Injury in non-aged podocyte as an accelerator of glomerular aging
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00344.2023. Online ahead of print.NO ABSTRACTPMID:38031730 | DOI:10.1152/ajprenal.00344.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Zhengying Fang Kyung Lee John Cijiang He Source Type: research
Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease
CONCLUSION: The single-cell platform CyTOF enables detection of significant changes in renal cells, especially in subsets of immune cells in ischemic human kidneys. Endogenous pro-repair cell types in RAS warrant future study for potential immune therapy.PMID:38031731 | DOI:10.1152/ajprenal.00234.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Xiang-Yang Zhu Nattawat Klomjit Aditya S Pawar Amrutesh S Puranik Zhi-Zhang Yang Esther Lutgens Alfonso Eirin Amir Lerman Stephen C Textor Lilach O Lerman Source Type: research
Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00162.2023. Online ahead of print.ABSTRACTProtease activated receptor 4 (PAR4) is a GPCR activated by thrombin. It not only contributes most of the platelet-derived thrombin, but also procoagulant microparticle formation, increased fibrin deposition, and initiation of platelet-stimulated inflammation. In addition, PAR4 is expressed on other cell types including endothelial cells. Under inflammatory conditions, PAR4 is overexpressed via epigenetic demethylation of the PAR4 gene, F2RL3. PAR4 knockout studies have determined a role for PAR4 in ischemia reperfusion...
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Kevin Erreger Shirong Cao Yu Pan Mengdi Jiang Ming-Zhi Zhang Raymond C Harris Heidi E Hamm Source Type: research
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy
In conclusion, first evidence is presented that pretreatment with an SGLT2 inhibitor can attenuate the AA-induced DNA damage response and subsequent nephropathy.PMID:38031729 | DOI:10.1152/ajprenal.00228.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Yuji Oe Young Chul Kim Viktoriya S Sidorenko Haiyan Zhang Sadhana Kanoo Natalia Lopez Helen A Goodluck Maria Crespo Masip Volker Vallon Source Type: research
Injury in non-aged podocyte as an accelerator of glomerular aging
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00344.2023. Online ahead of print.NO ABSTRACTPMID:38031730 | DOI:10.1152/ajprenal.00344.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Zhengying Fang Kyung Lee John Cijiang He Source Type: research
Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease
CONCLUSION: The single-cell platform CyTOF enables detection of significant changes in renal cells, especially in subsets of immune cells in ischemic human kidneys. Endogenous pro-repair cell types in RAS warrant future study for potential immune therapy.PMID:38031731 | DOI:10.1152/ajprenal.00234.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Xiang-Yang Zhu Nattawat Klomjit Aditya S Pawar Amrutesh S Puranik Zhi-Zhang Yang Esther Lutgens Alfonso Eirin Amir Lerman Stephen C Textor Lilach O Lerman Source Type: research
Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00162.2023. Online ahead of print.ABSTRACTProtease activated receptor 4 (PAR4) is a GPCR activated by thrombin. It not only contributes most of the platelet-derived thrombin, but also procoagulant microparticle formation, increased fibrin deposition, and initiation of platelet-stimulated inflammation. In addition, PAR4 is expressed on other cell types including endothelial cells. Under inflammatory conditions, PAR4 is overexpressed via epigenetic demethylation of the PAR4 gene, F2RL3. PAR4 knockout studies have determined a role for PAR4 in ischemia reperfusion...
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Kevin Erreger Shirong Cao Yu Pan Mengdi Jiang Ming-Zhi Zhang Raymond C Harris Heidi E Hamm Source Type: research
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy
In conclusion, first evidence is presented that pretreatment with an SGLT2 inhibitor can attenuate the AA-induced DNA damage response and subsequent nephropathy.PMID:38031729 | DOI:10.1152/ajprenal.00228.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Yuji Oe Young Chul Kim Viktoriya S Sidorenko Haiyan Zhang Sadhana Kanoo Natalia Lopez Helen A Goodluck Maria Crespo Masip Volker Vallon Source Type: research
Injury in non-aged podocyte as an accelerator of glomerular aging
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00344.2023. Online ahead of print.NO ABSTRACTPMID:38031730 | DOI:10.1152/ajprenal.00344.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Zhengying Fang Kyung Lee John Cijiang He Source Type: research
Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease
CONCLUSION: The single-cell platform CyTOF enables detection of significant changes in renal cells, especially in subsets of immune cells in ischemic human kidneys. Endogenous pro-repair cell types in RAS warrant future study for potential immune therapy.PMID:38031731 | DOI:10.1152/ajprenal.00234.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Xiang-Yang Zhu Nattawat Klomjit Aditya S Pawar Amrutesh S Puranik Zhi-Zhang Yang Esther Lutgens Alfonso Eirin Amir Lerman Stephen C Textor Lilach O Lerman Source Type: research
Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00162.2023. Online ahead of print.ABSTRACTProtease activated receptor 4 (PAR4) is a GPCR activated by thrombin. It not only contributes most of the platelet-derived thrombin, but also procoagulant microparticle formation, increased fibrin deposition, and initiation of platelet-stimulated inflammation. In addition, PAR4 is expressed on other cell types including endothelial cells. Under inflammatory conditions, PAR4 is overexpressed via epigenetic demethylation of the PAR4 gene, F2RL3. PAR4 knockout studies have determined a role for PAR4 in ischemia reperfusion...
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Kevin Erreger Shirong Cao Yu Pan Mengdi Jiang Ming-Zhi Zhang Raymond C Harris Heidi E Hamm Source Type: research
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy
In conclusion, first evidence is presented that pretreatment with an SGLT2 inhibitor can attenuate the AA-induced DNA damage response and subsequent nephropathy.PMID:38031729 | DOI:10.1152/ajprenal.00228.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Yuji Oe Young Chul Kim Viktoriya S Sidorenko Haiyan Zhang Sadhana Kanoo Natalia Lopez Helen A Goodluck Maria Crespo Masip Volker Vallon Source Type: research
Injury in non-aged podocyte as an accelerator of glomerular aging
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00344.2023. Online ahead of print.NO ABSTRACTPMID:38031730 | DOI:10.1152/ajprenal.00344.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Zhengying Fang Kyung Lee John Cijiang He Source Type: research
Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease
CONCLUSION: The single-cell platform CyTOF enables detection of significant changes in renal cells, especially in subsets of immune cells in ischemic human kidneys. Endogenous pro-repair cell types in RAS warrant future study for potential immune therapy.PMID:38031731 | DOI:10.1152/ajprenal.00234.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Xiang-Yang Zhu Nattawat Klomjit Aditya S Pawar Amrutesh S Puranik Zhi-Zhang Yang Esther Lutgens Alfonso Eirin Amir Lerman Stephen C Textor Lilach O Lerman Source Type: research
Role of protease activated receptor 4 (PAR4) in mouse models of acute and chronic kidney injury
Am J Physiol Renal Physiol. 2023 Nov 30. doi: 10.1152/ajprenal.00162.2023. Online ahead of print.ABSTRACTProtease activated receptor 4 (PAR4) is a GPCR activated by thrombin. It not only contributes most of the platelet-derived thrombin, but also procoagulant microparticle formation, increased fibrin deposition, and initiation of platelet-stimulated inflammation. In addition, PAR4 is expressed on other cell types including endothelial cells. Under inflammatory conditions, PAR4 is overexpressed via epigenetic demethylation of the PAR4 gene, F2RL3. PAR4 knockout studies have determined a role for PAR4 in ischemia reperfusion...
Source: Am J Physiol Renal P... - November 30, 2023 Category: Urology & Nephrology Authors: Kevin Erreger Shirong Cao Yu Pan Mengdi Jiang Ming-Zhi Zhang Raymond C Harris Heidi E Hamm Source Type: research
