Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation
In the autoimmune skin disease psoriasis, an overproduction of interleukin-17A and interleukin-23 leads to an aberrant activation of keratinocytes, influx of myeloid cells and skin inflammation. These inflammatory conditions led to a higher activation of neutrophil granulocytes in a mouse model of chronic severe psoriasis based on IL-17A overexpression in the skin (K14-IL-17Aind/+ mice versus IL-17Aind/+ controls) seen by upregulated production of reactive oxygen species (ROS) and significant increase of mRNA expression ofmyeloperoxidase (Mpo),proteinase 3 (Prt3), andneutrophil elastase (Elane). In skin of psoriatic mice, ...
Source: BioFactors - May 5, 2023 Category: Biochemistry Authors: Theresa Schaller,
Julia Ringen,
Berenice Fischer,
Tabea Bieler,
Katharina Perius,
Tanja Knopp,
Katharina S. Kommoss,
Thomas Korn,
Mathias Heikenw älder,
Matthias Oelze,
Andreas Daiber,
Thomas Münzel,
Daniela Kramer,
Philip Wenzel,
Johannes Tags: RESEARCH ARTICLE Source Type: research
Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho ‐associated kinase pathway
This study evaluated possible mitigating effect of adropin on lung injury in diabetic rats, targeting role of Rho A/Rho-associated kinase pathway. Rats were allocated into four groups: control, adropin, diabetic, and diabetic+adropin groups. At the termination of the experiment, serum fasting glucose, insulin and adropin levels and insulin resistance were calculated. Wet/dry ratio, histopathological, immunohistochemical analyses, and relative real time gene expression of lung tissue was determined. Interleukin-6, tumor necrosis factor alpha, malondialdehyde, 8-Oxo-2 ′-deoxyguanosine, reduced glutathione, superoxide dismu...
Source: BioFactors - April 28, 2023 Category: Biochemistry Authors: Fatma H. Rizk,
Mervat H. El ‐Saka,
Rowida Raafat Ibrahim,
Omnia Safwat El‐Deeb,
Hoda A. Ibrahim,
Amira A. El Saadany,
Shaimaa S. Mashal,
Leila Ammar,
Amal M. Abdelsattar,
Ramez A. Barhoma Tags: RESEARCH ARTICLE Source Type: research
The in vitro anti ‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma
Our findings revealed that combining aprepitant and 5-ALA synergistically regulates the proliferation and invasiveness of glioblastoma cells by altering the levels of apoptosis-related genes and intracellular PpIX levels, inhibiting cell migration, and reducing MMP-2 and MMP-9 activities. These findings suggest that the concurrent combination of aprepitant and 5-ALA may be ideal for further evaluation in the clinical setting. AbstractGlioblastoma multiforme (GBM) is the most malignant type of cerebral neoplasm in adults with a poor prognosis. Currently, combination therapy with different anti-cancer agents is at the forefr...
Source: BioFactors - April 25, 2023 Category: Biochemistry Authors: Safieh Ebrahimi,
Farshad Mirzavi,
Seyed Isaac Hashemy,
Maryam Khaleghi Ghadiri,
Walter Stummer,
Ali Gorji Tags: RESEARCH ARTICLE Source Type: research
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia
AbstractPreeclampsia (PE) was first reported thousands of years ago, yet there is still a shortage of biomarkers to determine the severity and type of PE. The importance of the expanded endocannabinoid system, or endocannabinoidome (eCBome), has emerged recently in placental physiology and pathology, though the potential alterations of the eCBome in PE have not been fully explored. Analysis by qRT-PCR using placental samples of normotensive and PE women demonstrate for the first time the presence of ABHD4, GDE1, and DAGL β in both normotensive and PE placental tissues. Interestingly, NAPE-PLD, FAAH-1, DAGLα, MAGL, and AB...
Source: BioFactors - April 24, 2023 Category: Biochemistry Authors: Jo ão Maia,
Fabio Arturo Iannotti,
Fabiana Piscitelli,
Bruno Miguel Fonseca,
António Braga,
Jorge Braga,
Natércia Teixeira,
Vincenzo Di Marzo,
Georgina Correia‐da‐Silva Tags: RESEARCH ARTICLE Source Type: research
Astrocytic aerobic glycolysis provides lactate to support neuronal oxidative metabolism in the hippocampus
Depolarizarion of hippocampal slices with high K+ evokes rapid monocarboxylate transporters 2 (MCT2)-dependent consumption of extracellular lactate by neurons. AbstractUnder physiological conditions, the energetic demand of the brain is met by glucose oxidation. However, ample evidence suggests that lactate produced by astrocytes through aerobic glycolysis may also be an oxidative fuel, highlighting the metabolic compartmentalization between neural cells. Herein, we investigate the roles of glucose and lactate in oxidative metabolism in hippocampal slices, a model that preserves neuron –glia interactions. To this purpose...
Source: BioFactors - April 18, 2023 Category: Biochemistry Authors: C ândida Dias,
Eliana Fernandes,
Rui M. Barbosa,
João Laranjinha,
Ana Ledo Tags: RESEARCH ARTICLE Source Type: research
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(Source: BioFactors)
Source: BioFactors - April 12, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - April 12, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - April 12, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - April 12, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
