Bioactive peptides in preterm human milk: Impact of maternal characteristics and their association to neonatal outcomes
Hormone content of very preterm human milk is partially determined by maternal factors most of them regarding metabolic health and obstetric characteristics. Human milk concentration impacts on growth and development of preterm infants during their stay in the neonatal unit. AbstractHuman milk adipokines in term babies seem partially determined by maternal factors and affect infant's development. We aimed to describe bioactive peptide concentration in very preterm human milk and associations to maternal characteristics and postnatal growth. Mothers delivering ≤32 weeks of gestation and their infant/s were recruited. At...
Source: BioFactors - August 17, 2023 Category: Biochemistry Authors: Carla Balcells ‐Esponera,
Cristina Borràs‐Novell,
Miriam López‐Abad,
Inmaculada Cubells Serra,
Anna Basseda Puig,
Montserrat Izquierdo Renau,
Ana Herranz Barbero,
Isabel Iglesias‐Platas Tags: RESEARCH ARTICLE Source Type: research
miR ‐34a/SIRT1/HIF‐1α axis is involved in cardiac angiogenesis of type 2 diabetic rats: The protective effect of sodium butyrate combined with treadmill exercise
This study aimed to evaluate the effects of NaB and treadmill exercise on heart angiogenesis through the miR-34a/SIRT1/FOXO1-HIF-1 α pathway. Diabetic animals received NaB (400 mg/kg daily, orally) and treadmill exercise for 6 weeks. The effect of NaB and treadmill exercise, alone or combined, on miR-34a expression, SIRT1, FOXO1, HIF-1α levels, and angiogenesis in diabetic heart tissue was measured. Diabetes caused increa sed miR-34a (p < 0.01) and FOXO1 (p < 0.001) expression levels. Also, SIRT1 (p < 0.001) and HIF-1α (not significant) expression levels were reduced in diabetic rats. NaB and...
Source: BioFactors - August 11, 2023 Category: Biochemistry Authors: Zeynab Sarlak,
Akram Eidi,
Vajihe Ghorbanzadeh,
Mehrnoush Moghaddasi,
Pejman Mortazavi Tags: RESEARCH ARTICLE Source Type: research
The role of P450 enzymes in malaria and other vector ‐borne infectious diseases
We review published research data on P450 enzymes from all players in vector-borne infections, that is, pathogens, vectors, and hosts, regarding the potential role of CYPs in disease. We discuss strategies on how to exploit cytochromes P450 in vector-borne disease control. AbstractVector-borne infectious diseases are still an important global health problem. Malaria is the most important among them, mainly pediatric, life-threatening disease. Malaria and other vector-borne disorders caused by parasites, bacteria, and viruses have a strong impact on public health and significant economic costs. Most vector-borne diseases co...
Source: BioFactors - August 10, 2023 Category: Biochemistry Authors: Oleksii Skorokhod,
Ekaterina Vostokova,
Gianfranco Gilardi Tags: REVIEW ARTICLE Source Type: research
Caffeic acid phenethyl ester surmounts acquired resistance of AZD9291 in non ‐small cell lung cancer cells
The objective of this study was therefore to establish and characterize a gefitinib resistant NSCLC line (HCC827GR) and evaluate the therapeutic effects of natural products in combination with third-generation EGFR-TKI, AZD9291. The IC50 of gefitinib and AZD9291 in HCC827GR were significantly higher than those of HCC827 (p < 0.05). Furthermore, anchorage-independent colony assay indicated that HCC827GR cells were more aggressive than their predecessors. This was reflected by the gene/protein expression changes observed in HCC827GR versus HCC827 profiled by cancer drug resistance real-time polymerase chain reaction ...
Source: BioFactors - August 9, 2023 Category: Biochemistry Authors: Yaw Twum,
Kent Marshall,
Weimin Gao Tags: RESEARCH ARTICLE Source Type: research
Roles of circular RNAs in osteogenic/osteoclastogenic differentiation
The present review provides a systematic overview of recent literature on the processes through which circRNAs regulate the dynamic balance between osteoblasts and osteoclasts that ultimately preserve bone homeostasis. It will also give insight that can shape current understanding of the pathogenesis of OP and other bone metabolic diseases to better guide diagnostic and treatment strategies for affected patients. AbstractThe process of bone remodeling occurs and is regulated through interactions between osteoclasts, which resorb bone, and osteoblasts, which generate bone tissue. When the homeostatic balance between these t...
Source: BioFactors - August 4, 2023 Category: Biochemistry Authors: Tao Wang,
Chao Zhang,
Lin Xu,
Xingnuan Li Tags: REVIEW ARTICLE Source Type: research
Rat brown adipose tissue thermogenic markers are modulated by estrous cycle phases and short ‐term fasting
This study confirmed that BAT exhibits morphological and functional changes in proestrus and diestrus. Moreover, BAT undergoes additional dynamic functional and morphological changes during short-term fasting. AbstractBrown adipose tissue (BAT) converts chemical energy into heat to maintain body temperature. Although fatty acids (FAs) represent a primary substrate for uncoupling protein 1 (UCP1)-dependent thermogenesis, BAT also utilizes glucose for the same purpose. Considering that estrous cycle effects on BAT are not greatly explored, we examined those of 6-h fasting on interscapular BAT (iBAT) thermogenic markers in pr...
Source: BioFactors - July 23, 2023 Category: Biochemistry Authors: Tamara Dakic,
Ksenija Velickovic,
Iva Lakic,
Aleksandra Ruzicic,
Andjela Milicevic,
Nikola Plackic,
Predrag Vujovic,
Tanja Jevdjovic Tags: RESEARCH ARTICLE Source Type: research
Protein concentrations and activities of fatty acid desaturase and elongase enzymes in liver, brain, testicle, and kidney from mice: Substrate dependency
The liver had the highest capacity for PUFA biosynthesis, with limited activity in the brain, testicles, and kidney, while we failed to detect activity in the heart and lung. The protein content and activity of the enzymes were significantly correlated. The capacity for PUFA synthesis in mice mainly resides in the liver, with enzymes having preference for n-3 PUFAs. AbstractThe synthesis rates of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in rodents and humans are not agreed upon and depend on substrate availability independently of the capacity for synthesis. Therefore, we aimed to assess the activities of the enzyme...
Source: BioFactors - July 21, 2023 Category: Biochemistry Authors: Rodrigo Valenzuela,
Adam H. Metherel,
Giulia Cisbani,
Mackenzie E. Smith,
Rapha ël Chouinard‐Watkins,
Brinley J. Klievik,
Luis A. Videla,
Richard P. Bazinet Tags: RESEARCH ARTICLE Source Type: research
Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome ‐mediated endothelial cell pyroptosis
Mechanism of SDSS in inhibiting endothelial cell pyroptosis. In the priming step, NLRP3, pro-Caspase-1, GSDMD-full, pro-IL-1 β, and pro-IL-18 were up-regulated. Furthermore, the translocation of CLIC4 from cytoplasm to the membrane induced chloride outflow, resulting in the assembly of NLRP3, ASC and Pro-Caspase-1 into a platform (activation step). By binding CLIC4 and blocking its membrane localization, SDSS inhibited c hloride outflow, thus inhibiting the activation of NLRP3 inflammasome and then the cleavage of pro-Caspase-1 into Caspase-1. This inhibited pyroptosis along with the release of IL-1β and IL-18, resulting...
Source: BioFactors - July 18, 2023 Category: Biochemistry Authors: Xiaolu Zhang,
Qiuyue Yang,
Ruifeng Zhang,
Yilin Zhang,
Wenyun Zeng,
Qun Yu,
Miao Zeng,
Jiali Gan,
Huhu Li,
Lin Yang,
Qing Gao,
Xijuan Jiang Tags: RESEARCH ARTICLE Source Type: research
