderasLuis RuilopeFernando VivancoGloria Alvarez-Llamas Source Type: research

Reduction of CTRP9, a novel anti-platelet adipokine, contributes to abnormal platelet activity in diabetic animals
Platelet hyper-reactivity is a crucial cause of accelerated atherosclerosis increasing risk of thrombotic vascular events in diabetic patients. The mechanisms leading to abnormal platelet activity during diabetes are complex and not fully defined. The current study attempted to clarify the role of CTRP9, a novel adiponectin paralog, in enhanced platelet activity and determined whether CTRP9 may inhibit platelet activity. Adult male C57BL/6 J mice were randomized to receive high-fat diet (HFD) or normal diet (ND). 8 weeks after HFD, animals were sacrificed, and both plasma CTRP9 and platelet aggregation were det...
Source: Cardiovascular Diabetology - January 11, 2016 Category: Cardiology Authors: Wenqing WangWayne LauYajing WangXinliang MaRong Li Source Type: research

Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
Background: Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. Methods: Based on albumin/creatinine ratio (ACR), 109 T2DM patients were divided into normoalbuminuria (ACR 300 mg/g). Serum betatrophin levels of 109 T2DM patients and 32 healthy subjects were determined by enzyme-linked immunosorbent assay (ELIS...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Chang-Chiang ChenHendra SusantoWen-Han ChuangTa-Yu LiuChih-Hong Wang Source Type: research

CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
Background: Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those core genes, is known to regulate glucose metabolism in rodent models. Cross-sectional studies in humans have reported associations between this locus and obesity, plasma glucose, hypertension and T2D prevalence, supporting its role in cardiovascular risk. However,...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Dolores CorellaEva. AsensioOscar ColtellJosé SorlíRamón EstruchMiguel Martínez-GonzálezJordi Salas-SalvadóOlga CastañerFernando ArósJosé LapetraLluís Serra-MajemEnrique Gómez-GraciaCarolina Ortega-AzorínMiquel FiolJavier EspinoAndrés Díaz-L Source Type: research

Lower-extremity amputation as a marker for renal and cardiovascular events and mortality in patients with long standing type 1 diabetes
Background: We evaluated the risks of renal and cardiovascular complications, and mortality associated with lower extremity amputation (LEA) in patients with type 1 diabetes. Methods: We studied two cohorts of people with long standing type 1 diabetes: GENEDIAB (n = 456) and GENESIS (n = 611). Subsets of the cohorts (n = 260, n = 544) were followed for 9 and 5 years, respectively. Outcomes were the incidence of end stage renal disease (ESRD), myocardial infarction, stroke and mortality during follow-up. Analyses were performed in pooled cohorts. Results: The prevalence of LEA at...
Source: Cardiovascular Diabetology - January 7, 2016 Category: Cardiology Authors: Kamel MohammediLouis PotierNarimène BelhatemNadia MatallahSamy HadjadjRonan RousselMichel MarreGilberto Velho Source Type: research

Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study
Background: Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells and induces insulin secretion. However, there are no previous longitudinal studies in humans. Methods: We analyzed the age- and sex-matched data of 240 normal weight and overweight Korean children from the Korean Metabolic disorders and Obesity Study in Elementary School children (K-MOSES), a prospective observational cohort study. Results: At bas...
Source: Cardiovascular Diabetology - January 6, 2016 Category: Cardiology Authors: Hye ChungMin LeeSoon HwangHyun LeeHye YooJi-A SeoSin KimNan KimSei BaikDong ChoiSeon KimKyung Choi Source Type: research

Coronary artery bypass surgery compared with percutaneous coronary interventions in patients with insulin-treated type 2 diabetes mellitus: a systematic review and meta-analysis of 6 randomized controlled trials
Background: Data regarding the long-term clinical outcomes in patients with insulin-treated type 2 diabetes mellitus (ITDM) revascularized by either coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI) are still controversial. We sought to compare the long-term (≥1 year) adverse clinical outcomes in patients with ITDM who underwent revascularization by either CABG or PCI. Methods: Randomized Controlled Trials (RCTs) comparing the long-term clinical outcomes in patients with ITDM and non-ITDM revascularized by either CABG or PCI were searched from electronic databases. Data for patients ...
Source: Cardiovascular Diabetology - January 6, 2016 Category: Cardiology Authors: Pravesh BundhunZi WuMeng-Hua Chen Source Type: research

Safety, tolerability and effects on cardiometabolic risk factors of empagliflozin monotherapy in drug-naïve patients with type 2 diabetes: a double-blind extension of a Phase III randomized controlled trial
Background: To investigate the long-term efficacy and safety of empagliflozin monotherapy compared with placebo and sitagliptin in drug-naïve patients with type 2 diabetes mellitus. Methods: Of 899 patients randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, placebo, or sitagliptin 100 mg once daily for 24 weeks, 615 continued in a double-blind extension trial for ≥52 weeks. Exploratory endpoints included changes from baseline in HbA1c, weight and blood pressure at week 76. Results: Compared with placebo, adjusted mean changes from baseline in HbA1c at week 76 were −0.78&n...
Source: Cardiovascular Diabetology - December 23, 2015 Category: Cardiology Authors: Michael RodenLudwig MerkerAnita ChristiansenFlavien RouxAfshin SalsaliGabriel KimPeter StellaHans WoerleUli BroedlOn behalf of the EMPA-REG EXTEND¿ MONO investigators Source Type: research

Temporal changes in the prevalence and associates of diabetes-related lower extremity amputations in patients with type 2 diabetes: the Fremantle Diabetes Study
Background: To determine temporal changes in the prevalence and associates of lower extremity amputation (LEA) complicating type 2 diabetes. Methods: Baseline data from the longitudinal observational Fremantle Diabetes Study (FDS) relating to LEA and its risk factors collected from 1296 patients recruited to FDS Phase 1 (FDS1) from 1993 to 1996 and from 1509 patients recruited to FDS Phase 2 (FDS2) from 2008 to 2011 were analysed. Multiple logistic regression was used to determine associates of prevalent LEA in individual and pooled phases. Generalised linear modelling was used to examine whether diabetes related LEA preva...
Source: Cardiovascular Diabetology - December 18, 2015 Category: Cardiology Authors: Mendel BabaWendy DavisPaul NormanTimothy Davis Source Type: research

Insulin treatment increases myocardial ceramide accumulation and disrupts cardiometabolic function
Conclusions: Collectively, these observations have two implications. First, they indicate a pathological role of insulin in heart complications stemming from mitochondrial disruption. Second, they identify ceramide as a possible mediator of insulin-related heart disorders. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - December 18, 2015 Category: Cardiology Authors: Aimee HodsonTrevor TippettsBenjamin Bikman Source Type: research

Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning
Background: Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been studied so far. Therefore, here we investigated the effect of acute hyperglycemia on cardioprotection by RIPerC. Methods: Wistar rats were divided into normoglycemic (NG) and acute hyperglycemic (AHG) groups. Acute hyperglycemia wa...
Source: Cardiovascular Diabetology - November 18, 2015 Category: Cardiology Authors: Tamás BaranyaiCsilla NagyGábor KoncsosZsófia OnódiMelinda Károlyi-SzabóAndrás MakkosZoltán VargaPéter FerdinandyZoltán Giricz Source Type: research

Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet
Background: It remains to be established if, and to what extent, the coronary microcirculation becomes compromised during the development of obesity and insulin resistance. Recent studies suggest that changes in endothelial glycocalyx properties contribute to microvascular dysfunction under (pre-)diabetic conditions. Accordingly, early effects of diet-induced obesity on myocardial perfusion and function were studied in rats under baseline and hyperaemic conditions. Methods: Rats were fed a high fat diet (HFD) for 6 weeks and myocardial microvascular perfusion was determined using first-pass perfusion MRI before and af...
Source: Cardiovascular Diabetology - November 17, 2015 Category: Cardiology Authors: Judith van HaareM. KooiHans VinkMark PostJurgen van TeeffelenJos SlenterChantal MuntsHanneke CobelensGustav StrijkersDennis KoehnMarc van Bilsen Source Type: research

Glucose and fatty acid metabolism in infarcted heart from streptozotocin-induced diabetic rats after 2 weeks of tissue remodeling
Background: The effects of streptozotocin (STZ)-induced diabetes on heart metabolism and function after myocardial infarction (MI) remodelling were investigated in rats. Methods: Fifteen days after STZ (50 mg/kg b.w. i.v.) injection, MI was induced by surgical occlusion of the left coronary artery. Two weeks after MI induction, contents of glycogen, ATP, free fatty acids and triacylglycerols (TG) and enzyme activities of glycolysis and Krebs cycle (hexokinase, glucose-6-phosphate dehydrogenase, phosphofructokinase, citrate synthase) and expression of carnitine palmitoyl-CoA transferase I (a key enzyme of mitochondrial...
Source: Cardiovascular Diabetology - November 9, 2015 Category: Cardiology Authors: Christiane MalfitanoAlcione de Souza JuniorMariana CarbonaroAndressa Bolsoni-LopesDiego FigueroaLeandro de SouzaKleiton SilvaFernanda Consolim-ColomboRui CuriMaria Irigoyen Source Type: research

Visceral adiposity is associated with altered myocardial glucose uptake measured by 18 FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes
Background: The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptake in hearts of subjects with normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) using [ 18 F]-fluorodeoxyglucose-positron emission tomography ( 18 FDG-PET) in association with visceral and subcutaneous adiposity, and metabolic laboratory parameters....
Source: Cardiovascular Diabetology - November 4, 2015 Category: Cardiology Authors: Gyuri KimKwanhyeong JoKwang KimYong-ho LeeEugene HanHye-jin YoonHye WangEun KangMijin Yun Source Type: research

Association between brachial-ankle pulse wave velocity and progression of coronary artery calcium: a prospective cohort study
Conclusions: Higher arterial stiffness measured by baPWV could be significantly associated with CAC progression. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 4, 2015 Category: Cardiology Authors: Jong-Young LeeSeungho RyuSung LeeByung KimBum-Soo KimJin-Ho KangEun CheongJang-Young KimJeong ParkKi-Chul Sung Source Type: research

The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus
Background: Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects of elevated intracellular cGMP-levels have been described in different heart diseases. In the current study we aimed at investigating the effects of pharmacological activation of sGC in diabetic cardiomyopathy. Methods: Type-1 DM was induced in rats by streptozotocin. Animals were treated either with the sGC activator cinaciguat (10 mg/kg/day) or with placebo orall...
Source: Cardiovascular Diabetology - October 31, 2015 Category: Cardiology Authors: Csaba MátyásBalázs NémethAttila OláhLászló HidiEde BirtalanDalma KellermayerMihály RuppertSevil Korkmaz-IcözGábor KökényEszter HorváthGábor SzabóBéla MerkelyTamás Radovits Source Type: research

Factors associated with no apparent coronary artery disease in patients with type 2 diabetes mellitus for more than 10 years of duration: a case control study
Background: Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain free of CAD even after many years of treatment for diabetes. The present study was aimed to identify the factors that are associated with a favorable CAD profile. Methods: A case–control study of 76 patients with type 2 diabetes mellitus who were on treatment for more than 10 years duration and undergoing a coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospita...
Source: Cardiovascular Diabetology - October 31, 2015 Category: Cardiology Authors: Mukund SrinivasanPadmanabh KamathNarayan BhatNarasimha PaiPoornima ManjrekarChakrapani Mahabala Source Type: research

Combined influence of nonalcoholic fatty liver and body size phenotypes on diabetes risk
Background: We aimed to determine the association between nonalcoholic fatty liver disease (NAFLD) and diabetes risk among body size phenotypes which was based on cross-classification of body mass index (BMI) categories (normal or overweight/obesity) and metabolic status (metabolically health or metabolically at-risk). Methods: We conducted a cross-sectional analysis using a cohort of 10,761 apparently healthy Chinese adults who underwent comprehensive health checkups including abdominal ultrasonography. Subjects were classified as metabolically at-risk by having any two of the following, consistent with the Adult Treatmen...
Source: Cardiovascular Diabetology - October 29, 2015 Category: Cardiology Authors: Tingting DuXuefeng YuGang YuanJianhua ZhangXingxing Sun Source Type: research

SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
Conclusions: Overexpression of SIRT1 reduces diabetes-exacerbated MI/R injury and oxidative stress via activating eNOS in diabetic rats. The findings suggest SIRT1 may be a promising novel therapeutic target for diabetic cardiac complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 21, 2015 Category: Cardiology Authors: Mingge DingJingyi LeiHongcheng HanWeibo LiYinxian QuEnqing FuFeng FuXiaoming Wang Source Type: research

Efficacy and safety of dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in diabetes mellitus
Although antidiabetic agents have been developed to target one or more of the core defects of type 2 diabetes mellitus (T2DM), many patients do not achieve glycemic goals. Inhibition of the sodium-glucose cotransporter 2 (SGLT2) induces glycosuria, reduces glucose toxicity and improves insulin sensitivity and β-cell function. As the mechanism of action of SGLT2 inhibitors is different from other agents and completely insulin-independent, the use of these drugs might potentially be efficacious alone or in combination with any other antidiabetic drug, including insulin. Dapagliflozin is a highly selective and reversible...
Source: Cardiovascular Diabetology - October 17, 2015 Category: Cardiology Authors: Paola FiorettoAndrea GiaccariGiorgio Sesti Source Type: research

Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry
Background: After acute myocardial infarction (AMI), the replicated phenomenon of obesity paradox, i.e., obesity appearing to be associated with increased survival, has not been evaluated in stabilized (i.e., without clinical events within 1 month post AMI) Asian patients with diabetes mellitus (DM). Methods: Among 1192 patients in the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry between April 2010 and June 2012, 2-year cardiac and all-cause death were compared according to obesity (body mass index ≥25 kg/m 2 ) in 1125 stabilized DM patients. Results: ...
Source: Cardiovascular Diabetology - October 15, 2015 Category: Cardiology Authors: Ki-Bum WonSeung-Ho HurYun-Kyeong ChoHyuck-Jun YoonChang-Wook NamKwon-Bae KimJang-Ho BaeDong-Ju ChoiYoung-Keun AhnJong-Seon ParkHyo-Soo KimRak-Kyeong ChoiDonghoon ChoiJoon-Hong KimKyoo-Rok HanHun-Sik ParkSo-Yeon ChoiJung-Han YoonHyeon-Cheol KwonSeung-Un Rh Source Type: research

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
Background: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. Methods: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. Results: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5–77.8) pg/mL and 43.89 (37.5–50.4), P  (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 12, 2015 Category: Cardiology Authors: Federico BiscettiGiuseppe StrafaceCarlo PorrecaGiovanni BertolettiClaudio VincenzoniFrancesco SniderEgidio StiglianoVincenzo ArenaFlavia AngeliniGiovanni PecoriniAntonio BianchiRaffaele LandolfiAndrea Flex Source Type: research

Erratum to: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes
No description available (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 9, 2015 Category: Cardiology Authors: Vincent MonnierWanjie SunXiaoyu GaoDavid SellPatricia ClearyJohn LachinSaul GenuthThe DCCT/EDIC Research Group Source Type: research

Effect of metformin monotherapy on cardiovascular diseases and mortality: a retrospective cohort study on Chinese type 2 diabetes mellitus patients
This study aims to evaluate the net effects of metformin monotherapy (MM) on the all-cause mortality and cardiovascular disease (CVD) events. Methods: A retrospective 5-year follow-up cohort study was conducted on Chinese adult patients with T2DM and without any CVD history under public primary care. Cox proportional hazard regressions were performed to compare the risk of all-cause mortality and CVD events (CHD, stroke, heart failure) between patients receiving lifestyle modifications plus MM (MM groups) and those with lifestyle modifications alone (control groups). Results: 3400 pairs of matched patients were compared. M...
Source: Cardiovascular Diabetology - October 9, 2015 Category: Cardiology Authors: Colman FungEric WanCarlos WongFangfang JiaoAnca Chan Source Type: research

Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy
Conclusions: Our results indicate that corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM. Corin deficiency leads to endothelial dysfunction and vascular remodeling. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 7, 2015 Category: Cardiology Authors: Aiming PangYahui HuPengfei ZhouGuangfeng LongXin TianLi MenYanna ShenYunde LiuYujie Cui Source Type: research

Adverse cardiovascular outcomes between insulin-treated and non-insulin treated diabetic patients after percutaneous coronary intervention: a systematic review and meta-analysis
Background: Type 2 diabetes mellitus (DM) patients have worse adverse cardiovascular outcomes after Percutaneous Coronary Intervention (PCI). However, the adverse cardiovascular outcomes between insulin-treated and non-insulin treated DM patients have been a subject of debate. We sought to compare the short-term ( (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 7, 2015 Category: Cardiology Authors: Pravesh BundhunNuo LiMeng-Hua Chen Source Type: research

High visceral fat with low subcutaneous fat accumulation as a determinant of atherosclerosis in patients with type 2 diabetes
This study was designed to elucidate whether high visceral fat with low subcutaneous fat accumulation enhances the risk for atherosclerosis in patients with type 2 diabetes. This is a cross-sectional study of 148 patients with type 2 diabetes (mean age 65 ± 12 years; 44.5 % female). Visceral fat area (VFA, cm 2 ) and subcutaneous fat area (SFA, cm 2 ) were assessed by abdominal computed tomography. Carotid intima media thickness (CIMT, mm) measured by ultrasonography was used for the assessment of atherosclerosis. Patients were divided into four groups: S...
Source: Cardiovascular Diabetology - October 7, 2015 Category: Cardiology Authors: Ryotaro BouchiTakato TakeuchiMomoko AkihisaNorihiko OharaYujiro NakanoRie NishitaniMasanori MurakamiTatsuya FukudaMasamichi FujitaIsao MinamiHajime IzumiyamaKoshi HashimotoTakanobu YoshimotoYoshihiro Ogawa Source Type: research

Clinical impact of diabetes mellitus in patients undergoing transcatheter aortic valve replacement
Conclusions: Following TAVR, DM patients seem to have similar peri-procedural and mid-term outcomes compared with patients without DM, while IDDM patients seem to suffer greater incidence of AKI. Further research in larger cohorts of patients is needed to validate our results. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2015 Category: Cardiology Authors: Anat BerkovitchAmit SegevIsrael BarbashYoni GrossmanElad MaorAharon ErezEhud RegevNoam FinkIsrael MazinAshraf HamdanIlan GoldenbergIlan HayDan SpiegelstienVictor GuettaPaul Fefer Source Type: research

Gender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD-DIABETES study
Conclusions: This study showed that the progression of vascular and renal TOD differs by gender. The increase in vascular and renal TOD was higher in women, especially in diabetic women. The PWV increase showed a positive association with mean HbA1c levels during the follow-up. Glomerular filtration was associated with BMI and the ABI was associated with duration since type 2 diabetes mellitus diagnosis.Trial registration: Clinical Trials.gov Identifier NCT01065155 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 1, 2015 Category: Cardiology Authors: Manuel Gómez-MarcosJosé Recio-RodríguezLeticia Gómez-SánchezCristina Agudo-CondeEmiliano Rodríguez-SanchezJoseAngel Maderuelo-FernandezMarta Gomez-SanchezLuís García-OrtizLOD-DIABETES Group Source Type: research

Patients with coronary artery disease and diabetes need improved management: a report from the EUROASPIRE IV survey: a registry from the EuroObservational Research Programme of the European Society of Cardiology
Background: In order to influence every day clinical practice professional organisations issue management guidelines. Cross-sectional surveys are used to evaluate the implementation of such guidelines. The present survey investigated screening for glucose perturbations in people with coronary artery disease and compared patients with known and newly detected type 2 diabetes with those without diabetes in terms of their life-style and pharmacological risk factor management in relation to contemporary European guidelines. Methods: A total of 6187 patients (18–80 years) with coronary artery disease and known glycae...
Source: Cardiovascular Diabetology - October 1, 2015 Category: Cardiology Authors: Viveca GybergDirk De BacquerGuy De BackerCatriona JenningsKornelia KotsevaLinda MellbinOliver SchnellJaakko TuomilehtoDavid WoodLars RydénPhilippe AmouyelJan BruthansAlmudena CondeRenata CifkovaJaap DeckersJohan De SutterMirza DilicMaryna DolzhenkoAndrej Source Type: research

Impact of long-term steroid therapy on epicardial and pericardial fat deposition: a cardiac MRI study
Background: Increased cardiac fat has been identified as a risk factor for coronary artery disease. Metabolic syndrome is associated with increased cardiac fat deposition. Steroids are known to imitate some effects of metabolic syndrome and are frequently used in patients with rheumatic disorders. Primary aim was to evaluate the impact of long-term steroid use on cardiac fat deposition in patients with rheumatic disorders. In addition, we sought to investigate if this effect might be dose-dependent. Methods: Patients were enrolled as follows: (1) rheumatic disorder; and (2) long-term steroid therapy, and (3) underwent card...
Source: Cardiovascular Diabetology - September 30, 2015 Category: Cardiology Authors: Daniel KittererJoerg LatusJoerg HenesStefan BirkmeierMaik BackesNiko BraunUdo SechtemM. Dominik AlscherHeiko MahrholdtSimon Greulich Source Type: research

Antidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes
The traditional oral pharmacological therapy for type 2 diabetes mellitus (T2DM) has been based on the prescription of metformin, a biguanide, as first line antihyperglycemic agent world over. It has been demonstrated that after 3 years of treatment, approximately 50 % of diabetic patients could achieve acceptable glucose levels with monotherapy; but by 9 years this had declined to only 25 %. Therefore, the implementation of a combined pharmacological therapy acting via different pathways becomes necessary, and its combination with a compound of the sulfonylurea group was along decades the most frequent...
Source: Cardiovascular Diabetology - September 29, 2015 Category: Cardiology Authors: Enrique FismanAlexander Tenenbaum Source Type: research

Erratum to: Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study
No description available (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 28, 2015 Category: Cardiology Authors: Stijn PeetersLian EngelenJacqueline BuijsNish ChaturvediJohn FullerCasper SchalkwijkCoen StehouwerEURODIAB Prospective Complications Study Group Source Type: research

Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study
Conclusions: The results show a possible protective effect of high levels of sRAGE at baseline against inflammation 5 years later, but not on arterial stiffness or wall thickness, in this cohort of adolescents and young adults with T1D. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 25, 2015 Category: Cardiology Authors: Martin HeierHanna MargeirsdottirMario GaarderKnut StensæthCathrine BrunborgPeter TorjesenIngebjørg SeljeflotKristian HanssenKnut Dahl-Jørgensen Source Type: research

Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling
Conclusions: We have identified changes in metabolic signaling in obese HFD fed MRL mice that confer resistance to diabetic cardiomyopathy. The changes include a reduction of cardiac pAMPK, Glut4 and hexokinase2 in the MRL HFD hearts. Overall the MRL hearts down regulate glucose metabolism and favor lipid metabolism. These adaptations are essential to pursue for the identification of novel therapeutic targets to combat obesity related cardiomyopathy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 25, 2015 Category: Cardiology Authors: Nathan RobertsMagdalis González-VegaTirsit BerhanuAaron MullJesús GarcíaAhlke Heydemann Source Type: research

Circulating interleukin-1β promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2
Conclusions: Elevated circulating IL-1β contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in DCM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 23, 2015 Category: Cardiology Authors: Zhongwei LiuNa ZhaoHuolan ZhuShunming ZhuShuo PanJing XuXuejun ZhangYong ZhangJunkui Wang Source Type: research