Downregulation of microRNA ‐326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer
This study reveals that miR-326-low/ZN322A-high profile is a biomarker to predict poor prognosis in lung cancer. AbstractZinc finger protein ZNF322A is an oncogenic transcription factor. Overexpression of ZNF322A activates pro-metastasis, cancer stemness, and neo-angiogenesis-related genes to enhance lung cancer progression. However, the upstream regulator of ZNF322A is not well defined. Dysregulation of microRNAs (miRNAs) can mediate cancer cell growth, migration, and invasion to promote tumorigenesis. Here, we uncover the mechanism of miRNA-mediated transcriptional regulation in ZNF322A-driven oncogenic events. ZNF322A h...
Source: BioFactors - August 31, 2023 Category: Biochemistry Authors: Shih ‐Hsuan Huang,
Hung‐Chia Hsieh,
Jiunn‐Min Shieh,
Wou‐Chou Su,
Yi‐Ching Wang Tags: RESEARCH ARTICLE Source Type: research
Biochemical and cellular studies of three human 3 ‐phosphoglycerate dehydrogenase variants responsible for pathological reduced L‐serine levels
In the brain, L-serine is produced through the phosphorylated pathway (PP). hPHGDH catalyzes the first and rate-limiting step in the PP. Three variants related to hPHGDH deficiency and Neu-Laxova syndrome have been studied. V261M, V425M, and V490M substitutions alter the kinetic and structural properties of hPHGDH. Variants ectopic expression results in protein aggregation and reduced L-serine level. AbstractIn the brain, the non-essential amino acid L-serine is produced through the phosphorylated pathway (PP) starting from the glycolytic intermediate 3-phosphoglycerate: among the different roles played by this amino acid,...
Source: BioFactors - August 31, 2023 Category: Biochemistry Authors: Giulia Murtas,
Elena Zerbini,
Valentina Rabattoni,
Zoraide Motta,
Laura Caldinelli,
Marco Orlando,
Francesco Marchesani,
Barbara Campanini,
Silvia Sacchi,
Loredano Pollegioni Tags: RESEARCH ARTICLE Source Type: research
Downregulation of microRNA ‐326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer
This study reveals that miR-326-low/ZN322A-high profile is a biomarker to predict poor prognosis in lung cancer. AbstractZinc finger protein ZNF322A is an oncogenic transcription factor. Overexpression of ZNF322A activates pro-metastasis, cancer stemness, and neo-angiogenesis-related genes to enhance lung cancer progression. However, the upstream regulator of ZNF322A is not well defined. Dysregulation of microRNAs (miRNAs) can mediate cancer cell growth, migration, and invasion to promote tumorigenesis. Here, we uncover the mechanism of miRNA-mediated transcriptional regulation in ZNF322A-driven oncogenic events. ZNF322A h...
Source: BioFactors - August 30, 2023 Category: Biochemistry Authors: Shih ‐Hsuan Huang,
Hung‐Chia Hsieh,
Jiunn‐Min Shieh,
Wou‐Chou Su,
Yi‐Ching Wang Tags: RESEARCH ARTICLE Source Type: research
Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers
This comprehensive review explores the latest advancements in the screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers. It discusses screening techniques, diverse synthesis strategies, and various modification approaches employed to enhance their properties. The review also highlights the broad range of biomedical applications where peptides and peptide aptamers have shown promise, including drug delivery, therapeutics, diagnostics, and biomaterials. AbstractPeptides and peptide aptamers have emerged as promising molecules for a wide range of biomedical applications due to their ...
Source: BioFactors - August 30, 2023 Category: Biochemistry Authors: Yijie Liu,
Xiaoling Lu,
Meilun Chen,
Zheng Wei,
Guangnan Peng,
Jie Yang,
Chunhua Tang,
Peng Yu Tags: REVIEW ARTICLE Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - August 26, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - August 26, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Preface
(Source: BioFactors)
Source: BioFactors - August 26, 2023 Category: Biochemistry Authors: Zrinka Kovarik Tags: PREFACE Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - August 26, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - August 26, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster
Curcumin supplementation, similar to the iron chelator bathophenanthroline, lowered the iron but also the cobalt content, and to a lesser extent affected the manganese and zinc status ofD. melanogaster. However, these alterations in trace metal balance did not affect catalase activity, oxidative stress tolerance, and polyamine status in fruit flies. In contrast, in curcumin-supplemented mice, the spleen exhibits an elevated spermidine production, which is most probably related to a compensatory growth due to curcumin-induced iron deficiency. AbstractRecent reports indicated that the phytochemical curcumin possesses iron-ch...
Source: BioFactors - August 20, 2023 Category: Biochemistry Authors: Kai L üersen,
Tobias Jöckel,
Dawn Chin,
Tobias Demetrowitsch,
Karin Schwarz,
Gerald Rimbach Tags: RESEARCH ARTICLE Source Type: research
Preface
(Source: BioFactors)
Source: BioFactors - August 19, 2023 Category: Biochemistry Authors: Zrinka Kovarik Tags: PREFACE Source Type: research
Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice
This study aimed to determine the underlying mechanism and examine the effect of dapagliflozin on diabetic cognitive impairment. To create an in vivo model of diabetic cognitive impairment, streptozotocin (STZ)-induced diabetic mice were used. Dapagliflozin was administered to mice for 8 weeks. The context fear condition and Morris water maze test was used to evaluate mice's behavioral change. Western blotting was used to evaluate protein expression. Hematoxylin and eosin (HE) and Nissl staining were applied to monitor morphological and structural changes. Congo red staining was performed to identify the formation of se...
Source: BioFactors - August 19, 2023 Category: Biochemistry Authors: Zichen Gui,
Jiawen Wang,
Yue Zhang,
Binbin Wan,
Zhiqiang Ke,
Zhanhong Ren,
Xiaosong Yang,
Min Lei,
Xiying Guo,
Xiufen Liu,
Changhan Ouyang,
Ninghua Wu,
Qingjie Chen Tags: RESEARCH ARTICLE Source Type: research
