Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD)
CONCLUSIONS: Males with CKD have higher resting sympathetic activity compared to females with CKD. However, there was no difference in vascular stiffness between sexes. There was no correlation between resting MSNA and cfPWV, suggesting that non-neural mechanisms may play a greater role in the progression of vascular stiffness in CKD, particularly in females.PMID:38385174 | DOI:10.1152/ajprenal.00308.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matias G Zanuzzi Jinhee Jeong Dana R DaCosta Jeanie Park Source Type: research
< em > In Chronic Kidney Disease Altered Cardiac < /em > < em > Metabolism < /em > < em > Precedes Cardiac Hypertrophy < /em >
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00416.2023. Online ahead of print.ABSTRACTConduit arterial disease in CKD is an important cause of cardiac complications. Cardiac function in CKD has not been studied in the absence of arterial disease. In an Alport syndrome model bred not to have conduit arterial disease, mice at 225 days of life (dol) had CKD equivalent to human stage 4-5 CKD. PTH and FGF23 levels were one log order elevated, circulating sclerostin was elevated, and renal activin A was strongly induced. Aortic Ca levels were not increased and VSMC transdifferentiation was absent. The CKD mice...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Matthew J Williams Carmen M Halabi Hiral M Patel Zachary Joseph Kyle McCommis Carla Weinheimer Attila Kovacs Florence Lima Brian Finck Hartmut Malluche Keith A Hruska Source Type: research
Distinct Developmental Reprogramming Footprint of MacrophagesDuring Acute Kidney Injury Across Species
Am J Physiol Renal Physiol. 2024 Feb 15. doi: 10.1152/ajprenal.00013.2024. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who are critically ill. Development of AKI is associated with several adverse outcomes including mortality, morbidity, progression to chronic kidney disease, and increase in health care expenditure. Despite the well-established negative impact of AKI and rigorous efforts to better define, identify, and implement targeted therapies, the overall approach to treatment of AKI continues to principally encompass supportive measures. Thi...
Source: Am J Physiol Renal P... - February 15, 2024 Category: Urology & Nephrology Authors: Michal Mrug Elias Mrug Frida Rosenblum Jiandong Chen Xiangqin Cui Anupam Agarwal Abolfazl Zarjou Source Type: research
Distinct Developmental Reprogramming Footprint of MacrophagesDuring Acute Kidney Injury Across Species
Am J Physiol Renal Physiol. 2024 Feb 15. doi: 10.1152/ajprenal.00013.2024. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who are critically ill. Development of AKI is associated with several adverse outcomes including mortality, morbidity, progression to chronic kidney disease, and increase in health care expenditure. Despite the well-established negative impact of AKI and rigorous efforts to better define, identify, and implement targeted therapies, the overall approach to treatment of AKI continues to principally encompass supportive measures. Thi...
Source: Am J Physiol Renal P... - February 15, 2024 Category: Urology & Nephrology Authors: Michal Mrug Elias Mrug Frida Rosenblum Jiandong Chen Xiangqin Cui Anupam Agarwal Abolfazl Zarjou Source Type: research
Distinct Developmental Reprogramming Footprint of MacrophagesDuring Acute Kidney Injury Across Species
Am J Physiol Renal Physiol. 2024 Feb 15. doi: 10.1152/ajprenal.00013.2024. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who are critically ill. Development of AKI is associated with several adverse outcomes including mortality, morbidity, progression to chronic kidney disease, and increase in health care expenditure. Despite the well-established negative impact of AKI and rigorous efforts to better define, identify, and implement targeted therapies, the overall approach to treatment of AKI continues to principally encompass supportive measures. Thi...
Source: Am J Physiol Renal P... - February 15, 2024 Category: Urology & Nephrology Authors: Michal Mrug Elias Mrug Frida Rosenblum Jiandong Chen Xiangqin Cui Anupam Agarwal Abolfazl Zarjou Source Type: research
Distinct Developmental Reprogramming Footprint of MacrophagesDuring Acute Kidney Injury Across Species
Am J Physiol Renal Physiol. 2024 Feb 15. doi: 10.1152/ajprenal.00013.2024. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is a common finding in hospitalized patients, particularly those who are critically ill. Development of AKI is associated with several adverse outcomes including mortality, morbidity, progression to chronic kidney disease, and increase in health care expenditure. Despite the well-established negative impact of AKI and rigorous efforts to better define, identify, and implement targeted therapies, the overall approach to treatment of AKI continues to principally encompass supportive measures. Thi...
Source: Am J Physiol Renal P... - February 15, 2024 Category: Urology & Nephrology Authors: Michal Mrug Elias Mrug Frida Rosenblum Jiandong Chen Xiangqin Cui Anupam Agarwal Abolfazl Zarjou Source Type: research
