A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00205.2023. Online ahead of print.ABSTRACTOur research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially reversing cyst growth and disease progression. The ketone ß-hydroxybutyrate (BHB) appears to underlie this effect. Additionally, we have demonstrated that naturally formed microcrystals within kidney tubules trigger a renoprotective response that facilitates tubular obstruction clearance in healthy animals but, alternatively, leads to cyst...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jacob A Torres Nickolas Holznecht David A Asplund Tselmeg Amarlkhagva Bradley Kroes Juliette Rebello Shagun Agrawal Thomas Weimbs Source Type: research
Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
L-carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells
In conclusion, carnitine insufficiency may be closely associated with severe heat-related illness and related AKI. Enhancement of the FAO pathway by L-carnitine pretreatment may prevent heat stress-induced AKI by restoring mitochondrial function.PMID:38095023 | DOI:10.1152/ajprenal.00196.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Hiroyasu Goto Hiroyuki Nakashima Kazuma Mori Keiko Tanoue Seigo Ito Bradley M Kearney Azusa Kato Masahiro Nakashima Toshihiko Imakiire Hiroo Kumagai Manabu Kinoshita Naoki Oshima Source Type: research
Beast of (renal) Burden? Bst1 expressing neutrophils in kidney injury
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00386.2023. Online ahead of print.NO ABSTRACTPMID:38095024 | DOI:10.1152/ajprenal.00386.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jason A Collett David P Basile Source Type: research
A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00205.2023. Online ahead of print.ABSTRACTOur research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially reversing cyst growth and disease progression. The ketone ß-hydroxybutyrate (BHB) appears to underlie this effect. Additionally, we have demonstrated that naturally formed microcrystals within kidney tubules trigger a renoprotective response that facilitates tubular obstruction clearance in healthy animals but, alternatively, leads to cyst...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jacob A Torres Nickolas Holznecht David A Asplund Tselmeg Amarlkhagva Bradley Kroes Juliette Rebello Shagun Agrawal Thomas Weimbs Source Type: research
Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research
Angiotensin II acts through Rac1 to upregulate pendrin: Role of NADPH oxidase
This study explored the role of the small GTPase, Rac1, in pendrin's regulation by angiotensin II. To do this, we generated intercalated cell Rac1 knockout mice and observed that IC Rac1 gene ablation reduced pendrin's relative abundance in the apical region of intercalated cells in angiotensin II-treated, but not from vehicle-treated mice. Similarly, the Rac1 inhibitor, EHT 1864, reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Truyen D Pham Jill W Verlander Chao Chen Vladimir Pech Hailey I Kim Young Hee Kim I David Weiner Ginger L Milne Roy Zent Fabian Bock Dennis Brown Amity Eaton Susan M Wall Source Type: research
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension
Conclusion: A FHS diet enhances the sensitivity of proximal tubule O2- production to Ang II, and this contributes to fructose-induced salt-sensitive hypertension.PMID:38059297 | DOI:10.1152/ajprenal.00289.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Beau R Forester Autumn Brostek Brett Schuhler Agustin Gonzalez-Vicente Jeffrey L Garvin Source Type: research
Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?
The objective of the present study was to investigate the mechanism of hyposthenuria in patients with sickle cell anemia. We performed an observational study of patients with homozygous SS sickle cell anemia and data available on the fasting plasma antidiuretic hormone (ADH) concentration. A total of 55 patients were analyzed. The fasting plasma ADH values ranged from 1.2 to 15.4 pg/mL, and 82% of the patients had elevated ADH values and low fasting urine osmolality (<505 mOsm/kg). Plasma ADH was negatively associated with plasma tonicity and natremia (P <0.001). None of the patients experienced polyuria and fasting ...
Source: Am J Physiol Renal P... - December 7, 2023 Category: Urology & Nephrology Authors: Quentin de Berny Camille Saint-Jacques Aline Santin Sarah Mattioni Olivier Steichen R émi Chieze Vincent Frochot Emmanuel Letavernier Francois Lionnet Jean-Philippe Haymann Source Type: research