The role of LncRNA ‐regulated autophagy in AKI
This article reviewed and analyzed the pathways of lncRNA regulation of autophagy in AKI in recent years. The results provide new ideas for further study of the pathophysiological process and targeted therapy for AKI. (Source: BioFactors)
Source: BioFactors - July 17, 2023 Category: Biochemistry Authors: Peihan Wang,
Wu Chen,
Sheng Zhao,
Fan Cheng Tags: REVIEW ARTICLE Source Type: research
P38 α contributes to TNF‐α‐induced IL‐8 production in human gingival cells
In conclusion, p38α plays an important role in TNF-α-induced IL-8 production, providing a potential therapeutic target to prevent and treat periodontal disease. (Source: BioFactors)
Source: BioFactors - July 15, 2023 Category: Biochemistry Authors: Dan Mao,
Hiroshi Inoue,
Takuya Notomi,
Seiji Goda Tags: RESEARCH ARTICLE Source Type: research
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK ‐mTOR pathway in sheep associated with prolificacy
In this study, we performed RNA-sequencing for the sheep pituitary gland associated with different fecundity, and identified a novel candidate lncRNA LOC105613571 targeting BDNF related to gonadotropin secretion. Our results showed that expression of lncRNA LOC105613571 and BDNF could be significantly upregulated by GnRH stimulation in sheep pituitary cellsin vitro. Notably, either lncRNA LOC105613571 or BDNF silencing inhibited cell proliferation while promoted cell apoptosis. Moreover, lncRNA LOC105613571 knockdown could also downregulate gonadotropin secretion via inactivation AKT, ERK and mTOR pathway. In addition, co-...
Source: BioFactors - July 12, 2023 Category: Biochemistry Authors: Yu Cai,
Hua Yang,
Zhen Wan,
Pei ‐Yong Chen,
Zhi‐Bo Wang,
Jin‐Jing Guo,
Daxiang Wang,
Feng Wang,
Yanli Zhang Tags: RESEARCH ARTICLE Source Type: research
The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol ‐based compound tuning glutathione and thioredoxin systems
The intracellular redox state of endothelial cells facing low oxygen and oxidative stress was regulated via the pro-glutathione molecule I-152, a co-drug of N-acetylcysteine and cysteamine. The principal redox couples, GSH/GSSG, and NAD(P)+/NAD(P)H were affected by hypoxia and in turn, modulated with I-152. Glutathione and thioredoxin-related pathways were enhanced after treatment and ROS production was alleviated. Strategies to fine-tune the redox balance could ameliorate the cell response to hypoxic environments. AbstractReduction in oxygen levels is a key feature in the physiology of the bone marrow (BM) niche where hem...
Source: BioFactors - July 7, 2023 Category: Biochemistry Authors: Michela Bruschi,
Federica Biancucci,
Sofia Masini,
Francesco Piacente,
Daniela Ligi,
Francesca Bartoccini,
Antonella Antonelli,
Ferdinando Mannello,
Santina Bruzzone,
Michele Menotta,
Alessandra Fraternale,
Mauro Magnani Tags: RESEARCH ARTICLE Source Type: research
Nomilin and its analogue obacunone alleviate NASH and hepatic fibrosis in mice via enhancing antioxidant and anti ‐inflammation capacity
Nomilin and obacunone exert beneficial effects on MCD-, BDL-, and CCl4-induced NASH mice. Nomilin and obacunone alleviate NASH and liver fibrosis via enhancing antioxidant and anti-inflammation capacity. AbstractNonalcoholic steatohepatitis (NASH) and hepatic fibrosis are leading causes of cirrhosis with rising morbidity and mortality worldwide. Currently, there is no appropriate treatment for NASH and hepatic fibrosis. Many studies have shown that oxidative stress is a main factor inducing NASH. Nomilin (NML) and obacunone (OBA) are limonoid compounds naturally occurring in citrus fruits with various biological properties...
Source: BioFactors - July 5, 2023 Category: Biochemistry Authors: Yongli Han,
Lingling Luo,
Hongli Li,
Lijun Zhang,
Yingxuan Yan,
Minglv Fang,
Jing Yu,
Xiaoyan Gao,
Ying Liu,
Cheng Huang,
Shengjie Fan Tags: RESEARCH ARTICLE Source Type: research
Correction to “Inhibition of succinate dehydrogenase sensitizes cyclin E‐driven ovarian cancer to CDK inhibition”
(Source: BioFactors)
Source: BioFactors - July 1, 2023 Category: Biochemistry Tags: ERRATUM Source Type: research
Rigosertib is more potent than wortmannin and rapamycin against adult T ‐cell leukemia‐lymphoma
HTLV-1 downregulation of the mRNA level may occur as a negative feedback response to increased PI3K-Akt-mTOR phosphorylation by HTLV-1. Rigosertib was more effective than wortmannin and rapamycin in inducing cell cycle arrest, as well as a significant late apoptosis in the Inf-3T3 and MT-2 cells. AbstractHuman T lymphotropic virus type 1 (HTLV-1) infection can cause adult T-cell lymphoblastic leukemia (ATLL), an incurable, chemotherapy-resistant malignancy. In a quest for new therapeutic targets, our study sought to determine the levels of AKT, mTOR, and PI3K in ATLL MT-2 cells, HTLV-1 infected NIH/3T3 cells (Inf-3T3), and...
Source: BioFactors - June 23, 2023 Category: Biochemistry Authors: Mohsen Ghorbanzadeh Neghab,
Mohammad Jalili ‐Nik,
Arash Soltani,
Amir R. Afshari,
Seyed Mahdi Hassanian,
Houshang Rafatpanah,
Seyed Abdolrahim Rezaee,
Hamid R. Sadeghnia,
Sajad Ataei Azimi,
Baratali Mashkani Tags: RESEARCH ARTICLE Source Type: research
SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80 ‐K307
We describes the role for SUMO2/3 during oxaliplatin resistance in CRC and assessed the contribution of Ku80 SUMOylation in this process. Overexpression of SUMO2/3-promoted CRC cell proliferation, invasion, migration in vitro and in vivo. SUMOylation of K307 in Ku80 attenuated the DNA damage of CRC cells caused by oxaliplatin and was consistent with an antiapoptotic role for SUMO2/3. AbstractColorectal cancer (CRC) is one of the most prevalent cancers worldwide and is typically treated with the FOLFOX regimen (folinic acid, 5-fluorouracil, and oxaliplatin). However, oxaliplatin resistance remains a serious clinical problem...
Source: BioFactors - June 21, 2023 Category: Biochemistry Authors: Dan Feng,
Jinsong He,
Min Yuan,
Qing Chen,
Xi Zeng,
Qilin Zhou,
Jian Wu,
Bin Han Tags: RESEARCH ARTICLE Source Type: research
