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Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury
In this study, we investigated the vascular-protective effect of the DPP-4 inhibitor, linagliptin, using vascular smooth muscle cells (VSMCs). Methods: Six-week-old male C57BL/6 mice were divided into control (n =19) and linagliptin (3 mg/kg/day, n =20) treated groups. Endothelial denudation injuries were induced in the femoral artery at 8 weeks of age, followed by evaluation of neointima formation at 12 weeks. To evaluate cell proliferation of rat aortic smooth muscle cells, a bromodeoxyuridine (BrdU) incorporation assay was performed. Results: Linagliptin treatment reduced vascular injury-induced neointima...
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Yuichi TerawakiTakashi NomiyamaTakako KawanamiYuriko HamaguchiHiroyuki TakahashiTomoko TanakaKunitaka MuraseRyoko NagaishiMakito TanabeToshihiko Yanase Source Type: research

The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report
Conclusions: These data suggest that the Mediterranean diet, using olive oil, prevents the acute hyperglycemia effect on endothelial function, inflammation and oxidative stress, and improves the action of GLP-1, which may have a favorable effect on the management of type 2 diabetes, particularly for the prevention of cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Antonio CerielloKatherine EspositoLucia La SalaGemma PujadasValeria De NigrisRoberto TestaLoredana BucciarelliMaurizio RondinelliStefano Genovese Source Type: research

Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway
Conclusion: GLP-1RA exenatide can inhibit human VSMCs calcification through NF-?B/ RANKL signaling. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Jun-Kun ZhanPan TanYan-Jiao WangYi WangJieyu HeZhi-Yong TangWu HuangYou-Shuo Liu Source Type: research

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury
In this study, we investigated the vascular-protective effect of the DPP-4 inhibitor, linagliptin, using vascular smooth muscle cells (VSMCs). Methods: Six-week-old male C57BL/6 mice were divided into control (n =19) and linagliptin (3?mg/kg/day, n =20) treated groups. Endothelial denudation injuries were induced in the femoral artery at 8?weeks of age, followed by evaluation of neointima formation at 12?weeks. To evaluate cell proliferation of rat aortic smooth muscle cells, a bromodeoxyuridine (BrdU) incorporation assay was performed. Results: Linagliptin treatment reduced vascular injury-induced neointima formation, com...
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Yuichi TerawakiTakashi NomiyamaTakako KawanamiYuriko HamaguchiHiroyuki TakahashiTomoko TanakaKunitaka MuraseRyoko NagaishiMakito TanabeToshihiko Yanase Source Type: research

Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease
Background: Secreted frizzled-related proteins (SFRP) are regulators of Wnt-signalling. SFRP4 has been shown to regulate insulin exocytosis and is overexpressed in type 2 diabetes mellitus.Here we characterized the relation of SFRP4 to glucose and triglyceride metabolism and outcomes in patients with stable coronary artery disease on statin treatment in the prospective Homburg Cream & Sugar Study (NCT00628524). Methods: Fasting SFRP4 concentrations were measured by ELISA in 504 consecutive patients with stable CAD confirmed by angiography. Results: The median age was 68?years and 83% of patients were male. Oral glucose...
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Michael HoffmannChristian WernerMichael BöhmUlrich LaufsKarl Winkler Source Type: research

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice
Conclusions: Subcutaneous immunization with AGE-LDL significantly inhibits atherosclerosis progression in hyperlipidemic diabetic mice possibly through activation of specific humoral and cell mediated immune responses and metabolic control improvement. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Lin ZhuZhiqing HeFeng WuRu DingQixia JiangJiayou ZhangMin FanXing WangBengtsson EvaNilsson JanChun LiangZonggui Wu Source Type: research

Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis
Conclusion: The protective effect of metformin against free fatty acid induced apoptosis is potentially clinically relevant as metformin is first line treatment for patients with T2D, a patient group which is rapidly increasing and carries a high burden of cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Linnéa ErikssonThomas Nyström Source Type: research

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice
Conclusions: Subcutaneous immunization with AGE-LDL significantly inhibits atherosclerosis progression in hyperlipidemic diabetic mice possibly through activation of specific humoral and cell mediated immune responses and metabolic control improvement. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Lin ZhuZhiqing HeFeng WuRu DingQixia JiangJiayou ZhangMin FanXing WangBengtsson EvaNilsson JanChun LiangZonggui Wu Source Type: research

Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis
Conclusion: The protective effect of metformin against free fatty acid induced apoptosis is potentially clinically relevant as metformin is first line treatment for patients with T2D, a patient group which is rapidly increasing and carries a high burden of cardiovascular disease. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 13, 2014 Category: Cardiology Authors: Linnéa ErikssonThomas Nyström Source Type: research

PPAR¿ activation but not PPAR¿ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors
Conclusions: In summary, activation of PPARγ by rosiglitazone improves angiogenic potential of diabetic ECs and PACs, but decreased expression of PPARγ in diabetes does not impair angiogenesis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Jerzy KotlinowskiAnna Grochot-PrzeczekHevidar TahaMagdalena KozakowskaBartosz PileckiKlaudia SkrzypekAleksandra BartelikRafal DerlaczAnton HorrevoetsAttila PapLaszlo NagyJozef DulakAlicja Jozkowicz Source Type: research

Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris
Background: Recent evidence demonstrated that the circulating adipokines were associated with the onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and acute myocardial infarction (AMI). As a novel adipokine, chemerin has been related to atherosclerosis and the presence of coronary artery disease. However, the plasma levels of chemerin in patients with ACS have yet to be investigated. Methods: Plasma levels of chemerin and adiponectin were measured by an enzyme-linked immunosorbent assay (ELISA) in 60 patients with stable angina pectoris (SAP), 60 patients with UAP, 60 patients with AMI and 40...
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Qingwei JiYingzhong LinZhishan LiangKunwu YuYuyang LiuZhe FangLing LiuYing ShiQiutang ZengChao ChangMeng ChaiYujie Zhou Source Type: research

Association of impaired fasting glucose, diabetes and their management with the presentation and outcome of peripheral artery disease: a cohort study
Conclusions: Non-medicated diabetes is common in peripheral artery disease patients and associated with poor outcomes. Impaired fasting glucose is also common but does not increase intermediate term complications. Peripheral artery disease patients with diabetes requiring insulin are at high risk of intermediate term mortality. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Jonathan GolledgeFrank QuigleyRamesh VeluPhillip WalkerJoseph Moxon Source Type: research

PPAR¿ activation but not PPAR¿ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors
Conclusions: In summary, activation of PPAR? by rosiglitazone improves angiogenic potential of diabetic ECs and PACs, but decreased expression of PPAR? in diabetes does not impair angiogenesis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 1, 2014 Category: Cardiology Authors: Jerzy KotlinowskiAnna Grochot-PrzeczekHevidar TahaMagdalena KozakowskaBartosz PileckiKlaudia SkrzypekAleksandra BartelikRafal DerlaczAnton HorrevoetsAttila PapLaszlo NagyJozef DulakAlicja Jozkowicz Source Type: research

Association between carotid intima-media thickness and index of central fat distribution in middle-aged and elderly Chinese
Background: Evidence has demonstrated that central fat distribution produces the most profound metabolic abnormalities and is associated with an increased risk of atherosclerotic cardiovascular diseases. We aimed to investigate whether the indexes of central fat distribution, including waist-to-height ratio (WHtR) and visceral fat area (VFA), were stronger risk factors of subclinical atherosclerosis than body mass index (BMI) in Chinese adults. Methods: A total of 3381 participants aged 40?years or older without history of cardiovascular diseases (CVD) were enrolled in the present cross-sectional study from the Songnan com...
Source: Cardiovascular Diabetology - October 30, 2014 Category: Cardiology Authors: Chenxi RenJie ZhangYu XuBaihui XuWanwan SunJichao SunTiange WangMin XuJieli LuWeiqing WangYufang BiYuhong Chen Source Type: research

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice
Conclusions: Glycemic control with empagliflozin significantly ameliorated cardiovascular injury and remodeling, vascular dysfunction, and cognitive decline in obese and type 2 diabetic mice. Thus, empagliflozin seems to be potentially a promising therapeutic agent for diabetic macrovascular disease and cognitive decline. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 26, 2014 Category: Cardiology Authors: Bowen LinNobutaka KoibuchiYu HasegawaDaisuke SuetaKensuke ToyamaKen UekawaMingJie MaTakashi NakagawaHiroaki KusakaShokei Kim-Mitsuyama Source Type: research

Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study
Conclusions: Brain atrophy is associated with resting aortic stiffness in T2DM, and resting Pexcess in healthy individuals. Central vascular mechanisms underlying structural brain changes may differ between healthy individuals and T2DM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 23, 2014 Category: Cardiology Authors: Rachel ClimieVelandai SrikanthRichard BeareLaura KeithJames FellJustin DaviesJames Sharman Source Type: research

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
Patients with type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and stroke are responsible for 75% of all death in patients with diabetes, who present a 2-4x increased incidence of death from coronary artery disease. Patients with diabetes are considered for cardiovascular disease secondary prevention because their risk level is similar to that reported in patients without diabetes who have already suffered a myocardial infarction. More recently, with a better risk factors control, mainly in intensive LDL cholesterol target...
Source: Cardiovascular Diabetology - October 22, 2014 Category: Cardiology Authors: Francisco SaraivaAndrei Sposito Source Type: research

Normal weight diabetic patients versus obese diabetics: relation of overall and abdominal adiposity to vascular health
Conclusions: Abdominal obesity defined by WC was associated with significantly higher AI and PWV in in both diabetic men and women; whereas overall obesity defined by BMI did not predict adverse vascular changes in this study population. Abdominal obesity was associated with an adverse effect on blood vessels, independently of age, sex, blood pressure, fasting glucose and BMI. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 22, 2014 Category: Cardiology Authors: Alla LukichDov GavishMarina Shargorodsky Source Type: research

Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance
Conclusion: The apoB/apoA-I performs no better than any of the traditional lipid ratios in correlating with IR. The TG/HDL-C, VAI and TyG are better markers for early identification of IR individuals. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 20, 2014 Category: Cardiology Authors: Tingting DuGang YuanMuxun ZhangXinrong ZhouXingxing SunXuefeng Yu Source Type: research

Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study
Conclusions: This finding suggests that more attention should be given to the management of cardiovascular risk in type 2 diabetic patients with high triglycerides levels. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2014 Category: Cardiology Authors: Maria-Agata MiselliEdoardo NoraAngelina PassaroFranco TomasiGiovanni Zuliani Source Type: research

Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study
Conclusion: The study shows that a 4-month treatment with add-on insulin significantly increases the outgrowth of EPC in patients with type 2 diabetes mellitus.Trial registration(Clinical Trials Identifier: NCT00523393). (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 11, 2014 Category: Cardiology Authors: Dimitrios OikonomouStefan KopfRüdiger von BauerZdenka DjuricRita CebolaAnja SanderStefan EnglertSpiros VittasAsa HidmarkMichael MorcosGrigorios KorosoglouPeter NawrothPer Humpert Source Type: research

Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50?mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15?days after STZ. Thirty days after streptozocin-ind...
Source: Cardiovascular Diabetology - October 10, 2014 Category: Cardiology Authors: Christiane MalfitanoCatarina BarbozaCristiano MostardaRenata da PalmaCamila dos SantosBruno RodriguesSarah FreitasAdriane Belló-KleinSusana LlesuyMaria-Cláudia IrigoyenKátia De Angelis Source Type: research

Visceral adiposity index and risks of cardiovascular events and mortality in prevalent hemodialysis patients
Conclusion: VAI is an optimal method to measure visceral adiposity to assess long-term CV outcomes and all-cause mortality in prevalent hemodialysis patients. VAI may provide a superior predictive power of CV outcomes to WC and WHtR.Trial registrationClinicalTrials.gov NCT01457625 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 4, 2014 Category: Cardiology Authors: Hung-Yuan ChenYen-Ling ChiuYi-Fang ChuangShih-Ping HsuMei-Fen PaiJu-Yeh YangYu-Sen Peng Source Type: research

Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus
Conclusions: Elevated circulating markers of endothelial dysfunction in young females with GDM history might reflect an early stage on the pathway to the manifestation of future cardiometabolic disorders. Timely identification of women at high risk and optimization of follow-up management might provide an opportunity to prevent disease progression. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 4, 2014 Category: Cardiology Authors: Christian GöblLatife BozkurtRajashri YarragudiThomas PrikoszovichAndrea TuraGiovanni PaciniRenate KoppensteinerAlexandra Kautzky-Willer Source Type: research

Endothelial Na + /H + exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal
Conclusion: MG elicits SGK1-dependent activation of endothelial Na+/H+ exchanger NHE1 which participates in MG-induced ROS production, upregulation of endothelial ICAM-1, leukocyte recruitment and microvascular hyperpermeability. Pharmacological inhibition of NHE1 attenuates the proinflammatory effects of excessive MG and may, thus, be beneficial in diabetes-associated inflammation. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 30, 2014 Category: Cardiology Authors: Syed QadriYang SuFrancisco CayabyabLixin Liu Source Type: research

Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes
Background: Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India. Methods: Type 2 diabetes patients from two secondary care diabetic centres (Europ...
Source: Cardiovascular Diabetology - September 26, 2014 Category: Cardiology Authors: Antonysunil AdaikalakoteswariRamamurthy JayashriNithya SukumarHema VenkataramanRajendra PradeepaKuppan GokulakrishnanRanjit AnjanaPhilip McTernanGyanendra TripathiVinod PatelSudhesh KumarViswanathan MohanPonnusamy Saravanan Source Type: research

A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy
Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. Howev...
Source: Cardiovascular Diabetology - September 13, 2014 Category: Cardiology Authors: Ren ZhangAbdul Abou-Samra Source Type: research

A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy
Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. Howev...
Source: Cardiovascular Diabetology - September 13, 2014 Category: Cardiology Authors: Ren ZhangAbdul Abou-Samra Source Type: research

Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism
Conclusions: This is the first report showing that high circulating adiponectin predicts increased CV mortality in men, but not in women with type 2 diabetes. Further studies are necessary to unravel the mechanisms through which adiponectin influences CV mortality in a sex-specific manner. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 10, 2014 Category: Cardiology Authors: Claudia MenzaghiMin XuLucia SalveminiConcetta De BonisGiuseppe PalladinoTao HuangMassimiliano CopettiYan ZhengYanping LiGrazia FiniFrank HuSimonetta BacciLu QiVincenzo Trischitta Source Type: research

Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3
Background: Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury. However, the mechanisms for this protection are poorly understood. Caveolae, sarcolemmal invaginations, and caveolins, scaffolding proteins in caveolae, localize molecules involved in cardiac protection. We tested the hypothesis that caveolae and caveolins are essential for exendin-4 induced cardiac protection using in vitro and in vivo studies in control and caveolin-3 (Cav-3) knockout mice (Cav-3 KO). Methods: Myocytes were treated with exendin-4 and then incubated with methyl-β...
Source: Cardiovascular Diabetology - September 7, 2014 Category: Cardiology Authors: Yasuo TsutsumiRie TsutsumiEisuke HamaguchiYoko SakaiAsuka KasaiYoshihiro IshikawaUtako YokoyamaKatsuya Tanaka Source Type: research

Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3
Background: Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury. However, the mechanisms for this protection are poorly understood. Caveolae, sarcolemmal invaginations, and caveolins, scaffolding proteins in caveolae, localize molecules involved in cardiac protection. We tested the hypothesis that caveolae and caveolins are essential for exendin-4 induced cardiac protection using in vitro and in vivo studies in control and caveolin-3 (Cav-3) knockout mice (Cav-3 KO). Methods: Myocytes were treated with exendin-4 and then incubated with methyl-?-cycl...
Source: Cardiovascular Diabetology - September 7, 2014 Category: Cardiology Authors: Yasuo TsutsumiRie TsutsumiEisuke HamaguchiYoko SakaiAsuka KasaiYoshihiro IshikawaUtako YokoyamaKatsuya Tanaka Source Type: research

Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients
Background: Brachial-ankle pulse wave velocity (baPWV) is a method to estimate arterial stiffness, which reflects the stiffness of both the aorta and peripheral artery; it would be applicable to general practice, since its measurementis automated. The aim of this study was to evaluate whether baPWV can be predictors of future cardiovascular events (CVE) in diabetic patients. Methods: We prospectively evaluated the association between baPWV or carotid intima-media thickness (carotid IMT) at baseline and new onset of CVE in 1040 type 2 diabetic patients without CVE. The predictability of baPWV and/or carotid IMT for identify...
Source: Cardiovascular Diabetology - September 5, 2014 Category: Cardiology Authors: Naoto KatakamiTakeshi OsonoiMitsuyoshi TakaharaMiyoko SaitouTaka-aki MatsuokaYoshimitsu YamasakiIichiro Shimomura Source Type: research

A score to quantify coronary plaque vulnerability in high-risk patients with type 2 diabetes: an optical coherence tomography study
Background: Patients with type 2 diabetes are at a high risk for acute cardiovascular events, which usually arise from the rupture of a vulnerable coronary lesion characterized by specific morphological plaque features. Thus, the identification of vulnerable plaques is of utmost clinical importance in patients with type 2 diabetes. However, there is currently no scoring system available to identify vulnerable lesions based on plaque characteristics. Thus, we aimed to characterize the diagnostic value of optical coherence tomography (OCT) - derived lesion characteristics to quantify plaque vulnerability both as individual p...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Mathias BurgmaierMartin HellmichNikolaus MarxSebastian Reith Source Type: research

Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models
Conclusions: We explored three animal models mimicking type 1 and 2 diabetes. While cardiac dysfunction was present in the three groups of mice, mitochondrial respiration impairment was only obvious in models reproducing features of type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Camille MarciniakXavier MarechalDavid MontaigneRemi NeviereSteve Lancel Source Type: research

Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease
Background: The interplay between the novel adipokine retinol-binding protein-4 (RBP4) and coronary artery disease (CAD) is still obscure. We investigated the relationship between RBP4 levels and the presence and severity of angiographically proven CAD and determined its possible role in acute myocardial infarction (AMI). Methods: 305 individuals with angiographically proven CAD (CAD-patients), were classified into 2 subgroups: 1) acute myocardial infarction (AMI, n?=?141), and 2) stable angina (SA, n?=?164). Ninety-one age- and sex-matched individuals without CAD, but with at least 2 classical cardiovascular risk factors,...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Vaia LambadiariNikolaos KadoglouVassilios StasinosEirini MaratouAias AntoniadisFotios KolokathisJohn ParissisErifili HatziagelakiEfstathios IliodromitisGeorge Dimitriadis Source Type: research

Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?
Conclusions: Increased heterogeneity of ventricular repolarization in type 2 diabetic patients was not reduced during the relatively short follow-up period despite significantly improved glycemic control. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Takayuki MikiToshiyuki TobisawaTatsuya SatoMasaya TannoToshiyuki YanoHiroshi AkasakaAtsushi KunoMakoto OgasawaraHiromichi MuraseShigeyuki SaitohTetsuji Miura Source Type: research

Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population
Background: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function. Methods: From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and p...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Takahiro FuseyaMasato FuruhashiSatoshi YudaAtsuko MuranakaMina KawamukaiTomohiro MitaShutaro IshimuraYuki WatanabeKyoko HoshinaMarenao TanakaKohei OhnoHiroshi AkasakaHirofumi OhnishiHideaki YoshidaShigeyuki SaitohKazuaki ShimamotoTetsuji Miura Source Type: research

Effects of the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) on biomedical outcomes, observed cardiovascular events and cardiovascular risks in primary care: a longitudinal comparative study
Background: To assess whether the Multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) led to improvements in biomedical outcomes, observed cardiovascular events and predicted cardiovascular risks after 12-month intervention in the primary care setting. Methods: A random sample of 1,248 people with diabetes enrolled to RAMP-DM for at least 12?months was selected and 1,248 people with diabetes under the usual primary care were matched by age, sex, and HbA1c level at baseline as the usual care group. Biomedical and cardiovascular outcomes were measured at baseline and at 12-m...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Fang JiaoColman FungCarlos WongYuk WanDaisy DaiRuby KwokCindy Lam Source Type: research

Nestin downregulation in rat vascular smooth muscle cells represents an early marker of vascular disease in experimental type I diabetes
Conclusions: Hyperglycaemia-mediated nestin downregulation and the concomitant reduction of cycling vascular smooth muscle cells represent early markers of vascular disease in experimental type I diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Kim TardifVanessa HertigCamille DumaisLouis VilleneuveLouis PerraultJean-François TanguayAngelino Calderone Source Type: research

Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease
Background: Although no receptor has yet been identified, changes in circulating levels of the adipokine designated as Omentin have been demonstrated in obesity and related comorbidities such as cardiovascular disease, insulin resistance, metabolic syndrome and chronic inflammation. Methods: Changes in Omentin levels at 1 and 5?days and 6 and 12?months in response to biliopancreatic diversion with duodenal switch bariatric surgery were evaluated, specifically to investigate if changes preceded gain of insulin sensitivity. Results: Pre-operative plasma Omentin was not different between men (n?=?18) vs women (n?=?48), or dia...
Source: Cardiovascular Diabetology - August 21, 2014 Category: Cardiology Authors: Marc LapointePaul PoirierJulie MartinMarjorie BastienAudrey AuclairKatherine Cianflone Source Type: research

Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B
Conclusions: These results suggest that in DM2, the most important predictor of HAPR is younger age. Younger DM2 patients may therefore require total daily ASA doses higher than 75 mg, preferably as a twice-daily regimen, to achieve full therapeutic effect. Higher BMI and lower HMW adiponectin concentration were also associated with less potent ASA effect. This is the first study to demonstrate an association of lower adiponectin concentration with higher serum TXB2 level in patients treated with ASA. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 15, 2014 Category: Cardiology Authors: Agnieszka Kaplon-CieslickaMarek PostulaMarek RosiakMichal PellerAgnieszka KondrackaAgnieszka SerafinEwa TrzeplaGrzegorz OpolskiKrzysztof Filipiak Source Type: research

EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice
Background: We have previously shown that EphrinA1/EphA expression profile changes in response to myocardial infarction (MI), exogenous EphrinA1-Fc administration following MI positively influences wound healing, and that deletion of the EphA2 Receptor (EphA2-R) exacerbates injury and remodeling. To determine whether or not ephrinA1-Fc would be of therapeutic value in the hyperglycemic infarcted heart, it is critical to evaluate how ephrinA1/EphA signaling changes in the hyperglycemic myocardium in response to MI. Methods: Streptozotocin (STZ)-induced hyperglycemia in wild type (WT) and EphA2-receptor mutant (EphA2-R-M) mi...
Source: Cardiovascular Diabetology - August 13, 2014 Category: Cardiology Authors: Augustin DuSablonSusan KentAnita CoburnJitka Virag Source Type: research

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice
Conclusions: Enhanced systolic function and reduced diastolic function indicates early ventricular remodeling in obese and diabetic mice. They have SAN dysfunction, and adrenoreceptor stimulation triggers cardiac arrhythmia originating in the SAN. Thus, dysfunction of the intrinsic cardiac pacemaker and remodeling of the autonomic nervous system may conspire to increase cardiac mortality in diabetic patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 12, 2014 Category: Cardiology Authors: Ewa SoltysinskaTobias SpeerschneiderSine WintherMorten Thomsen Source Type: research

Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies
Background: Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the most commonly used medication for patients with DM, on AF has not been investigated. The primary aim of this study was to examine whether metformin prevented the occurrence of AF in type 2 DM patients by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated the effect of metformin on tachycardia-induced myolysis and oxidative stress in atrial cells. Methods: The study popu...
Source: Cardiovascular Diabetology - August 10, 2014 Category: Cardiology Authors: Shang-Hung ChangLung-Sheng WuMeng-Jiun ChiouJia-Rou LiuKuang-Hui YuChang-Fu KuoMing-Shien WenWei-Jan ChenYung-Hsin YehLai-Chu See Source Type: research

Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program
Background: Growing evidence demonstrates subtle left ventricular myocardial dysfunction in patients with metabolic syndrome (MetS), with central obesity, glucose intolerance and inflammation emerging as important contributors. Whether these results can be translated to the right ventricle (RV) is not yet fully elucidated. Furthermore, although lifestyle intervention favorably impacts MetS components and inflammatory biomarkers, its effect on RV myocardial function remains unknown today. Methods: Thirty-nine MetS adults free of diabetes were enrolled in a three month lifestyle intervention program including diet and physic...
Source: Cardiovascular Diabetology - August 3, 2014 Category: Cardiology Authors: Juan Serrano-FerrerGuillaume WaltherEdward CrendalAgnès VinetFrédéric DutheilGeraldine NaughtonBruno LesourdRobert ChapierDaniel CourteixPhilippe Obert Source Type: research

High or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes
Background: We investigated the effects of dietary calcium (Ca) and magnesium (Mg) intakes on cardiovascular disease risks in older patients with diabetes. Methods: In this cross-sectional study, 197 patients with type 2 diabetes aged 65?years and above were recruited. The 24-h dietary recalls and 1-week self-reported typical dietary intake patterns were collected. The Ca and Mg intakes of 100% of RDA were defined as low, moderate, and high Ca and Mg intakes, respectively. Anthropometric measurements were determined and biochemical analysis of blood and urine was performed. Results: Our data indicated that 60.9% and 87.3% ...
Source: Cardiovascular Diabetology - August 1, 2014 Category: Cardiology Authors: Jui-Hua HuangLeih-Ching TsaiYu-Chen ChangFu-Chou Cheng Source Type: research

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage
Conclusions: Our data suggest that moderate hyperinsulinemia in response to insulin resistance or lowering of TNF-α levels within the aorta attenuates vascular damage, this protective effect being mediated by UCP-2 expression levels through iNOS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 31, 2014 Category: Cardiology Authors: Almudena Gómez-HernándezLiliana PerdomoNatalia de las HerasNuria BeneitÓscar EscribanoYolanda OteroCarlos GuillénSabela Díaz-CastroverdeBeatriz Gozalbo-LópezVictoria CachofeiroVicente LaheraManuel Benito Source Type: research