Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
L-carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells
In conclusion, carnitine insufficiency may be closely associated with severe heat-related illness and related AKI. Enhancement of the FAO pathway by L-carnitine pretreatment may prevent heat stress-induced AKI by restoring mitochondrial function.PMID:38095023 | DOI:10.1152/ajprenal.00196.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Hiroyasu Goto Hiroyuki Nakashima Kazuma Mori Keiko Tanoue Seigo Ito Bradley M Kearney Azusa Kato Masahiro Nakashima Toshihiko Imakiire Hiroo Kumagai Manabu Kinoshita Naoki Oshima Source Type: research
Beast of (renal) Burden? Bst1 expressing neutrophils in kidney injury
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00386.2023. Online ahead of print.NO ABSTRACTPMID:38095024 | DOI:10.1152/ajprenal.00386.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jason A Collett David P Basile Source Type: research
A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00205.2023. Online ahead of print.ABSTRACTOur research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially reversing cyst growth and disease progression. The ketone ß-hydroxybutyrate (BHB) appears to underlie this effect. Additionally, we have demonstrated that naturally formed microcrystals within kidney tubules trigger a renoprotective response that facilitates tubular obstruction clearance in healthy animals but, alternatively, leads to cyst...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jacob A Torres Nickolas Holznecht David A Asplund Tselmeg Amarlkhagva Bradley Kroes Juliette Rebello Shagun Agrawal Thomas Weimbs Source Type: research
Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
L-carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells
In conclusion, carnitine insufficiency may be closely associated with severe heat-related illness and related AKI. Enhancement of the FAO pathway by L-carnitine pretreatment may prevent heat stress-induced AKI by restoring mitochondrial function.PMID:38095023 | DOI:10.1152/ajprenal.00196.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Hiroyasu Goto Hiroyuki Nakashima Kazuma Mori Keiko Tanoue Seigo Ito Bradley M Kearney Azusa Kato Masahiro Nakashima Toshihiko Imakiire Hiroo Kumagai Manabu Kinoshita Naoki Oshima Source Type: research
Beast of (renal) Burden? Bst1 expressing neutrophils in kidney injury
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00386.2023. Online ahead of print.NO ABSTRACTPMID:38095024 | DOI:10.1152/ajprenal.00386.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jason A Collett David P Basile Source Type: research
A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00205.2023. Online ahead of print.ABSTRACTOur research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially reversing cyst growth and disease progression. The ketone ß-hydroxybutyrate (BHB) appears to underlie this effect. Additionally, we have demonstrated that naturally formed microcrystals within kidney tubules trigger a renoprotective response that facilitates tubular obstruction clearance in healthy animals but, alternatively, leads to cyst...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jacob A Torres Nickolas Holznecht David A Asplund Tselmeg Amarlkhagva Bradley Kroes Juliette Rebello Shagun Agrawal Thomas Weimbs Source Type: research
Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
L-carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells
In conclusion, carnitine insufficiency may be closely associated with severe heat-related illness and related AKI. Enhancement of the FAO pathway by L-carnitine pretreatment may prevent heat stress-induced AKI by restoring mitochondrial function.PMID:38095023 | DOI:10.1152/ajprenal.00196.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Hiroyasu Goto Hiroyuki Nakashima Kazuma Mori Keiko Tanoue Seigo Ito Bradley M Kearney Azusa Kato Masahiro Nakashima Toshihiko Imakiire Hiroo Kumagai Manabu Kinoshita Naoki Oshima Source Type: research
Beast of (renal) Burden? Bst1 expressing neutrophils in kidney injury
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00386.2023. Online ahead of print.NO ABSTRACTPMID:38095024 | DOI:10.1152/ajprenal.00386.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jason A Collett David P Basile Source Type: research
A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00205.2023. Online ahead of print.ABSTRACTOur research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially reversing cyst growth and disease progression. The ketone ß-hydroxybutyrate (BHB) appears to underlie this effect. Additionally, we have demonstrated that naturally formed microcrystals within kidney tubules trigger a renoprotective response that facilitates tubular obstruction clearance in healthy animals but, alternatively, leads to cyst...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jacob A Torres Nickolas Holznecht David A Asplund Tselmeg Amarlkhagva Bradley Kroes Juliette Rebello Shagun Agrawal Thomas Weimbs Source Type: research
Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00343.2023. Online ahead of print.ABSTRACTVasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involve...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: H éctor Carbajal-Contreras Adrian Rafael Murillo-de-Ozores Germ án Magaña-Avila Alejandro Marquez-Salinas Laurent Bourqui Michelle Tellez-Sutterlin Jessica P Bahena-Lopez Eduardo Cortes-Arroyo Sebasti án González-Behn-Eschemburg Alejandro Lopez-Saave Source Type: research
L-carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells
In conclusion, carnitine insufficiency may be closely associated with severe heat-related illness and related AKI. Enhancement of the FAO pathway by L-carnitine pretreatment may prevent heat stress-induced AKI by restoring mitochondrial function.PMID:38095023 | DOI:10.1152/ajprenal.00196.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Hiroyasu Goto Hiroyuki Nakashima Kazuma Mori Keiko Tanoue Seigo Ito Bradley M Kearney Azusa Kato Masahiro Nakashima Toshihiko Imakiire Hiroo Kumagai Manabu Kinoshita Naoki Oshima Source Type: research
Beast of (renal) Burden? Bst1 expressing neutrophils in kidney injury
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00386.2023. Online ahead of print.NO ABSTRACTPMID:38095024 | DOI:10.1152/ajprenal.00386.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jason A Collett David P Basile Source Type: research
