Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases
AbstractThis review aimed to identify preclinical and clinical studies examining the effects of rosmarinic acid (RA), carnosic acid (CaA), rosmanol (RO), carnosol (CA), and ursolic acid (UA) against allergic and immunologic disorders. Various online databases, including PubMed, Science Direct, EMBASE, Web of Sciences, Cochrane trials, and Scopus, were searched from inception until October 2022. Due to the suppression of the nuclear factor- κB (NF-κB) pathway, the main factor in allergic asthma, RA may be a promising candidate for the treatment of asthma. The other ingredients comprising CA and UA reduce the expression of...
Source: BioFactors - December 24, 2022 Category: Biochemistry Authors: Faegheh Farhadi,
Vafa Baradaran Rahimi,
Neda Mohamadi,
Vahid Reza Askari Tags: REVIEW ARTICLE Source Type: research
Topical application of gemcitabine generates microvesicle particles in human and murine skin
AbstractChemotherapy has remained the mainstay for the treatment of multiple types of cancers. In particular, topical use of chemotherapy has been used for skin cancers. Though effective, topical chemotherapy has been limited due to adverse effects such as local and even systemic toxicities. Our recent studies demonstrated that exposure to pro-oxidative stressors, including therapeutic agents induces the generation of extracellular vesicles known as microvesicle particles (MVP) which are dependent on activation of the Platelet-activating factor-receptor (PAFR), a G-protein coupled receptor present on various cell types, an...
Source: BioFactors - December 23, 2022 Category: Biochemistry Authors: Anita Thyagarajan,
Krishna Awasthi,
Christine M. Rapp,
R. Michael Johnson,
Yanfang Chen,
Kelly L. R. Miller,
Jeffrey B. Travers,
Ravi P. Sahu Tags: RESEARCH ARTICLE Source Type: research
Oxidized phospholipids and lipoprotein ‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update
AbstractInflammation and oxidative stress conditions lead to a variety of oxidative modifications of lipoprotein phospholipids implicated in the occurrence and development of atherosclerotic lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is established as an independent risk biomarker of atherosclerosis-related cardiovascular disease (ASCVD) and mediates vascular inflammation through the regulation of lipid metabolism in the blood and in atherosclerotic lesions. Lp-PLA2 is associated with low- and high-density lipoproteins and Lipoprotein (a) in human plasma and specifically hydrolyzes oxidized phospholipids in...
Source: BioFactors - December 22, 2022 Category: Biochemistry Authors: Despoina Pantazi,
Constantinos Tellis,
Alexandros D. Tselepis Tags: REVIEW ARTICLE Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - December 22, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - December 22, 2022 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Oxidized phospholipids and lipoprotein ‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update
AbstractInflammation and oxidative stress conditions lead to a variety of oxidative modifications of lipoprotein phospholipids implicated in the occurrence and development of atherosclerotic lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is established as an independent risk biomarker of atherosclerosis-related cardiovascular disease (ASCVD) and mediates vascular inflammation through the regulation of lipid metabolism in the blood and in atherosclerotic lesions. Lp-PLA2 is associated with low- and high-density lipoproteins and Lipoprotein (a) in human plasma and specifically hydrolyzes oxidized phospholipids in...
Source: BioFactors - December 22, 2022 Category: Biochemistry Authors: Despoina Pantazi,
Constantinos Tellis,
Alexandros D. Tselepis Tags: REVIEW ARTICLE Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - December 22, 2022 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - December 22, 2022 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Interrelationships among platelet ‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors
AbstractTraditionally cardiovascular disease (CVD) risk has been assessed through blood lipids and inflammatory marker C-reactive protein (hsCRP). Recent clinical interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A2 (Lp-PLA2) recognizes that vascular damage can exist in the absence of traditional risk factors. This cross-sectional study investigated the potential relationship between circulating PAF, Lp-PLA2, hsCRP, and traditional risk factors for CVD. One hundred adults (49 ± 13 years, 31% male) with variable CVD risk were recruited. Fasting infla...
Source: BioFactors - December 21, 2022 Category: Biochemistry Authors: Carolyn J. English,
Anna E. Lohning,
Hannah L. Mayr,
Mark Jones,
Dianne P. Reidlinger Tags: RESEARCH ARTICLE Source Type: research
Cutaneous Nrf2 ‐Keap1 pathway modulation by environmental factors: The Dead Sea area as a test case
AbstractThe skin is constantly exposed to exogenous environmental stressors and has to cope with excessive oxidative stress and tissue damage. However, exposure to moderate environmental stressors may be beneficial for the cutaneous tissue and assist in protecting against oxidative damage via the enhanced activation of the nuclear factor erythroid 2-related factor 2 –Kelch-like ECH-associated protein 1 (Nrf2–Keap1) pathway. Such moderate stressors can be found in various locations around the globe. In this manuscript, we chose to focus on the Dead Sea (DS) area as a test case to study the effect of moderate stressors o...
Source: BioFactors - December 18, 2022 Category: Biochemistry Authors: Dror Cohen,
Meital Portugal ‐Cohen,
Miriam Oron,
Marina Frusic‐Zlotkin,
Yoram Soroka,
Ze'evi Ma'or,
Dalit Amar,
Ron Kohen Tags: RESEARCH ARTICLE Source Type: research
Cardiac troponins: Mechanisms of release and role in healthy and diseased subjects
AbstractThe cardiac troponins (cTns), cardiac troponin C (cTnC), cTnT, and cTnI are key elements of myocardial apparatus, fixed as protein complex on the thin filament of sarcomere and are involved in the regulation of excitation –contraction coupling of cardiomyocytes in the presence of Ca2+. Circulating cTnT and cTnI (cTns) increase following cardiac tissue necrosis, and they are consolidated biomarkers of acute myocardial infarction (AMI). However, the use of high sensitivity (hs)-immunoassay tests for cTnT and cTnI has made it possible to identify a multitude of other clinical conditions associated with increased cir...
Source: BioFactors - December 15, 2022 Category: Biochemistry Authors: Rosetta Ragusa,
Silvia Masotti,
Veronica Musetti,
Silvia Rocchiccioli,
Concetta Prontera,
Marco Perrone,
Claudio Passino,
Aldo Clerico,
Chiara Caselli Tags: REVIEW ARTICLE Source Type: research
