Preface
(Source: BioFactors)
Source: BioFactors - December 12, 2023 Category: Biochemistry Authors: Maria Fabiana Drincovich Tags: PREFACE Source Type: research
Glycosaminoglycan dermatan sulfate supplementation decreases diet ‐induced obesity and metabolic dysfunction in mice
Dermatan sulfate supplementation opposed high-fat diet-induced obesity in mice by opposing high-fat diet-induced “bleaching” of brown adipose tissue. It also favored the expansion of hyperplastic versus hypertrophic adipose tissue, upregulated insulin response and genes related to substrate uptake in muscle, and reduced pro-inflammatory lipid levels in brown adipose tissue and liver. AbstractGlycosaminoglycans are complex carbohydrates used as nutraceuticals for diverse applications. We studied the potential of the glycosaminoglycan dermatan sulfate (DS) to counteract the development of diet-induced obesity (DIO) using...
Source: BioFactors - December 9, 2023 Category: Biochemistry Authors: Bojan Stojni ć,
Sebastiá Galmés,
Alba Serrano,
Maria Sulli,
Lana Sušak,
Ndioba Seye,
Andreu Palou,
Gianfranco Diretto,
M. Luisa Bonet,
Joan Ribot Tags: RESEARCH ARTICLE Source Type: research
A glimpse into the structural properties of α‐synuclein oligomers
α-Synuclein (αS) aggregation is central to synucleinopathies like Parkinson's disease (PD). Early-stage αS oligomers play a key role in disease development. Their structure and conversion mechanisms are not well-understood. This review examines recent discoveries on αS oligomers, offering valuab le insights for advancing targeted therapies and diagnostics in PD. Abstractα-Synuclein (αS) aggregation is the main neurological hallmark of a group of debilitating neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson's disease is the most prevalent. αS oligomers formed during the i...
Source: BioFactors - December 8, 2023 Category: Biochemistry Authors: Jaime Santos,
Irantzu Pallar ès,
Salvador Ventura Tags: REVIEW ARTICLE Source Type: research
Endogenous chemicals guard health through inhibiting ferroptotic cell death
Ferroptosis is a new form of regulated cell death caused by iron-dependent accumulation of lethal polyunsaturated phospholipids peroxidation. It has received considerable attention owing to its putative involvement in a wide range of pathophysiological processes such as organ injury, cardiac ischemia/reperfusion, degenerative disease and its prevalence in plants, invertebrates, yeasts, bacteria, and archaea. To counter ferroptosis, living organisms have evolved a myriad of intrinsic efficient defense systems, such as cyst(e)ine-GSH-glutathione peroxidase 4 (GPX4) system, GCH1-BH4 system, FSP1-CoQ10 system, and so forth. Am...
Source: BioFactors - December 8, 2023 Category: Biochemistry Authors: Yuan ‐Hao Song,
Hong‐Xu Lei,
Dou Yu,
Hao Zhu,
Meng‐Zhu Hao,
Rong‐Hua Cui,
Xiang‐Shuai Meng,
Xie‐Huang Sheng,
Lei Zhang Tags: REVIEW ARTICLE Source Type: research
Investigating rutin as a potential transforming growth factor ‐β type I receptor antagonist for the inhibition of bleomycin‐induced lung fibrosis
This study confirmed that rutin inhibits transforming growth factor- β-induced extracellular matrix components and epithelial-mesenchymal transition, and bleomycin-mediated lung fibrosis. Molecular docking simulation predicted that rutin possibly binds to ALK5, which inhibits suppressor of mothers against decapentaplegic-mediated fibrotic signaling pathway. AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic lung condition characterized by the abnormal regulation of extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT). In this study, we investigated the potential of rutin, a natural flavonoid, in at...
Source: BioFactors - November 26, 2023 Category: Biochemistry Authors: Wisurumuni Arachchilage Hasitha Maduranga Karunarathne,
Kyoung Tae Lee,
Yung Hyun Choi,
Chang ‐Hee Kang,
Mi‐Hwa Lee,
Sang‐Hun Kim,
Gi‐Young Kim Tags: RESEARCH ARTICLE Source Type: research
Pax ‐8: Molecular biology, pathophysiology, and potential pathogenesis
1. Pax-8, as an important transcription factor, has been described as a distinct temporal and spatial expression pattern and tissue-specific manner during growth and differentiation in the developing embryo. 2. The up-regulation or down-regulation of Pax-8 is involved in many pathological processes, including cell apoptosis, ventricular septum defect formation, adipocyte-like cell differentiation, angiogenesis, and tumor progression. 3. PPFP is a Pax-8-PPAR γ fusion protein produced by a specific gene fusion, participating in adipocyte-like cell differentiation and tumor progression. 4. Pax-8 may be an attractive therapeu...
Source: BioFactors - November 22, 2023 Category: Biochemistry Authors: Qinyi Zhou,
Heng Li,
Yaqiong Cheng,
Xiaofeng Ma,
Shilin Tang,
Chaoke Tang Tags: REVIEW ARTICLE Source Type: research
A new strategy for screening novel functional genes involved in reduction of lipid droplet accumulation
In this study, we aimed to develop a strategy to identify new genes that reduces accumulation of LDs in cancer cells using an RNA interference (RNAi) screening system employing artificial sequence-enriched shRNA libraries. Monitoring LDs by fluorescent activated cell sorting, the subsequently collected cumulative LDs cells, and shRNA sequence analysis identified a clone that potentially functioned to accumulate LDs. The clone showed no identical sequence to human Refseq. It showed very similar sequence to seven genes by allowing three mismatches. Among these genes, we identified the mediator complex subunit 6 (MED6) gene a...
Source: BioFactors - November 21, 2023 Category: Biochemistry Authors: Ryuto Maruyama,
Yasuhiro Kudo,
Tomoyasu Sugiyama Tags: RESEARCH ARTICLE Source Type: research
Dietary restriction alters insulin signaling pathway in the brain
Insulin in the brain could be one of the most important contributing factors to age-related cognitive decline. Reduced dietary intake (DR), can influence insulin levels and insulin signaling in the aging hippocampus, and thus brain health. Beneficial effects of DR are, however, highly dependent on the DR onset and duration. AbstractInsulin is known to be a key hormone in the regulation of peripheral glucose homeostasis, but beyond that, its effects on the brain are now undisputed. Impairments in insulin signaling in the brain, including changes in insulin levels, are thought to contribute significantly to declines in cogni...
Source: BioFactors - November 18, 2023 Category: Biochemistry Authors: Smilja Todorovic,
Valentina Simeunovic,
Milica Prvulovic,
Tamara Dakic,
Tanja Jevdjovic,
Srdjan Sokanovic,
Selma Kanazir,
Aleksandra Mladenovic Tags: RESEARCH ARTICLE Source Type: research
