REVERBA couples the circadian clock to Leydig cell steroidogenesis
This study aimed to confirm the role of the REVERBA (NR1D1) gene in controlling the transcription of key genes related to Leydig cell steroid production. We investigated daily variations by collecting Leydig cells from rats at various times within a 24-h period. Chromatin immunoprecipitation study showed a time-dependent pattern for genes linked to steroid production (Nur77,Star,Cyp11a1, andCyp17a1), which closely matched the 24-h REVERBA levels in Leydig cells, peaking between zeitgeber time (ZT) 7 –11. To understand the physiological significance of REVERBA's interaction with promoters of steroidogenesis-related genes,...
Source: BioFactors - December 27, 2023 Category: Biochemistry Authors: Aleksandar Z. Baburski,
Alisa P. Becin,
Dijana Z. Travicic,
Marija L J. Medar,
Silvana A. Andric,
Tatjana S. Kostic Tags: RESEARCH ARTICLE Source Type: research
Epigallocatechin ‐3‐gallate attenuates arsenic‐induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, is known to have antioxidant and epigenetic modulation properties. Whether EGCG, through its antioxidant and epigenetic modulating activities, can attenuate fibrogenesis is not known. In this context, the novel findings of this study suggest that EGCG, through its antioxidant and epigenetic modulation capacities, has protective effects against arsenic-induced cytotoxicity and fibrogenic changes in kidney epithelial cells. AbstractRenal fibrosis is a pathogenic intermediate stage of chronic kidney disease (CKD). Nephrotoxicants including arsenic can cause kidney fib...
Source: BioFactors - December 26, 2023 Category: Biochemistry Authors: Mary Sonia Iheanacho,
Ramji Kandel,
Priti Roy,
Kamaleshwar P. Singh Tags: RESEARCH ARTICLE Source Type: research
Correction to “Attenuative role of mangiferin in oxidative stress mediated liver dysfunction in arsenic intoxicated murines”
(Source: BioFactors)
Source: BioFactors - December 23, 2023 Category: Biochemistry Tags: CORRECTION Source Type: research
PON1 has palmitoyl ‐protein thioesterase (PPT) activity, and can affect the presence of SR‐B1 on the endothelial cell membrane
This study shows that PON1 can hydrolyze palmitoyl-cysteine thioester bonds in vitro, has direct or indirect PPT activity in vivo, and can significantly decrease the presence of SR-B1 in the endothelial membrane. (Source: BioFactors)
Source: BioFactors - December 23, 2023 Category: Biochemistry Authors: Rasha Ashkar,
Ali Khattib,
Sanaa Musa,
Doron Goldberg,
Soliman Khatib Tags: RESEARCH ARTICLE Source Type: research
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration
Extracellular vesicles paracrine effects play a primary role in the regenerative ability. EVs and the bioactive molecules contained in the human dental pulp stem cells influence the differentiation process toward cardiomyogenic lineage. Differentiation of dental pulp stem cells into cardiomyocytes induced by EVs derived modulating the differentiation process toward cardiomyogenic lineage. AbstractMesenchymal stem cells (MSCs) treatment has been widely explored as a therapy for myocardial infarction, peripheral ischemic vascular diseases, dilated cardiomyopathy, and pulmonary hypertension. Latest in vitro studies suggest th...
Source: BioFactors - December 22, 2023 Category: Biochemistry Authors: Francesca Diomede,
Simone Guarnieri,
Paola Lanuti,
Fani Konstantinidou,
Valentina Gatta,
Thangavelu Soundara Rajan,
Sante D. Pierdomenico,
Oriana Trubiani,
Guya Diletta Marconi,
Jacopo Pizzicannella Tags: RESEARCH ARTICLE Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - December 18, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - December 18, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Melatonin protects Kir2.1 function in an oxidative stress ‐related model of aging neuroglia
The inward rectifying K+ channel Kir2.1 plays a major role in extracellular potassium buffering in the brain. Here we show that in cellular models of aging neuroglia characterized by an elevated oxidative stress, the Kir2.1-induced current is dramatically reduced. This loss of function resulted from a reduction in protein abundance, with no alterations in transcript levels and trafficking to the cell surface. Importantly, the antioxidant biofactor melatonin reverted these changes. We suggest that inhibition of Kir2.1 function by oxidative stress might alter the extracellular K+ buffering in the brain, therefore contributin...
Source: BioFactors - December 15, 2023 Category: Biochemistry Authors: Alessia Remigante,
Sara Spinelli,
Paolo Zuccolini,
Paola Gavazzo,
Angela Marino,
Michael Pusch,
Rossana Morabito,
Silvia Dossena Tags: RESEARCH ARTICLE Source Type: research
Preface
(Source: BioFactors)
Source: BioFactors - December 12, 2023 Category: Biochemistry Authors: Maria Fabiana Drincovich Tags: PREFACE Source Type: research
