Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases
AbstractThe medicinal properties of cannabis and cannabinoid-derivative are entirely investigated and known. In addition, the identification of psychotropic plant cannabinoids has led to more studies regarding the cannabinoid system and its therapeutic features in the treatment and management of clinical symptoms of neuroinflammatory disorders, such as multiple sclerosis (MS), Parkinsons disease (PD), and Alzheimers disease (AD). In fact, cannabinoid agonists are able to control and regulate inflammatory responses. In contrast to the cannabinoid receptor type 1 (CB1) and its unwanted adverse effects, the cannabinoid recept...
Source: BioFactors - January 14, 2023 Category: Biochemistry Authors: Bahareh Abd ‐Nikfarjam,
Amirhossein Dolati‐Somarin,
Vafa Baradaran Rahimi,
Vahid Reza Askari Tags: REVIEW ARTICLE Source Type: research
Melatonin ameliorates arsenic ‐induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats
AbstractChronic arsenic (As) exposure, mainly as a result of drinking contaminated water, is associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, and autophagy have been suggested as the molecular etiology of As cardiotoxicity. Melatonin (Mel) is a powerful antioxidant. Mel improves diabetic cardiomyopathy, cardiac remodeling, and heart failure. Following pre-treatment with Mel (10, 20, or 30 mg/kg/day i.p.), rats were orally gavaged with As (15 mg/kg/day) for 28 days. Electrocardiographic findings showed that Mel decreased the As-mediated QT interval prolo...
Source: BioFactors - January 8, 2023 Category: Biochemistry Authors: Fatemeh Yarmohammadi,
Samira Barangi,
Seyed Hamid Aghaee ‐Bakhtiari,
Hossein Hosseinzadeh,
Zahra Moosavi,
Russel J. Reiter,
A. Wallace Hayes,
Soghra Mehri,
Gholamreza Karimi Tags: RESEARCH ARTICLE Source Type: research
Effect of nano ‐curcumin on various diseases: A comprehensive review of clinical trials
AbstractThe antioxidant, anti-inflammatory, and antibacterial properties of curcumin have made it a valuable herbal product for improving various disorders, such as COVID-19, cancer, depression, anxiety, osteoarthritis, migraine, and diabetes. Recent research has demonstrated that encapsulating curcumin in nanoparticles might improve its therapeutic effects and bioavailability. To our knowledge, the efficacy of nano-curcumin on different aspects of health and disease has not been summarized in a study. Therefore, this review aimed to evaluate nano-curcumin's efficacy in various diseases based on the findings of clinical tr...
Source: BioFactors - January 7, 2023 Category: Biochemistry Authors: Shirin Hassanizadeh,
Mehrnaz Shojaei,
Mohammad Bagherniya,
Alexander N. Orekhov,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR ‐7/m‐TOR/SREBP1 pathway on prostate cancer
This study aimed to investigate the effects and underlying molecular mechanisms of icariin (ICA) and curcumol on autophagy, ferroptosis, and lipid metabolism in prostate cancer (PCa),in vitro andin vivo. Normal prostate epithelial cells RWPE-1 and PCa cell lines DU145 and PC-3 were treated with ICA and curcumol. Ferrostatin-1 (Fer-1) or 3-MA was added to treat DU145 and PC-3 cells. In addition, we knocked down miR-7. The mechanism of ICA and curcumol in PCa cells after the knockdown of miR-7 was verified byin vitro nude mice tumorigenesis experiments. ICA and curcumol had no significant effect on the viability of RWPE-1 ce...
Source: BioFactors - January 4, 2023 Category: Biochemistry Authors: Wenjing Xu,
Jin Ding,
Bonan Li,
Tiansong Sun,
Xujun You,
Qinghu He,
Wen Sheng Tags: RESEARCH ARTICLE Source Type: research
Redox ‐metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation
AbstractAdaptive responses to environmental and physiological challenges, including exposure to low environmental temperature, require extensive structural, redox, and metabolic reprogramming. Detailed molecular mechanisms of such processes in the skin are lacking, especially the role of nuclear factor erythroid 2-related factor 2 (Nrf2) and other closely related redox-sensitive transcription factors Nrf1, Nrf3, and nuclear respiratory factor (NRF1). To investigate the role of Nrf2, we examined redox and metabolic responses in the skin of wild-type (WT) mice and mice lacking functional Nrf2 (Nrf2 KO) at room (RT, 24 ±...
Source: BioFactors - December 31, 2022 Category: Biochemistry Authors: Tamara Zakic,
Sara Stojanovic,
Aleksandra Jankovic,
Aleksandra Korac,
Vanja Pekovic ‐Vaughan,
Bato Korac Tags: RESEARCH ARTICLE Source Type: research
Rosa gallica and its active compound, cyanidin ‐3,5‐O‐diglucoside, improve skin hydration via the GLK signaling pathway
AbstractRosa gallica has been previously reported to display anti-inflammatory, anti-oxidative, and anti-skin wrinkle activities. However, the effect ofRosa gallica on skin hydration and its active components are largely unknown. Herein, we aimed to investigate the skin hydration effect of rose petal extract (RPE) in humans and elucidate the underlying molecular mechanism. A double-blinded clinical study was performed to investigate the effect of RPE on skin hydration. Stratum corneum moisture analysis demonstrated that RPE treatment significantly improved hydration levels in human skin. Furthermore, HAS2 and hyaluronic ac...
Source: BioFactors - December 28, 2022 Category: Biochemistry Authors: Ji ‐Won Seo,
Seongin Jo,
Young Sung Jung,
Mohammad‐Al Mijan,
Joy Cha,
Seungpyo Hong,
Sanguine Byun,
Tae‐Gyu Lim Tags: RESEARCH ARTICLE Source Type: research
Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases
AbstractThis review aimed to identify preclinical and clinical studies examining the effects of rosmarinic acid (RA), carnosic acid (CaA), rosmanol (RO), carnosol (CA), and ursolic acid (UA) against allergic and immunologic disorders. Various online databases, including PubMed, Science Direct, EMBASE, Web of Sciences, Cochrane trials, and Scopus, were searched from inception until October 2022. Due to the suppression of the nuclear factor- κB (NF-κB) pathway, the main factor in allergic asthma, RA may be a promising candidate for the treatment of asthma. The other ingredients comprising CA and UA reduce the expression of...
Source: BioFactors - December 24, 2022 Category: Biochemistry Authors: Faegheh Farhadi,
Vafa Baradaran Rahimi,
Neda Mohamadi,
Vahid Reza Askari Tags: REVIEW ARTICLE Source Type: research
