Regulation of the water channel Aquaporin-2 by Cullin E3 ubiquitin ligases

In conclusion, CRLs play a vital role in mediating some of the effects of VP to increase AQP2 plasma membrane accumulation and AQP2 abundance. Whether modulation of cullin activity can contribute to body water homeostasis requires further studies.PMID:38545647 | DOI:10.1152/ajprenal.00049.2024

Source: Am J Physiol Renal P... - March 28, 2024 Category: Urology & Nephrology Authors: Sathish K Murali James A McCormick Robert A Fenton Source Type: research