SUMO2/3 promotes the progression and oxaliplatin resistance of colorectal cancer through facilitating the SUMOylation at Ku80 ‐K307
We describes the role for SUMO2/3 during oxaliplatin resistance in CRC and assessed the contribution of Ku80 SUMOylation in this process. Overexpression of SUMO2/3-promoted CRC cell proliferation, invasion, migration in vitro and in vivo. SUMOylation of K307 in Ku80 attenuated the DNA damage of CRC cells caused by oxaliplatin and was consistent with an antiapoptotic role for SUMO2/3. AbstractColorectal cancer (CRC) is one of the most prevalent cancers worldwide and is typically treated with the FOLFOX regimen (folinic acid, 5-fluorouracil, and oxaliplatin). However, oxaliplatin resistance remains a serious clinical problem...
Source: BioFactors - June 21, 2023 Category: Biochemistry Authors: Dan Feng,
Jinsong He,
Min Yuan,
Qing Chen,
Xi Zeng,
Qilin Zhou,
Jian Wu,
Bin Han Tags: RESEARCH ARTICLE Source Type: research
Adipose tissue ‐derived mesenchymal stem cells ameliorate cognitive impairment in Alzheimer's disease rat model: Emerging role of SIRT1
The present study aimed to investigate the therapeutic potential of adipose tissue-derived mesenchymal stem cells (Ad-MSCs) in Alzheimer's disease (AD) rat model, and to explore the possible implication of SIRT1. Our data demonstrated that transplantation of Ad-MSCs alleviated cognitive impairment in AD rats. Additionally, they exhibited anti-amyloidogenic, anti-apoptotic, anti-inflammatory, as well as neurogenic effects. Furthermore, Ad-MSCs were found to mediate their therapeutic effects, at least partially, via modulating both central and systemic SIRT1 levels. Hence, the current study portrays Ad-MSCs as an effective t...
Source: BioFactors - June 16, 2023 Category: Biochemistry Authors: Mohamed Nabil,
Dina H. Kassem,
Azza A. Ali,
Hala O. El ‐Mesallamy Tags: RESEARCH ARTICLE Source Type: research
Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae
Production of a postbiotic extract using sugarcane straw as substrate of fermentation process andSaccharomyces cerevisiae as fermentative microorganism. The extract obtained showed antioxidant and anti-inflammatory activities in skin cells, as well as beneficial for skin microbiota modulation applications. This sustainable produced postbiotic extract can be used for cosmetic and skincare ingredients development AbstractPostbiotics are defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” They can be produced by fermentation, using culture media with gl...
Source: BioFactors - June 15, 2023 Category: Biochemistry Authors: Marco Duarte,
Maria Jo ão Carvalho,
Nelson Mota Carvalho,
João Azevedo‐Silva,
Adélia Mendes,
Inês Pinto Ribeiro,
João Carlos Fernandes,
Ana L. S. Oliveira,
Carla Oliveira,
Manuela Pintado,
Ana Amaro,
Ana Raquel Madureira Tags: RESEARCH ARTICLE Source Type: research
Quercetin attenuates angiotensin II ‐induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo
This study addresses pharmacologic and mechanistic perspectives of quercetin against Ang-II-induced vascular injury and the increase of blood pressure. (Source: BioFactors)
Source: BioFactors - June 10, 2023 Category: Biochemistry Authors: Farman Ali,
Di Wang,
Ying Cheng,
Meizhu Wu,
Muhammad Zubair Saleem,
Lihui Wei,
Yi Xie,
Mengchao Yan,
Jiangfeng Chu,
Yanyan Yang,
Aling Shen,
Jun Peng Tags: RESEARCH ARTICLE Source Type: research
Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity
Angiotensin II type 2 receptor as a noval activator of brown adipose tissue in obesity. AbstractThe angiotensin II type 2 receptor (AT2R) exerts vasorelaxant, anti-inflammatory, and antioxidant properties. In obesity, its activation counterbalances the adverse cardiovascular effects of angiotensin II mediated by the AT1R. Preliminary results indicate that it also promotes brown adipocyte differentiation in vitro. Our hypothesis is that AT2R activation could increase BAT mass and activity in obesity. Five-week-old male C57BL/6J mice were fed a standard or a high-fat (HF) diet for 6 weeks. Half of the animals were treated...
Source: BioFactors - June 8, 2023 Category: Biochemistry Authors: Fabiola Alvarez ‐Gallego,
Raquel González‐Blázquez,
Marta Gil‐Ortega,
Beatriz Somoza,
María Calderón‐Dominguez,
Javier Moratinos,
Virginia Garcia‐Garcia,
Paloma Fernández,
Daniel González‐Moreno,
Marta Viana,
Martín Alcalá Tags: RESEARCH ARTICLE Source Type: research
Correction to “Growth differentiation factor‐15 is independently associated with metabolic syndrome and hyperglycemia in non‐elderly subjects”
(Source: BioFactors)
Source: BioFactors - June 7, 2023 Category: Biochemistry Tags: CORRIGENDUM Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - June 6, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - June 6, 2023 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - June 6, 2023 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
