Promotion of degradative autophagy by 6 ‐bromoindirubin‐3′‐oxime attenuates neuropathy
Tunicamycin increases peripheral neuropathy subsequently treatment with 6-BIO reduces peripheral neuropathy and increases degradative autophagy and reduces secretory autophagy. AbstractDamage to the central or peripheral nervous system causes neuropathic pain. Endoplasmic reticulum (ER) stress plays a role in peripheral neuropathy. Increase in ER stress is seen in diabetic neuropathy. Inducers of ER stress also give rise to peripheral neuropathy. ER stress leads to the formation of autophagosome but as their degradation is also stalled during ER stress accumulation of autophagosomes is seen. Accumulation of autophagosomes ...
Source: BioFactors - May 31, 2023 Category: Biochemistry Authors: Praveen Jaiswar,
Mitali Bhate,
Avadhesha Surolia Tags: RESEARCH ARTICLE Source Type: research
Stachydrine, N ‐acetylornithine and trimethylamine N‐oxide levels as candidate milk biomarkers of maternal consumption of an obesogenic diet during lactation
Reverting to a healthy maternal diet during lactation normalizes the altered milk metabolome found in obese rats. Stachydrine,N-acetylornithine and TMAO levels are proposed as candidate biomarkers of maternal consumption of an obesogenic diet during lactation. AbstractWe aimed to evaluate whether improving maternal diet during lactation in diet-induced obese rats reverts the impact of western diet (WD) consumption on the metabolome of milk and offspring plasma, as well as to identify potential biomarkers of these conditions. Three groups of dams were followed: control-dams (CON-dams), fed with standard diet (SD); WD-dams, ...
Source: BioFactors - May 29, 2023 Category: Biochemistry Authors: Pedro Castillo,
Ondrej Kuda,
Jan Kopecky,
Catalina Amadora Pomar,
Andreu Palou,
Mariona Palou,
Catalina Pic ó Tags: RESEARCH ARTICLE Source Type: research
Torpor ‐responsive microRNAs in the heart of the Monito del monte, Dromiciops gliroides
In this study, the expression of 82 miRNAs was assessed in the hearts of active and torpidD.gliroides, finding that 14 were significantly differentially expressed during torpor. These 14 miRNAs were then used in bioinformatic analyses to identify Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were predicted to be most affected by these differentially expressed miRNAs. Overexpressed miRNAs were predicted to primarily regulate glycosaminoglycan biosynthesis, along with various signaling pathways such as Phosphoinositide-3-kinase/protein kinase B and transforming growth factor- β. Similarly, signaling pathways ...
Source: BioFactors - May 24, 2023 Category: Biochemistry Authors: Sarah A. Breedon,
Anchal Varma,
Julian F. Quintero ‐Galvis,
Juan Diego Gaitán‐Espitia,
Carlos Mejías,
Roberto F. Nespolo,
Kenneth B. Storey Tags: RESEARCH ARTICLE Source Type: research
Platelet ‐activating factor as an endogenous cofactor of food anaphylaxis
PAF is an endogenous factor of food anaphylaxis. AbstractAnaphylaxis is a severe, acute, life-threatening generalized or systemic hypersensitivity reaction. The incidence of anaphylaxis is increasing worldwide, with medications and food contributing to most cases. Physical exercise, acute infections, drugs, alcohol, and menstruation are the external cofactors associated with more severe systemic reaction. The aim of this review is to show that platelet-activating factor contributes to the development of severe anaphylactic reaction, and even to anaphylactic shock. (Source: BioFactors)
Source: BioFactors - May 19, 2023 Category: Biochemistry Authors: Pa łgan Krzysztof,
Tretyn Andrzej Tags: REVIEW ARTICLE Source Type: research
Therapeutic potential of phytochemicals for cystic fibrosis
In conclusion, while curcumin, genistein, and resveratrol have demonstrated effectiveness in this regard, it should be emphasized that coumarins, quercetin, and other herbal medicines also have beneficial effects on transporter function, transmembrane conductivity, and overall channel activity. AbstractThe aim of this review was to review and discuss various phytochemicals that exhibit beneficial effects on mutated membrane channels, and hence, improve transmembrane conductance. These therapeutic phytochemicals may have the potential to decrease mortality and morbidity of CF patients. Four databases were searched using key...
Source: BioFactors - May 17, 2023 Category: Biochemistry Authors: Hamed Baharara,
Prashant Kesharwani,
Thomas P. Johnston,
AmirHossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases
We identified 56 differential serum proteins that recapitulate some of the main cellular processes orchestrating liver regeneration in its early phase. Our results provide a protein-based molecular framework to assess early liver regeneration by noninvasive procedures in patients subjected to liver resection or liver transplant. AbstractThe liver is the only solid organ capable of regenerating itself to regain 100% of its mass and function after liver injury and/or partial hepatectomy (PH). This exceptional property represents a therapeutic opportunity for severe liver disease patients. However, liver regeneration (LR) mig...
Source: BioFactors - May 13, 2023 Category: Biochemistry Authors: Lorena Carmona ‐Rodríguez,
Aaron S. Gajadhar,
Irene Blázquez‐García,
Laura Guerrero,
Manuel A. Fernández‐Rojo,
Iker Uriarte,
Maricruz Mamani‐Huanca,
Ángeles López‐Gonzálvez,
Sergio Ciordia,
Antonio Ramos,
José Ignacio Herrero, Tags: RESEARCH ARTICLE Source Type: research
Modulation of the ubiquitin ‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors
Modulation of the ubiquitin-proteasome system (UPS) attracted tremendous interest since it affects the homeostasis of proteins critically engaged in various cell functions, for example, cell metabolism, survival, proliferation, and differentiation. Phytochemicals, with their safe and multimodal actions, are among the promising therapeutic tools capable of turning the operation of various UPS elements. The present study, along with an updated outline of the role of UPS dysregulation in multiple cancers, provided a detailed discussion on the impact of phytochemicals on the UPS function in malignancies, especially brain tumor...
Source: BioFactors - May 11, 2023 Category: Biochemistry Authors: Mehdi Sanati,
Amir R. Afshari,
Seyed Sajad Ahmadi,
Seyed Adel Moallem,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Endogenously produced hyaluronan contributes to the regulation of peritoneal adhesion development
The role of endogenously-produced hyaluronic acid was studied in the context of peritoneal fibrosis and the peritoneal adhesion formation. The attenuation of HA production was related to the reduction of pro-fibrotic markers. Endogenous HA was identified as an important regulator of peritoneal fibrosis, not just a passive player during this pathological process. AbstractPeritoneal adhesions are postsurgical fibrotic complications connected to peritoneal inflammation. The exact mechanism of development is unknown; however, an important role is attributed to activated mesothelial cells (MCs) overproducing macromolecules of e...
Source: BioFactors - May 9, 2023 Category: Biochemistry Authors: Anna Kocurkova,
Michaela Kerberova,
Kristina Nesporova,
Katerina Lehka,
Miriam Sandanusova,
Matej Simek,
Vladimir Velebny,
Lukas Kubala,
Gabriela Ambrozova Tags: RESEARCH ARTICLE Source Type: research
