A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF ‐κB inhibition and Nrf2 activation
AbstractDifferent toxins, including chemicals and natural, can be entered from various routes and influence human health. Herbal medicines and their active components can attenuate the toxicity of agents via multiple mechanisms. For example, kaempferol, as a flavonoid, can be found in fruits and vegetables, and has an essential role in improving disorders such as cardiovascular disorders, neurological diseases, cancer, pain, and inflammation situations. The beneficial effects of kaempferol may be related to the inhibition of oxidative stress, attenuation of inflammatory factors such as tumor necrosis factor-alpha (TNF- α)...
Source: BioFactors - December 6, 2022 Category: Biochemistry Authors: Azar Hosseini,
Alieh Alipour,
Vafa Baradaran Rahimi,
Vahid Reza Askari Tags: REVIEW ARTICLE Source Type: research
Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy
AbstractFerroptosis is a form of regulated cell death (RCD) characterized by intracellular iron ion accumulation and reactive oxygen species (ROS)-induced lipid peroxidation. Ferroptosis in cancer and ferroptosis-related anticancer drugs have recently gained interest in the field of cancer treatment. Boron is an essential trace element playing an important role in several biological processes. Recent studies have described contrasting effects of boric acid (BA) in cancer cells, ranging from protective/mitogenic to damaging/antiproliferative. Interestingly, boron has been shown to interfere with critical factors involved in...
Source: BioFactors - December 5, 2022 Category: Biochemistry Authors: Alessandro Corti,
Silvia Dominici,
Simona Piaggi,
Alfonso Pompella Tags: RESEARCH ARTICLE Source Type: research
