Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
