Glucose Dilates Renal Afferent Arterioles via Glucose Transporter-1.
In conclusion, we demonstrated that an increase in glucose concentration dilates the Af-Art by stimulation of the endothelium derived NO production mediated by GLUT1. PMID: 29513069 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Zhang J, Jiang S, Wei J, Yip KP, Wang L, Lai EY, Liu R Tags: Am J Physiol Renal Physiol Source Type: research

Endothelial progenitor cells accelerate endothelial regeneration in an in vitro model of Shigatoxin-2a-induced injury via soluble growth factors.
t N Abstract Endothelial injury with consecutive microangiopathy and endothelial dysfunction plays a central role in the pathogenesis of the post-enteropathic hemolytic uremic syndrome (D+HUS). To identify new treatment strategies, we examined the regenerative potential of endothelial progenitor cells (EPC) in an in vitro model of Shiga toxin (Stx) 2a-induced glomerular endothelial injury present in D+HUS and the mechanisms of EPC-triggered endothelial regeneration. We simulated the pro-inflammatory milieu present in D+HUS by priming human renal glomerular endothelial cells (HRGEC) with Tumor Necrosis Factor (TNF)...
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Patry C, Betzen C, Fathalizadeh F, Fichtner A, Westhoff JH, Fleming T, Eckstein V, Bruckner T, Bielaszewska M, Karch H, Hoffmann GF, Tönshoff B, Rafat N Tags: Am J Physiol Renal Physiol Source Type: research

Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease.
In this study, we aimed to identify genes aberrantly regulated by STAT6 to better understand how increased IL13/STAT6 signaling may contribute to PKD progression. We demonstrate that the expression of periostin, galectin-3 and interleukin-24 (IL24) are up regulated in various forms of PKD and that their aberrant regulation is mediated by IL13 and STAT6 activity. Periostin and galectin-3 have previously been implicated in PKD progression. We support these findings by showing that periostin expression is increased after IL13 treatment in kidney epithelial cells, that galectin-3 expression is increased after injecting IL13 in...
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Olsan EE, West JD, Torres JA, Doerr N, Weimbs T Tags: Am J Physiol Renal Physiol Source Type: research

Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine (ADMA) & dimethylarginine dimethylaminohydrolase (DDAH) 1.
Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine (ADMA) & dimethylarginine dimethylaminohydrolase (DDAH) 1. Am J Physiol Renal Physiol. 2018 Mar 07;: Authors: Bell T, Araujo M, Luo Z, Tomlinson J, Leiper J, Welch WJ, Wilcox CS Abstract BACKGROUND: Nitric oxide prevents hypertension yet paradoxically reduces proximal tubule Na+ reabsorption. Nitric oxide synthase is inhibited by asymmetric dimethylarginine (ADMA) that is metabolized by dimethylarginine dimethylaminohydrolase (DDAH) whose type 1 isoform is expressed abundantly in the PT. HYP...
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Bell T, Araujo M, Luo Z, Tomlinson J, Leiper J, Welch WJ, Wilcox CS Tags: Am J Physiol Renal Physiol Source Type: research

Modulation of Tubular Solute Reuptake in UMOD knockout mice.
PMID: 29513073 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Friedman DJ, Alper SL Tags: Am J Physiol Renal Physiol Source Type: research

Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2/STAT3 pathway.
CONCLUSIONS Our study revealed a long-term beneficial effect of triptolide in PKD which probably through inhibition of the JAK2/STAT3 pathway. PMID: 29513074 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Jing Y, Wu M, Zhang D, Chen D, Yang M, Mei S, He L, Gu J, Qi N, Fu L, Li L, Mei C Tags: Am J Physiol Renal Physiol Source Type: research

Identification of transcripts associated with renal damage due to ureteral obstruction as candidate urinary biomarkers.
Abstract Renal obstruction is a common cause of renal failure in adults and children and is suspected when hydronephrosis is detected on imaging. Since not all cases of hydronephrosis are associated with renal damage, biomarkers are needed to guide intervention to relieve obstruction. We performed gene expression profiling on the kidneys from adult mice over a detailed time course after obstruction and compared these data to a neonatal model of bilateral high grade obstruction induced by conditional deletion of the calcineurin ß1 (Cnb1) gene. Having identified a set of 143 transcripts modulated in both adult...
Source: Am J Physiol Renal P... - February 28, 2018 Category: Urology & Nephrology Authors: Wu B, Gong X, Kennedy WA, Brooks JD Tags: Am J Physiol Renal Physiol Source Type: research

Hemicentin 1 influences podocyte dynamic changes in glomerular diseases.
Abstract Different complex mechanisms control the morphology of podocyte foot processes and their interactions with the underlying basement membrane. Injuries to this system often cause glomerular dysfunction and albuminuria. The present study aimed at identifying early markers of glomerular damage in diabetic nephropathy. For this purpose, we performed a microarray analysis on kidneys of 3-week-old PPARγ null and AZIP/F1 mice, which are two models of diabetic nephropathy due to lipodystrophy. This was followed by functional annotation of the enriched clusters of genes. One of the significant changes in the ...
Source: Am J Physiol Renal P... - February 28, 2018 Category: Urology & Nephrology Authors: Toffoli B, Zennaro C, Winkler C, Giordano Attianese GMP, Bernardi S, Carraro M, Gilardi F, Desvergne B Tags: Am J Physiol Renal Physiol Source Type: research

Am J Physiol Renal Physiol; +37 new citations
37 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2018/01/24PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - January 25, 2018 Category: Urology & Nephrology Tags: Report Source Type: research

Corrigendum.
Authors: PMID: 29351399 [PubMed - in process] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - January 1, 2018 Category: Urology & Nephrology Tags: Am J Physiol Renal Physiol Source Type: research

Corrigendum.
Authors: PMID: 29351400 [PubMed - in process] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - January 1, 2018 Category: Urology & Nephrology Tags: Am J Physiol Renal Physiol Source Type: research

Corrigendum.
Authors: PMID: 29351401 [PubMed - in process] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - January 1, 2018 Category: Urology & Nephrology Tags: Am J Physiol Renal Physiol Source Type: research

Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.
In this study, we show that pregnane X receptor (PXR), a xenobiotic nuclear receptor, is epigenetically altered and upregulated, and may have a possible function in the diabetic kidney. PXR has been shown to play a critical role in metabolic changes in obesity and diabetes; however, its distribution and function in the kidney are unknown. In the normal kidney, PXR was selectively expressed in the proximal tubular cells with demethylation in the promoter DNA. In db/db mice, significant increases in Pxr mRNA, further demethylation of DNA, and stimulatory histone marks in the promoter were observed. Epigenetic changes are lik...
Source: Am J Physiol Renal P... - December 6, 2017 Category: Urology & Nephrology Authors: Watanabe A, Marumo T, Kawarazaki W, Nishimoto M, Ayuzawa N, Ueda K, Hirohama D, Tanaka T, Yagi S, Ota S, Nagae G, Aburatani H, Kumagai H, Fujita T Tags: Am J Physiol Renal Physiol Source Type: research

Changes in the fluid volume balance between intra- and extracellular water in a sample of Japanese adults aged 15-88 years old: a cross-sectional study.
In conclusion, the fluid imbalance between ICW and ECW contents is driven by decreased cell volume associated with aging and muscle attenuation. Therefore, our proposed formula may serve as a useful assessment tool for the calculation of body fluid composition. PMID: 29212765 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 6, 2017 Category: Urology & Nephrology Authors: Ohashi Y, Joki N, Yamazaki K, Kawamura T, Tai R, Oguchi H, Yuasa R, Sakai K Tags: Am J Physiol Renal Physiol Source Type: research

Cutting-edge microangio-CT: new dimensions in vascular imaging and kidney morphometry.
Djonov V Abstract In the last decades the contrast-enhanced microCT-imaging of whole animal kidney became increasingly important. The visualization was mainly limited to middle-sized vessels. Since modern desktop microCT-scanners provide the necessary detail resolution, we developed an approach for rapid visualization and consistent assessment of kidney vasculature and glomeruli number. This method is based on μAngiofil®, a new polymerizing contrast agent with homogenous X-ray absorption, which provides continuous filling of the complete vasculature and enables correlative imaging approaches. For rapid and...
Source: Am J Physiol Renal P... - November 22, 2017 Category: Urology & Nephrology Authors: Hlushchuk R, Zubler C, Barré S, Correa Shokiche C, Schaad L, Röthlisberger R, Wnuk ML, Daniel C, Khoma O, Tschanz SA, Reyes M, Djonov V Tags: Am J Physiol Renal Physiol Source Type: research

Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model.
We examined the effect of canagliflozin on the accumulation of uremic toxins in chronic kidney disease using adenine-induced renal failure mice. Two-week canagliflozin (10 mg/kg, p.o.) treatment did not influence the impaired renal function; however, it significantly reduced the plasma levels of p-cresyl sulfate and indoxyl sulfate in renal failure mice (a 75% and 26% reduction, respectively, compared with the vehicle group). Additionally, canagliflozin significantly increased cecal short-chain fatty acids in the mice, suggesting the promotion of bacterial carbohydrate fermentation in the intestine. Analysis of the cecal m...
Source: Am J Physiol Renal P... - November 22, 2017 Category: Urology & Nephrology Authors: Mishima E, Fukuda S, Kanemitsu Y, Saigusa D, Mukawa C, Asaji K, Matsumoto Y, Tsukamoto H, Tachikawa T, Tsukimi T, Fukuda NN, Ho HJ, Kikuchi K, Suzuki C, Nanto F, Suzuki T, Ito S, Soga T, Tomioka Y, Abe T Tags: Am J Physiol Renal Physiol Source Type: research

Advances in our Understanding of the Pathogenesis of Hemolytic Uremic Syndromes.
Abstract Hemolytic uremic syndrome (HUS) is major global health care issue as it is the leading cause of acute kidney injury in children. It is a triad of acute kidney injury, microangiopathic hemolytic anemia and thrombocytopenia. It is classified as a glomerular thrombotic microangiopathy. In recent years major advances in our understanding of complement driven inherited rare forms of HUS have been achieved. However, 90% of cases of HUS are associated with a Shiga toxin producing enteric pathogen. The precise pathological mechanisms in this setting are yet to be elucidated. The purpose of this review is to discu...
Source: Am J Physiol Renal P... - November 22, 2017 Category: Urology & Nephrology Authors: Bowen EE, Coward RJM Tags: Am J Physiol Renal Physiol Source Type: research

Podocytes Exhibit a Specialized Protein Quality Control Employing Derlin-2 in Kidney Disease.
Abstract Podocytes are terminally differentiated cells of the kidney filtration barrier with a limited proliferative capacity, and are the primary glomerular target for various sources of cellular stress. Accordingly, it is particularly important for podocytes to cope with stress efficiently to circumvent cell death and avoid compromising renal function. Improperly folded proteins within the endoplasmic reticulum (ER) are associated with increased cellular injury and cell death. To relieve ER stress, protein quality control mechanisms like ER-associated degradation (ERAD) are initiated. Derlin-2 is an important di...
Source: Am J Physiol Renal P... - November 22, 2017 Category: Urology & Nephrology Authors: Ren G, Tardi NJ, Matsuda F, Koh KH, Ruiz P, Wei C, Altintas MM, Ploegh H, Reiser J Tags: Am J Physiol Renal Physiol Source Type: research

IL-33 deficiency slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer.
In conclusion, even though the cancer grows slower in IL-33 deficient mice, the data that IL-33 deficiency does not protect against AKI in a clinically relevant model, suggest that IL-33 inhibition may not be useful to attenuate AKI in patients with cancer. However, serum IL-33 may serve as a biomarker of AKI. PMID: 29070568 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Ravichandran K, Holditch S, Brown CN, Wang Q, Ozkok A, Weiser-Evans MC, Nemenoff RA, Miyazaki M, Thiessen-Philbrook H, Parikh CR, Ljubanovic D, Edelstein CL Tags: Am J Physiol Renal Physiol Source Type: research

Dexamethasone Enhances Vasopressin-Induced Aquaporin-2 Gene Expression in the mpkCCD Cells.
Abstract The cortical collecting duct cell (mpkCCD) has been an instrumental cell model for studying vasopressin-mediated aquaporin-2 regulation. This cell line was first developed by the Vandewalle's group from a transgenic mouse carrying the transforming SV40 antigens driven by the pyruvate kinase promoter. To immortalize the cells, four hormone supplements (dexamethasone, epidermal growth factor, insulin and triiodothyronine) were used to enhance SV40 antigen expression; however, these hormones appear to have various effects on aquaporin-2 gene expression in the cells. Here, we evaluated the effects of each hor...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Kuo KT, Yang CW, Yu MJ Tags: Am J Physiol Renal Physiol Source Type: research

Hypoxia/reoxygenation enhances murine afferent arteriolar vasoconstriction by angiotensin II.
Abstract We tested the hypothesis that hypoxia/reoxygenation (H/R) augments vasoreactivity to angiotensin II (Ang II). In particular, we compared an in situ live kidney slice model with isolated afferent arterioles (C57Bl6 mice) to assess the impact of tubules on microvessel response. H&E staining was used to estimate slice viability. Arterioles in the slices were located by DIC microscopy, and responses to vasoactive substances were assessed. Cytosolic calcium transients and NADPH oxidase mRNA expression were studied in isolated afferent arterioles. SOD activity was measured in live slices. Both experimental ...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Pahlitzsch TM, Liu ZZ, Al-Masri A, Braun D, Dietze S, Persson PB, Schunck WH, Blum M, Kupsch E, Ludwig M, Patzak A Tags: Am J Physiol Renal Physiol Source Type: research

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
Abstract Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary concentrating defect. Li-NDI is due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. Earlier, we have shown that the carbonic anhydrase (CA) inhibitor acetazolamide attenuated Li-induced downregulation in mouse collecting duct (mpkCCD) cells. Of the eight CAs present in mpkCCD cells, siRNA and drug treatments showed that downregulation of CA9 and to some ex...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Alsady M, de Groot T, Kortenoeven MLA, Carmone C, Neijman K, Bekkenkamp-Grovenstein M, Engelke U, Wevers R, Baumgarten R, Korstanje R, Deen PMT Tags: Am J Physiol Renal Physiol Source Type: research

Glucagon-like peptide-1 analog prevents obesity-related glomerulopathy by inhibiting excessive autophagy in podocytes.
CONCLUSION: Excess autophagy in podocytes was induced by inhibition of Glut4 translocation to the plasma membrane and was involved in the pathology of ORG. GLP-1 restored insulin sensitivity and ameliorated renal injury by decreasing the level of autophagy. PMID: 29070572 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Guo H, Wang B, Li H, Ling L, Niu J, Gu Y Tags: Am J Physiol Renal Physiol Source Type: research

MiR-34c-5p and CaMKII are involved in aldosterone-induced fibrosis in kidney collecting duct cells.
Abstract Mineralocorticoids trigger a pro-fibrotic process in kidney. In mouse cortical collecting duct cells (mpkCCDc14 cells), the present study addressed two main questions: 1) what are miRNAs and their target genes changed by aldosterone? and 2) what do miRNAs in response to aldosterone regulate signaling pathways related to fibrosis? Microarray chip assay was done in cells in the absence or presence of aldosterone treatment (10(-6)M, 3 d). The candidate miRNAs were identified by the criteria of more than 30% of fold-change among the significantly changed miRNAs (P value 1.3-fold) and 27 miRNAs were down-regulated (
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Park EJ, Jung HJ, Choi HJ, Cho JI, Park HJ, Kwon TH Tags: Am J Physiol Renal Physiol Source Type: research

Cell adhesion molecule-1 (CADM1) shedding induces apoptosis of renal epithelial cells and exacerbates human nephropathies.
Abstract Chronic kidney disease (CKD) is an important problem throughout the world, associated with the increase of blood urea nitrogen (BUN) and serum creatinine (sCre), and renal tubular injuries. It is crucial to elucidate the molecular mechanisms of renal injuries in order to identify the new therapeutics and early diagnostic methods. We focused on cell adhesion molecule-1 (CADM1) protein. CADM1, its isoform SP4, is expressed in the epithelial cells of various tissues including renal distal tubules, localized on the lateral cell membrane, mediates cell-cell adhesion via trans-homophilic binding, and interacts ...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Kato T, Hagiyama M, Takashima Y, Yoneshige A, Ito A Tags: Am J Physiol Renal Physiol Source Type: research

Saphenous Nerve Stimulation Normalizes Bladder Underactivity Induced by Tibial Nerve Stimulation in Cats.
This study in α-chloralose anesthetized cats aimed at investigating the bladder responses to saphenous nerve stimulation (SNS). A urethral catheter was used to infuse the bladder with saline and to record changes in bladder pressure. With the bladder fully distended, SNS at 1 Hz frequency and an intensity slightly below the threshold (T) for inducing an observable motor response of the hindlimb muscles induced large amplitude (40-150 cmH2O) bladder contractions. Application of SNS (1 Hz, 2-4T) during cystometrograms (CMGs), when the bladder was slowly (1-3 ml/min) infused with saline, significantly (p
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Li S, Li X, Theisen K, Browning J, Shen B, Wang J, Roppolo JR, de Groat WC, Tai C Tags: Am J Physiol Renal Physiol Source Type: research

Am J Physiol Renal Physiol; +24 new citations
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/10/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - October 21, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

ATP induces PAD4 in renal proximal tubule cells via P2X7 receptor activation to exacerbate ischemic AKI.
Abstract We previously demonstrated that renal tubular peptidylarginine deiminase-4 (PAD4) is induced after ischemia reperfusion (IR) injury and this induction of PAD4 exacerbates ischemic acute kidney injury (AKI) by promoting renal tubular inflammation and neutrophil infiltration. However, the mechanisms of renal tubular PAD4 induction after IR remain unknown. Here, we tested the hypothesis that ATP, a pro-inflammatory danger associated molecular pattern (DAMP) ligand released from necrotic cells after IR injury, induces renal tubular PAD4 and exacerbates ischemic AKI via P2 purinergic receptor activation. ATP a...
Source: Am J Physiol Renal P... - October 11, 2017 Category: Urology & Nephrology Authors: Rabadi MM, Kim M, Li H, Han SJ, Choi Y, D'Agati VD, Lee HT Tags: Am J Physiol Renal Physiol Source Type: research

Attenuation of Accelerated Renal Cystogenesis in Pkd1 Mice by Renin Angiotensin System Blockade.
CONCLUSIONS: These results indicate that suppressing Agt using an ASO slowed the progression of accelerated cystic kidney disease induced by unilateral nephrectomy in Pkd1 mice by suppressing intrarenal RAS, mTOR pathway and cell proliferation. PMID: 29021226 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - October 11, 2017 Category: Urology & Nephrology Authors: Fitzgibbon WR, Dang Y, Bunni MA, Baicu CF, Zile MR, Mullick AE, Saigusa T Tags: Am J Physiol Renal Physiol Source Type: research

Physiological Regulation of the Epithelial Na+ Channel by Casein Kinase II.
Abstract The Epithelial Na+ Channel, ENaC, is the final arbiter of sodium excretion in the kidneys. As such, discretionary control of ENaC by hormones is critical to the fine-tuning of electrolyte and water excretion and consequently, blood pressure. Casein kinase 2 (CK2) phosphorylates ENaC. Phosphorylation by CK2 is necessary for normal ENaC activity. We tested the physiological importance of CK2 regulation of ENaC as the degree to which ENaC activity is dependent on CK2 phosphorylation in the living organism is unknown. This was addressed using patch clamp analysis of ENaC in split-open collecting ducts in comp...
Source: Am J Physiol Renal P... - October 11, 2017 Category: Urology & Nephrology Authors: Berman JM, Mironova E, Stockand JD Tags: Am J Physiol Renal Physiol Source Type: research

Am J Physiol Renal Physiol; +26 new citations
26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/10/04PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - October 4, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

PGC1 α in the kidney.
PGC1α in the kidney. Am J Physiol Renal Physiol. 2017 Sep 20;:ajprenal.00263.2017 Authors: Lynch MR, Tran MT, Parikh SM Abstract Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal effects of PGC1α make it a prime ...
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Authors: Lynch MR, Tran MT, Parikh SM Tags: Am J Physiol Renal Physiol Source Type: research

Three-dimensional morphometric analysis of the renal vasculature.
We present a semi-supervised method for three-dimensional morphometric analysis of renal vasculature images generated by computed tomography. We derive quantitative vascular attributes important to mass transport between arteries, veins and the renal tissue, and present methods for their computation for a three-dimensional vascular geometry. To validate the algorithm, we compare automated vascular estimates with subjective manual measurements for a portion of rabbit kidney. While increased image resolution can improve outcomes, our results demonstrate that the method can quantify the morphological characteristics of artery...
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Authors: Khan Z, Ngo JP, Le B, Evans RG, Pearson JT, Gardiner BS, Smith DW Tags: Am J Physiol Renal Physiol Source Type: research

Contribution of myo-inositol oxygenase in age: rage mediated renal tubulo-interstitial injury in the context of diabetic nephropathy.
CONTRIBUTION OF MYO-INOSITOL OXYGENASE IN AGE: RAGE MEDIATED RENAL TUBULO-INTERSTITIAL INJURY IN THE CONTEXT OF DIABETIC NEPHROPATHY. Am J Physiol Renal Physiol. 2017 Sep 20;:ajprenal.00434.2017 Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Abstract Advanced glycation end products (AGEs) play a role in pathogenesis of diabetic nephropathy (DN). Myo-inositol Oxygenase (MIOX) has been implicated in tubulo-interstitial injury in the context of DN. We investigated the effect of AGEs on MIOX expression and delineated mechanisms that lead to tubulo-interstitial injury. Status of MIOX, RAGE and relevant ...
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Tags: Am J Physiol Renal Physiol Source Type: research

Am J Physiol Renal Physiol; +49 new citations
49 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/09/19PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

Complement C5a receptors C5L2 and C5aR in renal fibrosis.
In conclusion, in experimental renal fibrosis C5L2 and C5aR both contribute to tubular injury, and, while C5aR acts profibrotic, C5L2 does not play a role in extracellular matrix accumulation, arguing against C5L2 functioning simply as a decoy receptor. PMID: 28903945 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - September 13, 2017 Category: Urology & Nephrology Authors: Martin IV, Bohner A, Boor P, Shagdarsuren E, Raffetseder U, Lammert F, Floege J, Ostendorf T, Weber SN Tags: Am J Physiol Renal Physiol Source Type: research

PPARA agonist fenofibrate enhances fatty acid β-oxidation and attenuates polycystic kidney and liver disease in mice.
In conclusion, our studies suggest that promoting PPARA activity to enhance mitochondrial metabolism may be a useful therapeutic strategy for ADPKD. PMID: 28903946 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - September 13, 2017 Category: Urology & Nephrology Authors: Lakhia R, Yheskel M, Flaten A, Quittner-Strom EB, Holland WL, Patel V Tags: Am J Physiol Renal Physiol Source Type: research

Am J Physiol Renal Physiol; +27 new citations
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/09/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - September 8, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

Am J Physiol Renal Physiol; +31 new citations
31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/08/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - August 9, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

Am J Physiol Renal Physiol; +22 new citations
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/07/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - July 27, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

Am J Physiol Renal Physiol; +19 new citations
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/07/26PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - July 26, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

Am J Physiol Renal Physiol; +35 new citations
35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2017/07/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - July 23, 2017 Category: Urology & Nephrology Tags: Report Source Type: research

Heterozygous Loss-of-Function Mutation in Odd Skipped Related 1 (Osr1) Is Associated with Vesico-Ureteric Reflux, Duplex Systems, and Hydronephrosis.
We describe a new domain of Osr1 expression in the ureteral mesenchyme and within the developing bladder in the mouse. OSR1 was sequenced in one hundred and eighty-six children with primary vesico-ureteric reflux and seventeen have single nucleotide polymorphisms. Fifteen children have a common synonymous variant, rs12329305, one child has a rare non-synonymous variant, rs3440471, and one child has a rare 5'UTR variant, rs45535040. The impact of these SNPs is not clear, therefore, the role of OSR1 in human disease remains to be elucidated. Osr1 is a candidate gene implicated in the pathogenesis of vesico-ureteric reflux an...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Fillion ML, El Andalousi J, Tokhmafshan F, Murugapoopathy V, Watt CL, Murawski IJ, Capolicchio JP, El-Sherbiny M, Jednak R, Gupta IR Tags: Am J Physiol Renal Physiol Source Type: research

Sex and Gender Differences in Hypertensive Kidney Injury.
Abstract Hypertension is a complex, multifaceted disorder, affecting approximately 1 on 3 adults in the United States. Although hypertension occurs in both men and women, there are distinct sex differences in the way in which they develop hypertension, with women having a lower incidence of hypertension until the sixth decade of life. Despite observed sex differences in hypertension, little is known about the molecular mechanisms underlying the development of hypertension in females, primarily due to their underrepresentation in both clinical and experimental animal studies. The first goal of this review is to pro...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Sullivan JC, Gillis E Tags: Am J Physiol Renal Physiol Source Type: research

Renal hemodynamic effects of glucagon like peptide-1 agonist are mediated by nitric oxide but not prostaglandin.
In conclusion, exenatide is a potent renal vasodilator and diuretic in the rat. These effects of exenatide are insensitive to COX inhibition but are mediated, in part, by NO. PMID: 28724607 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Thomson SC, Kashkouli A, Liu ZZ, Singh P Tags: Am J Physiol Renal Physiol Source Type: research

ErbB4 deletion accelerates renal fibrosis following renal injury.
In conclusion, increased expression of ErbB4 in the early stages of renal injury may reflect a compensatory effect to lessen tubulointerstitial injury. PMID: 28724608 [PubMed - as supplied by publisher] (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Zeng F, Miyazawa T, Kloepfer LA, Harris RC Tags: Am J Physiol Renal Physiol Source Type: research

Thy-1+/- fibroblast subsets in the human peritoneum.
Abstract Fibrotic thickening of the peritoneum develops in patients receiving peritoneal dialysis (PD) for renal failure. For unknown reasons, however, in some patients it progresses to extensive fibrosis that compromises dialysis capacity of the peritoneum. It is increasingly clear that fibroblasts display large heterogeneity not only between but also within tissues. Differential surface expression of glycoprotein Thy-1 (CD90) has been shown to identify functionally distinct fibroblast subsets in several organs. Here, we isolated Thy-1+/- subsets of human peritoneal fibroblasts (HPFB) and analyzed them in terms o...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Kawka E, Witowski J, Bartosova M, Catar R, Rudolf A, Philippe A, Rutkowski R, Schaefer B, Schmitt CP, Dragun D, Joerres A Tags: Am J Physiol Renal Physiol Source Type: research

Developing Better Mouse Models to Study Cisplatin-Induced Kidney Injury.
Abstract Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI) (29, 30). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD) (5, 14, 31). Unfortunately, there are no therapeutic interventions for the treatment of AKI. It has been suggested that the lack of therapies is due in part to the fact that the established mouse model used to study cisplatin-induced AKI does not recapitulate the cisplatin dosing regimen patients re...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Sharp CN, Siskind LJ Tags: Am J Physiol Renal Physiol Source Type: research

Tumor necrosis factor-alpha, Kidney function and hypertension.
Abstract Hypertension is considered to be a low-grade inflammatory condition characterized by the presence of various pro-inflammatory cytokines. The inflammatory cytokine Tumor Necrosis Factor-alpha (TNF-α) is a constituent of the pro-inflammatory environment that is associated with salt-sensitive hypertension (SSH) and related renal injury. Elevated angiotensin II (AngII) and other factors such as oxidative stress conditions promote TNF-α formation. Many recent studies have provided evidence that TNF-α exerts a direct renal action by regulating hemodynamic and excretory function in the kidney. ...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Mehaffey E, Majid DSA Tags: Am J Physiol Renal Physiol Source Type: research

Regulation of PDZ domain containing 1 (PDZK1) Expression by Hepatocyte Nuclear Factor 1 alpha (HNF1 α) in Human Kidney.
Regulation of PDZ domain containing 1 (PDZK1) Expression by Hepatocyte Nuclear Factor 1 alpha (HNF1α) in Human Kidney. Am J Physiol Renal Physiol. 2017 Jul 19;:ajprenal.00650.2016 Authors: Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE Abstract In the renal proximal tubule the secretion and reabsorption of glomerularly filtrated compounds is realized by a functional network of uptake and efflux transporters. The activity and localization of several transporters expressed at the apical tubular membrane is regulated by the membrane associated prote...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE Tags: Am J Physiol Renal Physiol Source Type: research