Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease
Conclusions: Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 17, 2013 Category: Cardiology Authors: Chi-Lun HuangYen-Wen WuChih-Cheng WuLin LinYu-Chin WuPei-Ying HsuYuh-Shiun JongWei-Shiung Yang Source Type: research

Insulin resistance is significantly associated with the metabolic syndrome, but not with sonographically proven peripheral arterial disease
ObjectiveInsulin resistance (IR) is the key feature of the metabolic syndrome (MetS); its association with peripheral arterial disease (PAD) is unclear. We hypothesized that IR is associated with both the MetS and sonographically proven PAD. Methods: IR was determined by the Homeostasis Model Assessment (HOMA) index in 214 patients with sonographically proven PAD as well as in 197 controls, who did not have a history of PAD and in whom coronary artery disease was ruled out angiographically; the MetS was defined according to NCEP-ATPIII criteria. Results: HOMA IR scores were significantly higher in MetS patients than in sub...
Source: Cardiovascular Diabetology - July 17, 2013 Category: Cardiology Authors: Alexander VonbankChristoph SaelyPhilipp ReinHeinz Drexel Source Type: research

Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension
Conclusions: Common genetic variants of FTO rs9939609 have positive associations with BMI and neck circumference and MC4R rs17782313 in women, but a negative association with diastolic and mean blood pressure in men with hypertension. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 12, 2013 Category: Cardiology Authors: Aline MarcadentiFlavio FuchsUrsula MatteFernanda SperbLeila MoreiraSandra Fuchs Source Type: research

Plaque vulnerability of coronary artery lesions is related to left ventricular dilatation as determined by optical coherence tomography and cardiac magnetic resonance imaging in patients with type 2 diabetes
This study investigated the to date incompletely understood relationship between plaque vulnerability and LV-dilatation using optical coherence tomography (OCT) and cardiac magnetic resonance imaging (CMR) in patients with type 2 diabetes and stable coronary artery disease. Methods: CMR was performed in 58 patients with type 2 diabetes, in which 81 coronary lesions were investigated using OCT. Results: A decreased minimal fibrous cap thickness (FCT) of coronary lesions was associated with an increase of several CMR-derived parameters including LV-end diastolic volume (LVEDV, r = 0.521, p
Source: Cardiovascular Diabetology - July 11, 2013 Category: Cardiology Authors: Mathias BurgmaierMichael FrickAna LibermanSimone BattermannMartin HellmichWalter LehmacherAgnes JaskolkaNikolaus MarxSebastian Reith Source Type: research

Effects of icosapent ethyl on lipid and inflammatory parameters in patients with diabetes mellitus-2, residual elevated triglycerides (200¿500 mg/dL), and on statin therapy at LDL-C goal: the ANCHOR study
Background: Icosapent ethyl (IPE) is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (>=500 mg/dL) hypertriglyceridemia. ANCHOR was a 12-week, phase 3 study that evaluated the efficacy and safety of IPE in patients (N = 702) with residual high fasting TG levels (>=200 and =40 and (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2013 Category: Cardiology Authors: Eliot BrintonChristie BallantyneHarold BaysJohn KasteleinRene BraeckmanParesh Soni Source Type: research

Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart
Conclusions: These data indicate that diabetes and exercise oppositely affect interactions between pro-hypertrophic transcription factors, and suggest that an increase in total cardiac O-GlcNAc is a mechanism by which exercise benefits type 2 diabetic hearts. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2013 Category: Cardiology Authors: Emily CoxSusan Marsh Source Type: research

Effects of icosapent ethyl on lipid and inflammatory parameters in patients with diabetes mellitus-2, residual elevated triglycerides (200--500 mg/dL), and on statin therapy at LDL-C goal: the ANCHOR study
Background: Icosapent ethyl (IPE) is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (>=500 mg/dL) hypertriglyceridemia. ANCHOR was a 12-week, phase 3 study that evaluated the efficacy and safety of IPE in patients (N = 702) with residual high fasting TG levels (>=200 and =40 and (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 9, 2013 Category: Cardiology Authors: Eliot BrintonChristie BallantyneHarold BaysJohn KasteleinRene BraeckmanParesh Soni Source Type: research

Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats
In this study, we evaluated the effects of caffeic acid phenethyl amide (CAPA) on glucose homeostasis and vascular function in streptozotocin (STZ)-induced type 1 diabetic rats. Methods: Diabetes (blood glucose levels> 350 mg/dL), was induced in Wistar rats by a single intravenous injection of 60 mg/kg STZ. Hypoglycemic effects were then assessed in normal and type 1 diabetic rats. In addition, coronary blood flow in Langendorff-perfused hearts was evaluated in the presence or absence of nitric oxide synthase (NOS) inhibitor. The thoracic aorta was used to measure vascular response to phenylephrine. Finally, the effect ...
Source: Cardiovascular Diabetology - July 6, 2013 Category: Cardiology Authors: Yi-Jin HoWen-Pin ChenTzong-Cherng ChiChing-Chia Chang ChienAn-Sheng LeeHsi-Lin ChiuYueh-Hsiung KuoMing-Jai Su Source Type: research

Hemoglobin A1c variability as an independent correlate of cardiovascular disease in patients with type 2 diabetes a cross-sectional analysis of the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study
This study was aimed at examining the association of HbA1c variability with cardiovascular disease (CVD) in the large cohort of subjects with type 2 diabetes from the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study. Methods: Serial (3--5) HbA1c values obtained during the 2-year period preceding recruitment, including that obtained at the enrolment, were available from 8,290 subjects from 9 centers (out of 15,773 patients from 19 centers). Average HbA1c and HbA1c variability were calculated as the intra-individual mean (HbA1c-MEAN) and standard deviation (HbA1c-SD), respectively, of 4.52+/-0....
Source: Cardiovascular Diabetology - July 5, 2013 Category: Cardiology Authors: Giuseppe PennoAnna SoliniGiacomo ZoppiniEmanuela OrsiCecilia FondelliGianpaolo ZerbiniSusanna MoranoFranco CavalotOlga LamacchiaRoberto TrevisanMonica VedovatoGiuseppe Pugliese Source Type: research

Stiffness memory of EA.hy926 endothelial cells in response to chronic hyperglycemia
Conclusions: Our results indicate that glycemic memory causes irreversible changes in stiffness of endothelialcells. The formation of the observed "stiffness memory" could be important in the context ofvascular complications which develop despite the normalization of the glucose level. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 27, 2013 Category: Cardiology Authors: Marta Targosz-KoreckaGrzegorz BrzezinkaKatarzyna MalekEwa Ste¿pie¿Marek Szymonski Source Type: research

Vitamin C further improves the protective effect of GLP-1 on the ischemia-reperfusion-like effect induced by hyperglycemia post-hypoglycemia in type 1 diabetes
Conclusions: This study shows that GLP-1 infusion, during induced hyperglycemia post hypoglycemia, reduces the generation of oxidative stress and inflammation, improving the endothelial dysfunction, in type 1 diabetes. Furthermore, the data support that vitamin C and GLP-1 may have an additive protective effect in such condition. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 27, 2013 Category: Cardiology Authors: Antonio CerielloAnna NovialsEmilio OrtegaSilvia CanivellGemma PujadasLucia La SalaLoredana BucciarelliMaurizio RondinelliStefano Genovese Source Type: research

Stiffness memory of EA.hy926 endothelial cells in response to chronic hyperglycemia
Conclusions: Our results indicate that glycemic memory causes irreversible changes in stiffness of endothelialcells. The formation of the observed "stiffness memory" could be important in the context ofvascular complications which develop despite the normalization of the glucose level. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 27, 2013 Category: Cardiology Authors: Marta Targosz-KoreckaGrzegorz BrzezinkaKatarzyna MalekEwa StepienMarek Szymonski Source Type: research

Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study
This study examined the utility of HDL-associated single nucleotide polymorphisms (SNPs) for CVD risk prediction in European Americans with T2D enrolled in the Diabetes Heart Study (DHS). Methods: Genetic risk scores (GRS) of HDL-associated SNPs were constructed and evaluated for potential associations with mortality and with coronary artery calcified atherosclerotic plaque (CAC), a measure of subclinical CVD strongly associated with CVD events and mortality. Two sets of SNPs were used to construct GRS; while all SNPs were selected primarily for their impacts on HDL, one set of SNPs had pleiotropic effects on other lipid p...
Source: Cardiovascular Diabetology - June 25, 2013 Category: Cardiology Authors: Laura RaffieldAmanda CoxFang-Chi HsuMaggie NgCarl LangefeldJ CarrBarry FreedmanDonald Bowden Source Type: research

Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus
ObjectiveType 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism is uncertain. We postulated that arterial stiffness, endothelial dysfunction and subclinical atherosclerosis may contribute to subclinical myocardial injury in patients with T2DM. Methods: Serum high-sensitivity troponin I (hs-TNI) an indicator of myocardial injury, was measured in 100 patients with T2DM without clinical evidence of macrovascular disease and 150 age and gender-matched controls. Elevated hs-TnI was defined as follow (derived from the 99th percentile from controls): Male>11.1 ng/L; f...
Source: Cardiovascular Diabetology - June 22, 2013 Category: Cardiology Authors: Kai-Hang YiuChun-Ting ZhaoYan ChenChung-Wah SiuYap-Hang ChanKui-Kai LauShasha LiuChu-Pak LauHung-Fat Tse Source Type: research

Association of arterial stiffness with single nucleotide polymorphism rs1333049 and metabolic risk factors
Background: Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction. Increased arterial stiffness could be the link between the 9p21 polymorphism and increased cardiovascular risk. Since the impact of a genetic polymorphism on arterial stiffness especially in Asian populations has not been well defined, we therefore aimed to investigate the association o...
Source: Cardiovascular Diabetology - June 21, 2013 Category: Cardiology Authors: Suphawadee PhababphaUpa KukongviriyapanPoungrat PakdeechoteLaddawan SenggunpraiVeerapol KukongviriyapanChatri SettasatianPyatat TatsanavivatPhongsak IntharaphetVichai SenthongNantarat KomanasinNongnuch SettasatianStephen Greenwald Source Type: research

Miglitol improves postprandial endothelial dysfunction in patients with acute coronary syndrome and new-onset postprandial hyperglycemia
Conclusions: Postprandial changes in glucose are related to endothelial dysfunction in ACS. Miglitol-based improvement in PPHG appears to improve endothelial function. The effect of miglitol on glucose-dependent endothelial function might improve outcomes of ACS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 19, 2013 Category: Cardiology Authors: Daisuke KitanoMasaaki ChikuYuxin LiYasuo OkumuraDaisuke FukamachiTadateru TakayamaTakafumi HiroSatoshi SaitoAtsushi Hirayama Source Type: research

Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats
Background: Diabetic patients, through incompletely understood mechanisms, endure exacerbated ischemic heart injury compared to non-diabetic patients. Intermedin (IMD) is a novel calcitonin gene-related peptide (CGRP) superfamily member with established cardiovascular protective effects. However, whether IMD protects against diabetic myocardial ischemia/reperfusion (MI/R) injury is unknown. Methods: Diabetes was induced by streptozotocin in Sprague--Dawley rats. Animals were subjected to MI via left circumflex artery ligation for 30 minutes followed by 2 hours R. IMD was administered formally 10 minutes before R. Outcome m...
Source: Cardiovascular Diabetology - June 18, 2013 Category: Cardiology Authors: Hong LiYunfei BianNana ZhangJia GuoCheng WangWayne LauChuanshi Xiao Source Type: research

Glucagon-like peptide-1 (GLP-1) and protective effects in cardiovascular disease: a new therapeutic approach for myocardial protection
Glucagon-like peptide-1 (GLP-1) is a member of the proglucagon incretin family implicated in the control of appetite and satiety. GLP-1 has insulinotropic, insulinomimetic, and glucagonostatic effects, thereby exerting multiple complementary actions to lower blood glucose in subjects with type 2 diabetes mellitus. A major advantage over conventional insulin is the fact that the insulinotropic actions of GLP-1 are dependent upon ambient glucose concentration, mitigating the risks of hypoglycemia. Recently, the crucial role of GLP-1 in cardiovascular disease has been suggested in both preclinical and clinical studies. The ex...
Source: Cardiovascular Diabetology - June 18, 2013 Category: Cardiology Authors: Ting Zhao Source Type: research

Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model
Conclusions: Our data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 18, 2013 Category: Cardiology Authors: Eduardo MorvanNathalia LimaJacqueline MachiCristiano MostardaKátia De AngelisMaria IrigoyenRogério WichiBruno RodriguesLaura Maifrino Source Type: research

Vascular complications and changes in body mass index in Japanese type 2 diabetic patients with abdominal obesity
Background: Although many Asian type 2 diabetic patients have been considered to be not obese and have low capacity of insulin secretion, the proportion of obese patients with visceral fat accumulation has increased in recent years. We found previously considerable number of Japanese non-obese subjects (body mass index (BMI) =85 cm for males and>=90 cm for females (corresponding to visceral fat area of 100 cm2). Subjects were divided into two groups; with or without abdominal obesity. Results: Hypertension, dyslipidemia and cardiovascular diseases were significantly more in the patients with abdominal obesity. The preva...
Source: Cardiovascular Diabetology - June 18, 2013 Category: Cardiology Authors: Hirofumi NagaoSusumu KashineHitoshi NishizawaTakuya OkadaTakekazu KimuraAyumu HirataShiro FukudaJunji KozawaNorikazu MaedaTetsuhiro KitamuraTetsuyuki YasudaKohei OkitaToshiyuki HibuseMamiko TsugawaAkihisa ImagawaTohru FunahashiIichiro Shimomura Source Type: research

Comparative effect of clopidogrel and aspirin versus aspirin alone on laboratory parameters: a retrospective, observational, cohort study
Conclusion: Our findings suggested that hematological adverse effects may be greater with combination therapy of clopidogrel plus aspirin than with aspirin monotherapy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 14, 2013 Category: Cardiology Authors: Yasuo TakahashiYayoi NishidaTomohiro NakayamaSatoshi Asai Source Type: research

Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients
Background: In the general population, metabolic syndrome (MetS) is correlated with visceral fat and a risk factor for cardiovascular disease (CVD); however, little is known about the significance of abdominal fat and its association with inflammation and medication use in peritoneal dialysis (PD) patients. We investigated the relationship of visceral fat area (VFA) with C-reactive protein (CRP) levels and medication use in PD patients and followed their clinical outcomes. Methods: In a prospective study from February 2009 to February 2012, we assessed diabetes mellitus (DM) status, clinical and PD-associated characteristi...
Source: Cardiovascular Diabetology - June 8, 2013 Category: Cardiology Authors: Jenq-Wen HuangChung-Yi YangHon-Yen WuKao-Lang LiuChi-Ting SuCho-Kai WuJen-Kuang LeeChih-Kang ChiangHui-Teng ChengYu-Chung LienKuan-Yu Hung Source Type: research

Remodelling of the intracardiac ganglia in diabetic Goto-Kakizaki rats: an anatomical study
Background: Although cardiac autonomic neuropathy is one of major complications of diabetes mellitus (DM), anatomical data on cardiac innervation of diabetic animal models is scant and controversial. We performed this study to check whether long-term diabetic state impacts the anatomy of intracardiac ganglia in Goto-Kakizaki (GK) rats, a genetic model of type 2 DM. Methods: Twelve GK rats (276 +/- 17 days of age; mean +/- standard error) and 13 metabolically healthy Wistar rats (262 +/- 5 days of age) as controls were used for this study. Blood glucose was determined using test strips, plasma insulin by radioimmunoassay. I...
Source: Cardiovascular Diabetology - June 7, 2013 Category: Cardiology Authors: Darius BatuleviciusThomas FreseElmar PeschkeDainius PauzaVaida Batuleviciene Source Type: research

New concept of myocardial longitudinal strain reserve assessed by a dipyridamole infusion using 2D-strain echocardiography: the impact of diabetes and age, and the prognostic value
AimsAlthough dipyridamole is a widely used pharmacological stress agent, the direct effects on myocardium are not entirely known. Diabetic cardiomyopathy can be investigated by 2D-strain echocardiography. The aim of this study was to assess myocardial functional reserve after dipyridamole infusion using speckle-tracking echocardiography. Methods: Seventy-five patients referred for dipyridamole stress myocardial perfusion gated SPECT (MPGS) were examined by echocardiography to assess a new concept of longitudinal strain reserve (LSR) and longitudinal strain rate reserve (LSRR) respectively defined by the differences of glob...
Source: Cardiovascular Diabetology - June 7, 2013 Category: Cardiology Authors: Thomas CognetPaul-Louis VervuerenLaurent DercleDelphine BastiéRainui RichaudMatthieu BerryPauline MarchalMatthieu GautierAudrey FouillouxMichel GalinierDidier CarriéPierre MassabuauIsabelle BerryOlivier Lairez Source Type: research

Diabetes severity and the role of leisure time physical exercise on cardiovascular mortality: the Nord-Tr[latin small letter o with stroke]ndelag Health study (HUNT), Norway
Conclusions: The data suggest a more favourable effect of exercise in people with diabetes who used medication than in those who did not, suggesting that physical exercise should be encouraged as a therapeutic measure additional to medical treatment. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 6, 2013 Category: Cardiology Authors: Børge MoeLiv Berit AugestadTom Nilsen Source Type: research

Selective peroxisome proliferator-activated receptoralpha modulators (SPPARMalpha): The next generation of peroxisome proliferator-activated receptor alpha-agonists
Dyslipidemia is a major risk factor for cardiovascular (CV) disease -- the primary cause of death, worldwide. Although reducing levels of low-density lipoprotein-cholesterol can significantly reduce CV risk, a high level of residual risk persists, especially in people with obesity-related conditions, such as metabolic syndrome and type 2 diabetes mellitus. Peroxisome proliferator-activated receptor alpha- (PPARalpha-) agonists (e.g. fibrates), play a central role in the reduction of macro- and microvascular risk in these patients. However, the currently available fibrates are weak (PPARalpha-agonists) with limited efficacy...
Source: Cardiovascular Diabetology - May 31, 2013 Category: Cardiology Authors: Jean-Charles Fruchart Source Type: research

Management of hyperglycemia in type 2 diabetes: evidence and uncertainty
The panoply of treatment algorithms, periodically released to improve guidance, is one mean to face therapeutic uncertainty in pharmacological management of hyperglycemia in type 2 diabetes, especially after metformin failure. Failure of recent guidelines to give advice on the use of specific antidiabetic drugs in patients with co-morbidity may generate further uncertainty, given the frequent association of type 2 diabetes with common comorbidity, including, although not limited to obesity, cardiovascular disease, impaired renal function, and frailty. The Italian Association of Diabetologists (Associazione Medici Diabetolo...
Source: Cardiovascular Diabetology - May 30, 2013 Category: Cardiology Authors: Katherine EspositoSandro GentileRiccardo CandidoAlberto De MicheliMarco GalloGerardo MedeaAntonio Ceriello Source Type: research

High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells
Conclusion: High glucose can increase the expression of the scavenger receptors SR-A, CD36 and LOX-1, which can increase the oxLDL-uptake capacity of DCs. High glucose induces a proinflammatory cytokine profile in human DCs, leading to DC maturation. These results support the hypothesis that atherosclerosis is aggravated by hyperglycaemia-induced DC activation and oxLDL uptake. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 29, 2013 Category: Cardiology Authors: Hao LuKang YaoDong HuangAijun SunYunzeng ZouJuying QianJunbo Ge Source Type: research

HbA1c versus oral glucose tolerance test as a method to diagnose diabetes mellitus in vascular surgery patients
Background: The diagnosis of diabetes mellitus (DM) is based on either fasting plasma glucose levels or an oral glucose tolerance test (OGTT). Recently, an HbA1c value of>= 48 mmol/mol (6.5%) has been included as an additional test to diagnose DM. The purpose of this study was to validate HbA1c versus OGTT as a method to diagnose DM in vascular surgery patients. Methods: The study population consisted of 345 patients admitted consecutively due to peripheral arterial disease. Sixty-seven patients were previously diagnosed with DM. Glucose levels of OGTT and HbA1c values were analyzed in 275 patients. The OGTT results wer...
Source: Cardiovascular Diabetology - May 25, 2013 Category: Cardiology Authors: Irene HjellestadMarianne AstorRoy NilsenEirik SøftelandTobjørn Jonung Source Type: research

Sex-specific-differences in cardiometabolic risk in type 1 diabetes: a cross-sectional study
Conclusions: Our data showed sex differences in lipids and overweight in patients with T1DM. Although glycaemic control and the frequency of diabetic complications were comparable between the sexes, the overall adherence to guidelines, particularly with respect to the prescription of statins and aspirin, was lower in women than in men. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 24, 2013 Category: Cardiology Authors: Alexandra Kautzky-WillerKathrin StichJuliane HintersteinerAlexander KautzkyMajid Reza KamyarJohannes SaukelJulienne JohnsonRosa Lemmens-Gruber Source Type: research

Association between non-alcoholic fatty pancreatic disease (nafpd) and the metabolic syndrome: case¿control retrospective study
Conclusion: The presence of fatty pancreas represents a meaningful manifestation of metabolic syndrome together with obesity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 20, 2013 Category: Cardiology Authors: Wan-Chen WuChih-Yuan Wang Source Type: research

Association between non-alcoholic fatty pancreatic disease (nafpd) and the metabolic syndrome: case--control retrospective study
Conclusion: The presence of fatty pancreas represents a meaningful manifestation of metabolic syndrome together with obesity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 20, 2013 Category: Cardiology Authors: Wan-Chen WuChih-Yuan Wang Source Type: research

Neck circumference as an independent predictive contributor to cardio-metabolic syndrome
Conclusions: Neck circumference was significantly associated with cardio-metabolic risk factors and independently contributed to the prediction of cardio-metabolic risks beyond the classical anthropometric indices in adults of China. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 16, 2013 Category: Cardiology Authors: Jing-ya ZhouHui GeMing-fan ZhuLi-jun WangLi ChenYao-zong TanYu-ming ChenHui-lian Zhu Source Type: research

Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction
Conclusions: We conclude that Kir6.2 subunits are critical in resistance to endotoxemia-induced cardiac dysfunction through reducing myocardial damage by inhibition of apoptosis and inflammation. KATP channels blockers are extensively used in the treatment of diabetes, their potential role should therefore be considered in the clinic when patients treated with antidiabetic sulfonylureas are complicated by endotoxemia. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 9, 2013 Category: Cardiology Authors: Zhong-Wei YangJi-Kuai ChenMin NiTing ZhaoYa-Ping DengXia TaoGuo-Jun JiangFu-Ming Shen Source Type: research

Impact of post-challenge hyperglycemia on clinical outcomes in japanese patients with stable angina undergoing percutaneous coronary intervention
Background: Post-challenge hyperglycemia (PH) is well-established as one of risk factors for coronary artery disease. However, it remains unclear whether PH affects clinical outcomes in patients with stable angina undergoing percutaneous coronary intervention (PCI). Methods: A total of 828 patients with stable angina undergoing PCI were retrospectively analyzed. Of these, 452 patients with previously diagnosed diabetes mellitus (DM) or fasting plasma glucose (PG)>=126 mg/dl and HbA1c>=6.5% were defined as known DM. The remaining 376 patients were divided into the two groups according to 2-h PG: PH (2-h PG>=140 mg/...
Source: Cardiovascular Diabetology - May 7, 2013 Category: Cardiology Authors: Shoichi KuramitsuHiroyoshi YokoiTakenori DomeiAkihiro NomuraHirotoshi WatanabeKyohei YamajiYoshimitsu SogaTakeshi AritaKatsuhiro KondoShinichi ShiraiKenji AndoKoyu SakaiMasashi IwabuchiHedeyuki NosakaMasakiyo Nobuyoshi Source Type: research

Parallel evolution of circulating FABP4 and NT-proBNP in heart failure patients
Background: Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. In vitro, FABP4 has exhibited cardiodepressant activity by suppressing cardiomyocyte contraction. We have explored the relationship between FABP4 and the N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) as a clinical parameter of heart failure (HF). Methods: We included 179 stable HF patients who were referred to a specialized HF unit, 108 of whom were prospectively followed for up to 6 months. A group of 163 non-HF patients...
Source: Cardiovascular Diabetology - May 4, 2013 Category: Cardiology Authors: Anna CabréPilar ValdovinosIolanda LázaroGil BonetAlfredo BardajíLluís Masana Source Type: research

Effects of 24-week treatment with acarbose on glucagon-like peptide 1 in newly diagnosed type 2 diabetic patients: a preliminary report
Conclusions: Twenty-four weeks of acarbose monotherapy in newly diagnosed patients with T2D is associated with significantly increased levels of both fasting and postprandial GLP-1 as well as significantly increased NO levels and NOS activity for those patients in whom postprandial GLP-1 levels were increased. Therefore, the benefits of acarbose on cardiovascular risk may be related to its stimulation of GLP-1 secretion. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 4, 2013 Category: Cardiology Authors: Miao-yan ZhengJu-hong YangChun-yan ShanHong-tao ZhouYan-guang XuYing WangHui-zhu RenBao-cheng ChangLi-ming Chen Source Type: research

Effects of co-administration of candesartan with pioglitazone on inflammatory parameters in hypertensive patients with type 2 diabetes mellitus: a preliminary report
Conclusions: Our data suggest that the pulse pressure value at baseline is a key predictive factor of changes in HbA1c. Co-administration of candesartan with pioglitazone, which have anti-inflammatory (changes in HMW-ADN and PAI-1) effects and protective effects on organs, could be an effective therapeutic strategy for treating hypertensive patients with type 2 diabetes mellitus.Trial registration: UMIN-CTR: UMIN000010142 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 2, 2013 Category: Cardiology Authors: Hirofumi SuzukiMasaya SakamotoTakeshi HayashiHiroyuki IuchiKennosuke OhashiTsuyoshi IsakaNoriko SakamotoYosuke KayamaKatsuyoshi TojoMichihiro YoshimuraKazunori Utsunomiya Source Type: research

The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study
Conclusions/interpretation: Single doses of empagliflozin 25 mg and 200 mg were not associated with QTcN prolongation and were well tolerated in healthy volunteers.Trial registration: ClinicalTrials.gov: NCT01195675 (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 24, 2013 Category: Cardiology Authors: Arne RingTobias BrandSreeraj MachaKerstin Breithaupt-GroeglerGudrun SimonsBeate WalterHans WoerleUli Broedl Source Type: research

TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction
Conclusion: TRPV1 activation by capsaicin might protect against hyperglycemia-induced endothelial dysfunction through a mechanism involving the PKA/UCP2 pathway. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 22, 2013 Category: Cardiology Authors: Jing SunYunfei PuPeijian WangSijiao ChenYu ZhaoChan LiuQianhui ShangZhiming ZhuDaoyan Liu Source Type: research

Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the diabetes heart study
Background: Risk stratification in individuals with type 2 diabetes (T2D) remains an important priority in the management of associated morbidity and mortality, including from cardiovascular disease (CVD). The current investigation examined whether estimated glomerular filtration rate (eGFR) and urine albumin:creatinine ratio (UACR) were independent predictors of CVD-mortality in European Americans (EAs) with T2D after accounting for subclinical CVD. Methods: The family-based Diabetes Heart Study (DHS) cohort (n=1,220) had baseline measures of serum creatinine, eGFR, UACR and coronary artery calcified plaque (CAC) assessed...
Source: Cardiovascular Diabetology - April 18, 2013 Category: Cardiology Authors: Amanda CoxFang-Chi HsuJ CarrBarry FreedmanDonald Bowden Source Type: research

Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes
This study investigated whether common single nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with the risk of coronary artery disease (CAD) and its angiographical severity in type 2 diabetes in Chinese population. Methods: 11 tagging SNPs were genotyped in 1110 subjects with or without CAD in type 2 diabetes. Variants of adiponectin gene were determined by Taqman polymerase chain reaction method. The plasma adiponectin concentrations were measured by sandwich enzyme-linked immunosorbent assay. The severity and extent of coronary atherosclerosis w...
Source: Cardiovascular Diabetology - April 17, 2013 Category: Cardiology Authors: Guoxin TongNingfu WangJianhang LengXiaoshan TongYun ShenJianmin YangXianhua YeLiang ZhouYujie Zhou Source Type: research

Early impairment of contractility reserve in patients with insulin resistance in comparison with healthy subjects
Background: Insulin resistance (IR) is currently considered a crucial cardiovascular (CV) risk factor, which seems to play a dominant role in the evolution toward cardiac and vascular impairment. Early IR-induced cardiac dysfunction can be assessed by Doppler-derived myocardial systolic strain rate (SR) index, measured at baseline and after dobutamine stress echocardiography (DSE). Methods: Thirty IR patients (HOMA-IR = 7 +/- 5.2, age 52.6 +/- 2.1 years), and 20 healthy, age and sex matched controls were studied. IR had been diagnosed in all patients in the 3 months preceding the study. Dobutamine echocardiography was perf...
Source: Cardiovascular Diabetology - April 16, 2013 Category: Cardiology Authors: Christian CadedduSilvio NoccoDavide PianoMartino DeiddaEfisio CossuMarco BaroniGiuseppe Mercuro Source Type: research

Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis
Background: Although hypercaloric interventions are associated with nutritional, endocrine, metabolic, and cardiovascular disorders in obesity experiments, a rational distinction between the effects of excess adiposity and the individual roles of dietary macronutrients in relation to these disturbances has not previously been studied. This investigation analyzed the correlation between ingested macronutrients (including sucrose and saturated and unsaturated fatty acids) plus body adiposity and metabolic, hormonal, and cardiovascular effects in rats with diet-induced obesity. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 15, 2013 Category: Cardiology Authors: Silvio JuniorCarlos PadovaniSergio RodriguesNilza SilvaPaula MartinezDijon CamposMarina OkoshiKatashi OkoshiMaeli PaiAntonio Cicogna Source Type: research

The adaptability of red blood cells
The most important function of red blood cells (RBCs) is the carrying of oxygen, but they are also involved in inflammatory processes and during coagulation. RBCs are extremely deformable and elastic, as they are exposed to shear forces as they travel through the vascular system. In inflammatory conditions, and in the presence of hydroxyl radicals, RBCs loose their discoid shape. Here, ultrastructure of RBCs is studied using a scanning electron microscope, and we determine how fast changes in healthy individuals are noted after exposure to iron and glucose. We compare shape changes in these experiments to RBCs from diabeti...
Source: Cardiovascular Diabetology - April 11, 2013 Category: Cardiology Authors: Etheresia Pretorius Source Type: research

Asymmetric dimethylarginine predicts decline of glucose tolerance in men with stable coronary artery disease: a 4.5-year follow-up study
Conclusions: ADMA predicts future deterioration of glucose tolerance independently of baseline insulin resistance in men with stable CAD. Whether this association reflects a contribution of endothelial dysfunction to accelerated decline of insulin sensitivity, or represents only an epiphenomenon accompanying pre-diabetes, remains to be elucidated. The observed relationship might contribute to the well-recognized ability of ADMA to predict cardiovascular outcome. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 11, 2013 Category: Cardiology Authors: Andrzej SurdackiOlga KruszelnickaTomasz RakowskiAleksandra Ja¿wi¿ska-KozubaJacek Dubiel Source Type: research

The role of co-morbidity in the selection of antidiabetic pharmacotherapy in type-2 diabetes
Metformin is, if not contraindicated and if tolerated, usually preferred over other antidiabetic drugs for the first line treatment of type-2 diabetes. The particular decision on which antidiabetic agent to use is based on variables such as efficacy, cost, potential side effects, effects on weight, comorbidities, hypoglycemia, risk, and patient preferences. However, there is no guidance how to consider these in the selection of antidiabetic drug treatment. In this work, we aimed to summarize available evidence and tried to give pragmatic treatment recommendations from a clinical practice perspective.There are clear contrai...
Source: Cardiovascular Diabetology - April 10, 2013 Category: Cardiology Authors: Diethelm TschöpeMarkolf HanefeldJuris MeierAnselm GittMartin HallePeter BramlagePetra-Maria Schumm-Draeger Source Type: research

Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
Conclusions: Diabetes abrogates the protective effect of gender on non-diabetic women, and postmenopausal diabetic females presented worsen cardiometabolic risk, including a more atherogenic lipid sketch and a pro-inflammatory and pro-angiogenic profile. The classical cardiovascular risk factors (CVRFs) fail to completely explain these differences, which are better clarified using "non-traditional" factors, such as HDL-c subpopulations, rather than total HDL-c content, and markers of inflammation and angiogenesis, namely TNF-alpha, hsCRP, uric acid and VEGF. Multi-therapeutic intervention, directed to obesity, at...
Source: Cardiovascular Diabetology - April 9, 2013 Category: Cardiology Authors: Filipa Mascarenhas-MeloDaniela MaradoFilipe PalavraJosé SerenoÁlvaro CoelhoRui PintoEdite Teixeira-LemosFrederico TeixeiraFlávio Reis Source Type: research

Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials
Background: In patients with type 2 diabetes mellitus (T2DM), hypertension and microalbuminuria are predictive markers for increased renal and cardiovascular risk. This post hoc analysis of data from a global development program aimed to evaluate the efficacy and safety of linagliptin in a population with joint prevalence of these two vascular risk factors. Methods: Data for patients with baseline microalbuminuria (urine albumin-to-creatinine ratio 30--300 mg/g) and hypertension (systolic blood pressure>= 140 mm Hg and/or diastolic blood pressure>= 90 mm Hg and/or a history of hypertension; and/or an antihypertensive...
Source: Cardiovascular Diabetology - April 9, 2013 Category: Cardiology Authors: Maximilian von EynattenYan GongAngela EmserHans-Juergen Woerle Source Type: research

Vildagliptin in addition to metformin improves retinal blood flow and erythrocyte deformability in patients with type 2 diabetes mellitus -- results from an exploratory study
This study investigated effects of vildagliptin in comparison to glimepiride on retinal microvascular blood flow and erythrocyte deformability in T2DM.Fourty-four patients with T2DM on metformin monotherapy were included in this randomized, exploratory study over 24 weeks. Patients were randomized to receive either vildagliptin (50 mg twice daily) or glimepiride individually titrated up to 4 mg in addition to ongoing metformin treatment. Retinal microvascular blood flow (RBF) and the arteriolar wall to lumen ratio (WLR) were assessed using a laser doppler scanner. In addition, the erythrocyte elongation index (EI) was meas...
Source: Cardiovascular Diabetology - April 8, 2013 Category: Cardiology Authors: Christine Berndt-ZipfelGeorg MichelsonMarkus DworakMichael MitryAndrea LöfflerAndreas PfütznerThomas Forst Source Type: research