Podocytes from Hypertensive and Obese Mice Acquire an Inflammatory, Senescent and Aged Phenotype
Am J Physiol Renal Physiol. 2024 Feb 29. doi: 10.1152/ajprenal.00417.2023. Online ahead of print.ABSTRACTPatients with hypertension or obesity can develop glomerular dysfunction characterized by injury and depletion of podocytes. To better understand the molecular processes involved, young mice were treated with either deoxycorticosterone acetate (DOCA) or fed a high-fat diet (HFD) to induce hypertension or obesity, respectively. The transcriptional changes associated with these phenotypes were measured by unbiased bulk mRNA-sequencing of isolated podocytes from experimental models and their respective controls. Key findin...
Source: Am J Physiol Renal P... - February 29, 2024 Category: Urology & Nephrology Authors: Sierra R McKinzie Natalya Kaverina Robert Allen Schweickart Christopher Chaney Diana G Eng Beatriz Maria Veloso Pereira Bryan Kestenbaum Jeffrey W Pippin Oliver Wessely Stuart J Shankland Source Type: research
Liver and spleen predominantly mediate calciprotein particle clearance in a rat model of chronic kidney disease
In this study, we examined the fate of CPP2 in a rat model of CKD. Calcification was induced in Sprague Dawley rats by a 5/6-nephrectomy (5/6-Nx) combined with a high phosphate diet. Control rats received a sham surgery and high phosphate diet. Twelve weeks after surgery kidney failure was significantly induced in 5/6-Nx rats as determined by enhanced creatinine and urea plasma levels and abnormal kidney histological architecture. Subsequently, radioactive and fluorescent (FITC)-labeled CPP2 ([89Zr]Zr-CPP2-FITC) were injected i.v. to determine clearance in vivo. Using positron emission tomography scans and radioactive biod...
Source: Am J Physiol Renal P... - February 29, 2024 Category: Urology & Nephrology Authors: Lara W Zeper Caro Bos Pieter A Leermakers Gerben M Franssen Ren é Raavé Joost G J Hoenderop Jeroen H F de Baaij Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
