Nifuroxazide repurposing for protection from diabetes ‐induced retinal injury in rats: Implication of oxidative stress and JAK/STAT3 axis
Nifuroxazide (Nifu), the potent STAT3 inhibitor successfully protected the diabetic rats against diabetic retinopathy as it ameliorated the retinal structure deterioration. This effect could be attributed to modulating JAK/STAT3 axis and oxidative stress. AbstractThe prevalence of diabetes mellitus (DM) is alarmingly increasing worldwide. Diabetic retinopathy (DR) is a prevailing DM microvascular complication, representing the major cause of blindness in working-age population. Inflammation is a crucial player in DR pathogenesis. JAK/STAT3 axis is a pleotropic cascade that modulates diverse inflammatory events. Nifuroxazid...
Source: BioFactors - September 23, 2023 Category: Biochemistry Authors: Nehal M. Elsherbiny,
Reem Altemani,
Waad Althagfi,
Maha Albalawi,
Zuhair M. Mohammedsaleh,
Mohamed El ‐Sherbiny,
Nada F. Abo El‐Magd Tags: RESEARCH ARTICLE Source Type: research
Preface
(Source: BioFactors)
Source: BioFactors - September 16, 2023 Category: Biochemistry Authors: Stefania Iametti Tags: EDITORIAL Source Type: research
Dietary lithium stimulates female fecundity in Drosophila melanogaster
Dietary lithium (0.1 –5 mM LiCl) improved the lithium status of the female fruit flyDrosophila melanogaster and substantially increased egg production. These findings were accompanied by alterations in mRNA levels of genes encoding proteins involved with chorion formation and yolk protein biosynthesis, which are essential steps inDrosophila oogenesis. (Image created withBioRender.com). AbstractThe trace element lithium exerts a versatile bioactivity in humans, to some extend overlapping with in vivo findings in the model organismDrosophila melanogaster. A potentially essential function of lithium in reproduction has be...
Source: BioFactors - September 15, 2023 Category: Biochemistry Authors: Katharina Jans,
Kai L üersen,
Jakob Frieling,
Thomas Roeder,
Gerald Rimbach Tags: RESEARCH ARTICLE Source Type: research
Exploring the therapeutic potential of naturally occurring piceatannol in non ‐communicable diseases
The natural stilbene Piceatannol is having a promising therapeutic potential for the prevention and treatment of a wide variety of complex human diseases like asthma, cancer, diabetes, and so forth. AbstractPiceatannol is a naturally occurring hydroxylated resveratrol analogue that can be found in a variety of fruits and vegetables. It has been documented to have a wide range of beneficial effects, including anti-inflammatory, antioxidant, anti-aging, anti-allergic, antidiabetic, neuroprotective, cardioprotective, and chemopreventive properties. Piceatannol has significantly higher antioxidant activity than resveratrol. Pi...
Source: BioFactors - September 14, 2023 Category: Biochemistry Authors: Himanshu Gandhi,
Shikha Mahant,
Abhishek Kumar Sharma,
Deepak Kumar,
Kamal Dua,
Dinesh Kumar Chellappan,
Sachin Kumar Singh,
Gaurav Gupta,
Alaa A. A. Aljabali,
Murtaza M. Tambuwala,
Deepak N. Kapoor Tags: REVIEW ARTICLE Source Type: research
Breast cancer diagnosis and management guided by data augmentation, utilizing an integrated framework of SHAP and random augmentation
The use of SHAP for feature engineering alongside random augmentation for data balancing for the diagnosis of breast cancer (BC) proposed some management strategies for BC before and after diagnosis Developed models that could help in the diagnosis of BC by prediction using various machine learning algorithms. AbstractRecent research indicates that early detection of breast cancer (BC) is critical in achieving favorable treatment outcomes and reducing the mortality rate associated with it. With the difficulty in obtaining a balanced dataset that is primarily sourced for the diagnosis of the disease, many researchers have r...
Source: BioFactors - September 12, 2023 Category: Biochemistry Authors: Chukwuebuka Joseph Ejiyi,
Zhen Qin,
Happy Monday,
Makuachukwu Bennedith Ejiyi,
Chiagoziem Ukwuoma,
Thomas Ugochukwu Ejiyi,
Victor Kwaku Agbesi,
Amarachi Agu,
Chiduzie Orakwue Tags: RESEARCH ARTICLE Source Type: research
Gut microbiota contribution to selenium deficiency ‐induced gut–liver inflammation
Se deficient imbalance the intestinal microbiota.
Se deficient effects gut –liver axis via lipopolysaccharide.Lactobacillus reuteri could alleviate selenium deficiency-induced gut –liver axis injury. AbstractThere is limited knowledge about the factors that drive gut –liver axis changes after selenium (Se) deficiency-induced gut or liver injuries. Thus, we tested Se deficiency in mice to determine its effects on intestinal bacterial balance and whether it induced liver injury. Serum Se concentration, lipopolysaccharide (LPS) level, and liver injury biomarkers were tested using a biochemical method, while pathological...
Source: BioFactors - September 8, 2023 Category: Biochemistry Authors: Guodong Wang,
Zhihui Jiang,
Yuwei Song,
Yueteng Xing,
Simin He,
P. Boomi Tags: RESEARCH ARTICLE Source Type: research
Modulatory effects of point ‐mutated IL‐32θ (A94V) on tumor progression in triple‐negative breast cancer cells
IL-32 θ (A94V) inhibits phosphorylation of FAK and IκBα. IL-32θ (A94V) inhibits the expression and translocation of β-catenin by inhibiting phosphorylated FAK. Additionally, NF-κB is inhibited by IL-32θ (A94V) via the suppression of phosphorylated IκBα. Thus, IL-32θ (A94V) reduces migration, pro liferation, and inflammation in breast cancer via the FAK-PI3K-GSK3 and NF-κB pathways. AbstractBreast cancer is a frequently diagnosed cancer and the leading cause of death among women worldwide. Tumor-associated macrophages stimulate cytokines and chemokines, which induce angiogenesis, metastasis, proliferation, and tu...
Source: BioFactors - September 3, 2023 Category: Biochemistry Authors: Hyo ‐Min Park,
Jae‐Young Park,
Na‐Yeon Kim,
Jinju Kim,
Thu‐Huyen Pham,
Jin Tae Hong,
Do‐Young Yoon Tags: RESEARCH ARTICLE Source Type: research
Biochemical and cellular studies of three human 3 ‐phosphoglycerate dehydrogenase variants responsible for pathological reduced L‐serine levels
In the brain, L-serine is produced through the phosphorylated pathway (PP). hPHGDH catalyzes the first and rate-limiting step in the PP. Three variants related to hPHGDH deficiency and Neu-Laxova syndrome have been studied. V261M, V425M, and V490M substitutions alter the kinetic and structural properties of hPHGDH. Variants ectopic expression results in protein aggregation and reduced L-serine level. AbstractIn the brain, the non-essential amino acid L-serine is produced through the phosphorylated pathway (PP) starting from the glycolytic intermediate 3-phosphoglycerate: among the different roles played by this amino acid,...
Source: BioFactors - September 1, 2023 Category: Biochemistry Authors: Giulia Murtas,
Elena Zerbini,
Valentina Rabattoni,
Zoraide Motta,
Laura Caldinelli,
Marco Orlando,
Francesco Marchesani,
Barbara Campanini,
Silvia Sacchi,
Loredano Pollegioni Tags: RESEARCH ARTICLE Source Type: research
